LOCUS       NM_030234               4294 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WD repeat domain 76 (Wdr76), transcript variant 1,
            mRNA.
ACCESSION   NM_030234 XM_001004264 XM_983142
VERSION     NM_030234.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4294)
  AUTHORS   Park,J.C., Jeong,W.J., Seo,S.H. and Choi,K.Y.
  TITLE     WDR76 mediates obesity and hepatic steatosis via HRas
            destabilization
  JOURNAL   Sci Rep 9 (1), 19676 (2019)
   PUBMED   31873167
  REMARK    GeneRIF: WDR76 mediates obesity and hepatic steatosis via HRas
            destabilization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4294)
  AUTHORS   Jeong,W.J., Park,J.C., Kim,W.S., Ro,E.J., Jeon,S.H., Lee,S.K.,
            Park,Y.N., Min,D.S. and Choi,K.Y.
  TITLE     WDR76 is a RAS binding protein that functions as a tumor suppressor
            via RAS degradation
  JOURNAL   Nat Commun 10 (1), 295 (2019)
   PUBMED   30655611
  REMARK    GeneRIF: Study identifies WD40-repeat protein 76 (WDR76) as one of
            the HRAS binding proteins using proteomic analyses of
            hepatocellular carcinomas tissue form human patients and mouse
            diethylnitrosamine-induced liver carcinogenesis model and
            demonstrates that WDR76 functions as a tumor suppressor via RAS
            degradation.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY019145.1, AK162181.1, BC094676.1 and AK031592.1.
            
            On or before Feb 7, 2007 this sequence version replaced
            XM_001004264.1, XM_983142.1, NM_030234.1.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK162181.1, BC117822.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                BY019145.1         1-50
            51-364              AK162181.1         2-315
            365-1954            BC094676.1         1-1590
            1955-3911           AK031592.1         1881-3837
            3912-4294           BC094676.1         3551-3933
FEATURES             Location/Qualifiers
     source          1..4294
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.41 cM"
     gene            1..4294
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /note="WD repeat domain 76"
                     /db_xref="GeneID:241627"
                     /db_xref="MGI:MGI:1926186"
     exon            1..141
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            142..528
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1947
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /note="isoform a is encoded by transcript variant 1; WD
                     repeat-containing protein 76"
                     /codon_start=1
                     /product="WD repeat-containing protein 76 isoform a"
                     /protein_id="NP_084510.2"
                     /db_xref="CCDS:CCDS38218.1"
                     /db_xref="GeneID:241627"
                     /db_xref="MGI:MGI:1926186"
                     /translation="MKALSSKADSLLLKSSVDAYTESTRLGPKRTSDSATLSVDAESS
                     DEDSAPGLDDFSGLSPYERKRLRNIRENANFFASLQLAESAARLRGMIKKRESPESKR
                     KRPKKKENEIGCRRSMRLLKVDPLGVSLPASPTQPTLVEEEENPLLPPGPLEMIPENQ
                     DDSSELLKASLKTWAEMSQTSNEKTKKGLSSIKSYKANLSGMVISEATVRKVTKGAIS
                     SVALHPSEVRTLVAAGAKSGQIGLWDLTQQSEDAMYVFYAHSRYVSCLSFSPTNPAHL
                     LSLSYDGTLRCGDFSSAVFEEVYRNEGNSPSSFDFLNDSSSLLVGHWDGHLSLVDRRT
