LOCUS       NM_001290313            7202 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WNK lysine deficient protein kinase 2 (Wnk2),
            transcript variant 2, mRNA.
ACCESSION   NM_001290313 XM_006516972
VERSION     NM_001290313.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7202)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 7202)
  AUTHORS   Izadifar,A., Courchet,J., Virga,D.M., Verreet,T., Hamilton,S.,
            Ayaz,D., Misbaer,A., Vandenbogaerde,S., Monteiro,L., Petrovic,M.,
            Sachse,S., Yan,B., Erfurth,M.L., Dascenco,D., Kise,Y., Yan,J.,
            Edwards-Faret,G., Lewis,T., Polleux,F. and Schmucker,D.
  TITLE     Axon morphogenesis and maintenance require an evolutionary
            conserved safeguard function of Wnk kinases antagonizing Sarm and
            Axed
  JOURNAL   Neuron 109 (18), 2864-2883 (2021)
   PUBMED   34384519
REFERENCE   3  (bases 1 to 7202)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7202)
  AUTHORS   Dutruel,C., Bergmann,F., Rooman,I., Zucknick,M., Weichenhan,D.,
            Geiselhart,L., Kaffenberger,T., Rachakonda,P.S., Bauer,A.,
            Giese,N., Hong,C., Xie,H., Costello,J.F., Hoheisel,J., Kumar,R.,
            Rehli,M., Schirmacher,P., Werner,J., Plass,C., Popanda,O. and
            Schmezer,P.
  TITLE     Early epigenetic downregulation of WNK2 kinase during pancreatic
            ductal adenocarcinoma development
  JOURNAL   Oncogene 33 (26), 3401-3410 (2014)
   PUBMED   23912455
REFERENCE   5  (bases 1 to 7202)
  AUTHORS   Rinehart,J., Vazquez,N., Kahle,K.T., Hodson,C.A., Ring,A.M.,
            Gulcicek,E.E., Louvi,A., Bobadilla,N.A., Gamba,G. and Lifton,R.P.
  TITLE     WNK2 kinase is a novel regulator of essential neuronal
            cation-chloride cotransporters
  JOURNAL   J Biol Chem 286 (34), 30171-30180 (2011)
   PUBMED   21733846
REFERENCE   6  (bases 1 to 7202)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BM941970.1, AK147550.1, AC160126.2, BC060187.1 and AI464179.1.
            
            On Mar 12, 2014 this sequence version replaced XM_006516972.1.
            
            Transcript Variant: This variant (2) contains alternate 3' exon
            structure, and it thus differs in the 3' coding region and 3' UTR,
            compared to variant 1. The encoded isoform (b) has a distinct
            C-terminus and is shorter than isoform a. This variant is partially
            supported by the mRNA BC060187.1; the 5' exon structure is inferred
            based on other transcript alignments at this gene.
