LOCUS       NM_001100454            2536 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WAP, FS, Ig, KU, and NTR-containing protein 1
            (Wfikkn1), mRNA.
ACCESSION   NM_001100454 XM_128578 XM_914842
VERSION     NM_001100454.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2536)
  AUTHORS   Feng,S., Bai,M., Rivas-Gonzalez,I., Li,C., Liu,S., Tong,Y.,
            Yang,H., Chen,G., Xie,D., Sears,K.E., Franco,L.M.,
            Gaitan-Espitia,J.D., Nespolo,R.F., Johnson,W.E., Yang,H.,
            Brandies,P.A., Hogg,C.J., Belov,K., Renfree,M.B., Helgen,K.M.,
            Boomsma,J.J., Schierup,M.H. and Zhang,G.
  TITLE     Incomplete lineage sorting and phenotypic evolution in marsupials
  JOURNAL   Cell 185 (10), 1646-1660 (2022)
   PUBMED   35447073
REFERENCE   2  (bases 1 to 2536)
  AUTHORS   Parente,A., Boukredine,A., Baraige,F., Duprat,N.,
            Gondran-Tellier,V., Magnol,L. and Blanquet,V.
  TITLE     GASP-2 overexpressing mice exhibit a hypermuscular phenotype with
            contrasting molecular effects compared to GASP-1 transgenics
  JOURNAL   FASEB J 34 (3), 4026-4040 (2020)
   PUBMED   31960486
REFERENCE   3  (bases 1 to 2536)
  AUTHORS   Dai,X., Jiang,W., Zhang,Q., Xu,L., Geng,P., Zhuang,S.,
            Petrich,B.G., Jiang,C., Peng,L., Bhattacharya,S., Evans,S.M.,
            Sun,Y., Chen,J. and Liang,X.
  TITLE     Requirement for integrin-linked kinase in neural crest migration
            and differentiation and outflow tract morphogenesis
  JOURNAL   BMC Biol 11, 107 (2013)
   PUBMED   24131868
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2536)
  AUTHORS   Lee,Y.S. and Lee,S.J.
  TITLE     Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2
  JOURNAL   Proc Natl Acad Sci U S A 110 (39), E3713-E3722 (2013)
   PUBMED   24019467
  REMARK    GeneRIF: GASP-1 and GASP-2 are important modulators of GDF-11 and
            MSTN activity in vivo.
REFERENCE   5  (bases 1 to 2536)
  AUTHORS   Kondas,K., Szlama,G., Trexler,M. and Patthy,L.
  TITLE     Both WFIKKN1 and WFIKKN2 have high affinity for growth and
            differentiation factors 8 and 11
  JOURNAL   J Biol Chem 283 (35), 23677-23684 (2008)
   PUBMED   18596030
REFERENCE   6  (bases 1 to 2536)
  AUTHORS   Liepinsh,E., Nagy,A., Trexler,M., Patthy,L. and Otting,G.
  TITLE     Second Kunitz-type protease inhibitor domain of the human WFIKKN1
            protein
  JOURNAL   J Biomol NMR 35 (1), 73-78 (2006)
   PUBMED   16791741
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159277.3.
            
            On or before Dec 18, 2007 this sequence version replaced
            XM_914842.2, XM_128578.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC147298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-995               AC159277.3         152510-153504
            996-2536            AC159277.3         154200-155740
FEATURES             Location/Qualifiers
     source          1..2536
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.97 cM"
     gene            1..2536
                     /gene="Wfikkn1"
                     /gene_synonym="Gasp2; Wfikkn"
                     /note="WAP, FS, Ig, KU, and NTR-containing protein 1"
                     /db_xref="GeneID:215001"
                     /db_xref="MGI:MGI:2670967"
     exon            1..995
                     /gene="Wfikkn1"
                     /gene_synonym="Gasp2; Wfikkn"
                     /inference="alignment:Splign:2.1.0"
     CDS             816..2474
                     /gene="Wfikkn1"
                     /gene_synonym="Gasp2; Wfikkn"
                     /note="WAP, kazal, immunoglobulin, kunitz and NTR
                     domain-containing protein 1; GASP-2; mGASP-2; growth and
                     differentiation factor-associated serum protein 2"
                     /codon_start=1
                     /product="WAP, Kazal, immunoglobulin, Kunitz and NTR
                     domain-containing protein 1 precursor"
                     /protein_id="NP_001093924.1"
                     /db_xref="CCDS:CCDS50038.1"
                     /db_xref="GeneID:215001"
                     /db_xref="MGI:MGI:2670967"
                     /translation="MPAPQPFLPLLFVFVLIHLTSETNLLPDPGSHPGMCPNELSPHL
                     WVDAQSTCERECTGDQDCAASEKCCTNVCGLQSCVAARFPSGGPAVPETAASCEGFQC
