LOCUS       NM_026323                708 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus WAP four-disulfide core domain 2 (Wfdc2), transcript
            variant 1, mRNA.
ACCESSION   NM_026323 XM_918034
VERSION     NM_026323.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 708)
  AUTHORS   Zhang,Y., Yang,W., Han,X., Qiao,Y., Wang,H., Chen,T., Li,T. and
            Ou,W.B.
  TITLE     Knockdown of HE4 suppresses tumor growth and invasiveness in lung
            adenocarcinoma through regulation of EGFR signaling
  JOURNAL   Oncol Res 32 (6), 1119-1128 (2024)
   PUBMED   38827327
  REMARK    GeneRIF: Knockdown of HE4 suppresses tumor growth and invasiveness
            in lung adenocarcinoma through regulation of EGFR signaling.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 708)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 708)
  AUTHORS   Ling,P., Tang,L., Lin,M., Bu,C., Yin,Y., Wang,F., Chen,D. and
            Jiang,S.W.
  TITLE     HE4 overexpression in mice leads to leydig cell hyperplasia and
            spermatogensis impairment: Pathological implications for
            oligospermia
  JOURNAL   Mol Cell Endocrinol 568-569, 111916 (2023)
   PUBMED   37031914
  REMARK    GeneRIF: HE4 overexpression in mice leads to leydig cell
            hyperplasia and spermatogensis impairment: Pathological
            implications for oligospermia.
REFERENCE   4  (bases 1 to 708)
  AUTHORS   Cao,Z., Huang,C., Lu,F., Jiang,X., Hu,Y., Cao,C. and Liu,Z.
  TITLE     Meis1 Regulates Nociceptor Development and Behavioral Response to
            Tactile Stimuli
  JOURNAL   Front Mol Neurosci 15, 901466 (2022)
   PUBMED   35875660
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 708)
  AUTHORS   Jeong,H., Lee,B., Kim,K.H., Cho,S.Y., Cho,Y., Park,J., Lee,Y.,
            Oh,Y., Hwang,B.R., Jang,A.R., Park,J.H., Park,J.H., Jeong,S.H.,
            Lee,D., Lee,Y.C., Lim,K.M., Goldenring,J.R. and Nam,K.T.
  TITLE     WFDC2 Promotes Spasmolytic Polypeptide-Expressing Metaplasia
            Through the Up-Regulation of IL33 in Response to Injury
  JOURNAL   Gastroenterology 161 (3), 953-967 (2021)
   PUBMED   34116028
  REMARK    GeneRIF: WFDC2 Promotes Spasmolytic Polypeptide-Expressing
            Metaplasia Through the Up-Regulation of IL33 in Response to Injury.
REFERENCE   6  (bases 1 to 708)
  AUTHORS   Yu,J., Valerius,M.T., Duah,M., Staser,K., Hansard,J.K., Guo,J.J.,
            McMahon,J., Vaughan,J., Faria,D., Georgas,K., Rumballe,B., Ren,Q.,
            Krautzberger,A.M., Junker,J.P., Thiagarajan,R.D., Machanick,P.,
            Gray,P.A., van Oudenaarden,A., Rowitch,D.H., Stiles,C.D., Ma,Q.,
            Grimmond,S.M., Bailey,T.L., Little,M.H. and McMahon,A.P.
  TITLE     Identification of molecular compartments and genetic circuitry in
            the developing mammalian kidney
  JOURNAL   Development 139 (10), 1863-1873 (2012)
   PUBMED   22510988
REFERENCE   7  (bases 1 to 708)
  AUTHORS   Langfelder,P., Castellani,L.W., Zhou,Z., Paul,E., Davis,R.,
            Schadt,E.E., Lusis,A.J., Horvath,S. and Mehrabian,M.
