LOCUS       NM_153138               4481 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WAS/WASL interacting protein family, member 1 (Wipf1),
            transcript variant 2, mRNA.
ACCESSION   NM_153138
VERSION     NM_153138.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4481)
  AUTHORS   Dong,Y., Jin,Q., Sun,M., Qi,D., Qu,H., Wang,X. and Quan,C.
  TITLE     CLDN6 inhibits breast cancer metastasis through WIP-dependent actin
            cytoskeleton-mediated autophagy
  JOURNAL   J Exp Clin Cancer Res 42 (1), 68 (2023)
   PUBMED   36935496
  REMARK    GeneRIF: CLDN6 inhibits breast cancer metastasis through
            WIP-dependent actin cytoskeleton-mediated autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4481)
  AUTHORS   Keppler,S.J., Burbage,M., Gasparrini,F., Hartjes,L., Aggarwal,S.,
            Massaad,M.J., Geha,R.S., Bruckbauer,A. and Batista,F.D.
  TITLE     The Lack of WIP Binding to Actin Results in Impaired B Cell
            Migration and Altered Humoral Immune Responses
  JOURNAL   Cell Rep 24 (3), 619-629 (2018)
   PUBMED   30021160
  REMARK    GeneRIF: WIP binding to actin, independent of its binding to WASp,
            is critical for actin cytoskeleton plasticity in B cells.
REFERENCE   3  (bases 1 to 4481)
  AUTHORS   Janssen,E., Tohme,M., Hedayat,M., Leick,M., Kumari,S., Ramesh,N.,
            Massaad,M.J., Ullas,S., Azcutia,V., Goodnow,C.C., Randall,K.L.,
            Qiao,Q., Wu,H., Al-Herz,W., Cox,D., Hartwig,J., Irvine,D.J.,
            Luscinskas,F.W. and Geha,R.S.
  TITLE     A DOCK8-WIP-WASp complex links T cell receptors to the actin
            cytoskeleton
  JOURNAL   J Clin Invest 126 (10), 3837-3851 (2016)
   PUBMED   27599296
REFERENCE   4  (bases 1 to 4481)
  AUTHORS   Keppler,S.J., Gasparrini,F., Burbage,M., Aggarwal,S., Frederico,B.,
            Geha,R.S., Way,M., Bruckbauer,A. and Batista,F.D.
  TITLE     Wiskott-Aldrich Syndrome Interacting Protein Deficiency Uncovers
            the Role of the Co-receptor CD19 as a Generic Hub for PI3 Kinase
            Signaling in B Cells
  JOURNAL   Immunity 43 (4), 660-673 (2015)
   PUBMED   26453379
  REMARK    GeneRIF: WIPf1 deficiency results in defective B cell function. By
            regulating the cortical actin cytoskeleton, WIPf1 influences the
            function of CD19 as a general hub for PI3K signaling.
REFERENCE   5  (bases 1 to 4481)
  AUTHORS   Franco-Villanueva,A., Wandosell,F. and Anton,I.M.
  TITLE     Neuritic complexity of hippocampal neurons depends on WIP-mediated
            mTORC1 and Abl family kinases activities
  JOURNAL   Brain Behav 5 (11), e00359 (2015)
   PUBMED   26664784
  REMARK    GeneRIF: These experiments identify WIP as a member of a signaling
            cascade comprised of Abl family kinases, mTORC1 and S6K, which
            regulates neuron development and specifically, neuritic branching
            and complexity.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4481)
  AUTHORS   Shu,H., Chen,S., Bi,Q., Mumby,M. and Brekken,D.L.
  TITLE     Identification of phosphoproteins and their phosphorylation sites
            in the WEHI-231 B lymphoma cell line
  JOURNAL   Mol Cell Proteomics 3 (3), 279-286 (2004)
   PUBMED   14729942
REFERENCE   7  (bases 1 to 4481)
  AUTHORS   Anton,I.M., Saville,S.P., Byrne,M.J., Curcio,C., Ramesh,N.,
            Hartwig,J.H. and Geha,R.S.
  TITLE     WIP participates in actin reorganization and ruffle formation
            induced by PDGF
  JOURNAL   J Cell Sci 116 (Pt 12), 2443-2451 (2003)
   PUBMED   12724353
  REMARK    GeneRIF: WIP participates in the actin reorganization that leads to
            ruffle formation.
