LOCUS       NM_011716               3564 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus wolframin ER transmembrane glycoprotein (Wfs1), mRNA.
ACCESSION   NM_011716
VERSION     NM_011716.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3564)
  AUTHORS   Tulva,K., Pirajev,A., Zeb,A., Aksoy,A.E., Bello,A., Lee,B.,
            Guethjonsson,B.F., Helgadottir,S.B., Jagomae,T., Garcia-Llorca,A.,
            Eysteinsson,T., Jurgenson,M., Plaas,M., Vasar,E., Kaasik,A. and
            Hickey,M.A.
  TITLE     Early trigeminal and sensory impairment and lysosomal dysfunction
            in accurate models of Wolfram syndrome
  JOURNAL   Exp Neurol 385, 115099 (2025)
   PUBMED   39662795
REFERENCE   2  (bases 1 to 3564)
  AUTHORS   Ahuja,K., Vandenabeele,M., Nami,F., Lefevere,E., Van Hoecke,J.,
            Bergmans,S., Claes,M., Vervliet,T., Neyrinck,K., Burg,T., De
            Herdt,D., Bhaskar,P., Zhu,Y., Looser,Z.J., Loncke,J., Gsell,W.,
            Plaas,M., Agostinis,P., Swinnen,J.V., Van Den Bosch,L.,
            Bultynck,G., Saab,A.S., Wolfs,E., Chai,Y.C., Himmelreich,U.,
            Verfaillie,C., Moons,L. and De Groef,L.
  TITLE     A deep phenotyping study in mouse and iPSC models to understand the
            role of oligodendroglia in optic neuropathy in Wolfram syndrome
  JOURNAL   Acta Neuropathol Commun 12 (1), 140 (2024)
   PUBMED   39198924
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3564)
  AUTHORS   Zhou,X., Xiao,Q., Liu,Y., Chen,S., Xu,X., Zhang,Z., Hong,Y.,
            Shao,J., Chen,Y., Chen,Y., Wang,L., Yang,F. and Tu,J.
  TITLE     Astrocyte-mediated regulation of BLAWFS1 neurons alleviates
            risk-assessment deficits in DISC1-N mice
  JOURNAL   Neuron 112 (13), 2197-2217 (2024)
   PUBMED   38642554
REFERENCE   4  (bases 1 to 3564)
  AUTHORS   Zheng,Y., Zhao,C., Song,Q., Xu,L., Zhang,B., Hu,G., Kong,X., Li,S.,
            Li,X., Shen,Y., Zhuang,L., Wu,M., Liu,Y. and Zhou,Y.
  TITLE     Histone methylation mediated by NSD1 is required for the
            establishment and maintenance of neuronal identities
  JOURNAL   Cell Rep 42 (12), 113496 (2023)
   PUBMED   37995181
REFERENCE   5  (bases 1 to 3564)
  AUTHORS   Zhang,B., Zhao,C., Shen,W., Li,W., Zheng,Y., Kong,X., Wang,J.,
            Wu,X., Zeng,T., Liu,Y. and Zhou,Y.
  TITLE     KDM2B regulates hippocampal morphogenesis by transcriptionally
            silencing Wnt signaling in neural progenitors
  JOURNAL   Nat Commun 14 (1), 6489 (2023)
   PUBMED   37838801
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3564)
  AUTHORS   Ishihara,H., Takeda,S., Tamura,A., Takahashi,R., Yamaguchi,S.,
            Takei,D., Yamada,T., Inoue,H., Soga,H., Katagiri,H., Tanizawa,Y.
            and Oka,Y.
  TITLE     Disruption of the WFS1 gene in mice causes progressive beta-cell
            loss and impaired stimulus-secretion coupling in insulin secretion
  JOURNAL   Hum Mol Genet 13 (11), 1159-1170 (2004)
   PUBMED   15056606
  REMARK    GeneRIF: The role of WFS1 in the etiology of Wolfram syndrome is
            examined in WFS1 mutant mice.
REFERENCE   7  (bases 1 to 3564)
  AUTHORS   Cryns,K., Thys,S., Van Laer,L., Oka,Y., Pfister,M., Van Nassauw,L.,
            Smith,R.J., Timmermans,J.P. and Van Camp,G.
