LOCUS       NM_001004185            3097 bp    mRNA    linear   ROD 08-AUG-2024
DEFINITION  Mus musculus WAS protein homolog associated with actin, golgi
            membranes and microtubules (Whamm), transcript variant 1, mRNA.
ACCESSION   NM_001004185 XM_485955
VERSION     NM_001004185.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3097)
  AUTHORS   Coulter,A.M., Cortes,V., Theodore,C.J., Cianciolo,R.E.,
            Korstanje,R. and Campellone,K.G.
  TITLE     WHAMM functions in kidney reabsorption and polymerizes actin to
            promote autophagosomal membrane closure and cargo sequestration
  JOURNAL   Mol Biol Cell 35 (6), ar80 (2024)
   PUBMED   38598293
  REMARK    GeneRIF: WHAMM functions in kidney reabsorption and polymerizes
            actin to promote autophagosomal membrane closure and cargo
            sequestration.
REFERENCE   2  (bases 1 to 3097)
  AUTHORS   Zhang,D., Deng,W., Jiang,T., Zhao,Y., Bai,D., Tian,Y., Kong,S.,
            Zhang,L., Wang,H., Gao,S. and Lu,Z.
  TITLE     Maternal Ezh1/2 deficiency impairs the function of mitochondria in
            mouse oocytes and early embryos
  JOURNAL   J Cell Physiol 239 (6), e31244 (2024)
   PUBMED   38529784
REFERENCE   3  (bases 1 to 3097)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3097)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3097)
  AUTHORS   Huang,X., Ding,L., Pan,R., Ma,P.F., Cheng,P.P., Zhang,C.H.,
            Shen,Y.T., Xu,L., Liu,Y., He,X.Q., Qi,Z.Q. and Wang,H.L.
  TITLE     WHAMM is required for meiotic spindle migration and asymmetric
            cytokinesis in mouse oocytes
  JOURNAL   Histochem Cell Biol 139 (4), 525-534 (2013)
   PUBMED   23160625
  REMARK    GeneRIF: data suggest that WHAMM is required for peripheral spindle
            migration and asymmetric cytokinesis during mouse oocyte maturation
REFERENCE   6  (bases 1 to 3097)
  AUTHORS   Campellone,K.G., Webb,N.J., Znameroski,E.A. and Welch,M.D.
  TITLE     WHAMM is an Arp2/3 complex activator that binds microtubules and
            functions in ER to Golgi transport
  JOURNAL   Cell 134 (1), 148-161 (2008)
   PUBMED   18614018
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140366.2.
            
            On Mar 31, 2023 this sequence version replaced NM_001004185.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220273.1, SRR7652917.1060680.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-645               AC140366.2         23916-24560
            646-819             AC140366.2         27197-27370
            820-970             AC140366.2         30802-30952
            971-1140            AC140366.2         37753-37922
            1141-1306           AC140366.2         38785-38950
            1307-1494           AC140366.2         41989-42176
            1495-1581           AC140366.2         44413-44499
            1582-1677           AC140366.2         44658-44753
            1678-2146           AC140366.2         46303-46771
            2147-3097           AC140366.2         48538-49488
FEATURES             Location/Qualifiers
     source          1..3097
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.71 cM"
     gene            1..3097
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /note="WAS protein homolog associated with actin, golgi
                     membranes and microtubules"
                     /db_xref="GeneID:434204"
                     /db_xref="MGI:MGI:2142282"
     exon            1..645
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            646..819
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..970
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1140
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1306
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1494
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1495..1581
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1677
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..2146
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..3097
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2719..2724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /note="hexamer: AATAAA"
     polyA_site      2741
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /note="major polyA site"
