LOCUS       NM_201370               2886 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WEE1 homolog 2 (S. pombe) (Wee2), mRNA.
ACCESSION   NM_201370 XM_355755
VERSION     NM_201370.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2886)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2886)
  AUTHORS   Nozawa,K., Liao,Z., Satouh,Y., Geng,T., Ikawa,M., Monsivais,D. and
            Matzuk,M.M.
  TITLE     Oocyte-specific Wee1-like protein kinase 2 is dispensable for
            fertility in mice
  JOURNAL   PLoS One 18 (8), e0289083 (2023)
   PUBMED   37527245
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2886)
  AUTHORS   Rong,Y., Ji,S.Y., Zhu,Y.Z., Wu,Y.W., Shen,L. and Fan,H.Y.
  TITLE     ZAR1 and ZAR2 are required for oocyte meiotic maturation by
            regulating the maternal transcriptome and mRNA translational
            activation
  JOURNAL   Nucleic Acids Res 47 (21), 11387-11402 (2019)
   PUBMED   31598710
REFERENCE   4  (bases 1 to 2886)
  AUTHORS   Sang,Q., Li,B., Kuang,Y., Wang,X., Zhang,Z., Chen,B., Wu,L.,
            Lyu,Q., Fu,Y., Yan,Z., Mao,X., Xu,Y., Mu,J., Li,Q., Jin,L., He,L.
            and Wang,L.
  TITLE     Homozygous Mutations in WEE2 Cause Fertilization Failure and Female
            Infertility
  JOURNAL   Am J Hum Genet 102 (4), 649-657 (2018)
   PUBMED   29606300
REFERENCE   5  (bases 1 to 2886)
  AUTHORS   Yu,C., Zhang,Y.L., Pan,W.W., Li,X.M., Wang,Z.W., Ge,Z.J.,
            Zhou,J.J., Cang,Y., Tong,C., Sun,Q.Y. and Fan,H.Y.
  TITLE     CRL4 complex regulates mammalian oocyte survival and reprogramming
            by activation of TET proteins
  JOURNAL   Science 342 (6165), 1518-1521 (2013)
   PUBMED   24357321
  REMARK    Erratum:[Science. 2014 May 2;344(6183):370]
REFERENCE   6  (bases 1 to 2886)
  AUTHORS   Oh,J.S., Susor,A. and Conti,M.
  TITLE     Protein tyrosine kinase Wee1B is essential for metaphase II exit in
            mouse oocytes
  JOURNAL   Science 332 (6028), 462-465 (2011)
   PUBMED   21454751
  REMARK    GeneRIF: findings demonstrate that exit from metaphase requires not
            only a proteolytic degradation of cyclin B but also the inhibitory
            phosphorylation of Cdc2 by Wee1B
REFERENCE   7  (bases 1 to 2886)
  AUTHORS   Oh,J.S., Han,S.J. and Conti,M.
  TITLE     Wee1B, Myt1, and Cdc25 function in distinct compartments of the
            mouse oocyte to control meiotic resumption
  JOURNAL   J Cell Biol 188 (2), 199-207 (2010)
   PUBMED   20083600
REFERENCE   8  (bases 1 to 2886)
  AUTHORS   Joshi,S., Davies,H., Sims,L.P., Levy,S.E. and Dean,J.
  TITLE     Ovarian gene expression in the absence of FIGLA, an oocyte-specific
            transcription factor
  JOURNAL   BMC Dev Biol 7, 67 (2007)
   PUBMED   17567914
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2886)
  AUTHORS   Han,S.J., Chen,R., Paronetto,M.P. and Conti,M.
  TITLE     Wee1B is an oocyte-specific kinase involved in the control of
            meiotic arrest in the mouse
  JOURNAL   Curr Biol 15 (18), 1670-1676 (2005)
   PUBMED   16169490
  REMARK    GeneRIF: Wee1B is a key maturation-promoting-factor inhibitory
            kinase in mouse oocytes, functions downstream of PKA, and is
            required for maintaining meiotic arrest.
REFERENCE   10 (bases 1 to 2886)
  AUTHORS   Nakanishi,M., Ando,H., Watanabe,N., Kitamura,K., Ito,K.,
            Okayama,H., Miyamoto,T., Agui,T. and Sasaki,M.
