LOCUS       NM_001013366            2759 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus WD repeat domain 91 (Wdr91), mRNA.
ACCESSION   NM_001013366 XM_145240
VERSION     NM_001013366.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2759)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2759)
  AUTHORS   Liu,N., Liu,K. and Yang,C.
  TITLE     WDR91 specifies the endosomal retrieval subdomain for
            retromer-dependent recycling
  JOURNAL   J Cell Biol 221 (12) (2022)
   PUBMED   36190447
REFERENCE   3  (bases 1 to 2759)
  AUTHORS   Xing,R., Zhou,H., Jian,Y., Li,L., Wang,M., Liu,N., Yin,Q.,
            Liang,Z., Guo,W. and Yang,C.
  TITLE     The Rab7 effector WDR91 promotes autophagy-lysosome degradation in
            neurons by regulating lysosome fusion
  JOURNAL   J Cell Biol 220 (8) (2021)
   PUBMED   34028500
  REMARK    GeneRIF: The Rab7 effector WDR91 promotes autophagy-lysosome
            degradation in neurons by regulating lysosome fusion.
REFERENCE   4  (bases 1 to 2759)
  AUTHORS   Liu,K., Xing,R., Jian,Y., Gao,Z., Ma,X., Sun,X., Li,Y., Xu,M.,
            Wang,X., Jing,Y., Guo,W. and Yang,C.
  TITLE     WDR91 is a Rab7 effector required for neuronal development
  JOURNAL   J Cell Biol 216 (10), 3307-3321 (2017)
   PUBMED   28860274
  REMARK    GeneRIF: WDR91 serves as a Rab7 effector that is essential for
            neuronal development by facilitating endosome conversion in the
            endosome-lysosome pathway.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC055046.1.
            
            On Mar 20, 2005 this sequence version replaced XM_145240.6.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055046.1, SRR17253014.2896291.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2759
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N-3"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 15.19 cM"
     gene            1..2759
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /note="WD repeat domain 91"
                     /db_xref="GeneID:101240"
                     /db_xref="MGI:MGI:2141558"
     exon            1..135
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..2259
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /codon_start=1
                     /product="WD repeat-containing protein 91"
                     /protein_id="NP_001013384.1"
                     /db_xref="CCDS:CCDS39457.1"
                     /db_xref="GeneID:101240"
                     /db_xref="MGI:MGI:2141558"
                     /translation="MAEAVERTDELVREYLLFRGFTHTLRQLDAEIKADKEKGFRVDK
                     IVDQLQQLMQVYDLAALRDYWSYLERRLFSRLEDIYRPTINKLKTSLFRFYLVYTIQT
                     NRNDKAQEFFAKQATELQNQAEWKDWFVLPFLPSPDTNPTFATYFSRQWADTFIISLH
                     NFLSVLFQCMPVPVILNFDAECQRTNQVQEENEVLRQKLFALQAEIHRLKKEEQQQEE
                     EAAALVQHKLPPYVSSMDRLGDSELALVCSQRPASLSQSPRVGFLSSLLPQSKKSPSR
                     LSPAQGPPQAQSSAKKDSFSSQATKGKDSVPGAKDGKSLLSGPVPGEASWTHQRQRRL
                     QDHGKERRELLSTSSSQSQCAERKPEVSGAEAEPCLELHMGPVEVLARVSTAGSEGDR
                     PEQPFIVLSQEEYGEHHSSIMHCRVDCSGRRVASLDVDGVIKVWSFNPIMQTKASSIS
                     KSPLLSLEWATKRDRLLLLGSGVGTVRLYDTEAKKNLCEININDDMPRILSLACSPNG
                     ASFVCSAAAPSLTSQTDSSAPDIGSKGMNQVPGKLLLWDTKTMKQQLQFSLDPEPIAI
                     NCTAFNHNGNLLVTGAADGVIRLFDMQQHECAMSWKAHCGEVYSVEFSCDENAVYSIG
                     EDRKFIQWNIHKSGLKVSESNLPSDATGPFVLSGYSGYKQVQVPRGRLFAFDSEGNYM
                     LTCSATGGLIYKLGSEEKVLENCLSLGGHRAPVVTVDWSTAMDCGTCLTASMDGKIKL
                     TTLLAHKL"
     exon            136..315
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            316..523
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            524..606
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            607..740
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            741..906
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            907..1065
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1259
