LOCUS       NM_199306               4175 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WD and tetratricopeptide repeats 1 (Wdtc1), transcript
            variant 1, mRNA.
ACCESSION   NM_199306 XM_204122
VERSION     NM_199306.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4175)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4175)
  AUTHORS   Li,T., Xu,L., Wei,Z., Zhang,S., Liu,X., Yang,Y., Gu,Y. and Zhang,J.
  TITLE     ELF5 drives angiogenesis suppression though stabilizing WDTC1 in
            renal cell carcinoma
  JOURNAL   Mol Cancer 22 (1), 184 (2023)
   PUBMED   37980532
  REMARK    GeneRIF: ELF5 drives angiogenesis suppression though stabilizing
            WDTC1 in renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4175)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4175)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4175)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   6  (bases 1 to 4175)
  AUTHORS   Wu,Y., Long,Q., Zheng,Z., Xia,Q., Wen,F., Zhu,X., Yu,X. and Yang,Z.
  TITLE     Adipose induces myoblast differentiation and mediates
            TNFalpha-regulated myogenesis
  JOURNAL   Biochim Biophys Acta 1839 (11), 1183-1195 (2014)
   PUBMED   25088174
  REMARK    GeneRIF: Adp is a positive modulator of myoblast differentiation.
REFERENCE   7  (bases 1 to 4175)
  AUTHORS   Suh,J.M., Zeve,D., McKay,R., Seo,J., Salo,Z., Li,R., Wang,M. and
            Graff,J.M.
  TITLE     Adipose is a conserved dosage-sensitive antiobesity gene
  JOURNAL   Cell Metab 6 (3), 195-207 (2007)
   PUBMED   17767906
  REMARK    GeneRIF: Data show that the anti-obesity function of adipose (Adp)
            (worm Y73E7A.9, fly adp, and murine Wdtc1) is conserved from worms
            to mammals.
REFERENCE   8  (bases 1 to 4175)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671882.6.
            
            On Oct 25, 2007 this sequence version replaced NM_199306.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC048824.1, SRR7652917.536852.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL671882.6         94254-94573         c
            321-467             AL671882.6         79086-79232         c
            468-551             AL671882.6         77430-77513         c
            552-598             AL671882.6         69018-69064         c
            599-710             AL671882.6         68565-68676         c
            711-898             AL671882.6         64007-64194         c
            899-1081            AL671882.6         61082-61264         c
            1082-1176           AL671882.6         59409-59503         c
            1177-1292           AL671882.6         58809-58924         c
            1293-1365           AL671882.6         57641-57713         c
            1366-1474           AL671882.6         56977-57085         c
            1475-1648           AL671882.6         55819-55992         c
            1649-1884           AL671882.6         52678-52913         c
            1885-2062           AL671882.6         51674-51851         c
            2063-2255           AL671882.6         50456-50648         c
            2256-4175           AL671882.6         47724-49643         c
FEATURES             Location/Qualifiers
     source          1..4175
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 66.25 cM"
     gene            1..4175
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /note="WD and tetratricopeptide repeats 1"
                     /db_xref="GeneID:230796"
                     /db_xref="MGI:MGI:2685541"
     exon            1..320
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            321..467
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     CDS             420..2453
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     and tetratricopeptide repeats protein 1"
                     /codon_start=1
