LOCUS       NM_009516               3419 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus WEE 1 homolog 1 (S. pombe) (Wee1), transcript variant
            1, mRNA.
ACCESSION   NM_009516
VERSION     NM_009516.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3419)
  AUTHORS   Feng,J., Xie,L., Lu,W., Yu,X., Dong,H., Ma,Y. and Kong,R.
  TITLE     Hyperactivation of p53 contributes to mitotic catastrophe in
            podocytes through regulation of the Wee1/CDK1/cyclin B1 axis
  JOURNAL   Ren Fail 46 (2), 2365408 (2024)
   PUBMED   38874119
  REMARK    GeneRIF: Hyperactivation of p53 contributes to mitotic catastrophe
            in podocytes through regulation of the Wee1/CDK1/cyclin B1 axis.
REFERENCE   2  (bases 1 to 3419)
  AUTHORS   Zhai,W., Tian,H., Liang,X., Wu,Y., Wen,J., Liu,Z., Zhao,X., Tao,L.
            and Zou,K.
  TITLE     Androgen blockage impairs proliferation and function of Sertoli
            cells via Wee1 and Lfng
  JOURNAL   Cell Commun Signal 22 (1), 498 (2024)
   PUBMED   39407201
  REMARK    GeneRIF: Androgen blockage impairs proliferation and function of
            Sertoli cells via Wee1 and Lfng.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3419)
  AUTHORS   Chen,Z.L., Xie,C., Zeng,W., Huang,R.Q., Yang,J.E., Liu,J.Y.,
            Chen,Y.J. and Zhuang,S.M.
  TITLE     Synergistic induction of mitotic pyroptosis and tumor remission by
            inhibiting proteasome and WEE family kinases
  JOURNAL   Signal Transduct Target Ther 9 (1), 181 (2024)
   PUBMED   38992067
  REMARK    GeneRIF: Synergistic induction of mitotic pyroptosis and tumor
            remission by inhibiting proteasome and WEE family kinases.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3419)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3419)
  AUTHORS   Han,B., Chen,Y., Song,C., Chen,Y., Chen,Y., Ferguson,D., Yang,Y.
            and He,A.
  TITLE     Autophagy modulates the stability of Wee1 and cell cycle G2/M
            transition
  JOURNAL   Biochem Biophys Res Commun 677, 63-69 (2023)
   PUBMED   37549603
  REMARK    GeneRIF: Autophagy modulates the stability of Wee1 and cell cycle
            G2/M transition.
REFERENCE   6  (bases 1 to 3419)
  AUTHORS   Cichutek,A., Brueckmann,T., Seipel,B., Hauser,H., Schlaubitz,S.,
            Prawitt,D., Hankeln,T., Schmidt,E.R., Winterpacht,A. and Zabel,B.U.
  TITLE     Comparative architectural aspects of regions of conserved synteny
            on human chromosome 11p15.3 and mouse chromosome 7 (including genes
            WEE1 and LMO1)
  JOURNAL   Cytogenet Cell Genet 93 (3-4), 277-283 (2001)
   PUBMED   11528126
REFERENCE   7  (bases 1 to 3419)
  AUTHORS   Craig,J.C., Eberwine,J.H., Calvin,J.A., Wlodarczyk,B., Bennett,G.D.
            and Finnell,R.H.
  TITLE     Developmental expression of morphoregulatory genes in the mouse
            embryo: an analytical approach using a novel technology
  JOURNAL   Biochem Mol Med 60 (2), 81-91 (1997)
   PUBMED   9169087
REFERENCE   8  (bases 1 to 3419)
  AUTHORS   Honda,R., Ohba,Y. and Yasuda,H.
  TITLE     14-3-3 zeta protein binds to the carboxyl half of mouse wee1 kinase
  JOURNAL   Biochem Biophys Res Commun 230 (2), 262-265 (1997)
   PUBMED   9016762
REFERENCE   9  (bases 1 to 3419)
  AUTHORS   Wlodarczyk,B.C., Craig,J.C., Bennett,G.D., Calvin,J.A. and
            Finnell,R.H.
  TITLE     Valproic acid-induced changes in gene expression during neurulation
            in a mouse model
  JOURNAL   Teratology 54 (6), 284-297 (1996)
   PUBMED   9098922
REFERENCE   10 (bases 1 to 3419)
  AUTHORS   Honda,R., Tanaka,H., Ohba,Y. and Yasuda,H.
  TITLE     Mouse p87wee1 kinase is regulated by M-phase specific
            phosphorylation
  JOURNAL   Chromosome Res 3 (5), 300-308 (1995)
   PUBMED   7551544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ130595.1, AK011212.1, AK039572.1 and BY631896.1.
