LOCUS       NM_009518               1977 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus wingless-type MMTV integration site family, member 10A
            (Wnt10a), mRNA.
ACCESSION   NM_009518
VERSION     NM_009518.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1977)
  AUTHORS   Sun,K., Yu,M., Wang,J., Zhao,H., Liu,H., Feng,H., Liu,Y. and Han,D.
  TITLE     A Wnt10a-Notch signaling axis controls Hertwig's epithelial root
            sheath cell behaviors during root furcation patterning
  JOURNAL   Int J Oral Sci 16 (1), 25 (2024)
   PUBMED   38480698
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1977)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1977)
  AUTHORS   Raju,R., Pina,J.O., Roth,D.M., Chattaraj,P., Kidwai,F.K.,
            Faucz,F.R., Iben,J., Fridell,G., Dale,R.K. and D'Souza,R.N.
  TITLE     Profiles of Wnt pathway gene expression during tooth morphogenesis
  JOURNAL   Front Physiol 14, 1316635 (2024)
   PUBMED   38274045
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1977)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1977)
  AUTHORS   Mitsiadis,T.A., Pagella,P., Gomes Rodrigues,H., Tsouknidas,A.,
            Ramenzoni,L.L., Radtke,F., Mehl,A. and Viriot,L.
  TITLE     Notch Signaling Pathway in Tooth Shape Variations throughout
            Evolution
  JOURNAL   Cells 12 (5), 761 (2023)
   PUBMED   36899896
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1977)
  AUTHORS   Pispa,J., Jung,H.S., Jernvall,J., Kettunen,P., Mustonen,T.,
            Tabata,M.J., Kere,J. and Thesleff,I.
  TITLE     Cusp patterning defect in Tabby mouse teeth and its partial rescue
            by FGF
  JOURNAL   Dev Biol 216 (2), 521-534 (1999)
   PUBMED   10642790
REFERENCE   7  (bases 1 to 1977)
  AUTHORS   Uusitalo,M., Heikkila,M. and Vainio,S.
  TITLE     Molecular genetic studies of Wnt signaling in the mouse
  JOURNAL   Exp Cell Res 253 (2), 336-348 (1999)
   PUBMED   10585256
  REMARK    Review article
REFERENCE   8  (bases 1 to 1977)
  AUTHORS   Loureiro,J.J.
  TITLE     The Wnts
  JOURNAL   Curr Biol 9 (1), R4 (1999)
   PUBMED   9889131
REFERENCE   9  (bases 1 to 1977)
  AUTHORS   Dassule,H.R. and McMahon,A.P.
  TITLE     Analysis of epithelial-mesenchymal interactions in the initial
            morphogenesis of the mammalian tooth
  JOURNAL   Dev Biol 202 (2), 215-227 (1998)
   PUBMED   9769173
REFERENCE   10 (bases 1 to 1977)
  AUTHORS   Wang,J. and Shackleford,G.M.
  TITLE     Murine Wnt10a and Wnt10b: cloning and expression in developing
            limbs, face and skin of embryos and in adults
  JOURNAL   Oncogene 13 (7), 1537-1544 (1996)
   PUBMED   8875992
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U61969.1.
            
            On May 1, 2009 this sequence version replaced NM_009518.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014737.1, U61969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1977              U61969.1           511-2487
FEATURES             Location/Qualifiers
     source          1..1977
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.54 cM"
     gene            1..1977
                     /gene="Wnt10a"
                     /note="wingless-type MMTV integration site family, member
                     10A"
                     /db_xref="GeneID:22409"
                     /db_xref="MGI:MGI:108071"
     exon            1..265
                     /gene="Wnt10a"
                     /inference="alignment:Splign:2.1.0"
     CDS             153..1406
                     /gene="Wnt10a"
                     /note="protein Wnt-10a; wingless related MMTV integration
                     site 10a"
                     /codon_start=1
                     /product="protein Wnt-10a precursor"
                     /protein_id="NP_033544.1"
