LOCUS       NM_027432               3553 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus WD repeat domain 77 (Wdr77), mRNA.
ACCESSION   NM_027432
VERSION     NM_027432.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3553)
  AUTHORS   Li,J., Zhang,R., Wang,C., Zhu,J., Ren,M., Jiang,Y., Hou,X., Du,Y.,
            Wu,Q., Qi,S., Li,L., Chen,S., Yang,H. and Hou,F.
  TITLE     WDR77 inhibits prion-like aggregation of MAVS to limit antiviral
            innate immune response
  JOURNAL   Nat Commun 14 (1), 4824 (2023)
   PUBMED   37563140
  REMARK    GeneRIF: WDR77 inhibits prion-like aggregation of MAVS to limit
            antiviral innate immune response.
            Erratum:[Nat Commun. 2023 Sep 25;14(1):5960. doi:
            10.1038/s41467-023-41712-w.. PMID: 37749076]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3553)
  AUTHORS   Fan,Y., Huo,X., Guo,B., Zhang,X., Yang,Y., Lian,J., Meng,X.,
            Shao,Y., Zou,Y., Guo,H., Wang,H., Sun,G., Dou,H., Wang,J., Shao,C.,
            Gong,Y. and Hu,H.
  TITLE     Cullin 4b-RING ubiquitin ligase targets IRGM1 to regulate Wnt
            signaling and intestinal homeostasis
  JOURNAL   Cell Death Differ 29 (9), 1673-1688 (2022)
   PUBMED   35197566
REFERENCE   3  (bases 1 to 3553)
  AUTHORS   Kim,H., Walsh,M.C., Yu,J., Laskoski,P., Takigawa,K., Takegahara,N.
            and Choi,Y.
  TITLE     Methylosome protein 50 associates with the purinergic receptor P2X5
            and is involved in osteoclast maturation
  JOURNAL   FEBS Lett 594 (1), 144-152 (2020)
   PUBMED   31432503
  REMARK    GeneRIF: MEP50 associated with the purinergic receptor P2X5 and is
            involved in osteoclast maturation.
REFERENCE   4  (bases 1 to 3553)
  AUTHORS   O'Bryant,D. and Wang,Z.
  TITLE     The essential role of WD repeat domain 77 in prostate tumor
            initiation induced by Pten loss
  JOURNAL   Oncogene 37 (30), 4151-4163 (2018)
   PUBMED   29706654
  REMARK    GeneRIF: Wdr77 ablation inhibited E2F3 activation and enhanced
            TGFbeta signaling, leading to attenuated cellular proliferation
            induced by loss of Pten.
REFERENCE   5  (bases 1 to 3553)
  AUTHORS   Norrie,J.L., Li,Q., Co,S., Huang,B.L., Ding,D., Uy,J.C., Ji,Z.,
            Mackem,S., Bedford,M.T., Galli,A., Ji,H. and Vokes,S.A.
  TITLE     PRMT5 is essential for the maintenance of chondrogenic progenitor
            cells in the limb bud
  JOURNAL   Development 143 (24), 4608-4619 (2016)
   PUBMED   27827819
REFERENCE   6  (bases 1 to 3553)
  AUTHORS   Gao,S., Wu,H., Wang,F. and Wang,Z.
  TITLE     Altered differentiation and proliferation of prostate epithelium in
            mice lacking the androgen receptor cofactor p44/WDR77
  JOURNAL   Endocrinology 151 (8), 3941-3953 (2010)
   PUBMED   20519372
  REMARK    GeneRIF: The AR cofactor p44/WDR77 plays important roles in
            prostate growth and differentiation by modulating AR-target gene
            expression.
REFERENCE   7  (bases 1 to 3553)
  AUTHORS   Vagin,V.V., Wohlschlegel,J., Qu,J., Jonsson,Z., Huang,X., Chuma,S.,
            Girard,A., Sachidanandam,R., Hannon,G.J. and Aravin,A.A.
  TITLE     Proteomic analysis of murine Piwi proteins reveals a role for
            arginine methylation in specifying interaction with Tudor family
            members
  JOURNAL   Genes Dev 23 (15), 1749-1762 (2009)
   PUBMED   19584108
REFERENCE   8  (bases 1 to 3553)
  AUTHORS   Peng,Y., Chen,F., Melamed,J., Chiriboga,L., Wei,J., Kong,X.,
            McLeod,M., Li,Y., Li,C.X., Feng,A., Garabedian,M.J., Wang,Z.,
            Roeder,R.G. and Lee,P.
  TITLE     Distinct nuclear and cytoplasmic functions of androgen receptor
            cofactor p44 and association with androgen-independent prostate
            cancer
  JOURNAL   Proc Natl Acad Sci U S A 105 (13), 5236-5241 (2008)
   PUBMED   18356297
REFERENCE   9  (bases 1 to 3553)
  AUTHORS   Zhou,L., Wu,H., Lee,P. and Wang,Z.