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1410
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1505
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1674
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..1783
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1896
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..2094
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2637
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2637
                     /gene="Wdr91"
                     /gene_synonym="9530020G05Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgcgcgcag cgatggcgga ggcggtggag cgcacagacg agctggtccg ggagtacctg
       61 ctcttccgtg gcttcacgca cacactgcgg cagctggatg cggagatcaa ggcggacaaa
      121 gagaaggggt tccgggtgga caagattgtg gaccagctgc aacagttgat gcaggtttac
      181 gacttggctg cccttcggga ttattggagc tacctggaac gcaggctctt cagccgcttg
      241 gaggatatct atcgacctac catcaacaaa ctgaaaacca gcctgttccg cttttatctt
      301 gtctacacaa tccagacaaa ccgaaatgac aaggcacagg agttctttgc aaagcaggcc
      361 acggagctcc agaaccaggc tgagtggaag gattggtttg tcctgccctt cttgccgtcc
      421 ccagacacca accccacctt tgctacctac ttttctcgac aatgggccga cacattcatt
      481 atttctctgc acaacttcct gagcgtcctc tttcagtgca tgccggttcc tgtgatcctg
      541 aactttgatg cggaatgcca gaggaccaac caggtccaag aagaaaatga agttctgcgc
      601 cagaagcttt ttgcactgca agctgaaatc catcgactaa agaaggaaga gcagcagcag
      661 gaagaagaag cagcagcttt ggtccagcat aagctgccgc cttatgtttc cagtatggac
      721 cgccttgggg actcggagct agcactggtg tgcagccaga ggcctgcctc cctctcccag
      781 tctcctcgag tggggttcct gtcctcactg ctgcctcaga gtaagaagag cccttcgagg
      841 ttgtcacctg cccaaggccc ccctcaggct cagagttcag ccaagaaaga ctccttcagc
      901 agtcaggcta ccaagggaaa ggactcagtg cccggggcca aggatgggaa gagccttctg
      961 agcgggccgg tccccgggga agccagctgg acacatcagc gacaacggcg tctgcaggac
     1021 cacggcaagg agaggaggga gctgctctct acgtcctcct cccagtcaca gtgtgcagag
     1081 aggaagccgg aagttagtgg cgcagaggct gagccctgcc tggaactcca catggggcca
     1141 gtagaggtgc tggcccgggt gtccacagcc gggtctgagg gagaccgtcc ggagcagccc
     1201 ttcatagtgc tgagccaaga agagtatgga gaacaccatt catccatcat gcactgcaga
     1261 gtggactgct ctggtaggag agtggccagc ttagacgtag atggggtcat caaggtgtgg
     1321 tccttcaatc ccatcatgca aaccaaagcg tcctccattt ctaagtcacc actgctctcc
     1381 ctagagtggg ccaccaagcg agacaggctg ctcctgctgg gcagtggtgt ggggacagtg
     1441 cgtctctatg atacagaagc caagaagaac ctctgtgaga tcaacatcaa tgatgacatg
     1501 cccagaatcc tgtctcttgc ctgcagcccc aacggggcct ctttcgtctg ttcagccgca
     1561 gctcccagcc tcacctccca gacagactcc tccgccccgg atatcggcag caaaggcatg
     1621 aaccaggttc ctggcaagct gctgttgtgg gatacaaaga ccatgaagca gcagcttcag
     1681 ttctcactgg acccagagcc cattgccatc aactgcacgg ctttcaatca caacgggaac
     1741 ctgctggtca caggggcggc tgacggtgtc atccggctct ttgacatgca gcagcacgag
     1801 tgtgctatga gctggaaggc ccactgcggc gaggtctact ctgtggaatt cagctgtgac
     1861 gagaatgctg tgtacagcat cggcgaggac cgcaagttca tccagtggaa tatccacaag
     1921 agtggcctca aggtgtctga gtccaacctc ccttcagatg ccaccggccc ctttgtcctg
     1981 tctggctaca gtggctacaa gcaggttcaa gttcccagag gccggctctt cgctttcgac
     2041 tctgagggca attacatgct gacgtgctct gccacagggg gcctcatcta caagctgggc
     2101 agtgaagaga aagttctaga aaattgtctg agcctgggtg gccaccgtgc ccctgtggtc
     2161 accgtggact ggagcaccgc catggactgt gggacgtgcc tcacagcctc catggatggc
     2221 aagatcaagc tgactaccct cctagcccat aagctctgat gtcgggcccg gctgacacgg
     2281 cacgggaagc agaaccgtct ctggcagaag agagatgaga cgggggacag gacagggctc
     2341 tggttctgca ctgccagggt ggtggatctt caggaaagcc cccaaggggg ctcagtcgtc
     2401 ctgacgaagc ccctggagca ggagatgtgg agcaggctgc gtgtactccc tggagactag
     2461 aaccgtggct atagcggagc atgctccaga gcacaggact gatgctaagg aaggagccac
     2521 agtggccggc gcaccctgtt cggtccaaga ggcattgact gtattttgta cataattgct
     2581 tatttttctt atttaagggg aaaaaaaaat cagagcaagg taatgctctt acagtcaaaa
     2641 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