  TITLE     The WFS1 gene, responsible for low frequency sensorineural hearing
            loss and Wolfram syndrome, is expressed in a variety of inner ear
            cells
  JOURNAL   Histochem Cell Biol 119 (3), 247-256 (2003)
   PUBMED   12649740
  REMARK    GeneRIF: may play a role in inner ear ion homeostasis as maintained
            by the canalicular reticulum
REFERENCE   8  (bases 1 to 3564)
  AUTHORS   Hurle,B., Lane,K., Kenney,J., Tarantino,L.M., Bucan,M.,
            Brownstein,B.H. and Ornitz,D.M.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
REFERENCE   9  (bases 1 to 3564)
  AUTHORS   Strom,T.M., Hortnagel,K., Hofmann,S., Gekeler,F., Scharfe,C.,
            Rabl,W., Gerbitz,K.D. and Meitinger,T.
  TITLE     Diabetes insipidus, diabetes mellitus, optic atrophy and deafness
            (DIDMOAD) caused by mutations in a novel gene (wolframin) coding
            for a predicted transmembrane protein
  JOURNAL   Hum Mol Genet 7 (13), 2021-2028 (1998)
   PUBMED   9817917
REFERENCE   10 (bases 1 to 3564)
  AUTHORS   Inoue,H., Tanizawa,Y., Wasson,J., Behn,P., Kalidas,K.,
            Bernal-Mizrachi,E., Mueckler,M., Marshall,H., Donis-Keller,H.,
            Crock,P., Rogers,D., Mikuni,M., Kumashiro,H., Higashi,K., Sobue,G.,
            Oka,Y. and Permutt,M.A.
  TITLE     A gene encoding a transmembrane protein is mutated in patients with
            diabetes mellitus and optic atrophy (Wolfram syndrome)
  JOURNAL   Nat Genet 20 (2), 143-148 (1998)
   PUBMED   9771706
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY063019.1, BY296480.1, AK144561.1, CX562372.1 and AC115722.12.
            
            On Dec 20, 2006 this sequence version replaced NM_011716.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046988.1, AF084482.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                BY063019.1         225-241
            18-358              BY296480.1         1-341
            359-984             AK144561.1         311-936
            985-1046            CX562372.1         615-676
            1047-3564           AC115722.12        106033-108550
FEATURES             Location/Qualifiers
     source          1..3564
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 19.46 cM"
     gene            1..3564
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /note="wolframin ER transmembrane glycoprotein"
                     /db_xref="GeneID:22393"
                     /db_xref="MGI:MGI:1328355"
     exon            1..117
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /inference="alignment:Splign:2.1.0"
     exon            118..357
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..2795
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /note="Wolfram syndrome 1 protein homolog; Wolfram
                     syndrome 1 homolog"
                     /codon_start=1
                     /product="wolframin"
                     /protein_id="NP_035846.1"
                     /db_xref="CCDS:CCDS19245.1"
                     /db_xref="GeneID:22393"
                     /db_xref="MGI:MGI:1328355"
                     /translation="MNSGTPPPSPSGPPPPPAPQPQARARLNATASLEQDKIEPPRAP
                     RPQADPSAGRSAGEAAAPEPRAPQTGSREETDRAGPMKADVEIPFEEVLEKAKAGDPK
