LOCUS       NM_138950               6976 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WD repeat domain 81 (Wdr81), mRNA.
ACCESSION   NM_138950 XM_001002633 XM_911699
VERSION     NM_138950.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6976)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6976)
  AUTHORS   Carpentieri,J.A., Di Cicco,A., Lampic,M., Andreau,D., Del
            Maestro,L., El Marjou,F., Coquand,L., Bahi-Buisson,N., Brault,J.B.
            and Baffet,A.D.
  TITLE     Endosomal trafficking defects alter neural progenitor proliferation
            and cause microcephaly
  JOURNAL   Nat Commun 13 (1), 16 (2022)
   PUBMED   35013230
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6976)
  AUTHORS   Wang,M., Tang,C., Xing,R., Liu,X., Han,X., Liu,Y., Wang,L., Yang,C.
            and Guo,W.
  TITLE     WDR81 regulates adult hippocampal neurogenesis through endosomal
            SARA-TGFbeta signaling
  JOURNAL   Mol Psychiatry 26 (2), 694-709 (2021)
   PUBMED   30531936
  REMARK    GeneRIF: WDR81 regulates adult hippocampal neurogenesis through
            endosomal SARA-TGFbeta signaling.
REFERENCE   4  (bases 1 to 6976)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6976)
  AUTHORS   Liu,X., Li,Y., Wang,X., Xing,R., Liu,K., Gan,Q., Tang,C., Gao,Z.,
            Jian,Y., Luo,S., Guo,W. and Yang,C.
  TITLE     The BEACH-containing protein WDR81 coordinates p62 and LC3C to
            promote aggrephagy
  JOURNAL   J Cell Biol 216 (5), 1301-1320 (2017)
   PUBMED   28404643
REFERENCE   6  (bases 1 to 6976)
  AUTHORS   Traka,M., Millen,K.J., Collins,D., Elbaz,B., Kidd,G.J., Gomez,C.M.
            and Popko,B.
  TITLE     WDR81 is necessary for purkinje and photoreceptor cell survival
  JOURNAL   J Neurosci 33 (16), 6834-6844 (2013)
   PUBMED   23595742
  REMARK    GeneRIF: This study provided evidence that the nur5 mutant mouse
            strain, which displays tremor and an abnormal gait, as well as
            Purkinje cell degeneration and photoreceptor cell loss
REFERENCE   7  (bases 1 to 6976)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   8  (bases 1 to 6976)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   9  (bases 1 to 6976)
  AUTHORS   Kile,B.T., Hentges,K.E., Clark,A.T., Nakamura,H., Salinger,A.P.,
            Liu,B., Box,N., Stockton,D.W., Johnson,R.L., Behringer,R.R.,
            Bradley,A. and Justice,M.J.
  TITLE     Functional genetic analysis of mouse chromosome 11
  JOURNAL   Nature 425 (6953), 81-86 (2003)
   PUBMED   12955145
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591496.13, CN721357.1, AK160585.1 and BC061040.1.
            
            On or before Jun 27, 2009 this sequence version replaced
            XM_911699.3, XM_001002633.2, NM_138950.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR10223969.10969.1,
                                           SRR11927937.5204052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164140
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3490              AL591496.13        96230-99719         c
            3491-3959           CN721357.1         1-469
            3960-6724           AK160585.1         2-2766
            6725-6976           BC061040.1         1262-1513
FEATURES             Location/Qualifiers
