LOCUS       NM_029896               4313 bp    mRNA    linear   ROD 18-NOV-2024
DEFINITION  Mus musculus WD repeat domain containing 82 (Wdr82), mRNA.
ACCESSION   NM_029896 XM_135109 XM_920961
VERSION     NM_029896.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4313)
  AUTHORS   Cui,G., Zhou,J., Sun,J., Kou,X., Su,Z., Xu,Y., Liu,T., Sun,L.,
            Li,W., Wu,X., Wei,Q., Gao,S. and Shi,K.
  TITLE     WD repeat domain 82 (Wdr82) facilitates mouse iPSCs generation by
            interfering mitochondrial oxidative phosphorylation and glycolysis
  JOURNAL   Cell Mol Life Sci 80 (8), 218 (2023)
   PUBMED   37470863
  REMARK    GeneRIF: WD repeat domain 82 (Wdr82) facilitates mouse iPSCs
            generation by interfering mitochondrial oxidative phosphorylation
            and glycolysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4313)
  AUTHORS   Yang,S., Sun,G., Wu,P., Chen,C., Kuang,Y., Liu,L., Zheng,Z., He,Y.,
            Gu,Q., Lu,T., Zhu,C., Wang,F., Gou,F., Yang,Z., Zhao,X., Yuan,S.,
            Yang,L., Lu,S., Li,Y., Lv,X., Dong,F., Ma,Y., Yu,J., Ng,L.G.,
            Shi,L., Liu,J., Shi,L., Cheng,T. and Cheng,H.
  TITLE     WDR82-binding long noncoding RNA lncEry controls mouse erythroid
            differentiation and maturation
  JOURNAL   J Exp Med 219 (4) (2022)
   PUBMED   35315911
REFERENCE   3  (bases 1 to 4313)
  AUTHORS   Austenaa,L.M.I., Piccolo,V., Russo,M., Prosperini,E., Polletti,S.,
            Polizzese,D., Ghisletti,S., Barozzi,I., Diaferia,G.R. and Natoli,G.
  TITLE     A first exon termination checkpoint preferentially suppresses
            extragenic transcription
  JOURNAL   Nat Struct Mol Biol 28 (4), 337-346 (2021)
   PUBMED   33767452
REFERENCE   4  (bases 1 to 4313)
  AUTHORS   Cao,Y., Li,M., Liu,F., Ni,X., Wang,S., Zhang,H., Sui,X. and Huo,R.
  TITLE     Deletion of maternal UHRF1 severely reduces mouse oocyte quality
            and causes developmental defects in preimplantation embryos
  JOURNAL   FASEB J 33 (7), 8294-8305 (2019)
   PUBMED   30995416
REFERENCE   5  (bases 1 to 4313)
  AUTHORS   Vethantham,V., Yang,Y., Bowman,C., Asp,P., Lee,J.H., Skalnik,D.G.
            and Dynlacht,B.D.
  TITLE     Dynamic loss of H2B ubiquitylation without corresponding changes in
            H3K4 trimethylation during myogenic differentiation
  JOURNAL   Mol Cell Biol 32 (6), 1044-1055 (2012)
   PUBMED   22252316
REFERENCE   6  (bases 1 to 4313)
  AUTHORS   Bi,Y., Lv,Z., Wang,Y., Hai,T., Huo,R., Zhou,Z., Zhou,Q. and Sha,J.
  TITLE     WDR82, a key epigenetics-related factor, plays a crucial role in
            normal early embryonic development in mice
  JOURNAL   Biol Reprod 84 (4), 756-764 (2011)
   PUBMED   21123813
  REMARK    GeneRIF: the result of a blocked WDR82 consists of stunted
            embryonic development and death. Thus, WDR82 can be considered a
            key epigenetic regulation-related factor crucial in the normal
            growth and development of embryos.
REFERENCE   7  (bases 1 to 4313)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
REFERENCE   8  (bases 1 to 4313)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 4313)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AW044996.1, AK037620.1, AK159240.1, CK621157.1, AK162537.1 and
            CN722892.1.
