LOCUS       NM_001372227            6093 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus widely-interspaced zinc finger motifs (Wiz),
            transcript variant 4, mRNA.
ACCESSION   NM_001372227
VERSION     NM_001372227.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6093)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6093)
  AUTHORS   Bukova,I., Szczerkowska,K.I., Prochazkova,M., Beck,I.M.,
            Prochazka,J. and Sedlacek,R.
  TITLE     Loss of Wiz Function Affects Methylation Pattern in Palate
            Development and Leads to Cleft Palate
  JOURNAL   Front Cell Dev Biol 9, 620692 (2021)
   PUBMED   34150743
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6093)
  AUTHORS   Isbel,L., Prokopuk,L., Wu,H., Daxinger,L., Oey,H., Spurling,A.,
            Lawther,A.J., Hale,M.W. and Whitelaw,E.
  TITLE     Wiz binds active promoters and CTCF-binding sites and is required
            for normal behaviour in the mouse
  JOURNAL   Elife 5, e15082 (2016)
   PUBMED   27410475
  REMARK    GeneRIF: Chromatin immunoprecipitation-DNA sequence analysis was
            performed in adult cerebellum and Wiz peaks were found at promoters
            and transcription factor CTCF binding sites.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6093)
  AUTHORS   Daxinger,L., Harten,S.K., Oey,H., Epp,T., Isbel,L., Huang,E.,
            Whitelaw,N., Apedaile,A., Sorolla,A., Yong,J., Bharti,V.,
            Sutton,J., Ashe,A., Pang,Z., Wallace,N., Gerhardt,D.J.,
            Blewitt,M.E., Jeddeloh,J.A. and Whitelaw,E.
  TITLE     An ENU mutagenesis screen identifies novel and known genes involved
            in epigenetic processes in the mouse
  JOURNAL   Genome Biol 14 (9), R96 (2013)
   PUBMED   24025402
REFERENCE   5  (bases 1 to 6093)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   6  (bases 1 to 6093)
  AUTHORS   Ueda,J., Tachibana,M., Ikura,T. and Shinkai,Y.
  TITLE     Zinc finger protein Wiz links G9a/GLP histone methyltransferases to
            the co-repressor molecule CtBP
  JOURNAL   J Biol Chem 281 (29), 20120-20128 (2006)
   PUBMED   16702210
  REMARK    GeneRIF: Wiz plays a major role in G9a/GLP heterodimer formation in
            cultured stem cells.
REFERENCE   7  (bases 1 to 6093)
  AUTHORS   Baust,C., Baillie,G.J. and Mager,D.L.
  TITLE     Insertional polymorphisms of ETn retrotransposons include a
            disruption of the wiz gene in C57BL/6 mice
  JOURNAL   Mamm Genome 13 (8), 423-428 (2002)
   PUBMED   12226707
REFERENCE   8  (bases 1 to 6093)
  AUTHORS   Matsumoto,K., Ishii,N., Yoshida,S., Shiosaka,S., Wanaka,A. and
            Tohyama,M.
  TITLE     Molecular cloning and distinct developmental expression pattern of
            spliced forms of a novel zinc finger gene wiz in the mouse
            cerebellum
  JOURNAL   Brain Res Mol Brain Res 61 (1-2), 179-189 (1998)
   PUBMED   9795207
REFERENCE   9  (bases 1 to 6093)
  AUTHORS   Funke,B., Puech,A., Saint-Jore,B., Pandita,R., Skoultchi,A. and
            Morrow,B.