     source          1..6976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 45.89 cM"
     gene            1..6976
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /note="WD repeat domain 81"
                     /db_xref="GeneID:192652"
                     /db_xref="MGI:MGI:2681828"
     exon            1..3924
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     CDS             279..6083
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /note="shakey 5"
                     /codon_start=1
                     /product="WD repeat-containing protein 81"
                     /protein_id="NP_620400.2"
                     /db_xref="CCDS:CCDS48849.1"
                     /db_xref="GeneID:192652"
                     /db_xref="MGI:MGI:2681828"
                     /translation="MAQGSRRRKVVLTAGSEGWSPSSGPDMEELLRSVERDLNIDARQ
                     LALAPGGTHVVALVSTRWLASLRERRLGPCPRAEGLGEAEVRTLLQRSVQRLPPGWTR
                     VEVHGLRKRRLSYPLGGGVPFEEGSCSPETLTRFMQEVAAQNYRNLWRHAYHTYGQPY
                     SHSTAPSALPALDSIRQALQRVYGCTFLPVGESIPCLSNVRDGPCPSRGSPACPSLLR
                     AEALLESPEMLYVVHPYVQFSLHDVVTFSPAKLTNSQAKVLFLLFRVLRAMDACHRQG
                     LACGALSLHHIAVDEKLCSELRLDLSAYEMPSEDENQEGSEEKNGTGIKSEKEGEGRT
                     ECPTCQKELRGLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVVDFTTPYG
                     RFRDLRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGSGEPPHVPHHISDVLSDITYYV
                     YKARRTPRSVLCGHVRAQWEPHEYPATMERMQTWTPDECIPEFYTDPSIFCSIHPDMP
                     DLDVPAWCSSNQEFVAAHRALLESWEVSQDLHHWIDLTFGYKLQGKEAVKEKNVCLHL
                     VDAHTHLTSYGVVQLFDQPHPQRLAGSPALAPEPPLIPRLLVQPIREATGQEDISGQL
                     INGAGRLVVEATPCETGWTRDRPGTGEDDLEQATEALDSISLPGKAGDQPGSSSSQAS
                     PGLLSFSAPSGSRPGRRSKAAGLDPGEGEEGKIVLPEGFSPIQALEELEKVGNFLAKG
                     LGSQLEEPEKPHAQPPVHLQSLFHRDMQVLGVLLAEMVFATRVRILQPDAPLWVRFEA
                     VRGLCIRHSKDIPVSLQPVLDTLLQLSGPKSPMVSKKGKLDPLFEYRPVSQGLPPPSP
                     AQLLSPFSSVVPFPPYFPALHKFILLYQARRVEDEVQGRELAFALWQQLGAVLNDITP
                     EGLEILLPFVLSLMSEEHTAVYTAWYLFEPVAKALGPKNANKYLLKPLIGAYESPCRL
                     HGRFYLYTDCFVAQLVVRLGLQAFLTHLLPHVLQVLAGVEASQEEGKGLVGTTEDEES
                     ELPVSGPGSCAFGEEIQMDGQPAASSGLGLPDYRSGVSFHDQADLPDTEDFQAGLYVA
                     ESPQPQEAEAVSLGQLSDKSSTSEASQGEERGGDDGGAPADKNSVKSGDSSQDLKQSE
                     GSEEEEEEEGCVVLEEDQEDEVTGTSELTLSDTMLSMETVVAPGDGRDREEEEEPLTE
                     QTEGKEQKILLDTACKMVRWLSAKLGPTVASRHVARNLLRLLTSCYVGPTRQQFTVSS
                     DDTPPLNAGNIYQKRPVLGDIVSGPVLSCLLHIAYLYGEPVLTYQYLPYISYLVAPGS
                     NSNPSRLNSRKEAGLLAAVTLTQKIIVYLSDTTLMDILPRISHEVLLPVLGFLTSFVT
                     GFPSGAQARTVLCVKTISLIALICLRIGQEMVQQHLSEPVATFFQVFSHLHELRQQDL
                     PLDPKGCTEGQLPEATFSDGQRRPVDPTLLEELQKVFTLEMAYTIYVPFSCLLGDIIR
                     KIIPNHELVGELAGLYLESMSPSSRNPASMEPTMASAGPEWDPQSGSCLQDDGHSGTF
                     GSVLVGNRIQIPDSQPQSPGPLGSLSGVGSSGGLSNRNEDNALKRELPRSAHGLSGNW
                     LAYWQYEIGVSQQDAHFHFHQIRLQSFPGHTGAVKCVAALSSEDFFLSGSKDRTVRLW
                     PLYNYGDGTNETASRLIYAQHRKSVFYVGQLEAPQYVVSCDGAVHVWDPFTGKTLRTV
                     DPSDSRVPLTAVAVMPAPHTSITMASSDSTLRFVDCRKPGLQHEFRLGGGLNPGLVRS
                     LAVSPSGRSVVAGFSSGFMVLLDTRTGLVLRGWPAHEGDILQIKAVEGSVLISSSSDH