REFERENCE   8  (bases 1 to 4481)
  AUTHORS   Kinley,A.W., Weed,S.A., Weaver,A.M., Karginov,A.V., Bissonette,E.,
            Cooper,J.A. and Parsons,J.T.
  TITLE     Cortactin interacts with WIP in regulating Arp2/3 activation and
            membrane protrusion
  JOURNAL   Curr Biol 13 (5), 384-393 (2003)
   PUBMED   12620186
REFERENCE   9  (bases 1 to 4481)
  AUTHORS   Benesch,S., Lommel,S., Steffen,A., Stradal,T.E., Scaplehorn,N.,
            Way,M., Wehland,J. and Rottner,K.
  TITLE     Phosphatidylinositol 4,5-biphosphate (PIP2)-induced vesicle
            movement depends on N-WASP and involves Nck, WIP, and Grb2
  JOURNAL   J Biol Chem 277 (40), 37771-37776 (2002)
   PUBMED   12147689
REFERENCE   10 (bases 1 to 4481)
  AUTHORS   Anton,I.M., de la Fuente,M.A., Sims,T.N., Freeman,S., Ramesh,N.,
            Hartwig,J.H., Dustin,M.L. and Geha,R.S.
  TITLE     WIP deficiency reveals a differential role for WIP and the actin
            cytoskeleton in T and B cell activation
  JOURNAL   Immunity 16 (2), 193-204 (2002)
   PUBMED   11869681
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY252790.1, BY285630.1, AJ437262.1, AK031046.1, AV338046.2,
            AK054142.1, BU756544.1 and BB740185.1.
            
            On Jan 25, 2014 this sequence version replaced NM_153138.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC049788.1, SRR9219379.35057.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-105               BY252790.1         2-106
            106-261             BY285630.1         63-218
            262-1681            AJ437262.1         63-1482
            1682-2675           AK031046.1         1649-2642
            2676-2993           AV338046.2         78-395
            2994-4077           AK054142.1         1-1084
            4078-4342           BU756544.1         154-418             c
            4343-4481           BB740185.1         274-412
FEATURES             Location/Qualifiers
     source          1..4481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 43.68 cM"
     gene            1..4481
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /note="WAS/WASL interacting protein family, member 1"
                     /db_xref="GeneID:215280"
                     /db_xref="MGI:MGI:2178801"
     exon            1..161
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            162..250
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1681
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /note="WASP interacting protein; Wiskott-Aldrich syndrome
                     protein interacting protein"
                     /codon_start=1
                     /product="WAS/WASL-interacting protein family member 1"
                     /protein_id="NP_694778.1"
                     /db_xref="CCDS:CCDS16131.1"
                     /db_xref="GeneID:215280"
                     /db_xref="MGI:MGI:2178801"
                     /translation="MPVPPPPAPPPPPTFALANTEKPTLNKTEQAGRNALLSDISKGK
                     KLKKTVTNDRSAPILDKPKGAGASAGGYGGGGGGGGGGGGGGGGSGGNFGGGGPPGLG
                     GLFQAGMPKLRSTANRDNDSGGSRPPILPPGGRATSAKPFSPPSGPGRFPAPSPGHRS
                     GPPEPPRNRMPPPRPDVGSKPDSLPPPVPNTPRPVPSSLHNRGSPAGLGAPRPPFPGN
                     RGAAFGAGSARQNPSGSSSPFPRPPLPPTPSRALDDKPPPPPPPVGNRPSMHREAVPP
                     PPSQTSKPPVPSTPRPGLGSQAPPPPPPPSRPGPPPLPPASNDEIPRLPQRNLSLTSS