            
            CCDS Note: This CCDS representation is partially supported by the
            mRNA BC060187.1. The 5' exon structure is inferred based on other
            transcript alignments at this gene.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               BM941970.1         1-316
            317-974             AK147550.1         4-661
            975-975             AC160126.2         209152-209152       c
            976-2969            AK147550.1         663-2656
            2970-7189           BC060187.1         1-4220
            7190-7202           AI464179.1         1-13                c
FEATURES             Location/Qualifiers
     source          1..7202
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 25.07 cM"
     gene            1..7202
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /note="WNK lysine deficient protein kinase 2"
                     /db_xref="GeneID:75607"
                     /db_xref="MGI:MGI:1922857"
     exon            1..567
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1250
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     CDS             570..7019
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /EC_number="2.7.11.1"
                     /note="isoform b is encoded by transcript variant 2;
                     serine/threonine-protein kinase WNK2; protein kinase with
                     no lysine 2; protein kinase lysine-deficient 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase WNK2 isoform b"
                     /protein_id="NP_001277242.1"
                     /db_xref="CCDS:CCDS70455.1"
                     /db_xref="GeneID:75607"
                     /db_xref="MGI:MGI:1922857"
                     /translation="MDGDGGRRDAPGALMEAGRGTGSAGMAEPRARAARLGPQRFLRR
                     SVVESDQEEPPGLEAAETPSAQPPQPLQRRVLLLCKTRRLIAERARGRPAAPAPAAPA
                     APPGSPSVPSDPGPERAGTQEPSPDPTTASAAAAQVPDGGPRQEEAPAPTQEDAGTTE
                     AKPEPGRARKDEPEEEEDDEDDLKAVATSLDGRFLKFDIELGRGSFKTVYKGLDTETW
                     VEVAWCELQDRKLTKLERQRFKEEAEMLKGLQHPNIVRFYDFWESSAKGKRCIVLVTE
                     LMTSGTLKTYLKRFKVMKPKVLRSWCRQILKGLLFLHTRTPPIIHRDLKCDNIFITGP
                     TGSVKIGDLGLATLKRASFAKSVIGTPEFMAPEMYEEHYDESVDVYAFGMCMLEMATS
                     EYPYSECQNAAQIYRKVTCGIKPASFEKVHDPEIKEIIGECICKNKEERYEIKDLLSH
                     AFFAEDTGVRVELAEEDHGRKSTIALRLWVEDPKKLKGKPKDNGAIEFTFDLEKETPD
                     EVAQEMIDSGFFHESDVKIVAKSIRDRVALIQWRRERIWPALQSQEPKDSGSPDKARG
                     LPAPLQVQVTYHAQSGQPGQPEPEEPEADQHLLPPTLPASVTSLASDSTFDSGQGSTV
                     YSDSQSSQQSMVLSSLVDTAPTPASCVCSPPVSEGPGLTHSLPTLGAFQQPATVPGLS
                     VGPVPPPARPPLLQQHFPESSMSFTPVLPPPSTPVPTGPSQPAPPVQQPLPMAQPPTL
                     PQVLAPQPMGTVQPVPSHLPPYLAPTSQVVAPAQLKPLQMPQPPLQPLAQVPPQMPQM
                     PVVPPITPLTGLDGLPQTLTDLPAANVAPVPPPQYFSPAVILPSLTTPLPTSPALPMQ
                     AVKLPHPPGTPLAVPCQTIVPNAPAAIPLLAVAPQGVAALSIHPAVAQIPAQPVYPAA
                     FPQMVPGDIPPSPHHTVQSLRATPPQLASPVPPQPVQPSVIHLPEQAAPTAASGTQVL
                     LGHPPSYTADVAAPVSAVSLPPAVLSPPLPDTLLPTVPDLLPKVPSSLAPTVVAASQS
                     APAQTSSLLLPTNPPLPTGPAVAGPCPAVQLMVEVAQEEQVSQDKPPGPPQSSESFGG