  TITLE     Roles of the androgen receptor cofactor p44 in the growth of
            prostate epithelial cells
  JOURNAL   J Mol Endocrinol 37 (2), 283-300 (2006)
   PUBMED   17032745
REFERENCE   10 (bases 1 to 3553)
  AUTHORS   Friesen,W.J., Wyce,A., Paushkin,S., Abel,L., Rappsilber,J., Mann,M.
            and Dreyfuss,G.
  TITLE     A novel WD repeat protein component of the methylosome binds Sm
            proteins
  JOURNAL   J Biol Chem 277 (10), 8243-8247 (2002)
   PUBMED   11756452
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK050391.1.
            
            On Jun 9, 2003 this sequence version replaced NM_027432.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050391.1, SRR1660815.236714.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3553
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.46 cM"
     gene            1..3553
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /note="WD repeat domain 77"
                     /db_xref="GeneID:70465"
                     /db_xref="MGI:MGI:1917715"
     exon            1..201
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1115
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /note="methylosome protein 50; MEP-50; WD
                     repeat-containing protein 77"
                     /codon_start=1
                     /product="methylosome protein WDR77"
                     /protein_id="NP_081708.1"
                     /db_xref="CCDS:CCDS17715.1"
                     /db_xref="GeneID:70465"
                     /db_xref="MGI:MGI:1917715"
                     /translation="MRKDTPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGSLLL
                     GVSSLSGRCWVGSLWFFKDPSAAPNEGFCSAGVQTEAGVADLTWVGDKGILVASDSGA
                     VELWELDENETLIVSKFCKYEHDDIVSTVTVLSSGTQAVSGSKDCCIKIWDLAQQVSL
                     NSYRAHAGQVTCVAASPHKDSVFLSCSEDSRILLWDTRCPKPASQMACNASGYLPTAL
                     AWHPQQSEVFVFGDENGSVSLVDTKNASCTLSSAVHSQGVTRLVFSPHSVPLLTSLSE
                     DCSLAVLDSSLSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDHQVIHHVVPLEPLPN
                     PGPDSVVE"
     exon            202..387
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     exon            388..529
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     exon            530..579
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     exon            580..650
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     exon            651..705
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     exon            706..777
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     exon            778..886
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     exon            887..955
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     exon            956..3553
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1962..1967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /note="hexamer: AATAAA"
     polyA_site      1982
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /note="major polyA site"
     regulatory      3143..3148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
                     /note="hexamer: AATAAA"
     polyA_site      3166
                     /gene="Wdr77"
                     /gene_synonym="2610003I18Rik; 2610312E17Rik; p44/MEP50"
ORIGIN      
        1 gaggtacacc acgtgtgcgg tccctccggc gccgagtcag ggtctctcgt cgagtctggg
       61 tctaggttag atttggaatc gtggagatgc ggaaggacac ccctcctccg ctcgtgcccc
      121 cggcggcccg cgagtggaac ctgcccccca atgcgcccgc atgcatggaa cgtcaattgg
      181 aggctgcacg gtaccggtct gatggttccc ttctgctcgg ggtctccagc ctgagtggtc
      241 gctgctgggt aggttctctg tggtttttca aggatcctag tgcggccccc aacgaaggtt
      301 tctgctctgc tggcgtccag accgaggctg gagtagctga cctcacttgg gtgggggaca
      361 aaggtatcct agtggcttct gattcaggtg ctgttgaatt gtgggagcta gatgagaacg
      421 agacacttat agtcagcaag ttctgcaagt atgagcatga tgacattgtg tctactgtca
