LOCUS       NM_001033500            5226 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus WD repeat domain 72 (Wdr72), transcript variant 1,
            mRNA.
ACCESSION   NM_001033500 XM_620763 XM_900559 XM_916668
VERSION     NM_001033500.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5226)
  AUTHORS   Husein,D., Alamoudi,A., Ohyama,Y., Mochida,H., Ritter,B. and
            Mochida,Y.
  TITLE     Identification of the C-terminal region in Amelogenesis Imperfecta
            causative protein WDR72 required for Golgi localization
  JOURNAL   Sci Rep 12 (1), 4640 (2022)
   PUBMED   35301423
  REMARK    GeneRIF: Identification of the C-terminal region in Amelogenesis
            Imperfecta causative protein WDR72 required for Golgi localization.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5226)
  AUTHORS   Katsura,K., Nakano,Y., Zhang,Y., Shemirani,R., Li,W. and Den
            Besten,P.
  TITLE     WDR72 regulates vesicle trafficking in ameloblasts
  JOURNAL   Sci Rep 12 (1), 2820 (2022)
   PUBMED   35181734
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5226)
  AUTHORS   Liu,X., Xu,C., Tian,Y., Sun,Y., Zhang,J., Bai,J., Pan,Z., Feng,W.,
            Xu,M., Li,C., Li,J. and Gao,Y.
  TITLE     RUNX2 contributes to TGF-beta1-induced expression of Wdr72 in
            ameloblasts during enamel mineralization
  JOURNAL   Biomed Pharmacother 118, 109235 (2019)
   PUBMED   31336344
  REMARK    GeneRIF: TGF-beta1 affects enamel mineralization by modulating
            RUNX2 and thus affecting the expression of Wdr72.
REFERENCE   4  (bases 1 to 5226)
  AUTHORS   Soulez,M., Saba-El-Leil,M.K., Turgeon,B., Mathien,S., Coulombe,P.,
            Klinger,S., Rousseau,J., Levesque,K. and Meloche,S.
  TITLE     Reevaluation of the Role of Extracellular Signal-Regulated Kinase 3
            in Perinatal Survival and Postnatal Growth Using New Genetically
            Engineered Mouse Models
  JOURNAL   Mol Cell Biol 39 (6), e00527-18 (2019)
   PUBMED   30642949
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5226)
  AUTHORS   Wang,S.K., Hu,Y., Yang,J., Smith,C.E., Nunez,S.M., Richardson,A.S.,
            Pal,S., Samann,A.C., Hu,J.C. and Simmer,J.P.
  TITLE     Critical roles for WDR72 in calcium transport and matrix protein
            removal during enamel maturation
  JOURNAL   Mol Genet Genomic Med 3 (4), 302-319 (2015)
   PUBMED   26247047
REFERENCE   6  (bases 1 to 5226)
  AUTHORS   Katsura,K.A., Horst,J.A., Chandra,D., Le,T.Q., Nakano,Y., Zhang,Y.,
            Horst,O.V., Zhu,L., Le,M.H. and DenBesten,P.K.
  TITLE     WDR72 models of structure and function: a stage-specific regulator
            of enamel mineralization
  JOURNAL   Matrix Biol 38, 48-58 (2014)
   PUBMED   25008349
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108944.4 and AC111087.9.