                     SDVTSGRDLSDSCEGTFGGGRLEGRTARKHHRRSTRARSRQERASRPRLTILNVCNTG
                     DKMVECQLETHNHKMVTFKFDLDGDAPDEIATYMVEHDFILPAERETFIEQMKDVMDK
                     AEDMLSEDTDADHGSDTGTSPPHLGTCGLATGEENRQSQANAPVYQQNVLHTGKRWFI
                     ICPVAEHPATDTSESSPPLPLSSLQPEASQDPAPYPDQLSLTDKPSFPAAQQLLSQAG
                     SSNPPGGASAPLAPSSPPVTTVIPAAPATSTVPESAAGTAMQAGGPGTHQGPASVHET
                     LQPLAETRSAQCTAQPLSTGQGPCTPALEASRCSTGLGEPISTREVSTQGEPLPASVP
                     EPSPPTGATQSVPGQPPPPLPITVGAISLAAPQLPSPPLGPTAPPPPPSALESDGEGP
                     PPRVGFVDNTIKSLDEKLRTLLYQEHVPTSSASAGTPMEASDRDFTLEPLRGDLPSAL
                     SDKTPSLTQQTQPSLEKSETAPAGWALAQREQGASSPMTAESSSSNTLGCDSDAGQVA
                     SDSSTAPSVPQDASGSSVPTHMDPKDQNSSVPREALAAPMQSGPGSFTVGSPAQLRGA
                     RDSGSPHKRPGQQDNSSPAKTVGRFSVVSTQDEWTLASPHSLRYSAPPDVYLDEIPSS
                     PEVKLAVRRVQTASSIEVGVEEPASSDSGDERPRRRSQVQKQSSLPGTGGVASDFVKK
                     ATAFLHRSSRAGSLGPETPSRAGVKVPTISITSFHSQSSYISSDNDSEFEDADIKKEL
                     RSLREKHLKEISELQSQQKQEIEALYRRLGKPLPPNVGFFHTAPPMGRRRKTSKSKLK
                     AGKLLNPLVQQLKVVASSTGHLSDSSRGPPTKDPAHASTPPGTKAVQTQQPCSVRASL
                     STDICSGLASDGGGARGQGWTVYHPTSERGAYKSSSKPRARFLSGPVSVSIWSALKRL
                     CLGKEHSSRSSTSSLAPGPEPGPQPTLHVQAQVNNSNNKKGTFTDDLHKLVDEWTTKT
                     VGAAQVKPTLNQLKQTQKLHDMEASGDARATSVPRAAVGASCLAPAPGPLSTTATPGA
                     TPALPVPIPDPESEKPD"
     exon            1251..1423
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1644
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1802
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1891
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..2111
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            2112..2403
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..2603
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            2604..2759
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2951
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3479
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            3480..3773
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            3774..3823
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            3824..3992
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            3993..4109
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            4110..4280
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            4281..4326
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            4327..4446
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            4447..5267
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            5268..5343
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            5344..5432
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            5433..6112
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            6113..6327
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            6328..6498
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            6499..6597
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            6598..6642