                     /product="WD and tetratricopeptide repeats protein 1
                     isoform 1"
                     /protein_id="NP_955010.1"
                     /db_xref="CCDS:CCDS18746.1"
                     /db_xref="GeneID:230796"
                     /db_xref="MGI:MGI:2685541"
                     /translation="MAKVNITRDLIRRQVKERGALSFERRYHVTDPFIRRLGLEAELQ
                     GHSGCVNCLEWNEKGDLLASGSDDQHTIVWDPLHHKKLLSMHTGHTANIFSVKFLPHA
                     GDRILITGAADSKVHVHDLTVKETIHMFGDHTNRVKRIATAPMWPNTFWSAAEDGLIR
                     QYDLRENSKHSEVLIDLTEYCGPMVEAKCLTVNPQDNNCLAVGASGPFVRLYDIRMIH
                     NHRKSMRQSPSAGVHTFCDRQKPLPDGAAQYYVAGHLPVKLPDYNSRLRVLVATYVTF
                     SPNGTELLVNMGGEQVYLFDLTYKQRPYTFLLPRKCHSVEVQNGKMSTNGVSNGVSNG
                     LHLHSNGFRLPESKGCISPQVELPPYLERVKQQANEAFACQQWTQAIQLYSQAVQKAP
                     HNAMLYGNRAAAYMKRKWDGDHYDALRDCLKAISLNPCHLKAHFRLARCLFELKYVAE
                     ALECLDDFKGKFPEQAHSSACDALGRDITAALFSKSDGEEKKAAGGGGGPVRLRSTSR
                     KDSISEDEMVLRERSYDYQFRYCGHCNTTTDIKEANFFGSNAQYIVSGSDDGSFFIWE
                     KETTNLVRVLQGDESIVNCLQPHPSYCFLATSGIDPVVRLWNPRPESEDLTGRVVEDM
                     EGASQANQRRMNANPLEAMLLDMGYRITGLSSGGAGASDDEDSAEGQVQCRPS"
     exon            468..551
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            552..598
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            599..710
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            711..898
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1081
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1176
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            1177..1292
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1365
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1474
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            1475..1648
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1884
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2062
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            2063..2255
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     exon            2256..4175
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4156..4161
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /note="hexamer: ATTAAA"
     polyA_site      4175
                     /gene="Wdtc1"
                     /gene_synonym="adipose; adp; Gm695"
                     /note="major polyA site"
ORIGIN      
        1 gcgggacttc tcctgggtcc ccagacagct ggaggagata aacagaggag gagggagggg
       61 agtgcgtgtg tgagagcgcg cgagggagtg tgagtgtgtg tgagcgcggg tgtgaggcgg
      121 tgcgcagggg cgggcggagg cgctgtccgg ccccggccag gcgccgggcg gggagcatgg
      181 gaagaggcta gagctgcccg ggtccccagc ccccttcccg ggatccgcac ccctgctccc
      241 gggagagggg ccgggccccc ccggaccgac atgggctcct gaagttgctc cgctgctggt
      301 cctgggaaga gacctgacag gtaattaaat gcttgtcttg tggacctggg cttggctgga
      361 atgtgcaagg gtcttgagga tccttgcgta gcttccctgt gttgaactat taagagaaga
      421 tggcaaaagt caacataact agagacctca ttcgtaggca agtcaaggag cggggtgccc
      481 tgagctttga acggcgatat catgtcacag acccctttat ccgacggctg ggcctggagg
      541 cggagcttca gggacactca ggctgtgtca actgtctgga gtggaatgag aaaggagacc
      601 tgctggcgtc tggttccgac gaccagcaca ccattgtgtg ggacccactg caccacaaga
      661 agctgctgtc catgcacaca ggacacacag caaatatctt ctctgtcaag ttcctgcctc
      721 atgctggaga ccgcattttg atcacggggg cagctgactc caaggtgcac gtccacgacc
      781 ttacggtaaa ggagacgatc cacatgtttg gagaccacac aaaccgggtg aagcgcattg
      841 ccacggcgcc catgtggcct aacacgttct ggagcgccgc agaggatggg cttatccgcc
      901 agtatgacct tcgggagaac agcaaacact cagaggtgct gattgaccta acagaatact
      961 gtggcccgat ggtggaggcc aagtgcctca ccgtcaaccc ccaggataac aactgcctgg
     1021 cagtaggggc cagtgggccc tttgtgaggc tctatgacat tcgaatgatc cacaaccaca
     1081 gaaagagcat gaggcagagc ccttccgcag gcgtgcatac cttctgtgac cgacagaagc