                     SLTVWKELEQKPTHHYKSASDPIHTFDLYGSEVVTGTVANKIGVCSLLEPPSQATTKL
                     SSENFRGTLTSLALLPTKRHLLLGSDNGIIRLLA"
     exon            3925..4032
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     exon            4033..4223
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     exon            4224..4414
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     exon            4415..4580
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     exon            4581..4746
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     exon            4747..5436
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     exon            5437..5582
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     exon            5583..5762
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     exon            5763..6909
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6879..6884
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /note="hexamer: AATAAA"
     polyA_site      6904
                     /gene="Wdr81"
                     /gene_synonym="Gm883; mFLJ00182; nur5"
                     /note="major polyA site"
ORIGIN      
        1 ggagatcaca tgacccgcat cagctgaccc gtcacggtgg agctcagcgc tggtgcttcg
       61 cgctccccgc cctgctgcgc cccggagcgc aggaccctgc ggaggggtaa gaaaaccccc
      121 aggctttctt tcctttgtcg ctggttcgcg cagtcacctg caccctaccc cccgctcctc
      181 gttcatccca gtcttcccgg cctggcaccc cggaagccac tgcgaggagg gccgtggcca
      241 ggctcagcct tgcgctgccc ccaggcggcc aggaccaaat ggcccagggg agcagaaggc
      301 ggaaagtggt tcttacagca gggtccgagg gctggtcccc ttcctcagga cctgacatgg
      361 aggagctgct ccggagcgtg gagagagatc tgaacattga tgcccggcag ctggccctgg
      421 cgccgggggg cactcatgta gtggccctag tgtccacgcg ttggctggct agtctccggg
      481 agcgccgact gggaccctgt ccccgggctg agggcctggg tgaagcagaa gtcaggactt
      541 tactgcaacg ttcggtacag aggctgcccc caggctggac tcgagtggag gtgcatgggc
      601 tgcggaaacg gagactgtcc tacccgctgg gtggaggcgt gccctttgag gaggggtcct
      661 gtagccctga aactctcact cggttcatgc aggaggtggc tgcccagaat taccggaacc
      721 tgtggcgcca tgcataccac acttatggac agccttacag ccacagcact gccccctcag
      781 ctctacctgc cctagactct atacgacaag ctctccagag ggtgtatgga tgcaccttct
      841 tgccagtggg tgaatccatc ccatgtctat caaatgtcag ggatgggccc tgcccctctc
      901 ggggcagccc tgcctgcccc agccttttgc gagctgaggc tttgctggag tcgcccgaga
      961 tgctctatgt ggtacaccct tatgtgcaat tctccctgca tgatgtagtt accttcagcc
     1021 ctgccaagct gaccaacagc caagccaagg tgctctttct tctcttccgt gttctgaggg
     1081 ccatggatgc ctgtcaccgc caggggctgg cctgtggggc tctgtctttg caccacattg
     1141 ctgtagacga gaagctatgc agtgagctcc ggctggacct gagcgcttac gagatgcctt
     1201 ccgaggatga aaaccaggag ggctctgaag agaaaaatgg gacaggcatt aagtctgaaa
     1261 aagaggggga agggagaact gagtgtccca cctgccagaa agaacttcgg ggccttgtgc
     1321 tagactgggt ccatggccga atcagcaact tccactacct catgcagctg aatcggttgg
     1381 caggtcgacg gcagggggat cccaactatc acccagtgct gccctgggtg gtggacttta
     1441 ccacacctta tgggcgcttc cgagaccttc gtaaatccaa gttccgactc aacaagggag
     1501 ataagcaatt ggacttcacc tatgagatga cccggcaggc atttgttgca ggtggtgcag
     1561 gaagtgggga gccaccccat gttcctcacc acatctctga cgtgctctct gacatcacgt
     1621 actatgtata caaggcccgt cgcacaccgc gctcggtgct ctgtggacat gtccgagcgc
     1681 agtgggaacc ccacgagtat cctgccacca tggagcggat gcagacctgg acaccggatg
