LOCUS       NM_023395               1169 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus WAP four-disulfide core domain 1 (Wfdc1), mRNA.
ACCESSION   NM_023395
VERSION     NM_023395.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1169)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1169)
  AUTHORS   Balasubramanian,R., Min,X., Quinn,P.M.J., Giudice,Q.L., Tao,C.,
            Polanco,K., Makrides,N., Peregrin,J., Bouaziz,M., Mao,Y., Wang,Q.,
            da Costa,B.L., Buenaventura,D., Wang,F., Ma,L., Tsang,S.H.,
            Fabre,P.J. and Zhang,X.
  TITLE     Phase transition specified by a binary code patterns the vertebrate
            eye cup
  JOURNAL   Sci Adv 7 (46), eabj9846 (2021)
   PUBMED   34757798
REFERENCE   3  (bases 1 to 1169)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1169)
  AUTHORS   Ressler,S.J., Dang,T.D., Wu,S.M., Tse,D.Y., Gilbert,B.E.,
            Vyakarnam,A., Yang,F., Schauer,I.G., Barron,D.A. and Rowley,D.R.
  TITLE     WFDC1 is a key modulator of inflammatory and wound repair responses
  JOURNAL   Am J Pathol 184 (11), 2951-2964 (2014)
   PUBMED   25219356
  REMARK    GeneRIF: WFDC1/ps20 modulates core host response mechanisms, in
            part, via regulation of osteopontin and MMP-9 activity. Release
            from WFDC1 regulation is likely a key component of inflammatory and
            repair response mechanisms.
REFERENCE   5  (bases 1 to 1169)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 1169)
  AUTHORS   Trimarchi,J.M., Cho,S.H. and Cepko,C.L.
  TITLE     Identification of genes expressed preferentially in the developing
            peripheral margin of the optic cup
  JOURNAL   Dev Dyn 238 (9), 2327-2329 (2009)
   PUBMED   19449303
REFERENCE   7  (bases 1 to 1169)
  AUTHORS   Jukkola,T., Lahti,L., Naserke,T., Wurst,W. and Partanen,J.
  TITLE     FGF regulated gene-expression and neuronal differentiation in the
            developing midbrain-hindbrain region
  JOURNAL   Dev Biol 297 (1), 141-157 (2006)
   PUBMED   16782087
REFERENCE   8  (bases 1 to 1169)
  AUTHORS   Rowan,S., Chen,C.M., Young,T.L., Fisher,D.E. and Cepko,C.L.
  TITLE     Transdifferentiation of the retina into pigmented cells in ocular
            retardation mice defines a new function of the homeodomain gene
            Chx10
  JOURNAL   Development 131 (20), 5139-5152 (2004)
   PUBMED   15459106
REFERENCE   9  (bases 1 to 1169)
  AUTHORS   McAlhany,S.J., Ressler,S.J., Larsen,M., Tuxhorn,J.A., Yang,F.,
            Dang,T.D. and Rowley,D.R.
  TITLE     Promotion of angiogenesis by ps20 in the differential reactive
            stroma prostate cancer xenograft model
  JOURNAL   Cancer Res 63 (18), 5859-5865 (2003)
   PUBMED   14522910
  REMARK    GeneRIF: ps20 may be a TGF-beta1-induced regulator of angiogenesis
            that functions by either promoting endothelial cell migration or by
            contributing to pericyte stabilization of newly formed vascular
            structures.
REFERENCE   10 (bases 1 to 1169)
  AUTHORS   Larsen,M., Ressler,S.J., Gerdes,M.J., Lu,B., Byron,M.,
            Lawrence,J.B. and Rowley,D.R.
  TITLE     The WFDC1 gene encoding ps20 localizes to 16q24, a region of LOH in
            multiple cancers
  JOURNAL   Mamm Genome 11 (9), 767-773 (2000)
   PUBMED   10967136
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132541.1 and AK161606.1.