                     PGTSYEKFFNSSLEKIRTVHVHPLSRQYFVTAGLRDVHVYDARFLKSRGSQPLISLTE
                     HSKSIASAYFSPVTGNRVVTTCADCKLRVFDSSSISSQLPLLSTIRHNTVTGRWLTRF
                     QAVWDPKQEDCFIVGSMDHPRRVEVFHESGKNVHSLWGECLVSVCSLSAVHPTRYILA
                     GGNSSGKLHVFMHQET"
     exon            529..621
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            622..677
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            678..807
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            808..909
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            910..953
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1107
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            1108..1263
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1478
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1631
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1685
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..4245
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4219..4224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /note="hexamer: AATAAA"
     polyA_site      4245
                     /gene="Wdr76"
                     /gene_synonym="5830411K18Rik; 6030457D09"
                     /note="major polyA site"
ORIGIN      
        1 ggctgagcgc ggatcgctta aagggctagg gtgagatttg cgcgcctttc gagcaagttt
       61 cccgccttcg acattttcca gaactggaag gtcctcctgt ctgacagttg tttcttttgg
      121 tttttggtaa ggtccaagaa ggtgaatgaa tataaagaaa atgaacatat tgcttatact
      181 tctctgagac cgatacagat tacaacttta aggaaaacag ctaaggttta tctttacccg
      241 ttttcactca gcaattccaa gctaggccta cttaagttgt ccaaatcccc ggttgtaaat
      301 aattctagca aatcagtggt ccataagaag aaagatcgga agaagactcg tagaaaggtt
      361 ttaacttcaa aaatgaaggc cttatcttcc aaggcagatt cccttctgct gaaatcatcc
      421 gtggatgctt atactgaaag taccaggctg ggacccaaga ggacctcgga ttcagcgact
      481 ctcagtgtgg acgcggaaag cagcgacgaa gacagtgcac caggcctgga tgatttttca
      541 ggattgtcac cttatgaaag gaagagactg aggaacatca gagaaaatgc aaactttttt
      601 gcttcccttc agttagctga gtcggctgca cggctccgtg ggatgataaa gaagcgcgag
      661 tcacctgagt caaagagaaa gaggcctaag aagaaagaaa atgaaattgg atgtcgaagg
      721 tccatgcggt tgttgaaagt agaccctttg ggagtttcat taccagcatc tccaacacag
      781 ccaacattag tagaagaaga agaaaatcct ttgttacctc ctggaccctt agaaatgatt
      841 cctgaaaacc aagatgacag cagtgaactg ttgaaagcat ctttgaagac atgggcagag
      901 atgagccaga caagtaatga gaagaccaag aaggggctgt ctagtattaa aagctataaa
      961 gccaatttaa gtggcatggt catcagtgag gctactgttc gtaaggtgac caaaggagca
     1021 atctcctccg tggccctcca cccatcagaa gtgagaacct tggtagcagc tggggccaag
     1081 tctggacaaa ttggactttg ggatttgacc cagcagagtg aagatgcgat gtacgttttc
     1141 tatgctcaca gtcggtatgt tagctgcctc tccttctcac ccaccaaccc agcccatcta
     1201 ctgtccctga gctatgacgg cacactgcga tgtggtgatt tttccagcgc tgtgtttgag
     1261 gaggtgtaca ggaatgaggg aaacagcccg tcctcctttg acttcttgaa cgattcctcc
     1321 agtctgctag tgggacactg ggatggacat ttgtcactgg tagatagacg gacacctgga
     1381 acttcttatg agaagttttt taattcatct ttggaaaaaa taagaactgt tcatgtccac
     1441 ccactatcca gacagtattt tgtcacagca ggattgaggg acgttcatgt ttacgatgcc
     1501 aggttcctga agtccagggg aagccagcct ctgatttcct tgactgagca ctcgaaaagc
     1561 attgcctctg catatttctc ccccgttact ggtaacagag tggtgactac atgtgctgac