                     PQQGSDCDIWDGQPVCRCRDRCEKEPSFTCASDGLTYYNRCYMDAEACLRGLHLHVVP
                     CKHILSWPPSSPGPPETTARPTPGAAPMPPALYNSPSPQAVHVGGTASLHCDVSGRPP
                     PAVTWEKQSHQRENLIMRPDQMYGNVVVTSIGQLVLYNAQLEDAGLYTCTARNAAGLL
                     RADFPLSVLQRATTQDRDPGIPALAECQADTQACVGPPTPHHVLWRFDPQRGSCMTFP
                     ALRCDGAARGFETYEACQQACVRGPGDVCALPAVQGPCQGWEPRWAYSPLLQQCHPFV
                     YSGCEGNSNNFETRESCEDACPVPRTPPCRACRLKSKLALSLCRSDFAIVGRLTEVLE
                     EPEAAGGIARVALDDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNVTAVDGPLVIM
                     GEVREGVAVLDANSYVRAASEKRVKKIVELLEKKACELLNRFQD"
     exon            996..2536
                     /gene="Wfikkn1"
                     /gene_synonym="Gasp2; Wfikkn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2514..2519
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wfikkn1"
                     /gene_synonym="Gasp2; Wfikkn"
                     /note="hexamer: AATAAA"
     polyA_site      2536
                     /gene="Wfikkn1"
                     /gene_synonym="Gasp2; Wfikkn"
                     /note="major polyA site"
ORIGIN      
        1 ctttttgaga cagtatgttc ttatgtggcc aaacgggcct ggaatttgct atgtagctat
       61 gggctggcct caatctggat cctcctgtgt cccgcctacc cagtgctggg gttacaagtg
      121 tgtaccacag atgccaagta ccctaggggt ttcttactcc atgccagtgg gaaaggtgcc
      181 ttacctatag ttatgacagg tgtggccctt ggctgccttt ggagaaaatc tagtctaata
      241 gctggggctg gactgggtcc ctatccaacc tcactgaata ggacactgaa gagcagagga
      301 caaaagccga aatttaccag ccctgcccct cctccctgaa tagagggtgg gagggtcttt
      361 aaggagactt tgatccctgt tgggctccag cttgtagagg gaggggctca ggttacagca
      421 tccccctccc tgattgagct ggcccttctc cgccccttgg tgaccctagt ggtcagttgc
      481 tctgggcttc agggcctctg gcccctcccc agcccttcct cttcttctat tcccagtcct
      541 atgctgacca gagcctggga gccacccaca gtggttggga gagggccagc cagtattttg
      601 tggacaggtt ctgagaggcc ccagaataac tattcagggt tcagagaaga gcagcatcac
      661 ctgtgagctc aagccttgcg gggtccaaga gtcccaggag agggtccttt gaggtagggg
      721 gtagtgatcc tgggcccagg accctatagg gtggatgcct atagggagtc tcagctggtg
      781 gccacacact cccactccct ggccctgtgg tccccatgcc tgccccacag ccattcctgc
      841 ctctgctctt tgtcttcgtg ctcatccatc tgacctcgga gaccaacctg ctgccagatc
      901 ccggaagcca tcctggcatg tgccccaacg agctcagccc ccacctgtgg gtcgacgccc
      961 agagcacctg tgagcgtgag tgtaccgggg accaggactg tgcggcatcc gagaagtgct
     1021 gcaccaatgt gtgtgggctg cagagctgcg tggctgcccg ctttcccagt ggtggcccag
     1081 ctgtacctga gacagcagcc tcctgtgaag gcttccaatg cccacaacag ggttctgact
     1141 gtgacatctg ggatgggcag ccagtttgtc gctgccgtga ccgctgtgaa aaagaaccca
     1201 gcttcacatg tgcttctgat ggccttacct attacaaccg ctgctacatg gacgcagaag
     1261 cctgcctgcg gggtctccac ctgcacgttg taccctgtaa gcacattctc agttggccgc
     1321 ccagcagccc gggaccaccc gagaccactg ctcgcccaac ccctggggct gctcccatgc
     1381 cacctgccct gtacaacagc ccctcaccac aggcagtgca tgttgggggg acagccagcc
     1441 tccactgtga tgttagtggc cgtccaccac ctgctgtgac ctgggagaag cagagccatc
     1501 agcgggagaa cctgatcatg cgccctgacc aaatgtatgg caacgtggtt gtcaccagta
     1561 tcggacagct agtcctctac aatgctcagt tggaggatgc gggcctgtat acctgcactg
     1621 cacgaaacgc tgccggcctg ctgcgggccg actttcccct ttccgtttta cagcgggcaa
     1681 ctactcagga cagggaccca ggtatcccag ccttggctga gtgccaggcc gacacacaag
     1741 cctgtgttgg gccacctact ccccatcatg tcctttggcg ctttgaccca cagagaggca
     1801 gctgcatgac attcccagcc ctcagatgtg atggggctgc ccggggcttt gagacctatg
     1861 aggcatgcca gcaggcctgt gttcgtggcc ccggggatgt ctgtgcactg cctgcagttc
     1921 aggggccctg ccagggctgg gagccacgct gggcctacag cccactgcta cagcagtgcc
     1981 acccctttgt atacagtggc tgtgaaggaa acagcaataa ctttgagacc cgggagagct
     2041 gtgaggatgc ttgccctgta ccacgcacac caccctgtcg tgcctgccgc ctcaagagca
     2101 agctggctct gagcttgtgc cgcagtgact ttgccatcgt ggggagactc acagaggtcc
     2161 tggaggagcc cgaggctgca ggcggcatag ctcgtgtggc cttggatgat gtgctaaagg
     2221 acgacaagat gggcctcaag ttcttgggca ccaaatacct ggaggtgaca ttgagtggca
     2281 tggactgggc ctgcccatgc cccaacgtga cagctgtcga tgggccactg gtcatcatgg
     2341 gtgaggttcg tgaaggtgtg gctgtgttgg acgccaacag ctatgtccgt gctgccagcg
     2401 agaagcgagt caagaagatt gtggaactgc tcgagaagaa ggcttgtgaa ctgctcaacc
     2461 gcttccaaga ctagttttat gcacgatccc catccctgcc ctccttcctg ctgaataaat
     2521 gtccttgcct gtggga
//