            
            On Aug 24, 2022 this sequence version replaced NM_001033500.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK142559.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-374               AC108944.4         86245-86618
            375-554             AC108944.4         110320-110499
            555-661             AC108944.4         115546-115652
            662-740             AC108944.4         119407-119485
            741-915             AC108944.4         120947-121121
            916-992             AC108944.4         121851-121927
            993-1112            AC108944.4         122851-122970
            1113-1294           AC108944.4         124121-124302
            1295-1391           AC108944.4         124640-124736
            1392-1533           AC108944.4         127500-127641
            1534-1782           AC108944.4         128325-128573
            1783-2003           AC108944.4         130838-131058
            2004-2199           AC108944.4         133173-133368
            2200-2402           AC108944.4         155433-155635
            2403-3217           AC108944.4         185892-186706
            3218-3309           AC108944.4         189200-189291
            3310-3389           AC108944.4         193159-193238
            3390-3585           AC108944.4         194496-194691
            3586-3690           AC111087.9         73213-73317         c
            3691-5226           AC111087.9         66050-67585         c
FEATURES             Location/Qualifiers
     source          1..5226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 41.06 cM"
     gene            1..5226
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /note="WD repeat domain 72"
                     /db_xref="GeneID:546144"
                     /db_xref="MGI:MGI:3583957"
     exon            1..374
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            375..554
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     CDS             402..3746
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 72"
                     /codon_start=1
                     /product="WD repeat-containing protein 72 isoform 1"
                     /protein_id="NP_001028672.2"
                     /db_xref="CCDS:CCDS23338.2"
                     /db_xref="GeneID:546144"
                     /db_xref="MGI:MGI:3583957"
                     /translation="MRGALQAVALWGRKAPPHSITAIMITDDQQTIVTGSQEGQLCLW
                     SLSPELKISAKELLFGHSASVTCLARARDFSKQPYVVSAAENGEMCMWNVSSGQCVEK
                     TSLPYRHTAICYYHCSFRMTGEGWLLCCGEYQDVLVLDAGTLAVLHTFTSLQSPDWMK
                     CMCIVHSVRIQEDSLLVVSITGELKVWDLSSSINSIQEKQDVHEKESKFLDSFNCQTI
                     RFCPYTERLLLVVFSKCWKIYDYCDFSLLWTEVSRDGQFFAGGEVLAAHRILVWTEDG
                     HSYIYQLLNRWAQMGATLRTFSGLSKCVCPADGGVLKGTVYPHLLCSTSVEENKSLHF
                     VMGYMNERKEPFYKVLFSGEVSGRITLWHIPDVPISKFDGSPREIPITTTWTLQDNFD
                     KHQMVSQSITDHFSGSRDEVGMTATITSSEYIPNLDKLICGCEDGTIFITKALNAAKA
                     GLLEGDSLLKDSPCHTLLRGHHQSVTSLLYPHNLASKLDQSWMVSGDRGSYVILWDIF
                     TEEILHTFFLEAGPVTRLLMSPENLKRSDGQILCCVCGDHSVALLHLEGRRCLLRARK
                     HLFPVRMIRWHPVENFLIVGCTDDSVYIWEIETGTLERHETGERARIILNCGDDAQLI
                     RSEPTLSVASETHKHKSIEQKSSNSHQPGPVPCPSVQLESSCKVADASSVPRPFNVLP
                     VKTKWSHIGFHVLLFDLENLVELLLPTPLSDVDPSGSFYGGDILRRAKSTVEKKTLTI
                     RRNKASCSSLQTEAQAKPSGDSLVLGDSTSKFSEENNGIKRQKKMKSSKKAHPKPPRK
                     VDASLTIDMAKLFLSCILPWGVDKDLDSLCTRHLSILKLQGPVSLGLASNEDLFSLML
                     PGWDACSTEMKEYSGVNLCSRKVLDLSSKYTATLLHQTGIPRGLESHCDSVQQSDAIV
                     YLLSRLFLVNKLVNMPLDLACEIDRPFKMETVHSKARFPGSDILNISSFYGHPKNGGN
                     ECRAPEADLSLLKLISCWRDQSVQVTEAIQAVLLAEVQQHMKSLRNTPVSSQPDPVAE
                     HSICERMQISAKMEWTEELELQYVGKSSPLKTSVSPVKHGNDLNSANFQDTEDILDRC
                     VLEESESAGQPRHRPWIAKVCSCRMC"
     exon            555..661
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            662..740
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            741..915