     1741 agtgcatacc cgagttctac acggacccct ctatcttttg ctctatccac cctgacatgc
     1801 ccgacctgga tgtgccggcc tggtgcagtt ctaaccagga atttgtggct gcccatcgag
     1861 ccctcctgga gagctgggag gtgtcccaag acctgcatca ctggattgat cttacctttg
     1921 gctacaaact ccagggcaaa gaagctgtga aggagaagaa tgtgtgtctg cacctggtgg
     1981 acgctcacac ccatctgacc agctatggcg tggtacagct atttgatcag ccacaccccc
     2041 aacgcctggc tggatctcct gccctggccc ctgaacctcc actcatcccc cggctgttgg
     2101 tccagcctat tcgggaggcc acaggccagg aggacatttc aggacaactt ataaatggtg
     2161 cgggcaggct tgtcgtagag gccactccat gtgagactgg ctggactaga gataggcctg
     2221 ggacaggaga agatgattta gaacaggcta cagaagctct ggattccatc tccctccccg
     2281 ggaaagcagg tgaccagcca ggctcttcct ccagtcaagc atcacctggc ctgttgtctt
     2341 tttctgcacc ctcggggtct cgaccaggcc gtaggagcaa agctgccggg ttggaccctg
     2401 gggagggtga agagggcaag attgtccttc cagagggctt cagtcccata caggccttgg
     2461 aagagctgga gaaagtgggt aacttcctgg ccaaaggcct agggagccag ttggaggagc
     2521 ctgaaaagcc tcacgcccag ccacctgtgc acctgcagag cctcttccat cgagacatgc
     2581 aggtcctggg tgtcctgttg gctgagatgg tgtttgccac cagggtccgg atactgcagc
     2641 ctgatgcacc tttgtgggta cgctttgagg ctgttcgggg tctctgcata cgccactcca
     2701 aggacatccc cgtgtctctg cagcctgtgc tagacacact cctacagctg agcggaccca
     2761 aaagtcccat ggtgtcgaag aagggcaagc tagacccact gtttgagtat aggccggttt
     2821 cccagggatt acccccaccc agcccagccc agctcctcag ccccttcagc tccgtggtcc
     2881 ccttccctcc atacttccca gcactgcaca agttcattct tttatatcag gcccggcgtg
     2941 tggaggatga ggtccagggt cgggagctgg cgtttgctct gtggcagcag ctgggtgcgg
     3001 tgttaaatga catcactccc gagggcttag agatcctcct gcctttcgtg ctgtcgctca
     3061 tgtctgagga gcacacggct gtgtacacag cctggtacct atttgaaccc gttgccaagg
     3121 ccctgggccc caaaaatgcc aacaagtacc tcctgaagcc tctcatcggt gcctatgaga
     3181 gcccctgccg cctgcatggc cgcttctacc tgtacaccga ctgttttgtg gcccagttgg
     3241 tggtgcggct gggcttgcag gccttcctca cccacctgct gccccatgtc ctccaggtac
     3301 tggctggggt ggaggcttcc caggaggagg gcaaaggcct ggtcgggacc actgaggatg
     3361 aggaaagtga gctcccggtg tccgggcctg gctcctgtgc ctttggggaa gagattcaga
     3421 tggatgggca gccggctgct tcctcaggac tggggctccc agactacagg tcgggcgtca
     3481 gcttccatga ccaggccgac ctgccggaca cggaggactt ccaagctgga ctctacgtgg
     3541 ctgaatctcc acagccccag gaggctgagg ccgtgagcct gggccagctg agtgataaga
     3601 gcagtaccag cgaagcctcc cagggcgagg agaggggtgg ggatgatggc ggtgcccctg
     3661 cggacaagaa cagcgtcaag tcaggggaca gcagccagga cttgaagcag agcgaaggct
     3721 ctgaggaaga ggaggaggag gaaggctgtg tggtgttgga ggaggaccag gaggatgaag
     3781 tcacgggaac atccgagctc actctgtctg acacgatgct gtccatggag acggtggtgg
     3841 ctcctggtga tgggagagac agagaagagg aagaggagcc gctgacagag cagacagaag
     3901 gcaaagaaca aaagatcctc cttgatacag cctgcaagat ggtccgctgg ctgtctgcca
     3961 agcttggccc cacagtagcc tctcgccatg tggcccggaa cctgctgcgc ctgctgacat
     4021 cttgttatgt tgggcccact cgacagcagt tcaccgtcag cagtgatgac acccctccac
     4081 tgaatgccgg caacatctac cagaagaggc cagtcctagg tgacatcgtg tcggggcctg
     4141 tgctcagctg cctcctccac attgcctacc tgtatggaga acccgttctc acctaccagt
     4201 acctgcccta catcagctac ctggtagccc cagggagcaa ctcaaacccc agccgactga
     4261 acagccgcaa ggaggccggg ctgctggcag cggtgacact gacgcagaaa atcatcgtat