  TITLE     Identification and characterization of human Wee1B, a new member of
            the Wee1 family of Cdk-inhibitory kinases
  JOURNAL   Genes Cells 5 (10), 839-847 (2000)
   PUBMED   11029659
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY725757.1, AK139573.1 and CJ200934.1.
            
            On Apr 2, 2008 this sequence version replaced NM_201370.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139573.1, BC080784.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                BY725757.1         2-43
            43-2879             AK139573.1         2-2838
            2880-2886           CJ200934.1         382-388
FEATURES             Location/Qualifiers
     source          1..2886
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 18.82 cM"
     gene            1..2886
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /note="WEE1 homolog 2 (S. pombe)"
                     /db_xref="GeneID:381759"
                     /db_xref="MGI:MGI:3027899"
     exon            1..322
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            323..690
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             367..2034
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /EC_number="2.7.10.2"
                     /note="mWee1B; wee1B kinase; wee1-like protein kinase 1B"
                     /codon_start=1
                     /product="wee1-like protein kinase 2"
                     /protein_id="NP_958758.2"
                     /db_xref="CCDS:CCDS20029.1"
                     /db_xref="GeneID:381759"
                     /db_xref="MGI:MGI:3027899"
                     /translation="MADTETDQGLNKKLSFSFCEEDTESEGQMTAQDIGGAQSQKPGR
                     EESEELEGPVPPTRDELHTSLSRDKESPGPDLWKSVSGPPKCPETPVLHSKSKLPVPT
                     NFSTPKNSLGQPEISLLEKLSSRSSRHMRLTPASLMDEKTSLSLVNINPFTPETYRKL
                     LLQSKGKRKTRDYLEETGEEESKSVQWLPAKRSILQETNMASRYEKEFFEIEKIGVGE
                     FGTVYKCIKRLDGCIYAIKRSAKSFSGLSNELDLHEVYAHAVLGHHPHVVRYYSSWIE
                     DDHVVIQNEYCNGGSLQAAISENTASNNHFQEPKLKDILLQISLGLKYIHNSGMVHLD
                     IKPSNIFICHKMQCDSPVGPEEAESEADWFLNASVMYKIGDLGHATSISKPKVEEGDT
                     RFLANEILQENYQHLPKADIFALGLTIAVAAGAESLPINGDMWHHIRKGNFPEISQEL
                     SDDFYGLLKNMIHPAPKERPSAAALARSRILWPFLEKTDELQKQLNLEKSKTATLKRE
                     LKKARHIQTPQREVHHCYYQICKGSRHLLVGGRRKAPSSFTRGTSSV"
     exon            691..887
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            888..939
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1112
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1231
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1378
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1486
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1572
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1573..1743
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..1886
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2886
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2567..2572
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /note="hexamer: AATAAA"
     polyA_site      2587
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
     regulatory      2859..2864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /note="hexamer: AATAAA"
     polyA_site      2882
                     /gene="Wee2"
                     /gene_synonym="Gm1065; Wee1B"
                     /note="major polyA site"
ORIGIN      
        1 aatcagcgct agctaagccc gcctccaggt ccaggataca cttggtgttt tatgtcaggc