     1621 tgtaagctca gggtctttga cagcagctcc atatcttccc agcttcctct cctcagtacc
     1681 atcaggcaca acactgtcac tgggaggtgg ctaacgaggt tccaggctgt gtgggaccct
     1741 aaacaagaag attgcttcat agttggtagc atggaccacc cacgacgggt ggaagtcttc
     1801 cacgagtcgg gaaagaatgt gcattctctt tggggagaat gtcttgtatc tgtgtgttcc
     1861 ctcagtgctg tgcatcctac gcgatatatc ctggctggag gtaattccag tggcaagtta
     1921 catgttttta tgcatcaaga aacctgagtc attggatagg ttcaacaaat tgttcaactt
     1981 gttctgcagc tagggaacct agagactcag cttagtgcat ctgtttggtc acgtgttata
     2041 tttagtaaat ataacactgc tttctcagtg agacctccac acagaatgta atattagcaa
     2101 gggaggaact tgaaggccat ttctagagga tgagggagag acctggagca gaaacgggtg
     2161 ttttcatgta ctttttgatt gttttgagtt aggatcttgt gtagcacagg ctagcctcag
     2221 attctgtagc caaggatgac ctagaactga gcctcctgcc ccgacctcct gagtgctaat
     2281 gtctcaggca cgttccagta cacttggcat ctttcaacac ttttaattag gctgtatttt
     2341 gcaaaattct aacaaattat aaagctttca gtggtcatta ttaatctttt gtgacagaat
     2401 gaaactattt tgatgcaata gtaatctata gatctgtgac ttatttagct tggggtgaat
     2461 aattatttct caacactgga ctaggtcctg aaagaccatc taagactaat tatgaaacat
     2521 tattgaatcc cagagactgt cacatgctag acaagtattc tacaattgac tcatacccca
     2581 cctttgaaac ttaaatgttt gttttgcgtc attcttgaga ctggatcttg ctatgtagcc
     2641 caggttagct ttgaacttag tccttctgcc tcacttttcc aagtgctggg aatataggtg
     2701 tgtactacca tgcccagcca gaacttagtt ttataagcta agaacttttt tggggatcct
     2761 tgtatctcag ctcagtttta cttgaaatct catgatattc actggagaac agttggcttc
     2821 tttgactctg gtctgcttgg agctcgctct gtcccctgcc tctgggcagc tcctgaaatg
     2881 ggccaggaca gcactgtttg accttgcgcc attatcttgt tttctagtga ctagctgtac
     2941 agactgggct ccagatgagg ggtttgtagt ttttcacatg aaaattttgg agttttgatt
     3001 tatttaaaaa cacagaaata taagactttt tgttttaatc ccacaatata gggctgcttc
     3061 atattgtccg cggcaggtga ctgtgatttg ccccatgctg tagcaggggt gtggttgtgc
     3121 cagctgcaga cagtttctgc aaatgcgtga catttggaat tctgggaact tttcagaggt
     3181 tatataaatg ctagagcccc cagtagacgg ggtggggtgg ttgttggttg ttcaggggga
     3241 ttggctgtga tttgttagta gttgtgctca aagaagcagc aaaaggaaag aaattagatt
     3301 cagggatctc ccttccccct atttctttcc cttctatctc tatcctcctc tctctgttat
     3361 ctagtgttgg ggagagtggg gggcgggggg gggggctggg cggcgtggat aaagggtggc
     3421 aagaaaaaat ccacaaagta gtaaagacca gctacagccc taaggtggaa tttaaaataa
     3481 aaattgagtc ccagtgttgg gtaccacttc tatccagtct aattcttttt ccttttgttt
     3541 cttctttgat catgactatt aacaaacagt aaccaaccaa acccccccac ccccagcagc
     3601 caataaccgc taacaatcct tcttggggcc cccacatttg cataccctct gaaaagttcc
     3661 cagagttcca aatgacatgc aattgaagaa attatctata gctggcaaaa ccacggctct
     3721 gctagagcac aatgcaaatc atagtcagct gctgtggaca tatcccacac ctgggattag
     3781 aacaacattc ttatagttct gtgggttttt tttttttttt tttttaagaa accaaaattc
     3841 tagaattctt attctaccct agcacttgag aagtagaagc aggagaatca ggagttcaag
     3901 gccaacctca ggtaatagta aattcaaggc caatgtggct caccttccct tctccccaga
     3961 ttaatagagc acacaaagta aaattatggt agttttattt tttagagtac tttaaaataa
     4021 aacttatctt catatgcata tatgtatata cgatatatgt ttatatatat tctgctggat
     4081 catatctgcc tggtgtcaca gtgtattcaa catttttcca ttgttatttg ccaaaattac
     4141 tactgaagga tttataaata aatagcttaa gcagtatgtt tggattgtaa aaaggaatac
     4201 ttaattatat gtcagagaaa taaagtgatg tggattttcc ttaaaaaaaa aaaaaaaaaa
     4261 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaa
//