            
            On or before Jul 25, 2007 this sequence version replaced
            XM_920961.2, XM_135109.7.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037620.1, AK159240.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-579               AW044996.1         1-579
            580-1525            AK037620.1         587-1532
            1526-1855           AK159240.1         1526-1855
            1856-2414           CK621157.1         45-603
            2415-3719           AK159240.1         2414-3718
            3720-4053           AK162537.1         1942-2275
            4054-4313           CN722892.1         319-578
FEATURES             Location/Qualifiers
     source          1..4313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 57.46 cM"
     gene            1..4313
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /note="WD repeat domain containing 82"
                     /db_xref="GeneID:77305"
                     /db_xref="MGI:MGI:1924555"
     exon            1..451
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     CDS             291..1232
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /codon_start=1
                     /product="WD repeat-containing protein 82"
                     /protein_id="NP_084172.1"
                     /db_xref="CCDS:CCDS40754.1"
                     /db_xref="GeneID:77305"
                     /db_xref="MGI:MGI:1924555"
                     /translation="MKLTDSVLRSFRVAKVFRENSDKINCFDFSPNGETVISSSDDDS
                     IVLYDCQEGKPKRTLYSKKYGVDLIRYTHAANTVVYSSNKIDDTIRYLSLHDNKYIRY
                     FPGHSKRVVALSMSPVDDTFISGSLDKTIRLWDLRSPNCQGLMHLQGKPVCSFDPEGL
                     IFAAGVNSEMVKLYDLRSFDKGPFATFKMQYDRTCEWTGLKFSNDGKLILISTNGSFI
                     RLIDAFKGVVMHTFGGYANSKAVTLEASFTPDSQFIMIGSEDGKIHVWNGESGIKVAV
                     LDGKHTGPITCLQFNPKFMTFASACSNMAFWLPTIDD"
     exon            452..549
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     exon            550..616
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     exon            617..716
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     exon            717..833
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     exon            834..989
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1059
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1202
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..4313
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3691..3696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /note="hexamer: TATAAA"
     polyA_site      3713
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /note="major polyA site"
     regulatory      4036..4041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
                     /note="hexamer: AATAAA"
     polyA_site      4054
                     /gene="Wdr82"
                     /gene_synonym="9430077D24Rik; CDW5/WDR82"
ORIGIN      
        1 gattttgctt ctcccttcaa gatggcggac acaatgagcc ggcggagcgc cggttggccc
       61 tgaattgact ccggagaaga acggtcagcg aggtcccgtc gtccgggcga gagagcgtcg
      121 cctgaggaag aggacgcggc agccccactg tcagccgtcc ttcggttcgt ctccagcgcg
      181 gcgcccgcac cgccggggtt ggccctgagc agcccgcccg atcgctcgcc tctcggcccc
      241 gccccggccc tgcgccgccg ctgccttcag cagcagcagc cgccgccgcc atgaagctga
      301 ccgacagcgt gctccggagc ttccgcgtcg ccaaggtgtt ccgcgagaac tcagacaaga
      361 tcaactgctt tgactttagt cccaatggcg agacggtcat ctctagcagc gatgatgact
      421 ccatcgtgct ctatgactgc caggagggca aaccaaagag aaccctgtac agtaagaagt
      481 acggtgtgga cctcatcaga tacacccatg cagccaacac agtcgtttac agctctaaca
      541 aaatagacga tactattcgt tacttgtcct tgcatgacaa taaatacatc agatactttc
      601 ctggacacag caagagggtg gtggccttgt ccatgtcacc tgtggatgac actttcattt
      661 ctgggtctct tgataagacc attcgactct gggatctccg gtctcctaac tgccagggcc
      721 tcatgcatct acagggcaaa cctgtctgtt cctttgatcc agaagggtta atttttgctg
      781 cgggcgtcaa ctcagaaatg gtcaaacttt atgaccttcg ttcttttgat aagggaccat
      841 ttgcaacatt taagatgcag tatgatagga cctgtgagtg gacaggactt aagttcagca
      901 atgatggcaa attgatactc atctccacca acggcagctt tatccgactg attgacgcat
      961 tcaagggtgt ggtgatgcac acatttgggg gttatgctaa cagcaaagct gtgacactcg
