LOCUS       NM_007969                567 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus WAP four-disulfide core domain 18 (Wfdc18), mRNA.
ACCESSION   NM_007969
VERSION     NM_007969.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 567)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 567)
  AUTHORS   Chen,A., Liao,S., Cheng,M., Ma,K., Wu,L., Lai,Y., Qiu,X., Yang,J.,
            Xu,J., Hao,S., Wang,X., Lu,H., Chen,X., Liu,X., Huang,X., Li,Z.,
            Hong,Y., Jiang,Y., Peng,J., Liu,S., Shen,M., Liu,C., Li,Q.,
            Yuan,Y., Wei,X., Zheng,H., Feng,W., Wang,Z., Liu,Y., Wang,Z.,
            Yang,Y., Xiang,H., Han,L., Qin,B., Guo,P., Lai,G.,
            Munoz-Canoves,P., Maxwell,P.H., Thiery,J.P., Wu,Q.F., Zhao,F.,
            Chen,B., Li,M., Dai,X., Wang,S., Kuang,H., Hui,J., Wang,L.,
            Fei,J.F., Wang,O., Wei,X., Lu,H., Wang,B., Liu,S., Gu,Y., Ni,M.,
            Zhang,W., Mu,F., Yin,Y., Yang,H., Lisby,M., Cornall,R.J.,
            Mulder,J., Uhlen,M., Esteban,M.A., Li,Y., Liu,L., Xu,X. and Wang,J.
  TITLE     Spatiotemporal transcriptomic atlas of mouse organogenesis using
            DNA nanoball-patterned arrays
  JOURNAL   Cell 185 (10), 1777-1792 (2022)
   PUBMED   35512705
REFERENCE   3  (bases 1 to 567)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 567)
  AUTHORS   Giraddi,R.R., Chung,C.Y., Heinz,R.E., Balcioglu,O., Novotny,M.,
            Trejo,C.L., Dravis,C., Hagos,B.M., Mehrabad,E.M., Rodewald,L.W.,
            Hwang,J.Y., Fan,C., Lasken,R., Varley,K.E., Perou,C.M., Wahl,G.M.
            and Spike,B.T.
  TITLE     Single-Cell Transcriptomes Distinguish Stem Cell State Changes and
            Lineage Specification Programs in Early Mammary Gland Development
  JOURNAL   Cell Rep 24 (6), 1653-1666 (2018)
   PUBMED   30089273
REFERENCE   5  (bases 1 to 567)
  AUTHORS   Karp,N.A., Speak,A.O., White,J.K., Adams,D.J., Hrabe de Angelis,M.,
            Herault,Y. and Mott,R.F.
  TITLE     Impact of temporal variation on design and analysis of mouse
            knockout phenotyping studies
  JOURNAL   PLoS One 9 (10), e111239 (2014)
   PUBMED   25343444
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 567)
  AUTHORS   Reichling,T., Goss,K.H., Carson,D.J., Holdcraft,R.W., Ley-Ebert,C.,
            Witte,D., Aronow,B.J. and Groden,J.
  TITLE     Transcriptional profiles of intestinal tumors in Apc(Min) mice are
            unique from those of embryonic intestine and identify novel gene
            targets dysregulated in human colorectal tumors
  JOURNAL   Cancer Res 65 (1), 166-176 (2005)
   PUBMED   15665292
REFERENCE   7  (bases 1 to 567)
  AUTHORS   Vogel,W.F., Aszodi,A., Alves,F. and Pawson,T.
  TITLE     Discoidin domain receptor 1 tyrosine kinase has an essential role
            in mammary gland development
  JOURNAL   Mol Cell Biol 21 (8), 2906-2917 (2001)
   PUBMED   11283268
REFERENCE   8  (bases 1 to 567)
  AUTHORS   Lee,M., Hwang,I., Choi,Y., Paik,S., Lee,H.B. and Baik,M.
  TITLE     EGF inhibits expression of WDNM1 and sulfated glycoprotein-2 genes
            in mammary epithelial cells
  JOURNAL   Biochem Biophys Res Commun 240 (1), 104-107 (1997)
   PUBMED   9367891
REFERENCE   9  (bases 1 to 567)
  AUTHORS   Marquis,S.T., Rajan,J.V., Wynshaw-Boris,A., Xu,J., Yin,G.Y.,
            Abel,K.J., Weber,B.L. and Chodosh,L.A.
  TITLE     The developmental pattern of Brca1 expression implies a role in
            differentiation of the breast and other tissues
  JOURNAL   Nat Genet 11 (1), 17-26 (1995)
   PUBMED   7550308
REFERENCE   10 (bases 1 to 567)
  AUTHORS   Morrison,B.W. and Leder,P.
  TITLE     neu and ras initiate murine mammary tumors that share genetic
            markers generally absent in c-myc and int-2-initiated tumors
  JOURNAL   Oncogene 9 (12), 3417-3426 (1994)
   PUBMED   7970700
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EH099462.1, EH105860.1 and EH109450.1.
            
            On Mar 1, 2007 this sequence version replaced NM_007969.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EH109450.1, EH094621.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-251               EH099462.1         28-278
            252-524             EH105860.1         279-551
            525-567             EH109450.1         431-473
FEATURES             Location/Qualifiers
     source          1..567
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.23 cM"
     gene            1..567
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /note="WAP four-disulfide core domain 18"
                     /db_xref="GeneID:14038"
                     /db_xref="MGI:MGI:107506"
     exon            1..196
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..339
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /note="extracellular peptidase inhibitor; Kallmann
                     syndrome 1 sequence; extracellular proteinase inhibitor;
                     WAP four-disulfide core domain protein 18"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 18
                     precursor"
                     /protein_id="NP_031995.3"
                     /db_xref="CCDS:CCDS25175.1"
                     /db_xref="GeneID:14038"
                     /db_xref="MGI:MGI:107506"
                     /translation="MKTATVFVLVALIFMTMTTAWALSNPKEKPGACPKPPPRSFGTC
                     DERCTGDGSCSGNMKCCSNGCGHACKPPVF"
     exon            197..339
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..544
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      504..509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /note="hexamer: AATAAA"
     polyA_site      524
                     /gene="Wfdc18"
                     /gene_synonym="Expi; Kal1; WDNM1"
                     /note="major polyA site"
ORIGIN      
        1 actggaaagc tgttttttct atatttcctg attgactgcc tcctcccaca cccatgcttc
       61 tacatttact gagggtataa attgcttcgt gagttcaacc cagtcagagc caacatgaag
      121 acagccacag tctttgttct ggtagctttg attttcatga caatgactac tgcctgggct
      181 ctgtctaacc ccaaagaaaa acctggcgct tgtcctaagc cgcccccacg cagttttgga
      241 acttgtgatg aacgatgcac aggagatgga tcgtgctctg gcaacatgaa gtgctgcagc
      301 aatggctgtg gtcatgcctg caaacctcct gtcttttaac catgtggaag atggatcttt
      361 ataagcagga ctgatggcta gccccagaag atttttttga acctacagac cccatgcttg
      421 gctcctcctt agacctagaa ttgcatcctt ggaagaggaa gatctatact gtggtgacag
      481 cttcctaacg tgtttgtgtc taaaataaac tatccttagc atccttcctg ttgaagagtt
      541 cttaaaaaaa aaaaaaaaaa aaaaaaa
//
