LOCUS       NM_031392               4087 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WD repeat domain 6 (Wdr6), mRNA.
ACCESSION   NM_031392
VERSION     NM_031392.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4087)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4087)
  AUTHORS   Yao,Z., Gong,Y., Chen,W., Shao,S., Song,Y., Guo,H., Li,Q., Liu,S.,
            Wang,X., Zhang,Z., Wang,Q., Xu,Y., Wu,Y., Wan,Q., Zhao,X., Xuan,Q.,
            Wang,D., Lin,X., Xu,J., Liu,J., Proud,C.G., Wang,X., Yang,R.,
            Fu,L., Niu,S., Kong,J., Gao,L., Bo,T. and Zhao,J.
  TITLE     Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin
            resistance in mice
  JOURNAL   Nat Metab 5 (10), 1706-1725 (2023)
   PUBMED   37735236
REFERENCE   3  (bases 1 to 4087)
  AUTHORS   Zhang,H., Chen,G., Feng,X., Song,H., Meng,L., Fu,Y., Yang,J.,
            Fan,Z., Ding,Y., Du,Z., Wang,J., Yang,L., Zhang,J., Sun,L., Liu,Z.,
            Zhang,Z., Li,Q. and Fan,X.
  TITLE     Targeting WDxR motif reprograms immune microenvironment and
            inhibits hepatocellular carcinoma progression
  JOURNAL   EMBO Mol Med 15 (5), e15924 (2023)
   PUBMED   36947051
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT571271.12 and CT010508.10.
            
            On Jan 25, 2023 this sequence version replaced NM_031392.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054367.1, AK165935.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               CT571271.12        6710-6879           c
            171-2652            CT571271.12        2317-4798           c
            2653-2748           CT571271.12        2121-2216           c
            2749-2774           CT571271.12        2001-2026           c
            2775-2865           CT010508.10        223457-223547       c
            2866-2984           CT010508.10        223252-223370       c
            2985-4087           CT010508.10        222074-223176       c
FEATURES             Location/Qualifiers
     source          1..4087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.51 cM"
     gene            1..4087
                     /gene="Wdr6"
                     /note="WD repeat domain 6"
                     /db_xref="GeneID:83669"
                     /db_xref="MGI:MGI:1930140"
     exon            1..170
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     CDS             71..3448
                     /gene="Wdr6"
                     /note="WD repeat-containing protein 6"
                     /codon_start=1
                     /product="tRNA (34-2'-O)-methyltransferase regulator WDR6"
                     /protein_id="NP_113569.1"
                     /db_xref="CCDS:CCDS23532.2"
                     /db_xref="GeneID:83669"
                     /db_xref="MGI:MGI:1930140"
                     /translation="MDAFGDYVWPRATSELILLPVTGLECVGDRLLAGEGPDLLVYNL
                     DLGGHLRMVKRVQNLLGHFLIHGFRVRPEPKGDLDSEAMIAVFGSKGLKVVKVSWGQS
                     HLRELWRSGLWNMSDWIWDVRWIEGNVAVALGHNSVVLYDPVIGCMLQDVPCTDRCTL
                     SSACLVGDTWKELTIVAGAVSNELLIWYPATALTDNKPVAPDRRVSGHVGVIFSMSYL
                     ESKGLLATASEDRSVRLWKVGDLRVPGGRVQNIGHCFGHSARVWQVKLLENYLISAGE
                     DCVCLVWSHEGEILQAFRGHRGRGIRAIATHERQAWVVTGGDDSGIRLWHLAGRGYPG
                     LGVSSLSFKSPSRPGALKAVTLAGSWRVLAVTDVGSLYLYDLEVKSWEQLLEDNRFRS