            
            On Sep 15, 2006 this sequence version replaced NM_009516.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK011212.1, SRR1660813.71489.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-224               CJ130595.1         24-247
            225-2691            AK011212.1         1-2467
            2692-3403           AK039572.1         2008-2719
            3404-3419           BY631896.1         392-407
FEATURES             Location/Qualifiers
     source          1..3419
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 57.7 cM"
     gene            1..3419
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /note="WEE 1 homolog 1 (S. pombe)"
                     /db_xref="GeneID:22390"
                     /db_xref="MGI:MGI:103075"
     exon            1..867
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..2232
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /EC_number="2.7.10.2"
                     /note="isoform 1 is encoded by transcript variant 1; WEE1
                     tyrosine kinase; wee1-like protein kinase; wee1A kinase"
                     /codon_start=1
                     /product="wee1-like protein kinase isoform 1"
                     /protein_id="NP_033542.2"
                     /db_xref="CCDS:CCDS21743.1"
                     /db_xref="GeneID:22390"
                     /db_xref="MGI:MGI:103075"
                     /translation="MSFLSRQQPPPTRRVGAAYSLRQKLIFSPGSDCEEEEEEEEEGS
                     GHSTGEDSAFQEPDSPLPSARSPAEAEAERRRRSPGAEPSSPGELEDDLLLQGGGGGA
                     QAAGGGAEGDSWEEEGFGSSSPVKSPSTAYFLSSPFSPVRCGGPGDASPQGCGAPRAM
                     DDPCSPQPDYPSTPPHKTFRKLRLFDTPHTPKSLLSKARVIDSGSVKLRGSSLFMDTE
                     KSGKREFDTRQTPQVNINPFTPDPVLLHSSGRCRGRKRAYFNDSSEDMEASDYEFEDE
                     TRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLA
                     GSVDEQNALREVYAHAVLGQHPHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYR
                     VMSYLTEVELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFISRTSIPNAVSEEGDEDD
                     WISNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYSHLPKADIFALALTVVC
                     AAGAEPLPRNGEQWHEIRQGRLPRIPQVLSQEVTELLRVMIHPDPERRPSAMELVKHS
                     VLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAAKVAAEERALFTDRMATRSTT
                     QSNRTSRLIGKKMNRSVSLTIY"
     exon            868..1073
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1134
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1307
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1429
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1430..1576
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1672
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1758
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1759..1929
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2075
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2076..3419
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3379..3384
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /note="hexamer: ATTAAA"
     polyA_site      3406
                     /gene="Wee1"
                     /gene_synonym="Wee1A"
                     /note="major polyA site"
ORIGIN      
        1 gtcgcgggaa gccgcggaac ccgaacttgc ggacgaactt gcggagcctt tcgccagcac
       61 tggaccggcc agtctccgct ggacatcccg cgccgcagcc gtcgccgtcg ccccgtcgtg
      121 agcttgacgg gcctcggagt tgccgccgcg caggcccgct gcagcctcag cccggcgcgc
      181 ccgatcgcac gtggcggacc cgccccctgt gccagccgcg acctggacgc cgccggcctc
      241 tgctcgccgg tcctgtgttc tcccgtgctc cgccgtgact gcagccggga aatgagcttc
      301 ctgagccgac agcagccgcc gcccacccgc cgcgtaggag ccgcttacag tctgcggcag
      361 aagctcatct tctcgccggg cagcgactgt gaggaagagg aggaggagga ggaggaaggc
