LOCUS       NM_028203               2981 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WD repeat domain 89 (Wdr89), mRNA.
ACCESSION   NM_028203 XM_001001795 XM_001476702 XM_001476717 XM_001479426
VERSION     NM_028203.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2981)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2981)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2981)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124742.4.
            
            On or before Apr 10, 2009 this sequence version replaced
            XM_001001795.2, XM_001479426.1, XM_001476702.1, XM_001476717.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132326.1, BC112430.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC124742.4         144998-145063       c
            67-2981             AC124742.4         106120-109034       c
FEATURES             Location/Qualifiers
     source          1..2981
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 32.89 cM"
     gene            1..2981
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
                     /note="WD repeat domain 89"
                     /db_xref="GeneID:72338"
                     /db_xref="MGI:MGI:1919588"
     exon            1..66
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            67..2981
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1257
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
                     /codon_start=1
                     /product="WD repeat-containing protein 89"
                     /protein_id="NP_082479.1"
                     /db_xref="CCDS:CCDS49090.1"
                     /db_xref="GeneID:72338"
                     /db_xref="MGI:MGI:1919588"
                     /translation="MEKIEDQFASLHIVRRSSEPKEPTYLLGIDTSKTVQADKGGLVA
                     VLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDARGA
                     SEKPVQLFKGYPSCSFISFDVNCKDHVICAGAEKVDEDALLVFWDARFTSQDLSTRDP
                     LGAYSETHSDDITQVRFHPSNPNLVVSGSTDGLVNVFDLSADKEEDALVATCNSVSSV
                     SCIGWCGKDYKQIYCMTHDEGFCWWDLNHLDTDEPITCLNIQDVREITDVKDGHLDYL
                     IGGLYHEKMDRLFVIGGTNTGKIHLLSCTSAGLTHVTSLHGGHAATVRSFCWNVSEDS
                     LLTGGEDAQLLLWKPGAMEKTFTKKDSLKIASSVQQRVRVHSSDSYKKRKQQ"
     regulatory      2536..2541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
                     /note="hexamer: AAGAAA"
     polyA_site      2549
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
                     /note="major polyA site"
     polyA_site      2552
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
     regulatory      2958..2963
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2981
                     /gene="Wdr89"
                     /gene_synonym="2600001A11Rik"
ORIGIN      
        1 gagttccagc cggccgtggg cagagcgtgc gttttctcca gctccagtgt ggggtttgct
       61 gcggagagct ttatacccct ggatgcttct actgacatgg agaagattga ggaccagttt
      121 gctagcctgc atattgttag gaggtcctcg gaaccaaaag aacccactta cctgcttggc
      181 atagacacgt caaagactgt acaagcagac aaaggaggct tggtggctgt tctgtgctca
      241 aatgggtcga taagaatata tgataaggag acactacatc tgctacgaga atttggtggc
      301 tctcccgggc ttcttagtgg agtcagcttt gcaaattcct gtgacagtgt ctactctgca
