LOCUS       NP_036045                379 aa            linear   ROD 04-MAR-2025
DEFINITION  wnt inhibitory factor 1 precursor [Mus musculus].
ACCESSION   NP_036045 XP_988322 XP_988358 XP_988395
VERSION     NP_036045.1
DBSOURCE    REFSEQ: accession NM_011915.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 379)
  AUTHORS   Bobzin,L., Nickle,A., Ko,S., Ince,M., Huang,A., Bhojwani,A.,
            Roberts,R. and Merrill,A.E.
  TITLE     FGFR2 directs inhibition of WNT signaling to regulate anterior
            fontanelle closure during skull development
  JOURNAL   Development 152 (2) (2025)
   PUBMED   39775862
REFERENCE   2  (residues 1 to 379)
  AUTHORS   Chen,B., Zou,J., Xie,L., Cai,Y., Li,B., Tan,W., Huang,J., Li,F. and
            Xu,H.
  TITLE     WNT-inhibitory factor 1-mediated glycolysis protects photoreceptor
            cells in diabetic retinopathy
  JOURNAL   J Transl Med 22 (1), 245 (2024)
   PUBMED   38448948
  REMARK    GeneRIF: WNT-inhibitory factor 1-mediated glycolysis protects
            photoreceptor cells in diabetic retinopathy.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 379)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 379)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   5  (residues 1 to 379)
  AUTHORS   Sulic,A.M., Das Roy,R., Papagno,V., Lan,Q., Saikkonen,R.,
            Jernvall,J., Thesleff,I. and Mikkola,M.L.
  TITLE     Transcriptomic landscape of early hair follicle and epidermal
            development
  JOURNAL   Cell Rep 42 (6), 112643 (2023)
   PUBMED   37318953
REFERENCE   6  (residues 1 to 379)
  AUTHORS   Hunter,D.D., Zhang,M., Ferguson,J.W., Koch,M. and Brunken,W.J.
  TITLE     The extracellular matrix component WIF-1 is expressed during, and
            can modulate, retinal development
  JOURNAL   Mol Cell Neurosci 27 (4), 477-488 (2004)
   PUBMED   15555925
  REMARK    GeneRIF: WIF-1 protein inhibits rod production, and anti-WIF-1
            antibodies increase rod production; in contrast, Wnt4 promotes rod
            production.
REFERENCE   7  (residues 1 to 379)
  AUTHORS   Diep,D.B., Hoen,N., Backman,M., Machon,O. and Krauss,S.
  TITLE     Characterisation of the Wnt antagonists and their response to
            conditionally activated Wnt signalling in the developing mouse
            forebrain
  JOURNAL   Brain Res Dev Brain Res 153 (2), 261-270 (2004)
   PUBMED   15527894
REFERENCE   8  (residues 1 to 379)
  AUTHORS   Heller,R.S., Dichmann,D.S., Jensen,J., Miller,C., Wong,G.,
            Madsen,O.D. and Serup,P.
  TITLE     Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in
            transgenic mice suggesting a role for Wnts in pancreas and foregut
            pattern formation
  JOURNAL   Dev Dyn 225 (3), 260-270 (2002)
   PUBMED   12412008
REFERENCE   9  (residues 1 to 379)
  AUTHORS   Bennett,C.N., Ross,S.E., Longo,K.A., Bajnok,L., Hemati,N.,
            Johnson,K.W., Harrison,S.D. and MacDougald,O.A.
  TITLE     Regulation of Wnt signaling during adipogenesis
  JOURNAL   J Biol Chem 277 (34), 30998-31004 (2002)
   PUBMED   12055200
REFERENCE   10 (residues 1 to 379)
  AUTHORS   Hsieh,J.C., Kodjabachian,L., Rebbert,M.L., Rattner,A.,
            Smallwood,P.M., Samos,C.H., Nusse,R., Dawid,I.B. and Nathans,J.
  TITLE     A new secreted protein that binds to Wnt proteins and inhibits
            their activities
  JOURNAL   Nature 398 (6726), 431-436 (1999)
   PUBMED   10201374
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK142443.1 and AK077698.1.
            
            On or before May 4, 2006 this sequence version replaced
            XP_988395.1, XP_988358.1, XP_988322.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK158359.1, AK077698.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..379
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 68.98 cM"
     Protein         1..379
                     /product="wnt inhibitory factor 1 precursor"
                     /calculated_mol_wt=38366
     sig_peptide     1..28
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=3242
     mat_peptide     29..379
                     /product="Wnt inhibitory factor 1. /id=PRO_0000007776"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WUA1.1)"
                     /calculated_mol_wt=38366
     Region          35..179
                     /region_name="WIF"
                     /note="Wnt-inhibitory factor-1 like domain; smart00469"
                     /db_xref="CDD:128745"
     Site            88
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WUA1.1)"
     Site            245
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9WUA1.1)"
     Region          348..379
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WUA1.1)"
     CDS             1..379
                     /gene="Wif1"
                     /gene_synonym="WIF-1"
                     /coded_by="NM_011915.2:340..1479"
                     /db_xref="CCDS:CCDS24209.1"
                     /db_xref="GeneID:24117"
                     /db_xref="MGI:MGI:1344332"
ORIGIN      
        1 marrrafpaf alrlwsilpc llllradagq ppeeslylwi dahqarvlig feedilivse
       61 gkmapfthdf rkaqqrmpai pvnihsmnft wqaagqaeyf yeflslrsld kgimadptvn
      121 vpllgtvphk asvvqvgfpc lgkqdgvaaf evnvivmnse gntilrtpqn aiffktcqqa
      181 ecpggcrngg fcnerrvcec pdgfygphce kalciprcmn gglcvtpgfc icppgfygvn
      241 cdkancsttc fnggtcfypg kcicppgleg eqcelskcpq pcrnggkcig kskckcpkgy
      301 qgdlcskpvc epgcgahgtc hepnkcqcre gwhgrhcnkr ygaslmhapr pagaglerht
      361 pslkkaedrr dppesnyiw
//