     4321 acctctctga cacgaccctc atggacattc tgccccgcat tagccacgag gtcttgctgc
     4381 ctgtgcttgg cttcctcacc tccttcgtca cagggttccc cagtggggcc caggcccgga
     4441 ctgtcctatg cgtgaaaacc atcagtctca tcgccctcat ctgcttgcgc atcgggcagg
     4501 agatggtcca gcagcacctg agtgagccag tggccacctt cttccaagtc ttctctcatc
     4561 tgcatgagct tcggcagcag gatctgccac tggatcctaa gggctgtact gagggccagc
     4621 tgccagaggc gaccttctct gatgggcagc gacgaccagt ggaccccacc ctgctggaag
     4681 agctgcagaa ggtgttcacc ctggaaatgg cgtacacaat ctacgtacct ttctcctgcc
     4741 tgttgggtga catcatccgg aaaatcatcc ccaaccatga gttggtcggg gagctggcag
     4801 ggctctatct ggaaagcatg agcccgagct ctcgaaaccc agccagcatg gaacccacca
     4861 tggctagtgc cggccctgaa tgggaccctc agagtgggag ctgtctccag gacgatggcc
     4921 actcagggac ctttgggagt gtcctggttg gaaatcgcat ccagatccct gactctcagc
     4981 cccagagtcc tgggccactg ggctccctct ctggagtggg tagtagcgga ggcctcagca
     5041 acaggaatga agacaacgcc ctgaagcggg agctgcctcg gagtgcccat gggctgagcg
     5101 ggaactggct ggcgtactgg cagtacgaga tcggtgtgag ccagcaggat gcccacttcc
     5161 acttccacca gatccgcctg cagagcttcc cagggcacac gggggccgtc aaatgcgtgg
     5221 ccgccctgag cagtgaagac ttctttctga gtggcagcaa ggaccggact gtgcgcctct
     5281 ggccgctgta caactatggg gacgggacca atgagacggc ttcccgcctc atctatgccc
     5341 agcaccgcaa aagcgtcttc tacgtgggcc agcttgaggc cccgcagtat gtggtgagct
     5401 gtgatggggc agtgcacgtc tgggacccct tcacaggaaa gacccttcgc acagtggatc
     5461 cttcagacag ccgggtgccc ctgacggctg tggctgtcat gcctgcccca cacaccagca
     5521 tcaccatggc cagctccgac tccactctgc gctttgtgga ctgcaggaag ccaggcttgc
     5581 agcatgagtt ccgactgggt ggagggctga accctgggct tgttcgctcg ttggccgtca
     5641 gccccagtgg ccggagtgtt gtggctggct tctcctcggg cttcatggtg ctcctagata
     5701 cccgcacggg cctggttcta cgaggctggc cagcccatga aggggacatt ctacagatca
     5761 aggctgtaga gggcagcgtg ctcatcagct cctcttccga ccattccttg actgtttgga
     5821 aggagctgga acagaagccc acgcaccact acaagtcagc gtccgaccca atccacacct
     5881 ttgacctgta cggcagcgag gtggtcaccg gcactgtagc caacaagatt ggtgtctgtt
     5941 ccctgcttga gccaccctct caggccacca caaagctcag ttccgagaac ttccgtggca
     6001 cgctcactag tctggctttg ctgcccacga aacgccacct cctgctgggc tcggacaatg
     6061 gcatcatccg cctcctggca tagggccagc caggagttgg ctgagggcag ggcgagatga
     6121 catctctcag ggcccgctcc tcattcttga tctcgaagcc gattcttcta ggcaagcccc
     6181 aggctctggc tacccacatg gcctgctgtc tgggattgca cagctcctga atctccaaag
     6241 ccttgaagtg gcttcatgaa actcgggaga tactgttcct aaccagcaag aattggggca
     6301 aggaaagcac tgtgatcccc attgctcccc agttctgcct tctggattca catggggaca
     6361 gggcagctcc aggaaatgaa aggagttggg cctttgctca gccagcttcc tctagccacg
     6421 ctctccttag ctctgtttct cccttgggta ggaaactgct cctgtctagg gttctgatgg
     6481 tactgggact ccaggctcag gagggctggc caggacctac gactttcagg gcttggtctg
     6541 gggttttagc attcattcag ccaggtcttc agtatgggac cagaaaaaag gggatgtgag
     6601 aacagggcta gggaaggggt tatatgggcc cagctggtcc aggaatgaat ccatgccttg
     6661 ccttggtacc cctaaccaca gcgtttgtgc cttcagccgg ggaggcagcc cttgggacca
     6721 gcatccctag ggacaggagg cagcgggaat catctctgta tctcgggttc tgcccagggg
     6781 atgggcagac tctgccatct cttgagtgtt cgtttggaga agcctgagat gtggcccctg
     6841 ctgccttctc actagttgca gtctatgtaa ataaggtcaa taaattcttt ggaagagcca
     6901 cggagctgaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     6961 aaaaaaaaaa aaaaaa
//
