LOCUS       NM_001081402            2151 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WD repeat domain 70 (Wdr70), transcript variant 1,
            mRNA.
ACCESSION   NM_001081402 XM_978582
VERSION     NM_001081402.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2151)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2151)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC107747.8, AK159714.1, AC123611.7 and AC130656.11.
            
            On Feb 6, 2007 this sequence version replaced XM_978582.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159714.1, AK160933.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC107747.8         53666-53683         c
            19-940              AK159714.1         1-922
            941-941             AC123611.7         61732-61732
            942-2144            AK159714.1         924-2126
            2145-2151           AC130656.11        136016-136022       c
FEATURES             Location/Qualifiers
     source          1..2151
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.82 cM"
     gene            1..2151
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /note="WD repeat domain 70"
                     /db_xref="GeneID:545085"
                     /db_xref="MGI:MGI:1921020"
     exon            1..91
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..2040
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 70"
                     /codon_start=1
                     /product="WD repeat-containing protein 70 isoform 1"
                     /protein_id="NP_001074871.1"
                     /db_xref="CCDS:CCDS37033.1"
                     /db_xref="GeneID:545085"
                     /db_xref="MGI:MGI:1921020"
                     /translation="MEHSGTSEVTGADTAGPDPQLAVTMGFTGFGKKARTFDLEAMFE
                     QTRRTAVERSRKTLEAREKEEEMNREKELRKQIEDMEPAPSSSSAARERSQSSCRDTS
                     SSDSESDDSSDSSDDELIGPPLPPKMVGESVTTVDEGTLGPLPPPLCEEGEDDDDDEL
                     DDEGEEDNPVQRIPDSHEITLRHGTKTVSALGLDPSGARLVTGGYDYDVKFWDFAGMD
                     ASFKAFRSLQPCECHQIKSLQYSNTGDMILVVSGSSQAKVIDRDGFEVMECIKGDQYI
                     VDMANTKGHTAMLHTGSWHPKIKGEFMTCSNDATVRLWEVENPKKQKSVFKPRTMQGK
                     KVIPTTCTYSRDGNLVAAACQNGSIQIWDRNLTVHPKFHYKQAHDPGTDTSCVAFSYD
                     GNVLASRGGDDTLKLWDVRQFNKPLFSASDLPTLFPMTDCCFSPDDKLIVTGTSVQRG
                     CGSGKLVFLERRTFQRVYEIHITDASVVRCLWHPKLNQIMVGTGNGLAKVYYDPNKSQ
                     RGAKLCVVKTQRKAKQAETLTQDYIITPHALPMFREPRQRSTRKQLEKDRLDPLKSHK
                     PEPPVAGPGRGGRVGTHGGTLSSYIVKNIALDKTDDSNPREAILRHAKAAEDNPYWVS
                     PAYSKTQPKTMFAQVESDDEESKNEPEWKKRKI"
     exon            92..157
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            158..241
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            242..362
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            363..567
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            568..627
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            628..761
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            762..915
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            916..992
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1167
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1267
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..1352
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1491
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1592
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1672
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1789
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..1952
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1953..2151
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2126..2131
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2149
                     /gene="Wdr70"
                     /gene_synonym="4833422F06Rik"
                     /note="major polyA site"
ORIGIN      
        1 acttccgtcg ggcttgccgg gagtcgcgcg ctgctgcatc cacggaggcg gtgggctcgg
       61 gcagtcatgg agcactcggg aaccagcgaa gtgacaggcg cagacacggc gggacccgac
      121 cctcagctgg cggtcaccat gggcttcaca ggattcggga agaaagctcg cacatttgac
      181 ttggaggcca tgttcgagca aactcgaagg acagcggtgg aaagaagccg gaaaacactg
      241 gaagcaagag aaaaagagga agaaatgaac agagaaaaag aattaagaaa acaaattgaa
      301 gatatggagc cagcaccgtc aagctcgagt gcagccagag agcgctcaca gtcatcatgc
      361 agggacacaa gcagcagtga cagtgagagt gacgacagtt ctgattcatc tgacgatgag
      421 ctaatcggcc ctcctttacc ccctaaaatg gtaggagaat ccgtaactac tgtggacgaa
      481 ggcacccttg gccctttacc tccacctctg tgtgaagaag gagaagatga tgatgatgac
      541 gagttagacg atgaaggaga agaggataac cctgtccaga ggattcctga ctcgcatgag
      601 ataacactga ggcatggcac taaaacagtt tctgctctgg gtctggaccc ctcaggtgcc
      661 cgtttggtca ctggaggata tgattacgat gttaaatttt gggattttgc tggaatggat
      721 gcttctttca aggcatttcg atcccttcaa ccttgtgaat gccatcagat caagtcgtta
      781 cagtacagta acacaggaga catgattctt gttgtttctg gaagctcaca ggccaaggtt
      841 attgacagag atggttttga agtcatggag tgtataaagg gagaccagta tatcgtagac
      901 atggccaaca ccaagggcca cacagcaatg cttcatactg gctcatggca tcccaaaata
      961 aaaggagaat ttatgacttg ctcaaatgat gctactgtga ggctctggga agttgaaaat
     1021 ccaaagaagc aaaaaagtgt ttttaaacct cggacaatgc agggtaaaaa ggtcattccc
     1081 acgacgtgca cgtacagcag agacgggaac cttgtggccg ctgcctgcca gaacggaagc
     1141 attcagatct gggaccggaa cctgacagtt caccctaaat tccactacaa gcaggctcac
     1201 gaccctggca cagacacgtc ttgtgtggct ttttcctatg atggtaatgt ccttgcctct
     1261 cgtggaggcg atgatacatt aaaattatgg gatgtccggc aatttaataa gccattattt
     1321 tcagcctcag accttcctac cttgttccca atgaccgact gctgcttcag ccctgacgac
     1381 aaactcatag ttaccggtac ctctgtccaa agggggtgtg gcagtggcaa acttgtcttc
     1441 ttggagcgca ggactttcca aagggtctat gaaatccaca tcacagatgc gagtgtggtc
     1501 cgctgcctgt ggcatccaaa gctgaaccag atcatggttg gaactggaaa tggactggca
     1561 aaagtgtact acgaccccaa caagagtcag aggggagcaa aactatgtgt ggttaaaacc
     1621 cagaggaagg caaaacaagc tgagacacta acccaggact acatcatcac ccctcatgcc
     1681 ttgcccatgt tccgtgagcc ccgccagcga agtacgagga aacagctgga gaaggacaga
     1741 ctggaccccc tgaagtccca caaaccagag cctcctgtag caggcccagg tcgtggtggc
     1801 cgagttggaa cccacggggg caccctgtcc tcctacattg tgaagaacat cgctttggac
     1861 aagaccgacg acagcaatcc ccgggaagcc attttgcgcc atgccaaagc agcagaagat
     1921 aacccatatt gggtttcgcc agcatattcc aaaactcagc caaaaaccat gtttgcccaa
     1981 gtggagtctg atgatgaaga gtcaaagaat gaaccagaat ggaaaaaacg taaaatttga
     2041 agaatctcgt tgaagagcta tttgcatgga gcaacaggat aggatacagt gttttttttt
     2101 tcaaccccct ccccaatgct tatgaaataa aaatacattt ttacaaacag a
//