  TITLE     Isolation and characterization of a human gene containing a nuclear
            localization signal from the critical region for velo-cardio-facial
            syndrome on 22q11
  JOURNAL   Genomics 53 (2), 146-154 (1998)
   PUBMED   9790763
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT485616.11 and CT033751.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMN00849374, SAMN00849375
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-245               CT485616.11        9845-10089          c
            246-318             CT485616.11        3356-3428           c
            319-2301            CT033751.4         168179-170161       c
            2302-2435           CT033751.4         160950-161083       c
            2436-2759           CT033751.4         159487-159810       c
            2760-3263           CT033751.4         153124-153627       c
            3264-3815           CT033751.4         150606-151157       c
            3816-4340           CT033751.4         149120-149644       c
            4341-4760           CT033751.4         148552-148971       c
            4761-4956           CT033751.4         148086-148281       c
            4957-6093           CT033751.4         145710-146846       c
FEATURES             Location/Qualifiers
     source          1..6093
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 17.52 cM"
     gene            1..6093
                     /gene="Wiz"
                     /note="widely-interspaced zinc finger motifs"
                     /db_xref="GeneID:22404"
                     /db_xref="MGI:MGI:1332638"
     exon            1..245
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..5116
                     /gene="Wiz"
                     /note="isoform 3 is encoded by transcript variant 4;
                     protein Wiz; widely-interspaced zinc finger-containing
                     protein"
                     /codon_start=1
                     /product="protein Wiz isoform 3"
                     /protein_id="NP_001359156.1"
                     /db_xref="GeneID:22404"
                     /db_xref="MGI:MGI:1332638"
                     /translation="MEGLLAGGLAAPDHPRGPAPREDIESGAEAAEGEGDIFPSSHYL
                     PITKEGPRDILDGRSGISDGQPHPGLSEALPRATSATHRISSCYWDGDSLDFQPGSPP
                     PHLLGPFPASLDVQGSWEHPMVQEAREGTPSEQRFKDSVIVRTMKPYAKLKGSRKFLH
                     HQGEVKFLEKYSPSHHKFDWLQDTDEQGPLKDTGLHLDLPAQPPTVTSFRRVIVPVDN
                     TPKTLDMEVMGTREDLEDFGQVAQPSEWGLHTSASEVATQTWTVNSEASVERLQPLLS
                     PVQTGPYLCELLQEVAGGVDSNEEEEEEPAVFPCIECSIYFKHKEHLLEHMSQHRRAP
                     GQEPPADLAPLACSECGWAFTEPTALEQHWQLHQASREKIIEEIQKLKQFPGDEGREA
                     RLQCSKCVFGTNSSRAFMQHAKLHVRGSLPSRQATEPFRGGSPVLDVSTLVYPSYGDS
                     SGLNTCVHCGFTAPSKSLLREHTRLVHAHHAHWEEVGEAFEDLTSQPCTSQDAYTHSP
                     DTATVDYFSKSEPLLASVWQENPSGYDPDLAFGPDYQQPGMRNFPLLNSGQQSLGKLA
                     FPSPMASASYSIQRNRNKSTVHLQRMEDKSHLWSEEEEEEDEDVVLTSERDFTPENGA
                     FPPLAIPSLIPQPALELKQTFQDALQAVDASETQQQQLQGMVPIVLMAKLRPQVIAAT
                     TRASPQLPPEEPELRSTHPLDFLLLDAPLGGSLGLNTLLEGDPAMALKHEERKCPYCP
                     DRFHNGIVIGLANHVRGHLNRVGVSYNVRHFISAEEVKAIERRFSFQKKKKKVANFDP
                     GTFSLMRCDFCGAGFDTRAGLSSHARAHLRDFGITNWELTISPINILQELLATSAAEL