  TITLE     A systems genetic analysis of high density lipoprotein metabolism
            and network preservation across mouse models
  JOURNAL   Biochim Biophys Acta 1821 (3), 435-447 (2012)
   PUBMED   21807117
  REMARK    GeneRIF: Causal testing implicates Wfdc2 and Hdac3 as novel genes
            affecting high density lipoprotein levels
REFERENCE   8  (bases 1 to 708)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 708)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   10 (bases 1 to 708)
  AUTHORS   Sivashanmugam,P., Hall,S.H., Hamil,K.G., French,F.S., O'Rand,M.G.
            and Richardson,R.T.
  TITLE     Characterization of mouse Eppin and a gene cluster of similar
            protease inhibitors on mouse chromosome 2
  JOURNAL   Gene 312, 125-134 (2003)
   PUBMED   12909348
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK005519.1.
            
            On Apr 5, 2007 this sequence version replaced NM_026323.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK005519.1, CA468764.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-708               AK005519.1         2-709
FEATURES             Location/Qualifiers
     source          1..708
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 85.2 cM"
     gene            1..708
                     /gene="Wfdc2"
                     /gene_synonym="1600023A02Rik; HE4; WAP5"
                     /note="WAP four-disulfide core domain 2"
                     /db_xref="GeneID:67701"
                     /db_xref="MGI:MGI:1914951"
     exon            1..89
                     /gene="Wfdc2"
                     /gene_synonym="1600023A02Rik; HE4; WAP5"
                     /inference="alignment:Splign:2.1.0"
     CDS             11..535
                     /gene="Wfdc2"
                     /gene_synonym="1600023A02Rik; HE4; WAP5"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; WAP four-disulfide core domain protein 2; WAP
                     domain-containing protein HE4"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 2 isoform
                     1 precursor"
                     /protein_id="NP_080599.1"
                     /db_xref="CCDS:CCDS17040.1"
                     /db_xref="GeneID:67701"
                     /db_xref="MGI:MGI:1914951"
                     /translation="MPACRLCLLAAGLLLGLLLFTPISATGTDAEKPGECPQLEPITD
                     CVLECTLDKDCADNRKCCQAGCSSVCSKPNGPSEGELSGTDTKLSETGTTTQSAGLDH
                     TTKPPGGQVSTKPPAVTREGLGVREKQGTCPSVDIPKLGLCEDQCQVDSQCSGNMKCC
                     RNGCGKMACTTPKF"
     exon            90..233
                     /gene="Wfdc2"
                     /gene_synonym="1600023A02Rik; HE4; WAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            234..389
                     /gene="Wfdc2"
                     /gene_synonym="1600023A02Rik; HE4; WAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            390..536
                     /gene="Wfdc2"
                     /gene_synonym="1600023A02Rik; HE4; WAP5"
                     /inference="alignment:Splign:2.1.0"
     exon            537..708
                     /gene="Wfdc2"
                     /gene_synonym="1600023A02Rik; HE4; WAP5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacctgcacc atgcctgcct gtcgcctctg cttgctggcc gctggcctcc tactagggtt
       61 gctactgttc acccccatct cagccacagg caccgatgca gagaaacccg gcgagtgccc
      121 ccagcttgaa ccaattacgg actgtgtgtt ggagtgcact ttggacaagg actgtgcgga
      181 caaccgcaag tgctgccagg cgggctgcag ctctgtctgc tccaagccta atggaccgag
      241 cgaaggagag ctctcaggga cagatactaa actctcagag actgggacta ctactcaatc
      301 agcgggcctt gaccacacta ctaaaccacc gggaggtcaa gtctccacga agccaccagc
      361 tgtgaccagg gaaggcttag gtgtccgaga aaagcagggc acctgcccca gcgtggacat
      421 acccaagctc ggcctctgtg aggaccagtg tcaggtggac agccagtgtt ctggcaacat
      481 gaaatgctgc cgcaatggat gtgggaagat ggcctgcacc acacccaaat tctgagcttc
      541 agcctccagc agcctgagga atggagagag gttgtttctg ccggactgtg catctggagt
      601 cgttcctgtg gcctcctttc tctctggtct ttgcatttct tcctggtccg atgaaagcat
      661 ctcctttttc taaccaataa agtgatcgct ttcagcaatg gagaagct
//
