LOCUS       NM_011915               2242 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus Wnt inhibitory factor 1 (Wif1), mRNA.
ACCESSION   NM_011915 XM_983228 XM_983264 XM_983301
VERSION     NM_011915.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2242)
  AUTHORS   Bobzin,L., Nickle,A., Ko,S., Ince,M., Huang,A., Bhojwani,A.,
            Roberts,R. and Merrill,A.E.
  TITLE     FGFR2 directs inhibition of WNT signaling to regulate anterior
            fontanelle closure during skull development
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39775862
REFERENCE   2  (bases 1 to 2242)
  AUTHORS   Chen,B., Zou,J., Xie,L., Cai,Y., Li,B., Tan,W., Huang,J., Li,F. and
            Xu,H.
  TITLE     WNT-inhibitory factor 1-mediated glycolysis protects photoreceptor
            cells in diabetic retinopathy
  JOURNAL   J Transl Med 22 (1), 245 (2024)
   PUBMED   38448948
  REMARK    GeneRIF: WNT-inhibitory factor 1-mediated glycolysis protects
            photoreceptor cells in diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2242)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2242)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   5  (bases 1 to 2242)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   6  (bases 1 to 2242)
  AUTHORS   Hunter,D.D., Zhang,M., Ferguson,J.W., Koch,M. and Brunken,W.J.
  TITLE     The extracellular matrix component WIF-1 is expressed during, and
            can modulate, retinal development
  JOURNAL   Mol Cell Neurosci 27 (4), 477-488 (2004)
   PUBMED   15555925
  REMARK    GeneRIF: WIF-1 protein inhibits rod production, and anti-WIF-1
            antibodies increase rod production; in contrast, Wnt4 promotes rod
            production.
REFERENCE   7  (bases 1 to 2242)
  AUTHORS   Diep,D.B., Hoen,N., Backman,M., Machon,O. and Krauss,S.
  TITLE     Characterisation of the Wnt antagonists and their response to
            conditionally activated Wnt signalling in the developing mouse
            forebrain
  JOURNAL   Brain Res Dev Brain Res 153 (2), 261-270 (2004)
   PUBMED   15527894
REFERENCE   8  (bases 1 to 2242)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   9  (bases 1 to 2242)
  AUTHORS   Bennett,C.N., Ross,S.E., Longo,K.A., Bajnok,L., Hemati,N.,
            Johnson,K.W., Harrison,S.D. and MacDougald,O.A.
  TITLE     Regulation of Wnt signaling during adipogenesis
  JOURNAL   J Biol Chem 277 (34), 30998-31004 (2002)
   PUBMED   12055200
REFERENCE   10 (bases 1 to 2242)
  AUTHORS   Hsieh,J.C., Kodjabachian,L., Rebbert,M.L., Rattner,A.,
            Smallwood,P.M., Samos,C.H., Nusse,R., Dawid,I.B. and Nathans,J.
  TITLE     A new secreted protein that binds to Wnt proteins and inhibits
            their activities
  JOURNAL   Nature 398 (6726), 431-436 (1999)
   PUBMED   10201374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142443.1 and AK077698.1.
            
            On Jun 19, 2009 this sequence version replaced NM_011915.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158359.1, AK077698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1735              AK142443.1         2-1736
            1736-2242           AK077698.1         1736-2242
FEATURES             Location/Qualifiers
     source          1..2242
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 68.98 cM"
     gene            1..2242
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /note="Wnt inhibitory factor 1"
                     /db_xref="GeneID:24117"
                     /db_xref="MGI:MGI:1344332"
     exon            1..487
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1479
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /codon_start=1
                     /product="wnt inhibitory factor 1 precursor"
                     /protein_id="NP_036045.1"
                     /db_xref="CCDS:CCDS24209.1"
                     /db_xref="GeneID:24117"
                     /db_xref="MGI:MGI:1344332"
