LOCUS       NM_138685                585 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WAP four-disulfide core domain 15B (Wfdc15b),
            transcript variant 1, mRNA.
ACCESSION   NM_138685
VERSION     NM_138685.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 585)
  AUTHORS   Andrade,A.D., Almeida,P.G.C., Mariani,N.A.P., Freitas,G.A.,
            Kushima,H., Filadelpho,A.L., Spadella,M.A., Avellar,M.C.W. and
            Silva,E.J.R.
  TITLE     Lipopolysaccharide-induced epididymitis modifies the
            transcriptional profile of Wfdc genes in micedagger
  JOURNAL   Biol Reprod 104 (1), 144-158 (2021)
   PUBMED   33034631
REFERENCE   2  (bases 1 to 585)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   3  (bases 1 to 585)
  AUTHORS   Hagiwara,K., Kikuchi,T., Endo,Y., Huqun, Usui,K., Takahashi,M.,
            Shibata,N., Kusakabe,T., Xin,H., Hoshi,S., Miki,M., Inooka,N.,
            Tokue,Y. and Nukiwa,T.
  TITLE     Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a
            single whey acidic protein motif
  JOURNAL   J Immunol 170 (4), 1973-1979 (2003)
   PUBMED   12574366
  REMARK    GeneRIF: The antibacterial protein SWAM1 is constitutively
            expressed in kidney and epididymis and inhibits the growth of both
            Escherichia coli and Staphylococcus aureus at an IC90 of 10 microM.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB954017.1, BC061041.1 and BB625483.1.
            
            On Sep 2, 2006 this sequence version replaced NM_138685.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CN833417.1, AF276974.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                CB954017.1         4-80
            78-572              BC061041.1         23-517
            573-585             BB625483.1         518-530
FEATURES             Location/Qualifiers
     source          1..585
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.72 cM"
     gene            1..585
                     /gene="Wfdc15b"
                     /gene_synonym="9230106L14Rik; SWAM1; Wfdc15"
                     /note="WAP four-disulfide core domain 15B"
                     /db_xref="GeneID:192201"
                     /db_xref="MGI:MGI:2445041"
     exon            1..77
                     /gene="Wfdc15b"
                     /gene_synonym="9230106L14Rik; SWAM1; Wfdc15"
                     /inference="alignment:Splign:2.1.0"
     exon            78..275
                     /gene="Wfdc15b"
                     /gene_synonym="9230106L14Rik; SWAM1; Wfdc15"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..433
                     /gene="Wfdc15b"
                     /gene_synonym="9230106L14Rik; SWAM1; Wfdc15"
                     /note="WAP four-disulfide core domain 15; WAP
                     four-disulfide core domain protein 15B; elafin-like
                     protein I; single WAP motif protein 1"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 15B
                     precursor"
                     /protein_id="NP_619626.1"
                     /db_xref="CCDS:CCDS38320.1"
                     /db_xref="GeneID:192201"
                     /db_xref="MGI:MGI:2445041"
                     /translation="MKLLGLSLLAVTILLCCNMARPEIKKKNVFSKPGYCPEYRVPCP
                     FVLIPKCRRDKGCKDALKCCFFYCQMRCVDPWESPE"
     exon            276..433
                     /gene="Wfdc15b"
                     /gene_synonym="9230106L14Rik; SWAM1; Wfdc15"
                     /inference="alignment:Splign:2.1.0"
     exon            434..574
                     /gene="Wfdc15b"
                     /gene_synonym="9230106L14Rik; SWAM1; Wfdc15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      551..556
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wfdc15b"
                     /gene_synonym="9230106L14Rik; SWAM1; Wfdc15"
                     /note="hexamer: AATAAA"
     polyA_site      574
                     /gene="Wfdc15b"
                     /gene_synonym="9230106L14Rik; SWAM1; Wfdc15"
                     /note="major polyA site"
ORIGIN      
        1 ggggacaacc tccctccacg tttatttcta caggagagtt ttagctttct ttcgcatacg
       61 gaggacagtt ctgctgggtc cttctgctga actactctgt gaaccacagg tccttctgag
      121 ggcggccctc ccatgaagct gacataacca cacctggccc ccacgctcac ctgcacagtt
      181 ttcttgggag atgaagctgc ttggcctctc tctactcgca gtgaccattc tgctttgctg
      241 taacatggct cgacctgaaa taaagaagaa gaacgttttt tccaaacctg gctattgccc
      301 agagtatcgg gttccctgcc cctttgtcct tatacctaaa tgcaggcgtg ataaaggctg
      361 caaggacgcc ctgaagtgtt gcttcttcta ctgccagatg cgctgtgtgg atccatggga
      421 gagcccagaa tagacaaacc ggagaaaaca catgtgattc agtttcagtc gaggatagcc
      481 ggcctctgtt tcctcctccg agaggcccat cctgaaacta aagattaagt gcttgttaat
      541 atgagtacaa aataaaggaa taaagtgttg tgtaaaaaaa aaaaa
//
