LOCUS       NM_001081957             485 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WAP four-disulfide core domain 17 (Wfdc17), mRNA.
ACCESSION   NM_001081957
VERSION     NM_001081957.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 485)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 485)
  AUTHORS   Yorgan,T.A., Peters,S., Amling,M. and Schinke,T.
  TITLE     Osteoblast-specific expression of Panx3 is dispensable for
            postnatal bone remodeling
  JOURNAL   Bone 127, 155-163 (2019)
   PUBMED   31202927
REFERENCE   3  (bases 1 to 485)
  AUTHORS   Ranganathan,P., Hamad,R., Mohamed,R., Jayakumar,C., Muthusamy,T.
            and Ramesh,G.
  TITLE     Histone deacetylase-mediated silencing of AMWAP expression
            contributes to cisplatin nephrotoxicity
  JOURNAL   Kidney Int 89 (2), 317-326 (2016)
   PUBMED   26509586
  REMARK    GeneRIF: Histone deacetylase-mediated silencing of AMWAP may
            contribute to cisplatin nephrotoxicity.
REFERENCE   4  (bases 1 to 485)
  AUTHORS   Karlstetter,M., Walczak,Y., Weigelt,K., Ebert,S., Van den
            Brulle,J., Schwer,H., Fuchshofer,R. and Langmann,T.
  TITLE     The novel activated microglia/macrophage WAP domain protein, AMWAP,
            acts as a counter-regulator of proinflammatory response
  JOURNAL   J Immunol 185 (6), 3379-3390 (2010)
   PUBMED   20709948
  REMARK    GeneRIF: AMWAP is a counter-regulator of proinflammatory
            microglia/macrophage activation and a potential modulator of innate
            immunity in neurodegeneration.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            W08116.1 and BC089618.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FJ007372.1, AA244943.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                W08116.1           1-27
            28-485              BC089618.1         1-458
FEATURES             Location/Qualifiers
     source          1..485
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.22 cM"
     gene            1..485
                     /gene="Wfdc17"
                     /gene_synonym="Amwap; Gm11428"
                     /note="WAP four-disulfide core domain 17"
                     /db_xref="GeneID:100034251"
                     /db_xref="MGI:MGI:3649773"
     exon            1..118
                     /gene="Wfdc17"
                     /gene_synonym="Amwap; Gm11428"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..267
                     /gene="Wfdc17"
                     /gene_synonym="Amwap; Gm11428"
                     /note="extracellular proteinase inhibitor family member"
                     /codon_start=1
                     /product="activated macrophage/microglia WAP domain
                     protein precursor"
                     /protein_id="NP_001075426.1"
                     /db_xref="CCDS:CCDS36257.1"
                     /db_xref="GeneID:100034251"
                     /db_xref="MGI:MGI:3649773"
                     /translation="MKTATVLFLVALITVGMNTTYVVSCPKEFEKPGACPKPSPESVG
                     ICVDQCSGDGSCPGNMKCCSNSCGHVCKTPVF"
     exon            119..267
                     /gene="Wfdc17"
                     /gene_synonym="Amwap; Gm11428"
                     /inference="alignment:Splign:2.1.0"
     exon            268..469
                     /gene="Wfdc17"
                     /gene_synonym="Amwap; Gm11428"
                     /inference="alignment:Splign:2.1.0"
     regulatory      449..454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wfdc17"
                     /gene_synonym="Amwap; Gm11428"
                     /note="hexamer: AATAAA"
     polyA_site      469
                     /gene="Wfdc17"
                     /gene_synonym="Amwap; Gm11428"
                     /note="major polyA site"
ORIGIN      
        1 aaattatttc atgagttcag ccgagccaga gccaacatga agacagccac agtcttgttt
       61 ctggtggctt tgatcactgt ggggatgaac actacctatg tagtgtcttg ccccaaagaa
      121 tttgaaaaac ctggagcttg tcccaagcct tcaccagaaa gtgttggaat ttgtgttgat
      181 caatgctcag gagatggatc ctgccctggc aacatgaagt gctgtagcaa tagctgtggt
      241 catgtctgca aaactcctgt cttttaaatg gttgacagcc atgtggaaga tggattcaat
      301 cttcataaac atgaatgatg gccagcccca gaagatttct tctgaattca cagagcctgt
      361 gcttggctac ttcctagccc tagaattgca ttcttggaca aggaagatct atattgtggt
      421 gacaatgccc taatatgtct gtgtccaaaa taaactaccc ttagcattca aaaaaaaaaa
      481 aaaaa
//