                     AQTEVGKHYLRLANDADEELNSCSAVAWLILAAKQGRREAVKLLRRCLADRKGITSEN
                     EAEVKQLSSETDLERAVRKAALVMYWKLNPKKKKQVAVSELLENVGQVNEQDGGAQPG
                     PVPKSLQKQRRMLERLVSSESKNYIALDDFVELTKKYAKGIIPTNLFLQDEDEDEDEL
                     AGKSPEDLPLRQKVVKYPLHAIMEIKEYLIDVASKAGMHWLSTIVPTHHINALIFFFI
                     ISNLTIDFFAFFIPLVVFYLSFVSMVICTLKVFQDSKAWENFRTLTDLLLRFEPNLDV
                     EQAEVNFGWNHLEPYIHFLLSVVFVIFSFPLASKDCIPCSELAVISTFFTVTSYMSLS
                     SSAEPYTRRALVTEVAAGLLSLLPTVPVDWRFLKVLGQTFFTVPVGHFIILNVSLPCL
                     LYVYLFYLFFRMAQLRNFKGTYCYLVPYLVCFMWCELSVVILLQSTGLGLVRASIGYF
                     LFLFALPILVAGLALMGTVQFARWFLSLDLTKIMVTTVICGVPLLFRWWTKANFSVMG
                     MVKSLTKSSMVKLILVWLTAILLFCWFYVYRSEGMKVYNSTLTWQQYGFLCGPRAWKE
                     TNMARTQILCSHLEGHRVTWTGRFKYVRVTEIDNSAESAINMLPFFLGDWMRCLYGEA
                     YPSCSSGNTSTAEEELCRLKQLAKHPCHIKKFDRYKFEITVGMPFGTNGNRGHEEDDI
                     TKDIVLRASSEFKDVLLNLRQGSLIEFSTILEGRLGSKWPVFELKAISCLNCMTQLSP
                     ARRHVKIEQDWRSTVHGALKFAFDFFFFPFLSAA"
     exon            358..440
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /inference="alignment:Splign:2.1.0"
     exon            441..585
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /inference="alignment:Splign:2.1.0"
     exon            586..756
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /inference="alignment:Splign:2.1.0"
     exon            757..837
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /inference="alignment:Splign:2.1.0"
     exon            838..989
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /inference="alignment:Splign:2.1.0"
     exon            990..3564
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3542..3547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /note="hexamer: AATAAA"
     polyA_site      3562
                     /gene="Wfs1"
                     /gene_synonym="wolframin"
                     /note="major polyA site"
ORIGIN      
        1 tttcccgggg ccgcgctgaa tgtagggccg cgcgctccgc ctgctcagct ggccgctgca
       61 atctccgcgg tttcggagca acttcgcggc gggctgggag gcccagcact gcggccggca
      121 agatgaactc aggcacccca cctccgagcc cctctggccc acctcctcca cccgcaccac
      181 agccccaggc ccgggcccgg ctcaatgcca ccgcctcact ggagcaggac aagattgaac
      241 cgcctcgtgc tcccagacct caggctgacc ccagtgctgg acgaagtgct ggggaagcag
      301 ccgctccgga gcctcgggcc cctcaaaccg gcagccggga agaaacggac agagctggtc
      361 ccatgaaggc agatgtggag atcccctttg aagaagtcct ggagaaagcc aaggctggag
      421 accccaaagc acagactgag gtgggcaaac actacctacg ccttgccaac gatgcagatg
      481 aagaactcaa cagctgctca gccgtagcct ggctaatcct ggcagccaag cagggcaggc
      541 gggaggccgt gaagctgctg aggcggtgcc tagctgaccg gaaaggcatc acttctgaga
      601 acgaggctga ggtgaagcag ctatcctctg agaccgacct ggaaagggct gtgcgcaagg
      661 ctgccctggt catgtactgg aaactcaacc ccaagaagaa gaagcaggtg gctgtgtccg
      721 agctgctgga gaatgttgga caggtcaacg agcaggatgg aggggcgcag ccaggcccag
      781 tccccaagtc cctgcagaag cagaggcgca tgctggagcg cctcgtcagc agtgaatcca
      841 agaactacat tgctctggac gattttgtgg agctcaccaa gaagtacgcc aagggcatca
      901 ttcccaccaa cctgttcctg caggatgagg atgaagatga ggacgagctg gcagggaaga
      961 gccccgagga cctgccacta cgccagaagg tggtgaagta ccctttacac gccatcatgg