                     PPSPLGREPGGPPRSFLTSRRPRLPLTMPFPPTWAEDPGPIYGDAQSLTTCEVCGACF
                     ETRKGLSSHARSHLRQLGVAESESSGAPIDLLYELVKQKGLPDAPLGLTPSLTKKSNS
                     PKEFLAGAARPGLLTLAKPMDAPAVNKAIKSPPGFSAKGLTHPSSSPLLKKAPLTLAG
                     SPTPKNPEDKSPQLSLSPRPTSPKAQWPQSEDEGPLNLTSGPEPTRDIRCEFCGEFFE
                     NRKGLSSHARSHLRQMGVTEWYVNGSPIDTLREILKRRTQSRPGGHLHPPGPSPKALA
                     KVLSTGGPGSSLEARSPSDLHISPLTKKLPPPPGSPLGHSPTASPPPTARKMFSGLAT
                     PSLPKKLKPEHMRVEIKREMLPGTLHGEPHPSEGPWGTPREDMAPLNLSRAEPVRDIR
                     CEFCGEFFENRKGLSSHARSHLRQMGVTEWSVNGSPIDTLREILKKKSKLCLIKKEPP
                     AGDLAPALTEDGSPTAAPGALHSPLPLSPLASRPGKPGAGPTQVPRELSLSPITGSKP
                     SAASYLGPVATKRPLQEDRFLPAEVKAKTYIQTELPFKAKTLHEKTSHSSTEACCELC
                     GLYFENRKALASHARAHLRQFGVTEWCVNGSPIETLSEWIKHRPQKVGAYRSYIQGGR
                     PFTKKFRSAGHGRDSDKRPPLGLAPGGLSLVGRSAGGEPGLEAGRAADSGERPLATSP
                     PGTVKSEEHQRQNINKFERRQARPSDASAARGGEEVNDLQQKLEEVRQPPPRVRPVPS
                     LVPRPPQTSLVKFVGNIYTLKCRFCEVEFQGPLSIQEEWVRHLQRHILEMNFSKADPP
                     PEEPQAPQAQTAAVEAP"
     exon            246..318
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            319..2301
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2435
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            2436..2759
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..3263
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3815
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            3816..4340
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            4341..4760
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            4761..4956
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     exon            4957..6093
                     /gene="Wiz"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6057..6062
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wiz"
                     /note="hexamer: ATTAAA"
     polyA_site      6079
                     /gene="Wiz"
                     /note="major polyA site"
ORIGIN      
        1 gcccacaatg tcctgctgaa cctgccaggt actgagtgaa gattcacggc tggcacccat
       61 ggaggggtta ctggcaggtg gcctggctgc cccggatcat cctcgaggcc ccgctccaag
      121 agaggacatc gagagtgggg ctgaggctgc tgagggggaa ggtgatatct ttccatcttc
      181 tcattacctg ccaatcacca aagaaggccc tcgagacatt ctggatggca gaagtggcat
      241 ttctgatggg cagccccatc ctggcctcag cgaagccctc ccccgtgcca cctccgccac
      301 ccatcggatc agcagctgct actgggatgg agacagcctg gactttcagc cgggctcccc
      361 accaccccat cttctgggtc ccttccctgc atcccttgat gttcaggggt cttgggaaca
      421 tcccatggtc caggaggcca gggagggtac cccatctgag cagaggttca aggactcagt
      481 tattgtgaga actatgaaac cttatgccaa gctcaagggc tctagaaagt tcttgcacca
      541 ccagggtgaa gtgaagttct tagagaaata ctctccaagc caccacaagt ttgattggct
      601 ccaagataca gatgaacagg ggcccctgaa ggatacaggg ttgcacctgg accttcctgc
      661 ccagcccccg actgtcactt cctttaggag ggtaattgtg ccagtggata acactcccaa
      721 gaccttggac atggaagtta tgggtaccag agaggaccta gaggactttg ggcaggtggc
      781 ccagccttct gagtggggtc ttcacacatc agcctcagaa gtggccaccc agacctggac
      841 agtgaactct gaagcatctg tggagcgact gcagccccta ctgtccccag tccagacagg