      481 ctgtcctgag ctctggcaca caagctgtca gtggtagcaa agactgctgc atcaaaattt
      541 gggacctggc tcagcaggta tcactgaatt cataccgagc tcacgctgga caggttacct
      601 gtgttgctgc ctctccccac aaagactctg tgtttctttc atgtagtgag gacagtagaa
      661 ttttgctctg ggatacccgc tgtcccaagc cggcatcaca gatggcctgc aatgcctctg
      721 gctacctccc taccgctttg gcttggcatc ctcagcagag tgaagtcttt gtttttggtg
      781 acgagaatgg atctgtctcc cttgtggaca ccaagaatgc aagctgtacc ctcagctcag
      841 ctgtgcactc ccagggtgtc actagactgg tattctcccc acacagtgtc cccctcctga
      901 cttctctcag tgaagactgt tcacttgctg tgctggattc aagcctttct gaggtgttta
      961 gaagtcgagc ccacagagac tttgtgagag atgctacgtg gtctccactc aatcactccc
     1021 ttcttaccac agttggctgg gaccatcagg tcatccacca tgttgtgccc ttagagcctc
     1081 tcccaaaccc tggacctgac agtgttgtgg agtagaatgg atttcagaaa aaccaaaaca
     1141 agccctccgt ctgtaagcga ctactcgatt gcccctgcct tccatgtgtg agagcacagg
     1201 agccttgtag agcatgtttc ctccctagcc ccgtgcagta acaggcagat tctcagcctg
     1261 agggaggctg catcccatag tgactcagag gaagaaactt cctctgtaaa tggatgtatg
     1321 tgagtacacg tgtgagtgcg gtatatagtt tggagtggag aaaattattc ttcagctttc
     1381 ccaaagcaat gctctttacc cctgacaaag tgaccagagg attttaatgc ttcccatgtc
     1441 tgggaattgg cgatgttagg gatatggaat gtgggtatcc ctagattttt gggaatactt
     1501 catactactc agaggtgcgt aacttatttt tatatagagt ttaattcact attatgggaa
     1561 ttacttccat atacaaaagt ctagcccact gtaccttgag aagacaaaac agttttgtac
     1621 aagtccctgt tatactgagt caaatccatt ttctgggtga ataaatttgg ccctgcagtg
     1681 tagctcttgt tcaccctttc cttccttggt gttgtgtgtg agagatgagt gttttcctgt
     1741 cctagatttc acagataagt tgtagggatg atggaccact taaaagtgtt tcagtgaagt
     1801 gggaaaattg acatggattg ttacagagaa atctgtcatt tttcccacct aaaaattgat
     1861 ctgggtacct tcctctggag agctgaagtc tgaatgtatt tttggactcc taagatttga
     1921 gatccagcat cagggaaact gtcggaaata ctaaaaggtg aaataaagac ttttatcctt
     1981 gattttccct ccccagagct gttacttatt acctgcttcg cttaggtgaa tcaccagtgt
     2041 cagacttagc tgcccactgt ctttgtaatc tactgtattc cactccatta gagactgtgg
     2101 atctgtaact gatcttattg gagctttcca acttgggttt aggaaaagca cataaaatgg
     2161 gcgccctgaa ggaatgtgat cgtcccttct agtcttgcca gtcatgagcc tctgttgtaa
     2221 ttaccctcga gcaaaacgct tgagagtttg cagtcaaggt cacctggggt tgggactgtg
     2281 gaagcaagga cttgcattgt tactaaattc agggaaggca taagataggt aggatcagtt
     2341 tctgcttctt agagataaag cttgtgcttt gtgtcactta ggtaaggaca ggtagtgcat
     2401 ttacatggcc tgctttgggg gctaagacta atagaggaaa agcctgaaag aaatgagtaa
     2461 atacgggttg tttcctttta ggtctgtatt ggtaaaagta atccacattg attaattcgt
     2521 gccacagatg tccaacttag tcaaagccac agtaaatgac aggcataatt ctacatagta
     2581 tattatgata tacaaggtaa tatacctcaa atcagatcag gaatatgagt tgtagcaagt
     2641 cattatctcg agaatagttc cagcactgca agcctcagtg aggtaacact agggttattt
     2701 tgatcgttga aaagcattta gtttttttca cgttagtgtt aactgttcaa atgtgtgaac
     2761 gagagtgaac acatttcctt agctttgttt ttcttactta gcctcactac tattgaactg
     2821 ctgacctctg gccagccaag gtctgagact tgttcctaga gtggtgggtg ctcgggagaa
     2881 gaaacattga agatctgtgt agtctcgggt gatgacaggt gttactagtt ttctaggtat
     2941 ctcactctgt agcacagctg gcccctggtg ctctagtgaa gagctagcta tatggatgtt
     3001 tcttgtggct cactgtcatg gcttcaaaaa tacccagtga gggccaggag attgttcagt
     3061 gggtaaaagt gttagccatc aagcctggga ctgacatggc aaaaggactc ttgactgcaa
     3121 gttgtctcca tgtatgcaca tgaataaaaa agtacccaaa ctcaaatctg cttgggggct
     3181 ctatcttttt gcaatacata aggaaggaca ggatattcag aaagaggcct tctaaaagtc
     3241 atcaacttca cacagcatcg taacattgct gtttttagaa tatacagctc cgattttaaa
     3301 aaggtattgt atgtggacag tgcataatgt cttgtatttt ctttgcgttt tggtagttgt
     3361 ttggtttagc tttaagccca cgaagtaaat gtgaatagaa aaagacattt ttaatgtctg
     3421 tgtattgtga aggcttaggg catctaacaa tccatgtgtg gaagaagcta aagacaattt
     3481 gtatctaatc aacatttgta ttgagttgct tattgctaat aaagataatg ttgggggtgg
     3541 ggagtttaga act
//