                     YCLLEAAPGPEGFGLCALANGEGLVKVVPINTPTAAVEQKLFQGKVHSLSWALRGYEE
                     LLLLASGPGGVIACLEISAAPTGKAIFVKERCRYLLPPSKQRWHTCSAFLPPGDFLVC
                     GDRRGSVMLFPVRPCLFKKPGAGSKAITAAEAPGAGSGSGGSESVPTGIGPVSTLHSL
                     HGKQGVTSVTCHGGYLYSTGRDSSYFQLFVHGGHLQPVLRQKACRGMNWVAGLRMVPD
                     GSMVILGFHANEFVVWSPRSHEKLHIVNCGGGHRSWAFSDTEAAMAFTYLKDGEVMLY
                     RALGGCIRPNVILREGLHGREITCVKRVGTVTLGPEFEVPNLEHPDSLEPGSEGPGLI
                     DIVITGSEDTTVCVLALPTTTGSAHALTSVCNHISSVRALAVWAVGTPGGPQDTRPGL
                     TAQVVSAGGRAEIHCFSVMVTPDASTPSRLACHVMHLSSHRLDEYWDRQRNKHKMIKV
                     DPETRYMSLAICELDNDRPGLGPGPLVAAACSDGAVRLFLLQDSGRILHLLAESFHHK
                     RCVLKVHSFTHEAPNQRRRLILCSAATDGSLAFWDLTTAMDKGSTTLELPAHPGLPYQ
                     MGTPSMTVQAHSCGVNSLHTLPTPEGHHLVASGSEDGSLHVFTLAVKMPEPEEADGEA
                     ELVPQLCVLEEYSVPCAHAAHVTGVKILSPKLMVSASIDQRLTFWRLGQGEPTFMNST
                     VYHVPDVADMDCWPVSPEFGHRCALAGQGLEVYNWYD"
     exon            171..2652
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2653..2748
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2749..2865
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2984
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     exon            2985..4087
                     /gene="Wdr6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4063..4068
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr6"
                     /note="hexamer: AATAAA"
     polyA_site      4087
                     /gene="Wdr6"
                     /note="major polyA site"
ORIGIN      
        1 agacggctgg ttctcgcgag aacgcagctc tcttcttgtc cgtggcagcc acagcagctc
       61 caggaacgtc atggacgctt tcggggacta tgtctggccg cgggcgactt ccgagctcat
      121 actcctcccg gttacgggtc tggagtgtgt tggggacagg ctgctggcgg gcgaggggcc
      181 tgatttactg gtgtacaact tggaccttgg tgggcatctc cgaatggtga agagagtcca
      241 gaacctgctt ggtcactttc tcatccatgg gttccgagtg cgaccagagc ctaaaggaga
      301 cctggactct gaggccatga tagctgtgtt tgggagcaag ggcctcaaag ttgtgaaagt
      361 cagctggggt caaagccatc ttcgggagct ctggcgctct ggcctgtgga acatgtccga
      421 ctggatctgg gatgtccgct ggatcgaggg taacgtagcc gtggccttgg gccacaactc
      481 ggtggtactg tatgacccag tgatagggtg catgctgcag gacgtcccct gcacagacag
      541 gtgtaccctg tcctcagcct gcctggttgg tgacacctgg aaggaactga ccatcgtggc
      601 tggcgcggtt tccaatgagc tcctgatctg gtacccagcc actgctttaa cagacaacaa
      661 acccgtggcc cctgaccggc gggttagtgg ccatgtgggt gtcatcttta gcatgtcata
      721 cctggaaagc aagggcctgc tggcaactgc ttcagaagac cgaagtgttc gtctctggaa
      781 ggtgggggac ctccgggtgc ctgggggtcg ggttcagaat attggccact gctttgggca
      841 cagtgcccga gtgtggcagg tgaagctctt agagaactat ctcatcagtg caggagaaga
      901 ctgtgtctgc ttggtgtgga gccacgaagg cgagatcctt caagcctttc ggggccaccg
      961 gggccgaggt atccgggcca tagccactca cgagaggcag gcctgggtgg tcactggggg
     1021 agacgactca ggcattcgac tctggcacct ggcaggccga gggtacccag gcttgggcgt
     1081 ctcatccctg tccttcaaat ctcctagccg gccaggtgcc ctcaaggctg tgactctggc
     1141 tggttcctgg cgagtcctgg cagtgactga tgtggggtcc ctgtacctct acgaccttga
     1201 ggtcaagtcc tgggagcagc tgctggagga caatcgcttt cggtcttact gcctgctaga
     1261 ggcagctcct gggcccgagg gctttggact ctgtgccttg gccaacgggg agggtcttgt
     1321 taaggtggtt cccatcaaca cccccaccgc tgccgtcgag cagaaactgt tccaggggaa
     1381 ggtgcacagc ctgagctggg cccttcgtgg ttacgaggag ctgcttttgt tagcatcggg