                     /translation="MARRRAFPAFALRLWSILPCLLLLRADAGQPPEESLYLWIDAHQ
                     ARVLIGFEEDILIVSEGKMAPFTHDFRKAQQRMPAIPVNIHSMNFTWQAAGQAEYFYE
                     FLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVNVIVMNSE
                     GNTILRTPQNAIFFKTCQQAECPGGCRNGGFCNERRVCECPDGFYGPHCEKALCIPRC
                     MNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCICPPGLEGEQCELS
                     KCPQPCRNGGKCIGKSKCKCPKGYQGDLCSKPVCEPGCGAHGTCHEPNKCQCREGWHG
                     RHCNKRYGASLMHAPRPAGAGLERHTPSLKKAEDRRDPPESNYIW"
     exon            488..627
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            628..736
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            737..877
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            878..973
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1069
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1165
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1261
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1357
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..2242
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agttcccgcg gttcctccct ctcgagtgtg ctcctctagc tgctggcgct gtgggacgtg
       61 ctggcattgc cagctttgcc agcatcgtgt ctctgcgtcc ccctctccct ccagccccca
      121 cctctttcta cgcggccgcg catccactcc ctccttgctc cctcctctcc agcactccca
      181 ggctcactcg caacggagac tggagacttg cacgcccagt cgtttaagta ggaacagctc
      241 cagccccgcc agctgcagcc aaggcgagaa cttcacaagc agcacaggtt gggtcgctgc
      301 ggcaggagtt gcaccaccag cgagaaggtc ctgagcacca tggctcggag aagagccttc
      361 cctgctttcg cgctccggct ctggagcatc ctaccttgcc tgctcctgct gcgagcggat
      421 gcagggcagc cacctgagga gagcttgtac ctgtggatcg acgcccatca ggctagagtg
      481 ctcataggat ttgaagaaga cattctgatt gtctcggagg ggaaaatggc cccctttaca
      541 catgatttca ggaaagccca acaaagaatg ccagccattc ctgtcaatat ccactccatg
      601 aattttacct ggcaagctgc ggggcaggca gaatacttct acgagttcct gtctctgcgc
      661 tccctggata aaggcatcat ggcagatcca actgtcaatg tccctttgct gggaacagtg
      721 cctcacaagg catcagttgt tcaagttggt ttcccgtgtc tcggcaaaca agacggggta
      781 gcagcatttg aagtgaatgt gattgtcatg aattctgaag gcaacaccat ccttaggacc
      841 cctcagaatg ccatcttctt taaaacatgt caacaagctg agtgtcccgg agggtgtcga
      901 aatggaggct tttgtaacga aaggcgggtc tgcgagtgtc cggatgggtt ctacgggcct
      961 cactgtgaga aagccctgtg cataccccga tgtatgaacg gtggtctgtg tgtcactcct
     1021 ggcttctgca tctgcccccc tggattctac ggtgtcaact gtgacaaagc aaactgctca
     1081 accacctgct ttaatggagg gacctgcttt tacccgggaa aatgtatttg ccctcctgga
     1141 ctcgagggag agcagtgtga actcagcaaa tgcccccaac cctgccgaaa tggaggtaaa
     1201 tgcattggta aaagcaagtg taagtgcccg aaaggttacc aaggagacct gtgctctaag
     1261 cccgtctgcg agcctggctg tggtgcccac ggaacctgcc acgaacccaa caagtgccag
     1321 tgtcgagagg gctggcacgg cagacactgc aataagaggt atggagccag cctcatgcat
     1381 gccccgaggc cagcaggcgc cgggctggag cgacacacgc cttcacttaa aaaggctgag
     1441 gatagaaggg atccacctga atccaattac atctggtgaa cccctacccc accatctgaa
     1501 acggttcaag ttacaccggg ttcacagcct ttgttaacct ttcgcgtgtt ggatgttcaa
     1561 atgctgttca ttacacttta gaacgccggc ctgaatttta ttagcttcat tataaatcac
     1621 tgggctgata tctactcttc cttttaggtt ttctaagcgt gtctagcatg atggtataga
     1681 ttttcttcct tcagtccttt tgggacagat cttatattgt gtcagttgat caggttaaaa
     1741 agaaaaaaaa tatctgtctt ttcagtgtgt agttgacaga tacttgcaaa atcacaacac
     1801 atttgtggtc ttagaatggg gagtgttaga gaggttaaac tgggcagaga tgcataaatt
     1861 acaaggtttc ggataaagcc aatagcagcg tttaagctac agtatttcca attttattgt
     1921 caaatatttg gacatctgtc taattaatac ttcaattgcc ccccccccca tcttgaatgc
     1981 atacaatcta tttcaccctt gctgttactc tagacagttc agttttgatg gggcggggga
     2041 caaagtttaa aaaaattaca ctgagttagc ggcatttaaa caatataata tattgtaaac
     2101 acgacgagat aaggaatata atgtatgaag cctttgcatt ggatggaagc aatataatat
     2161 attgtaaaca aaacacagct cttacatagt aaacgtttta tactgtttgt atgtatgaaa
     2221 taaaggtgac gctttcactt tc
//
