LOCUS       NM_138684                775 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus WAP four-disulfide core domain 12 (Wfdc12), mRNA.
ACCESSION   NM_138684
VERSION     NM_138684.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 775)
  AUTHORS   Zhao,F., Zhang,C., Li,G., Zheng,H., Gu,L., Zhou,H., Xiao,Y.,
            Wang,Z., Yu,J., Hu,Y., Zeng,F., Wang,X., Zhao,Q., Hu,J., Yue,C.,
            Zhou,P., Huang,N., Hao,Y., Wu,W., Cui,K., Li,W. and Li,J.
  TITLE     A role for whey acidic protein four-disulfide-core 12 (WFDC12) in
            the pathogenesis and development of psoriasis disease
  JOURNAL   Front Immunol 13, 873720 (2022)
   PUBMED   36148224
  REMARK    GeneRIF: A role for whey acidic protein four-disulfide-core 12
            (WFDC12) in the pathogenesis and development of psoriasis disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 775)
  AUTHORS   Andrade,A.D., Almeida,P.G.C., Mariani,N.A.P., Freitas,G.A.,
            Kushima,H., Filadelpho,A.L., Spadella,M.A., Avellar,M.C.W. and
            Silva,E.J.R.
  TITLE     Lipopolysaccharide-induced epididymitis modifies the
            transcriptional profile of Wfdc genes in micedagger
  JOURNAL   Biol Reprod 104 (1), 144-158 (2021)
   PUBMED   33034631
REFERENCE   3  (bases 1 to 775)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   4  (bases 1 to 775)
  AUTHORS   Clauss,A., Lilja,H. and Lundwall,A.
  TITLE     The evolution of a genetic locus encoding small serine proteinase
            inhibitors
  JOURNAL   Biochem Biophys Res Commun 333 (2), 383-389 (2005)
   PUBMED   15950183
REFERENCE   5  (bases 1 to 775)
  AUTHORS   Hagiwara,K., Kikuchi,T., Endo,Y., Huqun, Usui,K., Takahashi,M.,
            Shibata,N., Kusakabe,T., Xin,H., Hoshi,S., Miki,M., Inooka,N.,
            Tokue,Y. and Nukiwa,T.
  TITLE     Mouse SWAM1 and SWAM2 are antibacterial proteins composed of a
            single whey acidic protein motif
  JOURNAL   J Immunol 170 (4), 1973-1979 (2003)
   PUBMED   12574366
  REMARK    GeneRIF: The antibacterial protein SWAM2 is constitutively
            expressed in tongue and inhibits the growth of both Escherichia
            coli and Staphylococcus aureus at an IC90 of 10 microM.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591512.11.
            
            On Oct 24, 2022 this sequence version replaced NM_138684.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030939.1, AK008999.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-171               AL591512.11        120963-121133       c
            172-322             AL591512.11        120661-120811       c
            323-775             AL591512.11        119756-120208       c
FEATURES             Location/Qualifiers
     source          1..775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.6 cM"
     gene            1..775
                     /gene="Wfdc12"
                     /gene_synonym="Swam2; WAP2"
                     /note="WAP four-disulfide core domain 12"
                     /db_xref="GeneID:192200"
                     /db_xref="MGI:MGI:2183434"
     exon            1..171
                     /gene="Wfdc12"
                     /gene_synonym="Swam2; WAP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..347
                     /gene="Wfdc12"
                     /gene_synonym="Swam2; WAP2"
                     /note="single WAP motif protein 2; WAP four-disulfide core
                     domain protein 12; whey acidic protein 2; elafin-like
                     protein II"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 12
                     precursor"
                     /protein_id="NP_619625.1"
                     /db_xref="CCDS:CCDS38318.1"
                     /db_xref="GeneID:192200"
                     /db_xref="MGI:MGI:2183434"
                     /translation="MWPNSILVLMTLLISSTLVTGGGVKGEEKRVCPPDYVRCIRQDD
                     PQCYSDNDCGDQEICCFWQCGFKCVLPVKDNSEEQIPQSKV"
     exon            172..322
                     /gene="Wfdc12"
                     /gene_synonym="Swam2; WAP2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..775
                     /gene="Wfdc12"
                     /gene_synonym="Swam2; WAP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      492..497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wfdc12"
                     /gene_synonym="Swam2; WAP2"
                     /note="hexamer: AATAAA"
     polyA_site      513
                     /gene="Wfdc12"
                     /gene_synonym="Swam2; WAP2"
                     /note="major polyA site"
ORIGIN      
        1 accagcacca gcaccagcct cggcaccagc accagcacca gcctcggcac cagcaccagc
       61 accagcctca gtctcagcct cacagcaaca tgtggccaaa cagtatcttg gtcctcatga
      121 cgctccttat ttcctctact ctggtaacgg gaggtggagt caaaggcgag gagaaaagag
      181 tttgcccgcc cgactacgtc cgctgcatca ggcaagatga tccccagtgt tacagtgaca
      241 atgactgtgg agatcaggag atatgctgct tctggcaatg tggcttcaaa tgcgtgctgc
      301 cggtgaaaga caacagtgaa gaacagatcc ctcagagtaa ggtgtgatat ctcataaaaa
      361 tggcctcaga ggactgcttc caccgtggaa ggacacagca agaagataca aagaccagaa
      421 accaggcctt tccagatact ggatctctgg gcaccttgat cttggactcc ccaacctcca
      481 gaactctgag aaataaatgt tgtttatagg ccattcagtc tatggtaatt tgttacagtg
      541 gtccaaatag actaatacaa cttaatagtt taaaaaaaaa tccttgttca atattatgtg
      601 tgtgtgtatg tgtgtgtgtg tgtgtgtatg tttgtttgtg tgtttgtgtg tgtatgtata
      661 tgtatgtaca tatacatgca tgaataattc tggaaatata catttttttg gaaaaactat
      721 taaactttat tatatgacat tttttacaaa tctgaataaa taggataaaa ttgtc
//