     1141 cccttccgga cggtgcagcg cagtattatg tcgcaggtca cctgccggtg aagctgcctg
     1201 actataacag ccgtctgaga gtgctggttg ccacctatgt gaccttcagc cccaatggca
     1261 cagagctgct agtcaacatg ggaggagagc aggtgtatct gtttgacttg acttacaagc
     1321 aacggccata taccttcctc ttgcctagaa aatgccactc cgtggaagtc cagaacggca
     1381 agatgtctac taacggggtg tccaacggcg tgtcgaatgg cctacacctt cacagcaacg
     1441 gcttccggct gccagagagc aaggggtgca tcagccccca ggtggagctg cccccatacc
     1501 tggagcgtgt gaagcagcag gccaatgaag ccttcgcctg ccagcagtgg acccaggcca
     1561 tccagctcta cagccaggct gtgcagaagg ccccgcacaa cgctatgctc tatggcaacc
     1621 gagctgccgc ctacatgaag cgcaagtggg acggggacca ctatgatgcc ctccgggact
     1681 gcctcaaggc catctcccta aacccttgcc acctgaaggc acacttccgt ctggcccggt
     1741 gcctctttga actgaagtat gtggccgagg ctctggagtg cctggatgac ttcaaaggga
     1801 agttcccaga gcaggcccac agcagtgcat gtgacgcatt aggccgggac atcacagctg
     1861 cccttttctc caaaagtgat ggtgaggaga agaaggcagc tggtggtggt ggtggtccag
     1921 ttcgccttcg aagcacaagt cgcaaggact ccatctcaga agacgaaatg gtgctacggg
     1981 aacggagcta cgactatcag ttccgctact gtgggcactg caacaccacc acggatatca
     2041 aggaggccaa tttctttggc agcaatgctc agtacattgt cagcggctct gatgacggct
     2101 ccttcttcat ctgggaaaag gagaccacca acctcgtccg agtgctgcag ggggatgagt
     2161 ccattgtcaa ctgcttgcag ccccatccca gctactgctt cctggccacc agtggcatcg
     2221 accctgttgt gcgactgtgg aacccacgac cagagagtga agacctcaca ggccgagttg
     2281 tggaagatat ggagggtgca tctcaggcca accagcggcg catgaatgcc aaccccctgg
     2341 aggcgatgct gctggacatg ggctatcgga tcacaggcct gagcagcggg ggcgccgggg
     2401 cctctgatga cgaggacagc gcagagggcc aggtgcagtg ccggcccagc tagaccctcc
     2461 tggccccagt acccagccct gtgcaggaga tcagagggct gggctctgtt ttggtttgtc
     2521 tttcccaccc ccatttttca ttctcccccc ccccctgttt tgtttgttag tttgactttg
     2581 tgggtgggga ttgctgcaac ttgctggctt tctgactctc gggctgattg tcccttgact
     2641 gtccccagcc ccagcagaaa agtaggaggg gaagcccctc cgtatgccct tacctcctgc
     2701 ttcggtgtct ctggaaggct ctggcccttc tcaaaatcct tcagcctcca gtggagaggc
     2761 aagagctgaa gctgtcttta cggactgccc agcccctccg cgggcaacag aaagggagtg
     2821 gaactccctg ctggccgagg cttgcctggc ctgttgttgc cactctcctg actcccgggc
     2881 tagctcccct gtggtctttc cggaaggtcc ctccacagcc accagtgttc gggtggaagc
     2941 ataggaaaca ggatcccgca gtggcaaggt caggccacct gcctgggggc agtggagctt
     3001 cctcccccgc tcctggcctg tcctaggctg tctcgctgtc tctgagggcc ttgcctttcc
     3061 tacagtgtga cggggtgggg tccctccctc cccacccacc tgcccattcg agtccttacg
     3121 cgccatggcc gctctcctgg ggcgcttctc ggcctcactg tgacctttct gccagagctc
     3181 cccgccaggc ctaccctgct gaggtggctc ttcctaagga ccctttgcac cctctccgcc
     3241 ctccttccca cccacatgct gagccgccac aaagaccaaa gaagtgatgg cttttctctg
     3301 tcccctgctg ctctgggggg aggggttggg aaagtcctta gctcagccat cccccctcag
     3361 cagccccgag ctttacactg gacacagcgg ccactccacc accaagcctc cctctccctc
     3421 tggccccttg gttcctgctc tggagccggg agttggttca tgccagcctc ccccagccct
     3481 gtgtgcttcc tctgggcggc agccctccag ctgcagcctc tggggagaag cagcctccct
     3541 tccctccctc cctccatccc tccctctctc tcctgtcctc tctccctccc tcacccctgt
     3601 ctctgccagg tgcctcctct cagtctagct tctgagcagc cctggagact ggagggccat
     3661 gttaaaagct ttttcacagt tttaaggaga cgaggggggt gaggctagtg gtggggggtc
     3721 tggcaccatc tcattgcttt aatctcagcg acacaggtgg cagcttctcc cccttcctgc
     3781 ccaccccagg tcctcttccc accctctctc ctagcttggt aatgaagtgt atttattggt
     3841 gaaggaaaca gctgctctgc tgcttctcct gctgctggga cttgctcccc tgtctcttcc
     3901 tcatgacctt tctcaagcca gggaggggta gcgagagtgt tgagctgggc cctggggcac
     3961 aagaactagc cagggtccct ttgctttcct gtgttcaagc cacctgccat cccccctgtc
     4021 catcctcctg tctcccgccc gcctgcctag cctggaccct gcagtgtgga gagacacata
     4081 agccttactg tcctctgggg caggagccga gccttttgtt gctctgctcc caggagagtg
     4141 agggtgacac aattgattaa aaccattttg ttcta
//