                     APPLPSPGRSGPLPPPPSERPPPPVRDPPGRSGPLPPPPPINRNGSTARALPATPQLP
                     SRSGMDSPRSGPRPPLPPDRPGAGAPPPPPPSTSVRNGFQDSSCEDEWESRFYFHPIS
                     DLPPPEPYVPTTKTYPSKLARNESRSGSNRRERGAPPLPPIPR"
     exon            251..380
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            381..560
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            561..1298
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1511
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1625
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..4481
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4051..4056
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /note="hexamer: ATTAAA"
     polyA_site      4075
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /note="major polyA site"
     regulatory      4456..4461
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
                     /note="hexamer: AATAAA"
     polyA_site      4479
                     /gene="Wipf1"
                     /gene_synonym="D2Ertd120e; Waspip; WIP"
ORIGIN      
        1 gggcgcacat ctcggcgaag ttcccggatg gtcgcagcct cccggcgcgg agcgcttttc
       61 ctgcccgccc cggctcagcc ctgcggaccc agagagaagt ttcccagaaa aaaatgcccc
      121 gcgcgccgcg gggccgagga gccgcccgga gccgctgcac gatttacctt caagactgct
      181 gaaattttaa ctacccaaga tgcctgtccc tcccccacca gcacccccac cgccaccaac
      241 atttgcactc gctaacactg agaagcccac cttgaacaag acagagcagg ctgggaggaa
      301 tgctcttctc tctgacatca gcaaagggaa gaagctaaag aagacggtca ccaatgacag
      361 aagtgcccca atattggaca aaccaaaggg agccggcgcc agtgctggtg gctatggtgg
      421 aggcggcgga ggtggtggtg gaggaggagg aggaggagga ggcagcggtg gaaattttgg
      481 agggggtggt cctccaggac tgggaggact attccaggct ggaatgccga agctgaggtc
      541 caccgccaac agggataatg attctggagg aagccgacca ccgattttgc caccgggagg
      601 aagagccaca tctgccaagc ccttttcacc cccgagtggc ccggggaggt ttcccgcacc
      661 ctccccaggc cacaggagtg ggcccccaga gccacccagg aacagaatgc ctcccccgag
      721 gcctgacgtg ggctcaaaac cagatagcct tccccctccg gtaccaaata cgccaagacc
      781 tgttccgtcg agtctgcaca accggggatc cccagcaggg ctgggagccc ccaggccccc
      841 ctttcccggg aaccgaggtg ctgcttttgg agcaggctct gcgcgccaga acccctccgg
      901 ctcctcctct ccgtttccta ggcccccttt gccccccacc ccaagccgag ccttggatga
      961 caagccccct ccaccacctc ctcccgtggg caacaggccc tccatgcaca gagaagcggt
     1021 gccccctccc ccctcacaga ccagcaaacc tccagtgcct tccaccccgc ggcctgggtt
     1081 gggttcgcag gcaccacctc ctcctccacc gcccagccgg ccagggcccc ctcctctgcc
     1141 tccagcttcc aacgacgaga tccccaggct gccacagcgg aacctgtccc tcacgtcctc
     1201 tgcacctcca ttgccttcac ctggacgctc agggcctctc cctcccccac ccagcgagag
     1261 gccccctcct cctgtaaggg atccaccagg cagatcaggc cccctcccac caccacctcc
     1321 aataaacaga aatggaagca cagctcgggc cctgcctgcc acccctcagt tgccatccag
     1381 gagtggaatg gacagtccca gaagtgggcc taggcctcct cttcctcctg acaggcctgg
     1441 tgctggggcg ccgcccccac ccccaccctc cacatcagtt cgaaatggct tccaagactc
     1501 atcgtgtgaa gatgagtggg aaagcagatt ctacttccat ccgatttctg acttgccgcc
     1561 tccagagcca tacgtaccga caaccaagac gtatcccagc aaactggcca gaaacgaaag
     1621 ccgaagtgga tccaacagaa gagaaagggg cgccccaccc cttcctccca tcccgaggtg
     1681 atctctgcct gctccgttct acccaagctc caaagctgct tctgttgttg ctgtttgaaa
     1741 actgcacacc cctcctctcg atttgccacg ccccccccag agagagtagg agggaggaac