      901 accatacctg tgtgaactgt tgcaggaagt agctggtgga gtggacagca atgaagaaga
      961 ggaagaggag ccagctgtgt ttccttgcat cgagtgcagc atctacttca agcacaagga
     1021 acacctccta gaacacatga gccagcaccg ccgagcacca ggccaggagc ccccagctga
     1081 cctggctcca ctggcctgca gcgaatgcgg ctgggccttc acagaaccca ctgccctgga
     1141 acagcactgg caactgcacc aggcttcccg ggagaagatt attgaagaga tccaaaagct
     1201 aaagcagttt ccaggtgatg agggccgtga ggcacgactg caatgctcca agtgcgtctt
     1261 tggcaccaat tcctctagag ccttcatgca gcatgccaag ctgcatgtgc gtgggtcact
     1321 gcccagccgg caggccacgg aacctttcag gggtggcagc ccagtcttag atgttagcac
     1381 cctcgtctat ccctcctatg gagactcctc aggcctcaat acctgtgttc actgtggttt
     1441 cacagcacct agcaagagtc tgctcaggga gcacacgagg ctagtccacg cccaccacgc
     1501 ccactgggag gaggttggag aggcctttga ggacctcact agccagccct gtactagcca
     1561 ggatgcatat actcactcac ccgacactgc caccgtggac tattttagca aatctgagcc
     1621 tctcttggcc tctgtctggc aagagaaccc ttctggatat gaccctgacc ttgcctttgg
     1681 tccagactat cagcagccag gcatgagaaa tttcccattg ttaaattcag gccagcagtc
     1741 tcttgggaag ctggcctttc cttcccctat ggcatctgct tcctattcta tacagcgcaa
     1801 tagaaacaaa agcactgtcc acctgcagag aatggaagac aagagtcatc tttggagtga
     1861 agaggaagag gaagaagatg aagatgtagt gctgacttct gaaagggatt ttactcctga
     1921 aaatggagcc tttccacccc tagccatccc tagcctcatc cctcagccag cccttgagtt
     1981 gaagcagact ttccaagatg ccctgcaggc agtcgatgcc tcagaaactc agcagcaaca
     2041 gctccaagga atggtaccta tcgttctgat ggcaaagctc aggccacaag tcatagctgc
     2101 caccacccga gcatccccac agctgccgcc tgaggagccc gagctgagaa gcacccaccc
     2161 gctggacttc ctgctcctag atgcaccttt gggtggctca ctgggtctga acacactcct
     2221 agaaggggac ccagccatgg cactaaagca tgaggagcgg aaatgcccct actgtcctga
     2281 tcgtttccac aatggtatcg ttatcgggct agccaaccat gtccggggcc acctgaaccg
     2341 agtgggtgtc agctataatg ttcggcattt catctctgca gaggaggtga aggctattga
     2401 acgcaggttt tccttccaga agaaaaagaa aaaagtggct aacttcgacc cgggcacctt
     2461 tagcctgatg cgatgtgact tctgtggggc tggttttgat actcgggctg gcctctccag
     2521 tcatgcccgg gcccaccttc gtgactttgg catcaccaac tgggaactca ccatctcacc
     2581 catcaacatc ctgcaagagc tgctggccac ctcagcagcg gagttgcccc caagtcccct
     2641 gggccgggag ccaggggggc cacccagaag cttcctgact tcaagacggc cacgcttacc
     2701 tctcaccatg cccttcccgc ctacctgggc tgaggaccct gggccaatct acggagatgc
     2761 ccagagcctg accacctgtg aggtctgcgg tgcctgcttt gagacacgaa agggcctgtc
     2821 cagccacgca cgttcacatc tgcggcagct tggggtcgca gagtcagaaa gcagtggtgc
     2881 tcccatcgac ctcctctacg agctggtgaa gcagaagggc ctgcctgatg ctccccttgg
     2941 gctgacccct agcctgacca agaagtccaa ctcaccaaag gagttccttg ctggggctgc
     3001 caggcctggc ctactcacac tggccaaacc tatggatgcc cctgctgtca acaaagccat
     3061 caaatcacct cctggcttct cagccaaggg cctgacccac ccatccagct ctccactcct
     3121 caagaaggcc ccactgactc tggcaggatc ccctacaccc aagaatcctg aggacaagag
     3181 cccccagctg tccctgagtc cccgaccaac ttccccaaag gcacaatggc cccagtctga
     3241 ggatgagggg ccgctgaatc tcacttcagg cccagagcca acaagagata tccgctgtga
     3301 gttctgtggt gagttctttg agaacagaaa gggcttgtct agccatgcac gctcccacct
     3361 gcgccagatg ggtgtaactg agtggtatgt gaacggctca cccatcgaca cacttcggga
     3421 gatcctgaag agacggaccc aatccaggcc agggggacac ctccacccac caggtcctag