     regulatory      3077..3082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /note="hexamer: ATTAAA"
     polyA_site      3097
                     /gene="Whamm"
                     /gene_synonym="mKIAA1971; Whdc1"
                     /note="major polyA site"
ORIGIN      
        1 agtagcggct cccggaaaat gtcgtggcct gtcgcagtct aagggtgtgc ggctgccatg
       61 gacagcgagc agcccgacag cctggatggc tgggttccgc tgcgtgagga cctcttcccg
      121 gagcccgagc gccatcagct gcgtttcctg gtggcctgga acgccgcgaa gggccagttc
      181 gccgtcacct gtcacgaccg cacggcgcag cggcggcggc gcgagcggcg ggaggccggc
      241 gacgggggat gtagctgggc cggggtgctg tcgcccgccg ggttccgcgg cgcgcaccgg
      301 cagctggcgg cgctgtggcc ggccctggag ccctgcttcc cgccgctgcc gcccgagctg
      361 gacgcggcga gcggcgcggg ctggggcctg ggacgcgggc tgtgggccct cctgtggccg
      421 ctcctgtggc cggcgcctgc ggaccctggc gactcggcgc tgcaggagct gtgccggcag
      481 ctggagcact acctgggcct ggcggccgaa ggatgcggcg gcgccaccgt gcgcgacgtg
      541 ctcttcccgg ccccgggtga ctcggcagac tgcgagggcc tgagcgagtt ccgcgagagg
      601 acgctgcgcg ctcgcctggg ccaaacggcc acccggctgc accaggttct tcaagatcac
      661 gggaaagcca ataccatggt agcattaatg aaagtttatc aagaggaaga tgagctctat
      721 caagaattag ttaccatggc aaccacattc ttccagtatt tactgcagcc atttagagac
      781 atgcgagaag ttgcaacttc atgtaagctt ggtattttga agtccctgga tgaggatgag
      841 ctgggtccta gaagggtggc tgccctacag aaggaagcca gtgaatggac cagacaggct
      901 gaagaagcag tgggctctat ccaagacatc actgtgaatt attttaaaga aacagtaaca
      961 gcactaacag gaatgcagaa acaaatggag caggatcaga agagatttgg ccaggctgcc
     1021 tgggccacag ccatgcccag gctagaaaat ctcaagctca tgttagctcg ggagactctg
     1081 cagcttatga gagccaaaga gctgtgtcta aaacacaggc aagctgaaat ccagagaaag
     1141 gtggaagatc ttccgcgcca aggaaagcag ttagatgttg tggatgagct ggagatacag
     1201 tgttatgaga tccagttgga gttgtatgat gtcaagcttg agatgctgag aaatgaggag
     1261 acaatccttg tcacgcggtt ggactctgtt aagagactta taacagagaa gcaggctgaa
     1321 gtgatctact acgacccgtg tgagagcccc gaggagctgc agagcctggc tcctgacctg
     1381 gaactgcacc ttggtgacaa cagagagctg agagcactca gccagcagtg ccagcggctg
     1441 gaggctcagc ggggccgcat ctgctccagg agagccctcc ttaggaacag aaaggatcac
     1501 tgccgagaaa atcatcagct cagactgcag caggccaaac aaagtctgag acaccttcac
     1561 cagcaccaca gtattcaaat gaagagagac aaagtaaaag aggaagaaca aaagaaaaaa
     1621 gaatggatag accatgaacg ccagaaaacc cttgagcggc taagagcata taaggagaag
     1681 tgcccggctc atcggtctgc actgaaaaca acttgttcag agtccatggt gtcaaacctg
     1741 ccaggtgggc gctctcagaa gaggctctca acggctcacc accacaagac agctcatcct
     1801 gcctccagca aaaccggaag tgctgttccc ttacctgaag ccagtgtgag accccctgag
     1861 catcaagacc cctgtggcag tgtccctgtc caggcttttg ttcctgttag tgaccagaca
     1921 ctgtctggat ccagtgaaga tctgtcacta ccaccacagc caccagctcc tcctctccct
     1981 cctcctcctc cccctcctcc ccctcctcct cttccccctg ctctgtcctc ttttcaaggt
     2041 accactcatc agaatttagg gctcaggact ttggcaacag aggaccggcc actcccacta
     2101 gcgtgtgacc catctgctgg gagaccatgt gactaccagg gtccaggctc tatggatgaa
     2161 gtgctggcct ctctccggca gggcaaagcc tctctccgga aagtagaaac gcccaccttg
     2221 ccccatcctg gcacctcagt caatgaacaa gttctggctg ccatcagaca gggcgtgcag
     2281 ctgaagaaag tccacacggg ccaaggtgtg gatcccggca agaagagcac cagcgacctg
     2341 gagaggagca tcagagaagc cctggagaga atcaagaaag tttctgccga ctcagaggag
     2401 gacaatgatg agccgagccc cactgagtgg gaccgctagg cttgctgtcc agctgacaga
     2461 tgcaggcagg cccacaaccc taggtcagcg aggccctgag aagctgcaac acggggaggt
     2521 cagtgaaggt gtgccaactg ccacacaaca ctcactgcgg ggtaggctgg acatggggac
     2581 aggactttgt ccactctagg gtcactggcc ctgcagggac agccctgagg tacacatgag
     2641 acaatatgct tccatgtata aacactggct cctcagactt caaggcttga atgtgaacat
     2701 gattttagca ataatcagaa taaattgtat atatcccaga attaccttaa aaattttatt
     2761 ttgtgtattg aacacagaaa ctcatactaa acaatattta tagtatatct gtattatgag
     2821 gaaatggtct ctgacccact gaaagcaaag ctcttcctgc ttgggggtag ttgaaaatgt
     2881 cccaggattc cagttgagct cgtgttaagg gcactaacgg catcgctcac ctcaggaact
     2941 ggtctcctga gaccctcttc actcgtgcta agtcagggat ggagagggac cgctacgtag
     3001 cagcctggtc actgctcaca ccgtccccac ctccgttcct ttaactactc accctagtcc
     3061 tcaatcatgg atccctatta aactaaatga acccaca
//