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            6643..6881
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            6882..6993
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     exon            6994..7197
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7170..7175
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /note="hexamer: AATAAA"
     polyA_site      7197
                     /gene="Wnk2"
                     /gene_synonym="1810073P09Rik; ESTM15; mKIAA1760"
                     /note="major polyA site"
ORIGIN      
        1 acctaggata tcctgaggtt gtctgttttg tcttggcata ggttccagga tttggctctc
       61 tggctaagtc acgttgtctg tggcctgcca cctccgggga aaatagagcc cctcaaggcc
      121 ccacagttca gcggaccact tccaaagagc ttcagggcca ggcgccggcc tggaaccctt
      181 gccgcaggtg gaggccatgg ggagcatccc gcaggtggcg gcgctcagcc gcagccaggt
      241 gggcgtgtca ggccccgccc cgcgctccgg tcttggggag ggtgggacga acggaagccc
      301 cgccctcccc gcgcgctagt tcggagccgg tgcgggagcg gaggcgcgcg gagccggcag
      361 gagcacgcgg gagcgcggcc ccgcagcggc ccggcccgag ggagcagcat cgtaggagca
      421 gaacggcctg gcgacccccg ctgcagccag gaccccgccc cagcgcgacg cggccccgag
      481 agaggactct ggccccggag cgcggcctcg ccctcctcgc tcgcccgggt ccccgggctg
      541 cgggcatgga cagcgcccgc tcgccctaga tggacggcga tggcggccgc cgagacgccc
      601 ccggcgcgct gatggaagcc gggcgcggca cggggtcggc gggcatggcg gagccgcggg
      661 cgagggcggc gcggctcggg ccccagcgct tcctgcggcg cagcgtggtg gagtcggacc
      721 aggaggagcc gccgggcctg gaggcggccg agacgccgag cgcgcagccc ccacagcctc
      781 tgcagcgcag ggtgcttcta ctctgcaaga cgcgccggct catcgcggag cgcgcccggg
      841 gccgccccgc cgcgcccgcg cccgccgcgc ccgctgcgcc tcccggctcc ccgagtgtcc
      901 cctcggaccc tggcccggag cgagcgggca cgcaggagcc cagcccagat cccaccaccg
      961 cctcagccgc agccgcgcag gtccccgacg gcggcccgag gcaggaagag gcgccggccc
     1021 caacacagga ggacgctgga accaccgagg caaagccgga gcccgggcgc gcacgcaagg
     1081 atgaacctga agaggaggaa gacgatgagg acgacctcaa ggccgtggcc acctctttgg
     1141 acggccgctt cctcaagttc gacatcgagc tgggccgggg ctccttcaag acggtctaca
     1201 aggggctgga cacggagacc tgggtggagg tagcatggtg tgaactgcag gaccggaagc
     1261 tcaccaagct tgaacggcag agattcaaag aggaggcgga gatgctgaaa ggtctacagc
     1321 accccaacat tgtgcgcttc tatgacttct gggagtccag tgccaagggc aagcgatgta
     1381 tcgtgctggt gacagagctg atgacctcgg gtacactgaa gacgtacctg aagcggttca
     1441 aggtgatgaa gccgaaggta ctgaggagct ggtgccggca gatcctgaag ggcctgctgt
     1501 tcctgcatac aaggacaccc cccatcatcc accgtgacct caagtgtgac aacatcttca
     1561 tcactgggcc caccggctct gtgaagattg gtgacttggg tctggccacc cttaaaagag
     1621 cgtcttttgc caaaagtgtg ataggtaccc ccgagttcat ggcacctgaa atgtacgagg
     1681 aacattacga cgagtcggtt gatgtctacg ccttcgggat gtgcatgctg gaaatggcta
     1741 cctcagagta cccctattcg gagtgccaga acgccgccca gatctatcgc aaggtcacct
     1801 gtggcatcaa accggccagc ttcgagaagg tgcatgatcc ggagattaag gagatcatcg
     1861 gggagtgcat ctgtaagaac aaagaggaga ggtatgagat taaggacctg ctgagccatg
     1921 ccttcttcgc ggaagacacg ggtgtccggg tggaacttgc cgaggaggac catggcagga
     1981 agtctaccat agccctgcgg ctttgggtgg aagaccccaa gaagctgaag ggcaagccca
     2041 aagacaatgg agccatagag tttacctttg acttggagaa ggagactccc gacgaggtgg
