LOCUS       NM_001276432            3474 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus WAP four-disulfide core domain 8 (Wfdc8), transcript
            variant 1, mRNA.
ACCESSION   NM_001276432
VERSION     NM_001276432.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3474)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   2  (bases 1 to 3474)
  AUTHORS   Sivashanmugam,P., Hall,S.H., Hamil,K.G., French,F.S., O'Rand,M.G.
            and Richardson,R.T.
  TITLE     Characterization of mouse Eppin and a gene cluster of similar
            protease inhibitors on mouse chromosome 2
  JOURNAL   Gene 312, 125-134 (2003)
   PUBMED   12909348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591478.19.
            
            On Jul 19, 2022 this sequence version replaced NM_001276432.1.
            
            Sequence Note:.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136599.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1270              AL591478.19        165427-166696       c
            1271-1585           AL591478.19        161853-162167       c
            1586-1703           AL591478.19        161639-161756       c
            1704-1844           AL591478.19        158837-158977       c
            1845-2012           AL591478.19        156224-156391       c
            2013-2153           AL591478.19        153020-153160       c
            2154-3474           AL591478.19        149529-150849       c
FEATURES             Location/Qualifiers
     source          1..3474
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.22 cM"
     gene            1..3474
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /note="WAP four-disulfide core domain 8"
                     /db_xref="GeneID:277343"
                     /db_xref="MGI:MGI:2685552"
     exon            1..1270
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1585
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /inference="alignment:Splign:2.1.0"
     CDS             1472..2752
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /note="isoform 1 is encoded by transcript variant 1; WAP
                     four-disulfide core domain protein 8; WAP-type serine
                     protease inhibitor; putative protease inhibitor WAP8C"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 8 isoform
                     1"
                     /protein_id="NP_001263361.1"
                     /db_xref="CCDS:CCDS71191.1"
                     /db_xref="GeneID:277343"
                     /db_xref="MGI:MGI:2685552"
                     /translation="MAKCGVPQRVPGDCFRPVSTRHPRQIPSCFSICFLTHEAQSLRA
                     LAHSWWSGALLLLLLFLFLSLEQTSTSYNAKIKQKVGECPRQRLECRNESLSSCKTDF
                     NCKAHFKCCQFACGRKCMDPYEEPCMLPSDKGNCQDILTRWYFDSQKHQCRAFLYSGC
                     RGNANNFLTKTDCRNACMFVEKKGQCPLFPFQMRMECPASCKNDMDCPEKEKCCESRC
                     GFICARVWLVSCFRPGQQPGRILSLIDKRDPFIFSVTFGVRSTHSVTQLSSCHFTGCS
                     SHCIHGIFGFVPAMHGVPVQRVPGLTGHHGLGLSHEHRAMPDTQPRLSSPLASQTTAS
                     LHSCRLCTRIWGEIPPHCTPRPPPWGGASSAPLTHPWTRCTLCQRPLATGSGLLLLSS
                     SPYCPCNLPAVPRCISVLNNCLKLIRFFYIFQTY"
     exon            1586..1703
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1844
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2012
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2153
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /inference="alignment:Splign:2.1.0"
     exon            2154..3474
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3451..3456
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /note="hexamer: AATAAA"
     polyA_site      3474
                     /gene="Wfdc8"
                     /gene_synonym="Gm706"
                     /note="major polyA site"
ORIGIN      
        1 agactgtggg gaaagggatc tggcatgctg gtcagggcct ctgctggcgg ttcccttccc
       61 tctctccatc cttctctttt ccttgagaca ggatttgacc tctcccaggc tggcctcaaa
      121 cttgctatgt agtagaagtt actgatccgt ctgcatccac ctccgcagga ctgggatcgc
      181 aggtctgcat cacctcaccc agtgagtgtg gggctggggg tggaatcagc tcttcacgca