      361 agcacagatg gcaccgtgaa gtgttgggac gctcggggag ctagcgaaaa gcctgtgcag
      421 ttgttcaagg gttacccttc ctgtagtttc atcagctttg atgtcaactg caaagatcat
      481 gtcatttgtg ctggtgcaga gaaagttgac gaggatgcat tgttggtatt ttgggatgca
      541 aggttcacat ctcaggatct gtcgacgaga gacccacttg gtgcctactc agagacgcac
      601 agtgatgata tcactcaagt gcgtttccat cccagcaatc ccaacttggt tgtctcaggg
      661 tccactgatg gtctggtcaa tgtgtttgat ctcagtgctg ataaggaaga ggacgcactg
      721 gttgccacct gtaactccgt ttcatcagtg agctgtatcg gttggtgtgg aaaagattat
      781 aagcaaatct actgcatgac acacgatgaa gggttttgtt ggtgggatct caatcatctg
      841 gatacagatg aaccgatcac gtgtttgaac atccaggatg taagagaaat aaccgatgtg
      901 aaagatgggc acttggacta tctgattggt ggcctgtatc atgagaagat ggacagactg
      961 tttgttattg gaggaaccaa caccggaaag attcacctac tgagctgcac ctcggcagga
     1021 ctgacccatg tgaccagcct tcatgggggc catgcagcca ccgtccgttc tttctgttgg
     1081 aacgtgtctg aggattctct gctgaccgga ggtgaagatg cacagctatt gctgtggaaa
     1141 cctggagcta tggagaagac gttcacaaag aaagacagct tgaaaattgc atcctccgtg
     1201 cagcagcgag ttcgagtcca cagcagcgat tcttacaaga aaaggaagca gcagtgacgt
     1261 catactggga actggaaaag ctcttccggt tttaaatcgt cttttgctac ctagagcaca
     1321 tctttttaaa gcttatctgt gaaagcaggc agttagcaca caacacccac cctgccccag
     1381 acaaatactg agaatggttt cattcaggtt cagatatatt ctacaatatt tttaaagcct
     1441 ccagttgagt ataaaaatca gtgacttgac aggggaatta taagccacat tttgaaaccc
     1501 atcagtggag ttagtaaatg ttaggtttga agtagccctg aagaggaatc ttcagtagac
     1561 agctggagag gcaagggagc gggtggctgg gttctgggct ttaaactctg ctccttacgt
     1621 ttgaagtgat acacttggtt atacagcatc agactgttta gtcgtttgaa gagcgtttgc
     1681 ctcctcacta cgctcaccgc ttcacctcgg gtcatcgaaa tcgaagcgtt ctagtgagtc
     1741 tgagcagaag tttacttttt taggaataaa gtataatatt ttcctaaaat gagaaaaata
     1801 tatttgataa ttacttgtat ctgtactttt tttttaatta atcaggagct atatttatac
     1861 tatatttaca tttggttagc cagcacccag gtactttgct gatgaaaaaa gaaattacct
     1921 tactagattc attttgagac ttaacataag acaggcaaaa gaaaatacaa cagcacggct
     1981 atttttttca aaatggcctt tcaggggctg gtgagatggc tcagtgggta agagcaccca
     2041 actgctcttc cgaaggtcca gagttcaaat cccacaacca catggtggct cacaaccatc
     2101 tgtaacaaga tctgatgccc tcttctggag tgtctgaaga cagcgctaca gtgtacttac
     2161 atataataaa taaatcttaa aaaaaaaaaa aaaagagctt ttcgccgccg gacgctgccg
     2221 aggtcgcacg cgtgaggtct gtcccccgca gccgacatgc gctacgtcgc ctcttacctg
     2281 ctggccgccc tcgggggcaa ctcctctcct agcgccaaag acatcaagaa aatactaggc
     2341 agcgtgggca tcgaagcgga cgatgatcgg ctcaacaagg tcatcagtga gctgaatgga
     2401 aagaacattg aggatgtcat tgctcagggt gttggcaagc tggccagtgt gcctgctggt
     2461 ggggctgtgg ctgtttctgc tgcccctggc tctgcagcac ctgctgctgg ttctgccccc
     2521 gctgcagcag aggagaagaa agatgagaag aaggaggagt ccgaggagtc ggatgacgac
     2581 atgggatttg gcttgtttga ttaaattcct gctcccctgc aaataaagtc tttttatgta
     2641 tcttgaaaaa aaaaaaagaa atgtttgttc ttttaaaaaa aaatggcctt tcaaaaatat
     2701 tatatgatta aatattcttt cttatctccc ccatcatttt acccttgaag ccttgtttac
     2761 tgcctctgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     2821 tctgttttct cttactcccc tgtgggaccc aggaatcaca gtccagtcct tagactgcac
     2881 agcagcctct acctaccaag ccacatttac tgttaatttt gtcatttttc ttaaaaaact
     2941 gttttgtaaa gtgccttaat aaaagaagtt gatactttta a
//