     2101 cccaggaaat gatcgattct ggatttttcc atgagagtga tgtgaagatt gtggccaagt
     2161 ccatccgtga ccgggtggca ctgattcagt ggcggcgtga gaggatctgg cctgcactgc
     2221 agtctcagga gccaaaggac tctggcagcc ctgacaaggc caggggtctg ccagcacccc
     2281 tgcaggtcca ggtgacctac cacgcacaga gtgggcagcc tgggcagcca gaacctgagg
     2341 agcctgaggc cgaccagcat ctcctgcccc ctaccttgcc agctagcgtt acctccttag
     2401 cctcggacag cacctttgac agtggccagg gctctaccgt gtactcggac tcccagagca
     2461 gccagcagag catggtgctc agctcgcttg tggacacggc cccaacccca gcctcgtgcg
     2521 tgtgcagccc ccctgtgagt gaggggcctg gcctgaccca cagcctgcct acgctagggg
     2581 ccttccagca gccggccact gtgcctggcc tgtctgtggg ccctgtgcca ccccctgccc
     2641 gccctccact cctccagcag cattttccag aatcttccat gagcttcacc cctgtgctgc
     2701 caccacccag cacccctgtg cccacgggcc caagccagcc agcaccccca gtccagcagc
     2761 ctcttccaat ggcccaacca cctaccctgc cacaggtcct ggccccacag cccatgggca
     2821 ctgtccagcc agtaccctct catttgcctc catacctggc tccaacctcc caggtcgtgg
     2881 cccctgctca gctgaagcct ctccagatgc cacagccacc tctgcaacct cttgctcaag
     2941 tccctccgca gatgcctcag atgcctgtgg tcccccccat caccccctta acaggactcg
     3001 atggcctccc tcagaccctc actgacctgc cggccgcaaa cgtggccccc gtgccaccac
     3061 ctcagtattt ctcacctgct gtgatcttgc caagcctcac aacacccctg cccacatcac
     3121 cggccctgcc tatgcaggct gtcaagttgc ctcatccccc tggaacaccc ctggctgtgc
     3181 cctgtcagac catcgtgcca aatgcaccag ctgctatccc cctgttggcc gtggccccgc
     3241 agggtgtggc tgcactgtct atccatccag cggtggccca gatcccagcc cagcctgtgt
     3301 acccagcagc ctttccacag atggtacctg gagacatccc accctcaccc caccacacgg
     3361 tgcagagctt acgggccacc cctccacagc tggcctcacc tgtgcctcct cagcctgtcc
     3421 agcccagtgt cattcatcta cctgagcagg ctgctccaac tgctgcctca gggacccagg
     3481 tcctgctggg ccaccctcct tcatacaccg cggacgttgc tgctccagtc tctgctgtgt
     3541 ccctgccgcc tgctgtcctt tcccctcctc tgccagatac tctgctgcct actgtccctg
     3601 acctcctgcc caaggtcccc agctctctgg cccctacagt ggtcgcagcc tctcagagtg
     3661 cgcccgcaca gacctcttca ctcctcctgc caacaaaccc acccctgccc actgggcctg
     3721 cagttgctgg cccctgccct gcagtccagc tgatggtgga agtggctcaa gaggagcagg
     3781 tctcacaaga caaaccccct ggccccccac agagctccga gagctttgga ggttctgatg
     3841 tcacctctgg aagagatctg agtgacagct gtgaaggcac ctttggaggg ggcaggctgg
     3901 agggaaggac cgcccggaaa caccaccgta ggtccactcg tgcacgctcg cggcaggaga
     3961 gggccagccg gccccggctc actatcctaa atgtgtgtaa cacgggggac aagatggtgg
     4021 agtgtcagct ggaaacgcat aaccataaga tggtgacctt caagtttgac ctcgatgggg
     4081 acgctccgga tgagattgcc acgtacatgg tagagcatga ctttatcctg cccgctgagc
     4141 gagagacctt catcgagcag atgaaggatg tcatggacaa ggcagaagac atgctcagtg
     4201 aggacacaga tgctgaccat ggctctgata cagggaccag ccctccacac ctgggtacct
     4261 gtggtctggc cacgggggag gagaacagac agtcccaagc caatgcccct gtctaccagc
     4321 agaatgtctt acacacggga aagaggtggt ttatcatctg tccagtggct gaacacccag
     4381 caacagacac ttctgaatca tcacccccac ttcctctaag ctccttgcag ccagaagcca
     4441 gccaagaccc agcgccctat ccagaccagc tgtccttgac ggacaaacct agtttcccag
     4501 ctgctcagca gctcctgagc caggcaggct ccagcaaccc tcctggtgga gcatcagccc
     4561 ccttggcccc gtcttcccct cctgtgacta ctgtaatccc ggcagcacca gccaccagca
     4621 ccgtgccaga gtcagcagca gggactgcca tgcaggcagg aggtccaggg actcatcaag