            
            On Dec 22, 2005 this sequence version replaced NM_023395.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161606.1, AK132541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1136              AK132541.1         2-1137
            1137-1169           AK161606.1         1003-1035
FEATURES             Location/Qualifiers
     source          1..1169
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 68.15 cM"
     gene            1..1169
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /note="WAP four-disulfide core domain 1"
                     /db_xref="GeneID:67866"
                     /db_xref="MGI:MGI:1915116"
     exon            1..296
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..812
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /note="WAP four-disulfide core domain protein 1; ps20
                     growth inhibitor; prostate stromal protein ps20"
                     /codon_start=1
                     /product="WAP four-disulfide core domain protein 1
                     precursor"
                     /protein_id="NP_075884.1"
                     /db_xref="CCDS:CCDS22711.1"
                     /db_xref="GeneID:67866"
                     /db_xref="MGI:MGI:1915116"
                     /translation="MGNCGRKVLRALSFLLLLGSSSAQGTWEAMLPARLAEKSRAEEV
                     AATGSRQPHADRCPPPPRTLPPGACQATRCQADSECPRHRRCCYNGCAYACLEAVPPP
                     PVLDWLVQPKPRWLGGNGWLLDGPEEVLQAETCSTTEDGAEPLLCPSGYECHILQPGD
                     EAQGIPNHGQCVKQRRQAEGRVLRQRLHKEYPEGDSKNVAEPGKGQQRHFP"
     exon            297..486
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            487..570
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            571..711
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            712..753
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            754..827
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1169
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1117..1122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /note="hexamer: AATAAA"
     polyA_site      1137
                     /gene="Wfdc1"
                     /gene_synonym="2310058A03Rik; ps20"
                     /note="major polyA site"
ORIGIN      
        1 acaagatccc agggaccctg tgtggaggac caaggctgca gcaggcaaag ttctgttgct
       61 ctctcaggcc ccacccaggc tatggtccct cctccctctt aacccctctt gcctcctctc
      121 cccggcctgc ggaggaggtc actcgtgcag aaggaaaccc tgccaccagc ctcgggatgg
      181 gtaactgcgg cagaaaagtc cttcgggctc tgagtttcct gttgctactg ggctccagtt
      241 ctgcccaggg cacttgggag gcaatgctgc cggccaggct ggccgagaag tcccgagctg
      301 aagaggttgc agcgacaggc tcccggcagc cccatgcaga ccgctgccca ccaccgccaa
      361 ggacactgcc cccgggtgcc tgtcaggcca cacgctgcca ggctgactct gagtgcccac
      421 gacacaggcg ctgctgctac aatggctgtg cctatgcctg cctggaggcg gtgccacctc
      481 cgccagttct agactggctg gtgcagccca aaccacgatg gctgggtggc aacggctggc
      541 tgctggacgg tcctgaggaa gtgttacaag cagagacttg cagcaccact gaggatgggg
      601 cagagccact cctctgtccc tcaggctatg agtgccatat cctgcagcca ggggacgaag
      661 cccagggcat acccaaccat ggacagtgtg ttaagcaacg ccggcaagca gaagggcggg
      721 tcctgcgaca gaggcttcac aaggaatatc cagaaggtga ctccaagaat gtggcagagc
      781 ctgggaaggg acaacagagg cactttccat aaagtgaagg ctggctgcct ttgcggggcc
      841 tttcctgtgt cttccacacg ctaagccttg gaaacagcca aagaatgacc ctagatgtca
      901 cactccattc cacagaacag cactcaagag ctcctgggaa atgggacttc agactcccaa
      961 gcccagagtg gcccagcctg gtgtggtcac ttggtggaag ctcctaacca gccctgggtc
     1021 cctgctcagc atccttgtca tgtgaacctg cagcttctag gtgactttgg cagattttgc
     1081 ctgcggaagg catatattca tccctaatgt tccccaaata aatctgccca ccgtgtagca
     1141 gaagtaagct actttatcag gcgtgagcc
//