     1801 ggaagctgag gaggggatcc ctgcgtgtgg gggtggggat cggggaaaga agcgcctagc
     1861 tgtttatgtt gtatatattc ctgagctatt gcttgtatca gctgcagcct gccagggtca
     1921 gacatccact gcttttttgc aacagactgt agttgttaaa tcccctgaga gctggttttc
     1981 tctatgcctt tcttgctcac atggcctctg gcctgtttcc acgaaccaca ccgcccaagc
     2041 gagttgcgag caagccctgt ggttacagaa cgtccgatct tcggctgtct gaggaaggct
     2101 ccaggacaga gctgtcttaa aagaaacata atgtgagccc cataccctgt ctgaaaatga
     2161 ctagcagcta tgttttataa aggtagaagg aaacagatga aaagaattgc attttactca
     2221 gcactgtgca tctgaaatat cacttcgact tgtattatta atgagctatt tacatttttg
     2281 gtactaagtc ctcacactcg agtaaccatt ctgtacttgg aacaagcaca ctgccagatt
     2341 tcaagtgtcc acaccggcct cagcaccaca ctgtcagacg gtctggaaga caggagttag
     2401 gacagcttgt gcctaaaaag gcaaattgag ttttagcaat tcaggagatg tcccaagacg
     2461 gagtcagaac ttgatacaat gtttggcagg cagtgagacc ttagattttt gacccttatt
     2521 ctgcctttgt ccttaatatg tatgtccagg tgtttcttca aagtatctta gtgagaaatg
     2581 tatctagtag agtttacagt cccgtttaca gtggattgca aactccactg caagaaaaca
     2641 aaactgtgtg ggtactccct ggcttagaac cagctggctt gtgcactgct ggtcactggc
     2701 cttgcgcatc ttctgtggct cttcagtcct ccaccccaga gaaaactcct tcctcaggtc
     2761 aggaaaggct agtagggcaa gataggagaa gaaagtcaga gaatgtatca gaactatggg
     2821 agaagaggat agcgttgatg atgggcagag ctctacacaa ccgactgggg tcaagtagat
     2881 taaggagctt accagtggaa cctagaaagc attggtgttg aatttcttgg gagaatcatt
     2941 gtcttggatc tgtgcaagta agttccacta aaggatggat cacaaaaagg gccaggcttg
     3001 ccttttttat atatatgact ttgtttacaa cattttactg ggactttcaa acctagctgt
     3061 agagttggaa aaagatttcc attttgatgt tttatataat catgtttaat gttaccattg
     3121 tctattaaag cacatggcca catatgtgta cctacctgaa ctttgtattt tgggtccagc
     3181 gtattgctca catgttgctg tcacatgttg ctgaaagatg ctaataaaaa aaaatcaatc
     3241 caaagaaaaa tggaaagaca ttcctattta tagaatgatt gtttcgttta tataaaagca
     3301 taacttagga gttctaatag atgaaaagtc taataaatta taaagtgatt gatttgaata
     3361 tattgtattt ttataacttt ccttgccaaa gcccagacct agttctttag agagtagttt
     3421 tcctcccttc tcctccacca tttgtcggtc ttccatgaga acaaagaaat aaaagggtta
     3481 acaagcttga caattttttt attcctaaca ttttaaaatg tatttcgaat tctttgatct
     3541 gatattcact aggataaaca tccttttcat agacgctcaa tgacctactt tactgaaagt
     3601 cgaattggtc cttccttgtg ctgtgtatgg aagagaaagg ttggactcaa agattgtggg
     3661 tctcagtttt ttaagggata gtgaaaattg gacaagttct ggtaaataaa tctcagtttt
     3721 caggtacatt tctaagtcag ggacgggtca cagctcaaag ttgccattca taataaagaa
     3781 ggtttagaat gcattttgca aagaatgttt cattaataca cctacatcct atctttggaa
     3841 gtcagtgacc caattgcatt taaaactctt gagaagttct gggtttagct taacctatgg
     3901 taaatcattt aaaaaaaaaa agtctatttt cttccctgaa atcaaagctt acatgtatgt
     3961 ttttccataa tatttccagt tatgtgtatt taagatgcaa tgcagtattt taacatttgc
     4021 aaatcatttt atatggaaat atattgcagt attaaaattc agtgttctgt gtctatttca
     4081 ctatgcattt tatttactga aagctgagaa aatatttaac ccaatggtgc cttactggtg
     4141 atctgaaaag aattgacttg ttatgtctaa gtagtggatt tgttgcatat ttgtaaaaac
     4201 tgttaggcct ttatatttta acttgtaata tcgattttgt tattttagta ccagaaacag
     4261 ggtgattatt gaagtctcct caaacttttg gtatgaaatt taactttccc tgttcatagg
     4321 caggagctgt agaggaattt tttcatacca ctgcactgtg taaacagaca cagacatctg
     4381 tgtcatcagg gtagttaaat ggtagggtag aatctaccat agacacctgc atgtttgtaa
     4441 attatccaga caatgaataa aaagcagaat gatacagtgt c
//