     4681 gaccagccag tgtccatgag accctccagc cactggccga gacacgctct gcccagtgta
     4741 ctgcccagcc ccttagtact ggccaaggac cttgcacccc agctctggaa gcctctcgct
     4801 gctccacagg tctgggggag cccatctcaa ccagggaggt cagcactcaa ggagagcccc
     4861 tgcctgcttc agtgccagaa cctagccctc ccactggggc cacacaatct gtaccgggtc
     4921 agccaccacc cccactgccc atcacagtag gggctatcag tctggcagct ccccagctcc
     4981 ccagtccccc cctgggacct actgctcccc caccaccccc ctcagccttg gaatctgatg
     5041 gggaagggcc gccccctagg gtgggcttcg tggacaacac catcaagagt ctggatgaga
     5101 aactgcggac tctgctctac caggagcacg tgcccacctc ctcagcctca gctgggaccc
     5161 ccatggaggc aagcgataga gacttcaccc tggagcccct gcgaggagac cttccctcag
     5221 ccttgagtga caagacccca agcctcaccc agcagaccca gccctcattg gaaaagtctg
     5281 aaacggcccc tgcaggatgg gccctggccc agagggaaca gggtgcatct tctccaatga
     5341 cagcagagtc atcttccagc aatacactgg gctgtgacag tgacgcaggg caggtggcct
     5401 cggactcctc cacagcaccc agtgtccccc aggatgcctc tggttcttcc gtccctacac
     5461 acatggatcc caaagatcag aacagtagtg ttcccagaga agccttggca gcacccatgc
     5521 aaagtggccc agggtccttc acagtgggca gcccagccca gctgcgtggc gcccgggact
     5581 ccgggtctcc tcataagcgg ccagggcagc aggacaacag ttctccagcc aaaactgtag
     5641 ggcgcttttc cgtggtcagc acacaggacg agtggactct ggcgtcacct cacagcctgc
     5701 ggtactctgc cccacccgat gtctacctgg atgagatccc ctctagccct gaggtgaagc
     5761 tggcagtgcg gcgggtacag acagcctcct ccatcgaggt tggcgttgag gaacctgcct
     5821 ctagtgactc tggggatgaa cgcccaagaa ggaggtccca ggtgcagaag cagtcctccc
     5881 tgccgggtac tggtggtgtg gcaagtgact ttgtgaagaa ggccactgcc ttcctgcaca
     5941 ggtcttcaag ggctggctcg ctgggacctg agacacccag tagggcaggt gtgaaggtcc
     6001 ctaccatcag catcacctcc ttccactccc agtcatccta catcagcagt gacaatgact
     6061 cagagtttga ggatgcagac ataaagaagg aactgcgcag tctgcgagaa aagcacctga
     6121 aggaaatctc ggagctacag agccagcaga agcaggagat cgaagccctg taccgacgct
     6181 tgggcaagcc gctccctccc aatgtggggt tcttccacac tgcaccccct atgggccgca
     6241 ggaggaaaac cagcaagagc aaattgaagg ctggcaagct gctgaacccc ttggtgcaac
     6301 agctcaaggt cgtggcctcc agcacaggtc atttgtctga ctccagcaga ggccctccca
     6361 ctaaggaccc tgcccacgcc agcacgcccc cgggcaccaa ggcagttcag acccagcagc
     6421 cctgctccgt tcgggcctct ctgtccacag acatctgctc cggtttagcc agtgatggag
     6481 gcggagcgcg tggccaaggc tggacggttt accacccaac gtctgagaga ggggcctata
     6541 agtctagtag caagcctcgt gctcgattcc tcagtggacc cgtatctgtg tccatctggt
     6601 cagccctgaa gcgtctctgc ctaggcaaag aacacagcag taggtcttcc accagcagcc
     6661 tggccccagg ccctgagcca ggtccccagc ccaccctgca cgtccaggcg caggtgaaca
     6721 acagcaacaa caagaaaggc accttcacgg acgacctgca caagttggtg gacgagtgga
     6781 caacgaagac cgtgggggca gcgcaagtga agcccacgct caaccagctg aagcagacgc
     6841 agaagctgca cgacatggag gcctctggag acgctcgggc tacatctgtg cctcgagcag
     6901 cagtgggggc atcgtgtctg gccccggccc ctggccctct gtccaccaca gccactcctg
     6961 gagccactcc agccctgcct gtgcccatac cagatcctga gagtgaaaag cccgactgag
     7021 ccggcctcca cgccaggccc acactgcatc atccaggaga agaagcggca gaccccaggg
     7081 cagccactcc tctagtccat tcacgatgtt ttgtaaccac tttctaacca tttttttatt
     7141 cacaattgga aacacaaatg taatgcaaga ataaagcata ttttggggga gacaggaaaa
     7201 aa
//