     3481 cccaaaagcc ctggccaagg tgctgagcac tggaggtcct ggcagctcac tagaagcccg
     3541 aagtccctct gatcttcaca tctcaccttt gaccaagaag ttgccaccac caccaggcag
     3601 tcctctgggc cactcaccaa ctgcttctcc tcctcccacg gcccggaaga tgttctcagg
     3661 ccttgctaca ccctccctgc ccaagaaact gaagcctgaa cacatgagag tggagatcaa
     3721 gagggagatg ctgccaggga cccttcatgg ggagccacac ccatctgagg gtccctgggg
     3781 cacgcctcga gaagatatgg cacccttgaa cctgtctcgg gcagagccag tgcgtgacat
     3841 ccggtgtgag ttttgtggtg agttcttcga gaaccgcaag ggcctatcca gccacgcacg
     3901 ctcccacctg cgccagatgg gtgtgactga gtggtctgtc aatggctctc ccattgacac
     3961 acttcgggag atcctgaaga agaagtccaa gctgtgcctc atcaaaaaag agcctcctgc
     4021 tggagacctg gctcctgccc tcactgaaga tggctctccc acagcagctc ctggggctct
     4081 gcattcccca ctgcctctgt cacccctggc tagccggcca ggaaaaccag gagctgggcc
     4141 gacccaagtt ccccgggagc tcagcctgtc acccatcaca gggtccaagc cctcagctgc
     4201 cagctacctg ggcccagtgg caaccaagcg gcccctccag gaggaccgct tcctcccagc
     4261 agaggtcaag gccaagacct acatccagac tgaactgccc ttcaaggcaa agactctcca
     4321 tgagaagacc tcccactcct ccaccgaggc ctgctgtgag ctctgtggcc tttactttga
     4381 aaaccgcaaa gccctagcca gccacgcgag ggcacatctg cggcagttcg gtgtgacgga
     4441 gtggtgtgtc aacggctctc ccatcgagac cctgagtgag tggatcaaac accggcctca
     4501 gaaagtgggt gcctaccgaa gctacatcca gggtggccgc ccctttacaa agaagtttcg
     4561 cagcgctggc catggccgtg acagtgacaa gcggccaccc ctggggctgg cacctggggg
     4621 cctgtccctg gttggccgaa gtgctggggg agaaccaggg cttgaagctg gaagggcagc
     4681 tgacagtggt gaacggcctc tggcaaccag cccacctggg accgtgaagt cagaggagca
     4741 tcaaaggcaa aatatcaaca aatttgaacg cagacaagcc cgcccctcag atgcctctgc
     4801 agctcgtggt ggtgaggaag tcaatgacct gcaacagaag ctggaagaag tgcggcaacc
     4861 cccgccccgg gtccgaccag tcccctccct ggtgcctcgg cccccccaaa cgtcactggt
     4921 caagtttgtg ggcaacatct ataccctcaa gtgcaggttc tgtgaagtgg aattccaggg
     4981 cccactctct atccaggaag agtgggtacg gcatttacag cggcacatcc tggagatgaa
     5041 cttctccaaa gcagaccctc cgcctgagga gccccaggcc ccgcaggcac agacagcagc
     5101 tgtagaggca ccctaacaca cagcattcca gatccccttt tgtgccacct atcccctccc
     5161 atttctcctc tgtcctctcc cccttttcca tctttctttt ccgtttccaa aggagcaagc
     5221 caaaacctca aaccggcgcc tcttggaggc cgggcacact acaacctggg cactgggagc
     5281 cagctagcca cccttccccc agcttaagga ctctggggcc acaagggtat ccttgagcct
     5341 acctggttgg tctcataggg gcagtagccg ggcccttggt ggtgaccaat ctgattgcag
     5401 gggagaacag cacttccctg tgtctagcaa ccaggcaggg ctacatctgc catccgtggc
     5461 catttgcaaa gaccccaaag accccctgtt ccctcttgcc ccatcaatat ctattttcac
     5521 gcacaggcaa acacacacac acatgcacct cgtgagacct gggatctgcc ctagccccct
     5581 cagttcccaa gtcaaacgac cacaacatgc cacggtgctt gctcagggga atccatgctc
     5641 cctctgctat cttcctaggg cttgggagct cccactgagc ccacaatgcc acggaaattc
     5701 ttgttggctg ccccctcccc cccaaaaggg tccttcctag cttggaagag ctcaaagctg
     5761 acagctgcct cctgccttgt cagagcctca ggggctccag ggctgggagg gtagagtgag
     5821 gggtgggact ctcctccccc acccctgctg ccctccccct tttcactgtt gctttctatg
     5881 tatagctccc tagatctttc acttttttaa aaaatgcgtt ttgtgtagag aataaggaac
     5941 gtggatcttt ttattttgca atcctgggcc agctagatac cgggagctaa ttgacctttt
     6001 aaccttttca gtggccacct tttggttatc aatgtaccta gaaatatgta aattagatta
     6061 aatttctctt ctggaaatat cccagggcaa aca
//