      421 agcggccaca gtacggggga ggactcggcc ttccaggaac cggattcgcc cctgccttct
      481 gcacgcagcc ctgccgaggc cgaggccgag cgccgccgtc gctcgcccgg cgcggagccc
      541 agcagcccgg gagagctgga ggacgacttg ctgctgcagg gcggcggcgg aggcgcgcaa
      601 gcggcgggtg gaggcgccga gggcgactct tgggaggagg agggtttcgg ctcctcgtcg
      661 cccgtcaaat caccttcgac cgcctacttt ctgagcagcc cgttctcgcc agtgcgctgc
      721 ggcggcccag gggatgcctc cccgcagggt tgcggggctc cgcgagccat ggacgacccc
      781 tgctcgccgc agcccgacta cccgagcacc cctccgcaca agaccttccg caagctgcgc
      841 ctgttcgaca cgccgcacac tcccaagagt ttgctttcca aagcgcgagt tattgattcc
      901 ggctctgtta aactccgggg tagttctcta ttcatggaca cagaaaagtc aggaaaaaga
      961 gaattcgata cacggcaaac tccccaagtg aatattaacc cctttactcc ggatcctgta
     1021 ctgctccatt cctcaggacg gtgtcgtggg agaaagagag cgtattttaa tgattcctct
     1081 gaagacatgg aagccagtga ttatgagttt gaagatgaaa caagacctgc caaaagaatt
     1141 acaattactg aaagcaacat gaagtcacgg tatacaactg aatttcatga gctggagaaa
     1201 attggttctg gagaatttgg ttctgtgttt aaatgtgtga agaggttaga tggatgcatt
     1261 tatgccatta aacgatcaaa aaaaccattg gctggctctg ttgatgagca gaatgctttg
     1321 agagaagtgt atgctcacgc tgtgcttgga cagcaccccc acgtcgttcg ctatttctct
     1381 gcctgggcag aggatgacca catgcttata cagaacgaat actgtaatgg tgggagttta
     1441 gctgatgcta taagtgagaa ctacagagtc atgagctact tgactgaagt agagctgaag
     1501 gatctccttt tgcaagttgg ccggggcttg agatacatac attcaatgtc tttggttcac
     1561 atggatataa aacctagtaa tatttttata tctcgaacct caatcccaaa tgctgtctct
     1621 gaggaaggag atgaagatga ctggatatcc aataaagtta tgtttaaaat aggtgatctt
     1681 gggcatgtaa caagaatctc tagtcctcaa gttgaagaag gtgatagtcg ttttctagca
     1741 aatgaagttt tacaagagaa ctatagccat ctaccgaaag cagatatttt tgctcttgct
     1801 ctcacagtcg tatgtgctgc tggtgctgaa ccccttccca gaaatggaga gcagtggcac
     1861 gagatccggc agggtcggtt acctcggatc ccacaagtgc tttcccagga ggtgacagag
     1921 ttgctgagag tcatgattca tcctgaccca gagagaaggc cttcagcaat ggagctggtg
     1981 aagcattcag tgttgttgtc tgcatctaga aagagcgcag agcagttacg aatagaattg
     2041 aatgctgaaa aattcaaaaa ttctcttttg cagaaagaac tcaagaaagc ccaaatggca
     2101 gccaaagttg cagctgagga acgggcactc ttcacagatc ggatggccac tagatccacc
     2161 acccagagta atagaacttc tcgacttatt ggaaagaaaa tgaaccgctc tgtcagcctt
     2221 actatatact gaactgctca cattccccag cccttcccca ctcaaaggaa aaaactgtga
     2281 caagaggaag ctaggttgga atcactgcta gagcccactt cgtgattact tgcccattgg
     2341 tatcagtagt tttcctaaaa cgtaacgcct tctgtgactt tgagaattac agttgagagc
     2401 tgtattctga cttggctctg tcaggctttt gtctcatctc ccgtctgttt catgtaggat
     2461 gtgggtcact gttggatgtt ccagccccct ttgcggggtg cgccactgtg gtggtgtgct
     2521 gcttctcatt cactgttgca gtgtggtgaa aggtgtcttt cctggttgtg acctctagaa
     2581 aggactcaag ggctttactg cgaacatcct ctcccttcaa aaagggaaat gctcagagac
     2641 tcagtactcc tctgcctcca atgtacctgt gtcagtcttg cgtttctttt ttctatgtga
     2701 attacacttg tatatccaac tgggagcact ttaggcatcg tgtgcgccat gggatggtca
     2761 ttctgtggag gccttgcctt gtgaatttgc tgctatttta gtttcctctt gctgtaaaac
     2821 tagcattaaa caatcattgt tgttaatagg ctttctttca gaacaattat gtgaaatata
     2881 tagctgctct tcatgaaaag cagcttcgca tctttttctt tggactttga agctactgca
     2941 ttgaaaaagt gcacctaccc ctccctgttt gaatgctgta ttaatgtagt ataattatta
     3001 ctggttttgt aaatttttct tataatgtcc cctgtcttta aaacatgttt ccttcctcct
     3061 gtcaagtctt gtacttggtt gtatggttag cctattttta aatgttttgc ccagtttctc
     3121 ttcaatattt gtgtatataa actgatcttg gtaatactgt acatagctgt ttaaaaatac
     3181 cagaatgact tctgactatt ccaagttttc cacaaaatac attttacctg tgaatagcca
     3241 tttgactaac aatatttggc tagtagatgc tgccctccaa aaggagggaa atgtctcact
     3301 tgttttccta ttaactttgg tctgaaacac atttgcactt gtctgtttga cttgtgtctt
     3361 attaacattg tctggtgtat taaaagtcat tccgtgctta ccttaattgt ctaaatctt
//