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            916..992
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1112
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1294
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1391
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1533
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1782
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..2003
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            2004..2199
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2402
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            2403..3217
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3309
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3389
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            3390..3585
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            3586..3690
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     exon            3691..5226
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4892..4897
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /note="hexamer: AATATA"
     polyA_site      4916
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /note="major polyA site"
     regulatory      5181..5186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /note="hexamer: ATTAAA"
     regulatory      5201..5206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
                     /note="hexamer: ATTAAA"
     polyA_site      5207
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
     polyA_site      5226
                     /gene="Wdr72"
                     /gene_synonym="D230040E23"
ORIGIN      
        1 gaggcctctg agcccggccc tgtcacctgt gggcttggtt cagctccggg aaggcgccca
       61 gctcctccct ctctgggagt ctgaacatcc gtgggagtgg gctgcggaca gctgcatgta
      121 gtgtccccac tttgggttct gctgggaaac tgctcccggg tgctttggga gagttctttt
      181 ttttttcccg tgaagagagt ttctcggact tttcaactag ctccctccgc agcagtagga
      241 agaacccggt ggaggtgagc tcttactggc tgtgacagct gaaggctgct cccaacacag
      301 agctgaggaa agcccctgct cccacctgta gccgagacag ccaagaagac ctgcttaacc
      361 aagaccagac tctttttctc tgtatctggt gttcatccag catgaggggt gctctgcagg
      421 ctgtggccct ctggggaaga aaagctcctc cccacagcat cacggccatc atgatcacag
      481 atgaccagca aaccatagtg actggaagtc aggagggtca gctctgcctc tggagcctct
      541 cacctgaact gaagatttca gctaaagaac ttctttttgg tcattcggct tcggtgacat
      601 gtttggcaag agcgagagac ttctccaaac agccttacgt tgtgagtgct gctgagaatg
      661 gggagatgtg tatgtggaat gtgagcagcg gccagtgtgt ggagaagacc agccttcctt
      721 acaggcacac agccatctgt tactaccact gctccttccg gatgactgga gagggctggc
      781 tgctgtgctg tggggaatat caagatgttc tcgtccttga tgctggaact ctggctgtcc
      841 tgcatacctt cacctcttta cagtcgcccg actggatgaa atgcatgtgc atcgttcact
      901 ccgtgagaat tcaagaagat tctctcttgg ttgtgtccat aaccggcgaa ctcaaagtat
      961 gggacctctc ctcgtccatc aacagcattc aggaaaagca agatgtccat gaaaaagaat
     1021 ccaagtttct tgactccttc aactgtcaga ccatacggtt ttgtccgtac acggagagac
     1081 tcctgttggt ggtgttttct aagtgttgga agatttatga ctattgtgac ttttcccttc
     1141 tgtggactga agttagtaga gatggacaat tctttgctgg tggagaggtg cttgctgccc
     1201 acaggatcct tgtttggaca gaagatggtc acagttatat ctatcagctg ctgaacaggt
     1261 gggctcagat gggagcgacg ctcagaacat tcagtgggct ttccaaatgc gtgtgccctg
     1321 ccgacggagg tgtcctgaag gggactgtct accctcactt actctgctcc acttctgtgg
     1381 aggaaaataa gagcctgcat ttcgtcatgg gctacatgaa tgaacggaaa gagccatttt
     1441 acaaggtgct tttctcagga gaagtctcgg ggagaataac gttgtggcat atcccagatg
     1501 tccccatatc taagtttgac ggttccccta gagaaatacc aataactacc acctggactc
     1561 ttcaggataa cttcgataag catcaaatgg tgtcacagag catcacagac catttctctg
     1621 ggtccagaga tgaggtggga atgacagcta ccatcacctc atcagagtac attccaaatc
     1681 ttgataaact catctgtggc tgtgaggatg ggaccatttt catcactaag gcattgaatg
     1741 ctgccaaagc tggacttcta gaaggggatt ctttattgaa agattctccg tgccacaccc
     1801 ttctcagagg ccatcaccag agtgtgactt cattacttta ccctcacaat cttgcttcaa
     1861 agttagacca aagttggatg gtgtctgggg atcgaggctc ctatgtgatc ctctgggata
     1921 tttttactga ggaaattctg cacacgttct ttttggaagc tggtccagta acaagactat