     1021 agatcaaaga gtacctgatt gacgtagcct ccaaggccgg catgcactgg ctctccacca
     1081 ttgtacccac ccatcacatc aacgccctca tcttcttctt catcatcagc aacctaacca
     1141 tcgacttctt cgccttcttc atccccctgg tggtcttcta tctgtccttt gtgtccatgg
     1201 tcatctgcac gctcaaggtg ttccaggaca gcaaggcctg ggagaacttc cgtactctca
     1261 ccgacctgct gctgcgcttc gagcccaacc tagacgtgga gcaggccgaa gtgaacttcg
     1321 gctggaacca cctggagccc tacatccact tcctactgtc agtcgtcttt gtcatcttct
     1381 ccttcccgct ggccagcaag gactgcatcc cctgctcgga gctggccgtc atctccacct
     1441 tcttcacggt gaccagctac atgagcctga gcagctctgc tgagccctat accaggcgtg
     1501 ccctggtcac cgaggtggct gccggcttgc tgtcccttct gcccaccgtg cctgtggact
     1561 ggcgcttcct gaaagtactc ggccagactt tcttcactgt gcccgttggc cacttcatca
     1621 tcctcaacgt cagcctcccc tgcctgctct atgtctatct cttttacctc ttcttccgca
     1681 tggcccagct gaggaacttc aagggcactt attgctacct ggtgccctac ctggtgtgct
     1741 tcatgtggtg tgaactgtcc gtggtcatcc tgctccagtc taccggcctg ggcttggtcc
     1801 gggcctccat cggctacttc ctcttcctct ttgccctccc catcctggtg gctggcctcg
     1861 ccttgatggg cacggtgcag tttgcccgat ggttcctgtc gctggacctc accaagatca
     1921 tggtcaccac ggtgatctgc ggcgtacccc tgcttttccg ttggtggacc aaggccaact
     1981 tctcagtgat ggggatggtc aagtccctga cgaagagctc catggtgaag ctcattctgg
     2041 tgtggctaac ggccatcctg ctcttctgct ggttctacgt gtaccgctca gaaggcatga
     2101 aggtctacaa ctccacactc acctggcagc aatatggctt cctatgtggg ccccgggcct
     2161 ggaaggaaac taacatggcc cggacccaga tcctgtgcag ccacctggag ggccacaggg
     2221 tcacgtggac aggccgcttc aagtatgtcc gagtgaccga gatcgacaac agtgctgagt
     2281 cggccatcaa catgctcccg ttcttcctgg gcgattggat gcgctgcctg tatggcgagg
     2341 cctacccatc ttgtagctct ggtaacacgt ccacggcaga ggaggagctc tgccgtctca
     2401 agcagctggc caagcacccc tgccacatca agaagtttga ccgctacaaa tttgagatca
     2461 cagtgggcat gccctttggc accaacggca accgcggcca tgaagaggac gacatcacca
     2521 aggacattgt tctccgtgcc agcagcgagt tcaaggacgt gctgctgaac ctgcgccagg
     2581 ggagcctcat agagttcagc accatcctcg agggccgcct gggtagcaag tggcccgtct
     2641 tcgagctcaa ggccatcagc tgcctcaact gcatgacgca gctgtcacct gcccggaggc
     2701 acgtgaagat cgaacaggac tggcgtagca cagtgcacgg tgccctcaag tttgccttcg
     2761 acttcttctt cttcccattc ctgtctgccg cctgaggagc gtccgccgct ggaggaggct
     2821 ttggtgcatg ttgctgtgaa gtccttccgt gtggccaccc agccagctgg agcagcactg
     2881 tgccgtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt atgtgtattc tgctctcgtg
     2941 tggttagatc ccaggctctc tgctcacctg tagatcgcag atcctgctgg agggtggttc
     3001 tctttagcac tgtccacttt gaatgccgag tgtcataaga aattgcatgc tatcttcact
     3061 cacaatcctg cccttccctc acagagctgg aactccaagc ctggccccaa agaccctcca
     3121 tcacgaagag cactttacag ataagaatct tcctccccag ttcttcatgc ctccttcctg
     3181 ccctttcctt actttgtgtt ggatttgttt tccaaatatg tgtgtatgta gacttcatgg
     3241 tagtgtttct tatttatttg gttgctgcta agccttgaca gtggttcacc ttcctgggct
     3301 gtccccagtg gtcacgtcct gcctggcttc ctacttgggt atagcatgtc caaactgggc
     3361 tctgaacact acagcctgcc ttggagctgg cctatctctg ggggtgttag agagtttgtg
     3421 gggatctctt ctgagtaccc caggacttgg gaaataatgc aagagtatcc ctttcagtac
     3481 ataggtaagc ttggctatgt tcaatatggc agagccaaaa gccaagttct aaggcagccg
     3541 aaataaaaag ctttgaaacc tata
//