                     /db_xref="CCDS:CCDS15057.1"
                     /db_xref="GeneID:22409"
                     /db_xref="MGI:MGI:108071"
                     /translation="MGSAHPRPWLRLPQGPQPRPEFWALLFFLLLLAAAVPRSAPNDI
                     LGLRLPPEPVLNANTVCLTLPGLSRRQMEVCVRHPDVAASAIQGIQIAIHECQHQFRD
                     QRWNCSSLETRNKVPYESPIFSRGFRESAFAYAIAAAGVVHAVSNACALGKLKACGCD
                     ASRRGDEEAFRRKLHRLQLDALQRGKGLSHGVPEHPAILPASPGLQDSWEWGGCSPDV
                     GFGERFSKDFLDSREPHRDIHARMRLHNNRVGRQAVMENMRRKCKCHGTSGSCQLKTC
                     WQVTPEFRTVGALLRNRFHRATLIRPHNRNGGQLEPGPAGAPSPAPGTPGLRRRASHS
                     DLVYFEKSPDFCEREPRLDSAGTVGRLCNKSSTGPDGCGSMCCGRGHNILRQTRSERC
                     HCRFHWCCFVVCEECRITEWVSVCK"
     exon            266..528
                     /gene="Wnt10a"
                     /inference="alignment:Splign:2.1.0"
     exon            529..908
                     /gene="Wnt10a"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1962
                     /gene="Wnt10a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1941..1946
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnt10a"
                     /note="hexamer: AATAAA"
     polyA_site      1962
                     /gene="Wnt10a"
                     /note="major polyA site"
ORIGIN      
        1 ggcgggcgcc gtctgctgcg ggagctgtga cctgagtagg agctgtgtgt cgcagccgcc
       61 ccacccctgc cgatcatgcg ccggcgaccc tggttcgcca gtcccactgg gctgtgagcc
      121 ccccactcct ggcctgtcac ggcccgcgcg ccatgggcag cgcccaccct cgcccctggc
      181 tgcggctccc acaagggccc cagccgcggc ctgagttctg ggcgctcctg ttcttcctac
      241 tgctgctggc tgccgctgtg cccaggtcag cacccaacga catcctgggc ctccgcctac
      301 ccccagagcc cgtgctcaac gccaacacag tgtgcctgac attgcccggc ctgagccggc
      361 ggcagatgga ggtgtgtgtg cgtcaccctg acgtggccgc ctctgctatc cagggcatcc
      421 agatcgccat ccatgagtgc cagcatcagt tccgggacca gcgctggaac tgctccagcc
      481 tggagactcg gaacaaagtc ccctacgaga gccccatctt cagccgaggt tttcgagaga
      541 gtgctttcgc ctacgccata gcagctgccg gggtggtgca cgcagtgtcc aacgcgtgcg
      601 ctctgggtaa actgaaggct tgcggttgcg acgcctccag acgtggggac gaagaagctt
      661 tccgtcggaa gctgcaccgc ttgcagctgg acgcgctgca gcgcggaaag ggcttgagcc
      721 acggggtccc tgaacacccg gccatacttc ctgccagccc aggtctgcag gactcctggg
      781 agtggggtgg ctgcagtccg gatgtgggct tcggagaacg cttctctaag gactttctgg
      841 actcccgaga gcctcacaga gacatccatg ctcgaatgag actccacaac aaccgtgtgg
      901 gccggcaggc ggtgatggag aacatgcggc gtaagtgcaa atgccacggc acctcaggca
      961 gctgccagct caagacctgc tggcaggtga cgcctgagtt ccgcacagta ggggcgctgc
     1021 tgcgcaaccg cttccaccgc gccacgctca tccggccgca caaccgcaac ggtggccagc
     1081 tggagcccgg ccccgcggga gcaccctcgc cagcaccggg cactccaggg ctgcgccgca
     1141 gggccagcca ctccgacctg gtctactttg agaaatctcc cgacttctgt gagcgcgagc
     1201 cgcgcctgga ctcggcaggc actgtgggcc gcctgtgcaa taagagcagc acgggtcccg
     1261 atggctgcgg cagcatgtgc tgtggccgcg gccacaacat tctgcgccag acgcgcagcg
     1321 agcgctgcca ctgccggttc cactggtgct gcttcgtggt ctgcgaagaa tgccgcatca
     1381 ccgagtgggt cagcgtctgc aagtgagcag acccaagctc ctctgggtct caagaatggt
     1441 tgtcctcttg gtgcctggct tctgccgcta gcggatctga gccaggcagc aagcagcagc
     1501 cttggctcct gagagaggtg gttggctctt acagccccga gggtctacaa tcaccagaca
     1561 gtccagatct gattgacatt cctccgctca cctctgtagg ttcccctctt tctgttccta
     1621 gctcagacag ctgggggtga tagtggagac tgttccacac cctaggacag gtcaccaaag
     1681 cagcccagcc tggcatgcct acctcctgtc atctcttctt cccttcccca ggagtgatag
     1741 gcaatgcact gaagctgatg ggcaccgggg aagaaaacta aaaggcagaa atggccgtca
     1801 tcgggctgaa gtgactctaa gggctccaga cctctgctcc tgtctttcac ttaacagata
     1861 tttatttttg cgctctcttt gagacactct ctggggaaaa agaagctccg gagtctacag
     1921 gctgattaag ggacatggac aataaaccag taaacacaca aaaaaaaaaa aaaaaaa
//