     1981 tgatgtcacc agagaactta aagcgaagtg atggtcagat cctctgctgt gtgtgtggtg
     2041 accattccgt ggctctcctt cacctggaag ggagacggtg cctcttgcgt gcccggaagc
     2101 accttttccc tgtgaggatg atcagatggc atccagtcga gaactttctc attgttggtt
     2161 gtacagatga ctcggtctac atctgggaaa ttgaaacagg cactttggaa aggcatgaga
     2221 caggagaaag agcaaggatt attctcaact gtggtgacga tgctcagctc attagatctg
     2281 agcctacact gtcagtggcc tctgagacac ataagcacaa aagtatagag cagaagtcat
     2341 ccaactccca ccagcctggg ccagtaccct gccccagtgt gcagctggag tcttcatgta
     2401 aggttgctga tgcttcatcg gtcccaagac ctttcaatgt cctgcctgtg aaaacaaaat
     2461 ggagtcacat tggtttccat gttctcctgt ttgatctgga aaatcttgtt gaactactgc
     2521 tgcccactcc cctaagtgat gttgaccctt ctggctcatt ctatggaggt gacatcttga
     2581 ggagagccaa gagcacagta gagaagaaga ccctgacaat aagaagaaac aaagcatcgt
     2641 gtagctctct ccagacagag gcacaggcca agcccagtgg ggacagcctg gtccttgggg
     2701 acagcaccag taagttctca gaggagaaca atggtattaa aagacagaag aaaatgaaga
     2761 gctccaaaaa ggcgcatcct aagccaccca ggaaggtgga tgccagcctc acaatagaca
     2821 tggcgaaatt gtttctgtct tgtattttgc catggggagt ggataaagat ttggacagcc
     2881 tctgcaccag gcatctcagt atcttaaagc tgcagggccc cgtgtctttg ggacttgcct
     2941 cgaatgaaga cctcttctcc ctgatgctgc ctgggtggga tgcatgcagt actgaaatga
     3001 aggagtattc aggggtaaat ctgtgctcca gaaaagtttt ggacttgtca agtaaataca
     3061 cagccactct tctgcaccag actggaattc cccgaggcct ggaaagtcac tgtgactctg
     3121 tgcagcaatc agatgctatt gtgtatttac tgagcagact ctttttagtt aataagttag
     3181 ttaacatgcc tttggatctg gcctgtgaaa tcgacagacc cttcaaaatg gagactgtac
     3241 acagcaaggc aagattccct ggaagtgaca tcttgaatat atcaagcttc tatggtcacc
     3301 caaaaaatgg tggaaatgag tgtcgcgcac ctgaggctga cctctcactt ttgaagctaa
     3361 tctcgtgctg gagagatcag tctgtccagg taactgaagc aatacaagct gtcctcttgg
     3421 ctgaagttca acagcatatg aagagtctga gaaatacacc agtcagtagt caaccagatc
     3481 cagtggcaga gcatagcatc tgtgagagga tgcagatctc agccaagatg gagtggactg
     3541 aagaattaga gctgcaatat gtggggaagt cttcacctct gaaaacttca gtcagtccgg
     3601 tcaagcatgg caacgacttg aactcggcaa acttccaaga tacagaggac attcttgaca
     3661 gatgtgtctt ggaagagtcg gagagtgcag gtcagccaag gcatcgtcca tggatagcga
     3721 aggtgtgctc ctgcaggatg tgctagatag atggagtccc gaaaaaggaa ttcaatctga
     3781 actaacagag aagcacagca cacactatct ctttaccatc aaataaaagc aacattgtca
     3841 ttggtctgta gcagattcgc taatatgtca gccaaagtct attaaaaatg ttaccactga
     3901 ttgaggatat ccaagtccta attcaaggca atgattgcct aagcgagtct ccttcctcct
     3961 ccttattttc tgtcaatatt tgcaacaaag aacgccagcc cacaggcata gatttaacac
     4021 catttcagat gttcatcttc tcagctcctg aactgcaaga gccaaaggaa ttcacaggac
     4081 tctcaattca ctgttgcttc aaggtattta acccaaaacg ttaccgactt tgccatgttg
     4141 agttaggaca tattgtttta gtgggtgctt caattcagac caggtcctgc acgtctcatc
     4201 cttaaacatg aaatgtcctt tagtcaatct ttgacacagt agctagcctt gtgagatcca
     4261 atcagcatgg agctctaatg acacaatgga gaatgtcttt aattaaatct tattagcctc
     4321 atagacctgg gggaggggat cctacttgca acacagcagg gctcatcctt tgttagaata
     4381 aacatctgca gttcttttcc cagaaagaag ctggactact gggaattcta aactaaaata
     4441 tgcaaagcag tatcaacaga aatggatgga aagtgctcac ctgttaaagg gatctgaatt
     4501 ttgtgttgtg atttttttat tgactgtcta acttataaaa aaaatcatga aagattttta
     4561 aagtatattt aaatgaatag aaatatgccc taactcatag aaagatggaa ttaaagatat
     4621 atgatatata catgtatgta cacatatgta tgtgtgtgtg tagttcatat aatttcataa
     4681 aattttaatt ctaattttct aagcaacagc ctgagatcct tgttgaaatg cggcagtcag
     4741 ggggaaagag agcttcaaaa tgagaaatac atctttaagc tgacttgccc tgtaagcttt
     4801 gggacttgca attaattatt gagctggatg aatgtgaata tggatctaat gatgaatatc
     4861 aaaaaactgt aatgccttca aagtagatga aaatatatct ttcatgtttc ccaaaatagc
     4921 atgtctctgc atgaagtcaa ttttgatttg tacttaaact gtaatatgtt gttaatagta
     4981 atacccatgg aaaccattat cttctgaaca ttttacctgt ttggatatgg ctatgagtca
     5041 tttgaagcaa gttacaaaca agtcaggcag gggatagatt ctgtctttca aggccatcac
     5101 aagcattttg ggtgatgaag tattaaatca gtgcatgttt tctaacaagg aaagttttaa
     5161 tagttaaatc ccaagtacat attaaaagtc tggtatgttt attaaaagta agttttatta
     5221 ttttca
//