     1441 ccctggtggg gtgatagctt gtttggagat ctcagctgca cccactggca aggctatctt
     1501 tgtcaaggaa cgttgccggt acctccttcc cccaagcaag caacgatggc acacatgtag
     1561 tgctttcctg cccccgggtg acttcctcgt ctgtggggac cgccgtggct ctgtgatgct
     1621 attccctgtc agaccatgtc tattcaaaaa gcctggggcc ggaagcaagg ctattactgc
     1681 agctgaggca cctggagctg gtagtgggag cggtgggtct gagagtgtcc caacaggaat
     1741 aggccccgtc tctacactcc attctctgca tgggaaacag ggtgtgacct cagttacctg
     1801 ccatggtggc tacctataca gcacagggcg ggatagctcc tacttccagc tctttgtaca
     1861 tggcggccac ctccagccgg tcctaaggca gaaagcctgt cgaggcatga actgggtagc
     1921 tgggcttcgg atggtgcctg atggaagtat ggtcatcttg ggtttccatg ccaacgagtt
     1981 tgtagtgtgg agcccccggt cccatgagaa gctgcatatc gtcaactgtg ggggagggca
     2041 ccgctcctgg gccttttctg atactgaggc agccatggcc tttacctacc tgaaggatgg
     2101 tgaggtcatg ctctatcggg ctctaggtgg ctgcatccgg cccaatgtga ttctccggga
     2161 gggtctgcat ggccgtgaaa tcacatgtgt aaagcgtgtg ggcacagtga ccctgggccc
     2221 tgaatttgag gtacccaact tggagcatcc tgactccctg gagcctggca gtgaggggcc
     2281 tggtctgatt gacatagtga taacaggcag tgaggacact actgtctgtg tcctagcact
     2341 tcccaccacc acaggctcag cccacgccct cacttctgtc tgtaaccata tctcctctgt
     2401 gcgagccctg gcagtgtggg ctgttggcac cccaggtggc ccacaggata ctcgaccagg
     2461 gctcactgct caggtagtgt ctgcaggggg ccgagcggag attcactgct tcagcgtcat
     2521 ggtcactccg gacgctagca cccccagccg ccttgcctgt catgtcatgc acctttcatc
     2581 ccaccggctg gatgagtact gggaccggca gcggaacaag cacaagatga tcaaggtgga
     2641 ccctgagacc aggtacatgt ctcttgctat ttgtgagctt gacaacgata ggcctggcct
     2701 cggccctggc ccccttgtgg ctgcagcctg tagtgatgga gcagtgaggc tctttctcct
     2761 gcaggactct gggcgaattc tgcatctcct agctgagtct ttccaccaca agcggtgtgt
     2821 cctcaaagtc cactccttca cacatgaggc acctaaccag cgtcggaggc tgatcctgtg
     2881 cagtgcagct acagatggca gcctagcctt ctgggatctc accacggcaa tggacaaagg
     2941 ctctactacc ctggagcttc cagcacaccc tgggcttccc taccagatgg gcaccccctc
     3001 catgaccgtg caagcccata gctgtggcgt caatagcctg cacactttgc ctacacctga
     3061 gggccaccac cttgtggcca gtggcagtga ggatgggtcc ctgcatgtct tcacacttgc
     3121 tgtgaagatg ccagagccgg aagaagctga tggggaggct gagctggtgc cccagttatg
     3181 tgtcctagag gaatattccg tcccctgcgc acatgctgcc catgtgacag gcgtcaagat
     3241 cctaagtccc aagctcatgg tctcagcctc catagaccag cggctgacct tctggcgtct
     3301 gggacagggt gagcccacct tcatgaatag cactgtgtac catgtgccag atgtggccga
     3361 catggactgc tggcctgtga gccctgagtt tggccaccgc tgtgctctgg caggtcaggg
     3421 acttgaggtt tacaactggt atgactgagt tatcccagtg ggtggagaac tgagcacagg
     3481 gcctgactgc agacagtaga gcagggatca gctgtctgtg tcacgctcag tgtgctctgg
     3541 ggaggcgagg cagtaccata gttctcgcaa gtattccagt agggtgttgc ataggaggac
     3601 caagaacacg cctcactctc acaataggat gaaactgtat ttattctgac tttaagtgcc
     3661 caacatctgt gaggtcttgt ttctttccca gttgatgctt ttataaacat tcccagttat
     3721 tgggccctta gatgtggctc agcggaggga ggcccagcat agccaagcct gtgtggaaca
     3781 cctcacgcac tgccctcaaa agctgtaggc gagcaaacat ctgaccaaag aggtgtggcc
     3841 gaggttcctg aaagaaaagc agccaggcgc atcctcattt cccgtgtgct cagccttgcc
     3901 cacatttccc gcagaccccc cttgctgtat gctcacccct agaatatgta ctcggttata
     3961 gtaggagctg aaatccatgc tgagctgcac caggaacttg catacctaga gacagacgtt
     4021 gagtcgttga gctgttgtct tttttcttgt gttacaaccc agaataaaga ataatgtgtg
     4081 aaatgtc
//