       61 tctattctgt tgggagcaag gccaacaacc ggctggccca gagaagaagt ggcaagtgat
      121 gtgacgcgag gaagggagaa ctgacctact cggaggcggt ggggaaagga tcagatcacc
      181 tggttcactg gcttgtaacc aagaacctgc tcctgggctc agaatttcag ctgatggtga
      241 cttctctgtt ggtaacctgt gccttccttt cccttggatg gttttttatg gccacccgtg
      301 gaacgctgag cctctgataa agatttatag tgttttccac tccgagacct ccttgtctgc
      361 actgagatgg ccgacacaga gactgaccag ggactgaaca agaaattaag cttctccttt
      421 tgtgaagaag acactgagag tgaagggcag atgactgcac aagacatcgg aggggcccag
      481 agccaaaagc ctgggaggga agaaagtgag gagttggagg gtcccgtgcc tcctaccaga
      541 gatgaacttc atacttctct gagcagagac aaggaaagtc caggtcctga tctttggaaa
      601 tcagtttcag gccctcccaa atgcccagag acaccagtat tacacagcaa gagcaagctg
      661 ccagtcccta ccaacttctc cactcccaaa aattcgctgg gtcagccaga gatttctctg
      721 ctagagaagc tctcctcccg aagctctaga catatgaggc tcacacctgc ttcccttatg
      781 gatgagaaga cctctttgtc tctggtcaat atcaacccat tcactccgga gacctacaga
      841 aaattactcc ttcaatcaaa gggcaagagg aagaccagag actatcttga ggaaactgga
      901 gaagaggaaa gcaaatcagt acagtggctg cctgctaaga gaagtattct acaagaaact
      961 aatatggctt cccgctatga aaaagaattc ttcgagatag aaaaaatcgg ggttggagaa
     1021 tttgggacag tctacaagtg cattaagagg ctggatggat gcatttatgc aataaagcgc
     1081 tctgcaaagt ccttttcagg attatcaaat gaattggatt tgcatgaagt ttatgctcat
     1141 gcagtgcttg gccatcatcc ccatgtggta cgctactact catcatggat agaagatgat
     1201 catgtggtca ttcaaaatga atactgtaat ggtgggagcc tgcaagctgc tatatctgaa
     1261 aacactgcgt ccaataatca cttccaagag cccaaactca aagacatcct tctgcagatt
     1321 tccttgggac ttaagtacat ccacaattct ggcatggtac acctggacat caaacccagt
     1381 aacatcttca tttgtcataa gatgcagtgt gactctcctg taggcccaga agaggctgaa
     1441 agtgaagctg actggtttct caatgccagt gtgatgtata aaattggtga cctgggccac
     1501 gcgacatcaa tcagcaaacc taaagtggaa gaaggagata ctcgtttcct ggctaatgag
     1561 atcttgcaag agaattacca acacctcccc aaagcagaca tatttgcctt aggattaaca
     1621 atcgcagtgg ctgcaggagc agagtcttta cccatcaatg gtgacatgtg gcatcatatc
     1681 cgcaaaggga actttccaga gatttcccaa gagctctcgg atgactttta tggtctactc
     1741 aagaacatga tccacccagc tccaaaggag agaccatctg cagcagctct ggccagaagt
     1801 cgaattctct ggcctttctt ggagaagact gatgaactcc agaaacaact gaatttggag
     1861 aaatccaaga cagccacact gaaaagggaa ctgaaaaaag ctcggcatat ccagacccct
     1921 cagagagaag tccaccattg ttattatcag atctgcaaag gctcaagaca cctcctggtg
     1981 ggaggaagga ggaaggcgcc ctcaagcttc acccgtggga catcctccgt gtaggaactc
     2041 acttctggcc ttttgctaca caacacagcc ttttgaaaac tcttacagga tacaaaactg
     2101 aaccagcttg aatgtacaaa gatctcaaaa gccatcctga tgtggcatct ataggtaaga
     2161 tcaccgagct tccagggttt ctccttagca acggtcttgt gtatcgtaag tactggagtc
     2221 ttcttttccc tagtgatgta tttctagagc tgcttactaa ggactcctaa tgaataatca
     2281 gaaaacatgg ctctgaactg aaaggagaag cagaaatgtg ctactttggc ctatggatta
     2341 agaagctgcc gttacttatt cttcactggg gtccaaagaa ctttccctgt acataaaaag
     2401 ggataaaata tggctttaag tgccagcttc caagagaatg ttgcctgtat ttcagagtgc
     2461 tttccaagat ctgtctgctc ctccaatcac cagctccttt gagcaaggaa tttgcctact
     2521 atactttctg aatggaagca atctcttttc tgattttgca ttattaaata aaagactatc
     2581 attgtgtgaa acaactagag taagactata atttggacat tcctgagctg cttattaatt
     2641 tgtgaaacac aatcagcaga ggcagaggac ccaggaattt tggtgtacct gttccccgtg
     2701 tgttcctcac gtcttaggtc tctgtggctg actccagttg cttttcagtt ttgaacatca
     2761 tagcatcatc tggttctctt gatttttttt tttttttaca ccagaactca tccttttgtt
     2821 ttcttgcttt ttaacatatt ttaatccaga tcattgtaaa taaagatttt atcttatcca
     2881 aagacg
//