     1021 aagcttcatt tactccagac tcacagttta ttatgatcgg ttcggaagac ggcaaaatcc
     1081 atgtctggaa cggagagagt ggtataaaag tggctgtatt ggatggcaaa cacactggtc
     1141 ccattacctg tttgcaattc aaccccaagt ttatgacctt tgccagcgcc tgttccaaca
     1201 tggccttctg gttgcccacc attgatgact gatcctgatg ctgctgggct atttatacag
     1261 tgagggcggc caacaggaaa agccagaggt gactgagatg acagtgagat tgattgatca
     1321 tttgactggg ctggagaaca tctttccacg gggccttccc agggatgtgc tgtccatcgc
     1381 tctaatgagt tactttgctg agcaccttca gaaggactcc tggtgctgca gactcagttg
     1441 gcgctcagcc tttccagctc tcactgcgcc aagctcttca gagtgtgact agacttatga
     1501 ttaggttaca gtggggctct tgaacccctt caattttgaa tgtactcgct gctgaggagc
     1561 cagtgaagtc cccactttct gcacatcctt ctcaccccag aaatgcatgg gaagccgcgg
     1621 ttctggtttt gagatgctag ggcagctcag caccccttgc cctcactctg catgtcttgt
     1681 tactgggtct ccctgtgtaa ttaattgtgg cattattcca caaccatcat gtttcttagg
     1741 tgccaaacat ttacaaaaat aagtcttcat ataccttggg gtcaaagaaa gaaacaggta
     1801 cagaaggacc ttgtttgtca ggaggctata tggtattctc tttttttttt ttttttggta
     1861 ttcttgtata ggtgggtggg gcagatcttg ggcttagatg ttgactaaca aaaggcccaa
     1921 gagtctgaaa gggagggaag ggggtagcag gtaaattctg agagctgaga gatttagcag
     1981 cttggtgcag ttcccccatc aagatgatcc cacagtctcc tgtggggggt cctgctgagc
     2041 ttggcttgta caaaagcaag cagtagttta tttttgtacc tgagtcacat cacgttctcc
     2101 tgtgggccag tattgtggag cgagtctgag ttgtttacac tgatgccttc cttccctgcc
     2161 caccacaaat tgtgtacata gtcaacagat gaaacccctc ctcttctcca gctcctaccc
     2221 aagagctggc tctaggcctg tgttatatgt tatatttagc ctttttatat atgacccttg
     2281 atctgtttgt atttgaacac tgtgtgtgtc cactttaata catttgtgca gacatgcaca
     2341 ttacatacgt gtatatgcct gtctctcatc tagattatca agggagaggg aaccttgcag
     2401 ccaagaatga ctctgtggat agtgtgtgcc acaagtgtta ttcttctctg ttaaccttag
     2461 ggatacaacg ggaagcagag cttctagtgt ttgctgtttc atggcagcta agtgggggcc
     2521 ttgggtgact cccttgtgct ctttaagcca cacttcgggg ccctctctac agtattagat
     2581 tcttttttgc ctgattatgc tctgtctgca cctgtgtatg tgtgacagtc acttttgcat
     2641 ggcttctgtg cctggcttgt ggcatttagg gacagggtgc tggaaccaca gtgtttagtt
     2701 tgtcagaact tgttggccaa ccataagtca ctgtcacctg ctgtgtctac actgttgccc
     2761 cttttcttgc ttttttcctg agagacttta gctaggccca gactagatga gttgcaggtg
     2821 accttctctt cccagctcgg cagctttaga gtagaacaaa cggccatcaa acattgatgc
     2881 aagcactatc cctgcagatc cagaaatcaa gactcaacag gttgtgattt gcccaagagt
     2941 acccagctgc tagcgtgctc agaccatcac tgcttctgtt cagtcgcaga tagccgtcca
     3001 gtcaccaatg cttttgactt gttccaactg aaaagttgga ctgtcactga agtctgttaa
     3061 gtattgctga acaatcctgc tataaaattc tgccttccca gaatggaccg acagaaggag
     3121 ccaggcaatc agctccatgt ttgaaagaac tgttgaaggc aaatgtctgt aatcgtagat
     3181 taatatggca gcttgcctga actgaacgca ggaaaactgt cttgagtgtc caggggttga
     3241 agcatcacac tcttagaaga cataccgcct cacggtctct gctgggccct gaggccacag
     3301 acctgagtta tgttccgaat tggtaggaaa aggtgcagct ggagtttata tggtcacagg
     3361 gtaataagaa agagggagaa agcagagatg gcagtttggg gatgtgtccc tgggatgtat
     3421 tcactgccct ctgatatgac agctggcact gcactgttca accaccagcc actggggtat
     3481 tttttaataa attattccct gttgtaactg acaattagtg cttatgaagg aaaattggaa
     3541 gatctttaag aaccagtttg ccacccaagt ggtaccactg tttaaatctt gatgttaaat
     3601 gttcctttag atatctctgt gcataaactt tggtgtttac atagttgtta ttctactgta
     3661 catacaattt tgtccttttt gtacttaaca tataaacttt ttttgccatg ttatcagtcg
     3721 taaacaggat tttatggttt acagtctctt ccattgagtt tctgtaacat tccctggctc
     3781 acttctgaca gaatgggttg ttcccatgtc ctggttccgg tggaaatgct tggcctctgg
     3841 gcaacagaaa cacacacccc tcccaggcac agtcccttaa ctccaaatgc caattaaatt
     3901 accacaggag cagtaatgag tgactagaaa aggtaagctt gactcaaccc cattcttcag
     3961 agaccacctc actgcctgcc ttgtgtccca cacagtttac ctcaaacttg gatcagattg
     4021 gcaagctctt gttagaataa attgcattct cccaggcctt gtttgatcag aagtgagcat
     4081 ctggcagtag gacctgctga gccatggctt ggctaatgca ttggaagtca ttggaattct
     4141 aggattgctg cttccttgac tgaatcagaa taggtgaaga ccttgacctt gacctttgga
     4201 agaaaatatt ctggcttggg tttagttgac tatgttggct ctccagctca gactgctcta
     4261 agaatgaaag ccctcaaagc ctggtgggat gtgcaacaag ttggatctgc ggc
//
