LOCUS       NM_145369               2324 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus WAP four-disulfide core domain 5 (Wfdc5), mRNA.
ACCESSION   NM_145369
VERSION     NM_145369.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2324)
  AUTHORS   Andrade AD, Almeida PGC, Mariani NAP, Freitas GA, Kushima H,
            Filadelpho AL, Spadella MA, Avellar MCW and Silva EJR.
  TITLE     Lipopolysaccharide-induced epididymitis modifies the
            transcriptional profile of Wfdc genes in micedagger
  JOURNAL   Biol Reprod 104 (1), 144-158 (2021)
   PUBMED   33034631
REFERENCE   2  (bases 1 to 2324)
  AUTHORS   Tang T, Li L, Tang J, Li Y, Lin WY, Martin F, Grant D, Solloway M,
            Parker L, Ye W, Forrest W, Ghilardi N, Oravecz T, Platt KA, Rice
            DS, Hansen GM, Abuin A, Eberhart DE, Godowski P, Holt KH, Peterson
            A, Zambrowicz BP and de Sauvage FJ.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   3  (bases 1 to 2324)
  AUTHORS   Clauss A, Lilja H and Lundwall A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591512.11, AY669505.1, AK131905.1 and AV091316.1.
            
            On Apr 30, 2010 this sequence version replaced NM_145369.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments. This RefSeq
            contains a uAUG that would result in an 18 aa N-terminal extension,
            but this has a very weak Kozak signal, is not conserved in any
            other mammal, and the extension would impact an N-terminal signal
            peptide in the protein, which belongs to a family of secreted
            proteinase inhibitors. The dAUG is therefore annotated.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK131905.1, BC019734.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AL591512.11        113267-113267       c
            2-1288              AY669505.1         1-1287
            1289-1937           AK131905.1         1237-1885
            1938-2318           AL591512.11        106856-107236       c
            2319-2324           AV091316.1         291-296
FEATURES             Location/Qualifiers
     source          1..2324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.6 cM"
     gene            1..2324
                     /gene="Wfdc5"
                     /gene_synonym="Prg5; Wap1"
                     /note="WAP four-disulfide core domain 5"
                     /db_xref="GeneID:209232"
                     /db_xref="MGI:MGI:2384800"
     exon            1..174
                     /gene="Wfdc5"
                     /gene_synonym="Prg5; Wap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..470
                     /gene="Wfdc5"
                     /gene_synonym="Prg5; Wap1"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 5
                     precursor"
                     /protein_id="NP_663344.2"
                     /db_xref="CCDS:CCDS17023.1"
                     /db_xref="GeneID:209232"
                     /db_xref="MGI:MGI:2384800"
                     /translation="MRVQSSLLLVVLLALETHLPVALCRKKGDKLGGCPPDDGLCNQN
                     TPPDQCLNDKQCPSSWKCCRRACFLQCMPRVFVKSGKCPVDQLRCLSPTKHMCNKDSD
                     CSGKKRCCASACGRDCRDPSKSTI"
     exon            175..318
                     /gene="Wfdc5"
                     /gene_synonym="Prg5; Wap1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..483
                     /gene="Wfdc5"
                     /gene_synonym="Prg5; Wap1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..2324
                     /gene="Wfdc5"
                     /gene_synonym="Prg5; Wap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgactcaac tgctctggca tctctgagac tgtaaatgtt aatctggggg cctctgagct
       61 ctgagcttat tgggtgccac gaaagaaaca tgagagtcca gagctccctc ctcctggtag
      121 tcctcctggc tttggagact cacttgcctg ttgccttgtg tagaaagaag ggagacaaat
      181 tggggggttg cccaccagac gatggactct gcaaccagaa tactcctcct gatcagtgct
      241 tgaatgacaa acagtgtccc tcttcttgga agtgctgtcg ccgagcctgc ttcctccagt
      301 gtatgcctcg tgtctttgta aagtcgggca aatgccccgt ggatcaactt cgctgcctca
      361 gtcccacaaa gcacatgtgt aacaaagact cggactgctc aggcaagaag cggtgctgtg
      421 ccagcgcctg tggccgggac tgccgagacc ccagcaaaag taccatttga gaccccagca
      481 aaggctaatt ctggcttacg atctatggct ctgcacccca ggtgtggttc ccaccagaaa
      541 gagatcatga tgtgccagcc agggatcctg cgacccagat cttctctcca gagacagttg
      601 tgaccttctg acaagcactg gcctgttgtc agctccctta caactcatgc ctcctgcatt
      661 ctcctctgag tgccaaggtc cacaccagac atcaaaagca tagctcatca ttcggctccg
      721 gcaccccaca ccactgttgt gctgggcttc ccatcccacc tcagaaccag tgttatatct
      781 ctctgtacat tgttccctcc acttcaaatg ccaagccagg cagccccttc tctcccgagc
      841 cctgaaccca cctgcagact atcctcccca aaataatgtg tgtccagaaa gaattttcca
      901 aacatcagtc catccacaca tgctgcctca gtccccatca tccctgcaga gccaccccgt
      961 aatgtgtaaa gttgtgtgaa gtacctctgt acatctactc acttaacgtc ttcatttaaa
     1021 cggctcactt ttggatgtta acaattcatt tccaagggat ggtgtgggag gggagggcag
     1081 aggaggtttg gtgtcgctaa ggtaaataag atctgcaaga tcaacggaca gaggcagcat
     1141 ggatcttcga agccaagtgt aatgaaaaca ataattccat tgagttcatt cgtgcttgat
     1201 ttaaataaca ccgttaaact ctagctaata gggccacctg ccaaggcaga gcctgattct
     1261 gttttaataa atggagatta acaagggtta aagagatgtc aagagatgca ggattctgac
     1321 tgagacagct tcctggcaga gtcaggagca aagagagagc ctctgaccca gggagtcgat
     1381 gatgcttcat gttgtagcca agtgcttgct aagaccgttt ggattgtccc atatccagga
     1441 aaaggggctc cagcagttgg gatgtcatgt gtagagtaca tctgtctcca ctactgggct
     1501 gtgtctcact tgccttgatt tcccagccta gagtcagggc caaacaaggg tttcttgaga
     1561 ggactcagca agggtctgtc cattccttgg acccagacag ctgagaaagg aggtgccttt
     1621 tgtctgatag acttggggca gactactatg gaggcgaact taaaaattgt gtctcttctg
     1681 tcctgttccc gtggccttgc ggtgtaaccc aggcgagtcc ttcaccactt ccctttgcag
     1741 tctggaagat ggagagagtg ccactttctg gttgctacag ccattctcac tagattcaaa
     1801 tgcccgaact gttggcttgt agtaacagtt gccaacaaca tggctccaag gtgacacgta
     1861 gagaaaagaa agctttctgg tgtcacagaa tctgtgagct cctggatatt tctgagcctc
     1921 cttctgggcc ttggttgctc cacccatcac attaacacag ataatataag ggaccatagt
     1981 ctctgcccac catgtccctt ctcgtcctca gactcactag atagtgtctg tcccattcgt
     2041 agtttataaa ttgccaactt ggcatagcct agaactgcct gaaagacaag cttctggaca
     2101 ttaccctgat atgctaattg atgtgggaag aaccactttg attgtgggtg tgacccttcc
     2161 ctaggtatta gatcctgaac tggacaaaac gatgcaagtg agctgagcat agcatgtgtg
     2221 catcatccat cactcccttc tgaatgcaaa tgtactgtaa ccagctgctt ccagctcctg
     2281 ctgccttgac ctccccacca taaaggactg tatcttgaac tgtg
//