      241 tgctgggcaa gcaacgatca gttgagctgc atactgtcct ggccgctgat tctcctcatc
      301 tctgggctaa ttatctgtgg ctttgaccct gtgtctcctt tgtctcctta caatgtctct
      361 ctgcctaggt ctcttcctcc ttcccctcag ccccctgtgg atgttccctc tcttgtcttt
      421 ggctcagaca tcatctttag tcaccaccca agagtaaatt ctgtcaggtg gacaggaagc
      481 caccattcct ggtgagcatc aggccaggag atggcacctc taaggcagga gaacaaggga
      541 agctgagagc ctctgtccca agtgcaggtt agcggggacc acaagaaaca atgactcagt
      601 cagctgcagg agggactaaa agtagttctc tgattgctct ggaatattcc ctcaacttaa
      661 atactgaagc tttagtgaag gagcgaatgc agtgtgggca caatgtgagc catgcagggg
      721 taaactgagg cagggaccgc tggcagcagc cacatgcact tgatgcaccc atctacaact
      781 gcaagagaca gtcccacagc gtctgctttg acaaaccgtg ctaaacgtcc atcagataaa
      841 accgaccatt ttcaggtcaa caatttcaag cccttgtgat actcatgaga ttgtgtgtcc
      901 tatctgctgg ttctgaaatg tttttaatct ctccagctgt aaaccctgtc tcatgagcaa
      961 tcactcgcta gccggctgca acccactcca gcccctgaga ctgcttccca tcttgtaggg
     1021 cttcctgcgg ttcctgtctt tgcctgtggt gagtcttcag tccggcgcct cacacacacg
     1081 ctccacctct gagttacatc cctagccctc tctttccttt cttaaacttt taagagagac
     1141 cattactacc gtgccccaac tggccttgga tatgtaatcc tcctgcctcc tgaggatgtg
     1201 atcacaggcc tgagctacca tgcctgactt ctgccctgga catttcttct gtatggagtc
     1261 atacagtaaa gtctccagac aatctccatc cctgtcatca gaggagcaga gcaaaggccc
     1321 cactgaatca tgtctgcagt ttcttcagac agaagcacag gaaagtcacc tgggaactgt
     1381 tccaaacgca gcgctgtgat gattcaagtg tgacctctta cccaggagcg agacagtggg
     1441 gaagtgacca agaaggacca gatgcagcgc aatggccaag tgtggggtgc cacagagagt
     1501 cccgggtgac tgcttcagac ctgtctcaac tcgccacccc aggcagatcc cttcttgctt
     1561 ctccatctgt ttcctcaccc atgaagcgca gtccctccgc gcccttgccc actcctggtg
     1621 gagtggagct ctgctgctgc tgctgctgtt tctcttcctc tccttggagc agacctcaac
     1681 atcatacaac gccaagatca aacaaaaagt gggagagtgt cctaggcagc ggttggaatg
     1741 cagaaacgag agtttgagct cctgcaaaac ggacttcaac tgtaaggcgc atttcaagtg
     1801 ctgccaattt gcctgtggga ggaaatgcat ggatccctat gaagagccct gcatgctacc
     1861 ctcagacaaa ggaaactgcc aggacatttt gacgcgctgg tattttgact ctcagaagca
     1921 ccagtgcaga gcctttctat acagtggatg ccgtgggaat gcgaacaact tcctcaccaa
     1981 gactgactgt agaaacgctt gcatgtttgt tgagaagaaa ggacagtgcc cgctgttccc
     2041 tttccaaatg cgaatggagt gcccagcctc ctgtaagaac gacatggatt gcccggagaa
     2101 ggagaaatgc tgcgagtcca ggtgtggctt catctgtgcc cgagtctggc tagtttcctg
     2161 ctttcggcct ggacagcaac caggaagaat tctttccctg atagacaaga gagacccttt
     2221 catcttttca gtcacctttg gggtgaggtc cacacactcg gtgacacaac tgtctagctg
     2281 ccacttcaca ggatgctcct cccactgcat ccatggaatc tttggctttg tccctgcgat
     2341 gcatggtgtg cctgtccaga gggtcccggg actcactggt caccatggac tgggcttgag
     2401 ccatgagcac agggcaatgc ctgacacaca gccacgcctc tcctcacctc tcgcctcaca
     2461 gacaactgcc agtcttcaca gctgcagact ctgtaccaga atatggggcg aaatccctcc
     2521 tcattgtacg cccagacccc ccccctgggg gggggcttcc tcagcaccgc taacacaccc
     2581 gtggaccaga tgcacattgt gccagcgccc ccttgccact gggtctggct tactgctact
     2641 cagttcctca ccttattgcc cgtgcaatct tcctgccgtt cctcggtgta tttcagtctt
     2701 gaataattgt ctaaagctga tccgtttttt ctatatattt caaacgtatt aacgctgagg
     2761 accagcttag catccaggta aaccgaggaa ggcagccagg tgtgtcatct gcaggggtca
     2821 aaacctgatg acccttgtct atttaattct ctcttggtgt tcttaggcca aaagttgaag
     2881 gcctctggca attactcctg ctgatagtag caggggatta agaaaagaaa cctagttact
     2941 tggactcttt gactcatggg cctcttactg gccaggccag gttctgctct ccagagccag
     3001 aaagaaaagg agagagaggg agggggaggg gagggggatg gggagaagca gaaacgggct
     3061 acatctttac tgttgtgttt ttctgaaaca ctttactgtt gttcttctcc cttctcagga
     3121 gagtggatca cacggccttt gaagcacttt tacatcccat aagttcatag caagtttaag
     3181 gcaatagttc atgtcatagg ttgataaggt ttagggagtt atagcagaat cgattacatg
     3241 tcttcccgtt aagactagta cctgactgaa catttcatta tctattgtct agctccatac
     3301 gttcgttgta agtttaaagc aatagttttt atgtcacaag ttagcacagt ttcatcaaga
     3361 gacaaatcgt ctgctttgtg ccatattatt ttgaagtctt gtatagataa actagtcaat
     3421 ctcttatttt ttttttgtcc ttgcatttaa aataaattgt ccattcccag ttta
//
