LOCUS       NM_134139               1220 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WD repeat domain 74 (Wdr74), mRNA.
ACCESSION   NM_134139
VERSION     NM_134139.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   Geng,K., Ma,X., Jiang,Z., Gu,J., Huang,W., Wang,W., Xu,Y. and Xu,Y.
  TITLE     WDR74 facilitates TGF-beta/Smad pathway activation to promote M2
            macrophage polarization and diabetic foot ulcer wound healing in
            mice
  JOURNAL   Cell Biol Toxicol 39 (4), 1577-1591 (2023)
   PUBMED   35982296
  REMARK    GeneRIF: WDR74 facilitates TGF-beta/Smad pathway activation to
            promote M2 macrophage polarization and diabetic foot ulcer wound
            healing in mice.
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   Cui,W., Dai,X., Marcho,C., Han,Z., Zhang,K., Tremblay,K.D. and
            Mager,J.
  TITLE     Towards Functional Annotation of the Preimplantation Transcriptome:
            An RNAi Screen in Mammalian Embryos
  JOURNAL   Sci Rep 6, 37396 (2016)
   PUBMED   27869233
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1220)
  AUTHORS   Maserati,M., Walentuk,M., Dai,X., Holston,O., Adams,D. and Mager,J.
  TITLE     Wdr74 is required for blastocyst formation in the mouse
  JOURNAL   PLoS One 6 (7), e22516 (2011)
   PUBMED   21799883
  REMARK    GeneRIF: Wdr74 is required for RNA transcription, processing and/or
            stability during preimplantation development and is an essential
            gene in the mouse
REFERENCE   5  (bases 1 to 1220)
  AUTHORS   Floyd,J.A., Gold,D.A., Concepcion,D., Poon,T.H., Wang,X.,
            Keithley,E., Chen,D., Ward,E.J., Chinn,S.B., Friedman,R.A.,
            Yu,H.T., Moriwaki,K., Shiroishi,T. and Hamilton,B.A.
  TITLE     A natural allele of Nxf1 suppresses retrovirus insertional
            mutations
  JOURNAL   Nat Genet 35 (3), 221-228 (2003)
   PUBMED   14517553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC019968.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019968.1, AK077521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.44 cM"
     gene            1..1220
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /note="WD repeat domain 74"
                     /db_xref="GeneID:107071"
                     /db_xref="MGI:MGI:2147427"
     exon            1..67
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1158
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /codon_start=1
                     /product="WD repeat-containing protein 74"
                     /protein_id="NP_598900.1"
                     /db_xref="CCDS:CCDS29541.1"
                     /db_xref="GeneID:107071"
                     /db_xref="MGI:MGI:2147427"
                     /translation="MATASARWNHVWVGTETGILKGVNLQRKHAANFTPSGQPRREEA
                     VNALCWGTGGETQILVGCADRTVRYFNAEEGTFLSQRYCPGGEGTFRGLAQADGTLIT
                     CVDSGILRVWCENDKEASSDPLLELKVGPGVCRMRQDPTHTHVVATCGKENALKVWDL
                     QGSEEPVFRAKNVRNDWLDLRVPIWDQDTQFLPGSQKLVTCTGYHQVRVYDPVSPQRR
                     PVLEATYGEYPLTAMTLTPEGNSVIVGNTHGQLAEIDFRQGRLLGCLKGLAGSVRGLQ
                     CHPSKPLLASCGLDRVLRIHRIRNPRGLEHKVYLKSQLNCLLLSGRDNWEDEPQEPQE
                     PNQVPSEDTETDELWASLEAAAKRKLPDLDQTQGALQRRKKKKRPGSTSP"
     exon            68..174
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            175..296
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            297..372
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            373..519
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            520..621
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            622..722
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            723..778
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            779..924
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            925..981
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1204
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1179..1184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1204
                     /gene="Wdr74"
                     /gene_synonym="5730436H21Rik"
                     /note="major polyA site"
ORIGIN      
        1 gcgatggcga ctgcctcggc tcgctggaac catgtgtggg tcggcactga gaccggcatc
       61 ctgaaagggg tgaaccttca gcggaaacat gcggcaaatt tcacaccgtc cggacagccg
      121 cggcgggagg aggcagtgaa tgctctgtgc tggggcactg gcggcgagac ccaaatcttg
      181 gtgggctgtg cggacagaac cgtgaggtac tttaatgctg aggagggtac attcctgagc
      241 cagagatact gcccaggcgg ggaaggcacg ttccgaggtc tcgcccaggc ggatggcacc
      301 cttatcacat gtgtggattc tgggatcctc agagtctggt gtgaaaatga caaagaggcg
      361 tcctctgacc cactcttgga actgaaggtg ggtcctgggg tgtgtaggat gcgccaagat
      421 cccacacata cacatgtggt tgccacatgt gggaaagaaa atgctttgaa agtatgggac
      481 ctacaggggt ctgaggagcc tgtattcagg gccaaaaatg tgcggaatga ttggcttgat
      541 ctccgagttc ctatttggga ccaagataca cagttcctcc ctgggtcaca gaaacttgtc
      601 acatgcacag ggtaccacca ggtccgtgtc tatgatccag tctcccccca gcgccggcca
      661 gtcctagagg ccacctatgg agagtaccca ctgacagcta tgacccttac tcctgagggc
      721 aattccgtca tcgtagggaa cactcatggg cagctggcag aaattgattt tcggcaaggg
      781 cgtctactgg gctgtctgaa ggggcttgca ggtagtgttc gtgggctgca gtgtcaccct
      841 tcaaagcccc tattagcctc atgtggcttg gacagagtct tgaggataca caggatccgc
      901 aatccacgtg ggctagagca taaggtttat ctcaagtctc aactgaactg ccttctcctg
      961 tcaggccggg ataactggga ggatgagccc caagaacctc aagagcccaa ccaagtaccc
     1021 tcagaagaca cagagacaga tgaactttgg gcctctttgg aggcagctgc caagcggaag
     1081 ctcccagatt tggaccagac acaaggtgct ctccaaagaa ggaagaaaaa gaagcggcct
     1141 ggatccacca gtccttgaag ccccttgctc atgttgttaa taaatagccc aacgcgcgta
     1201 ctgaaaaaaa aaaaaaaaaa
//
