LOCUS       NM_001170743            5155 bp    mRNA    linear   ROD 13-FEB-2025
DEFINITION  Mus musculus WD repeat domain 59 (Wdr59), transcript variant 1,
            mRNA.
ACCESSION   NM_001170743
VERSION     NM_001170743.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5155)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5155)
  AUTHORS   Watanabe,K., Nakayama,K., Ohta,S., Matsumoto,A., Tsuda,H. and
            Iwamoto,S.
  TITLE     ILDR2 stabilization is regulated by its interaction with GRP78
  JOURNAL   Sci Rep 11 (1), 8414 (2021)
   PUBMED   33863978
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5155)
  AUTHORS   Kowalsky,A.H., Namkoong,S., Mettetal,E., Park,H.W., Kazyken,D.,
            Fingar,D.C. and Lee,J.H.
  TITLE     The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase
            activation
  JOURNAL   J Biol Chem 295 (7), 1769-1780 (2020)
   PUBMED   31915252
REFERENCE   4  (bases 1 to 5155)
  AUTHORS   Peng,M., Yin,N. and Li,M.O.
  TITLE     SZT2 dictates GATOR control of mTORC1 signalling
  JOURNAL   Nature 543 (7645), 433-437 (2017)
   PUBMED   28199315
  REMARK    Erratum:[Nature. 2018 Jun;558(7710):E2. doi:
            10.1038/s41586-018-0114-2.. PMID: 29769712]
REFERENCE   5  (bases 1 to 5155)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 5155)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 5155)
  AUTHORS   Higa,L.A., Wu,M., Ye,T., Kobayashi,R., Sun,H. and Zhang,H.
  TITLE     CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat
            proteins and regulates histone methylation
  JOURNAL   Nat Cell Biol 8 (11), 1277-1283 (2006)
   PUBMED   17041588
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127356.4 and AC124985.16.
            
            On Mar 22, 2022 this sequence version replaced NM_001170743.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK173301.1, SRR17784651.224351.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-164               AC127356.4         132494-132657
            165-214             AC127356.4         148644-148693
            215-350             AC127356.4         150115-150250
            351-436             AC127356.4         152018-152103
            437-517             AC124985.16        170785-170865       c
            518-555             AC124985.16        168320-168357       c
            556-644             AC124985.16        166555-166643       c
            645-761             AC124985.16        163996-164112       c
            762-839             AC124985.16        162443-162520       c
            840-996             AC124985.16        160040-160196       c
            997-1076            AC124985.16        156664-156743       c
            1077-1209           AC124985.16        155086-155218       c
            1210-1334           AC124985.16        154838-154962       c
            1335-1499           AC124985.16        151608-151772       c
            1500-1595           AC124985.16        150504-150599       c
            1596-1752           AC124985.16        150191-150347       c
            1753-1822           AC124985.16        149056-149125       c
            1823-1976           AC124985.16        145792-145945       c
            1977-2033           AC124985.16        142378-142434       c
            2034-2167           AC124985.16        136537-136670       c
            2168-2249           AC124985.16        135537-135618       c
            2250-2362           AC124985.16        131904-132016       c
            2363-2513           AC124985.16        130510-130660       c
            2514-2586           AC124985.16        130331-130403       c
            2587-2713           AC124985.16        128671-128797       c
            2714-2856           AC124985.16        128359-128501       c
            2857-5155           AC124985.16        118529-120827       c
FEATURES             Location/Qualifiers
     source          1..5155
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     gene            1..5155
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /note="WD repeat domain 59"
                     /db_xref="GeneID:319481"
                     /db_xref="MGI:MGI:2442115"
     exon            1..164
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..3092
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 59; CUL4- and DDB1-associated
                     WDR protein 12; GATOR complex protein WDR59; GATOR2
                     complex protein WDR59"
                     /codon_start=1
                     /product="GATOR2 complex protein WDR59 isoform 1"
                     /protein_id="NP_001164214.1"
                     /db_xref="CCDS:CCDS52672.1"
                     /db_xref="GeneID:319481"
                     /db_xref="MGI:MGI:2442115"
                     /translation="MAARWSSENVVVEFRDSQATAMSVDCLGQHAVLSGRRFLYIVNL
                     DAPFEGHRKISRQSKWDIGAVQWNPHDSFAHYFAASSNQRVDLYKWKDGSGEVGTTLQ
                     GHTRVISDLDWAVFEPDLLVTSSVDTYIYIWDIKDTRKPTVALSAVAGASQVKWNKKN
                     ANYLATSHDGDVRIWDKRKPSTAVEYLAAHLSKIHGLDWHPDSEHIFATSSQDNSVKF
                     WDYRQPRKYLNILPCQVPVWKARYTPFSNGLVTVMVPQLRRENSLLLWNASDLNAPVH
                     TFVGHDDVVLEFQWRRQKEGSKDYQLVTWSRDQTLRMWRVDYQMQRLCANDILDGVDE
                     FIESISLLPEPEKTPHPQDIDHQPSLSHGEEDAIKEDPPSSLLEEKRSDQLGLPQTLQ
                     QEFSLINVQIRNVNVEMDAADRSCTVSVHCSNHRVKMLVTFPAQYPNNAAPSFQFINP
                     TTITSAVKAKLLKILKDTSLQKVKRNQSCLEPCLRQLVSCLESFVNQEDSASSNPFAL
                     QNSVTPPLPTFARVTTAYGSYQDANIPFPRTSGARFCGAGYLVYFTRPMTMHRAVSPT
                     EPTPRSLSALSAYHTGLIAPMKIRTEAPGNLRLYSGSPTRSEKEQVSISSFYYKERMS
                     PRSARRRWSIQAINDFPKSRRWKSKREGSDSGNRPIKAAGKVIIQDVSCLLPVHKSLG
                     ELYILNVNDTQETCQKNATSAMLVGRKDLVQVWSLATVATDLCLGPKSDPDLETPWAR
                     HPFGRQLLESLLAHYCQLRDVQTLAMLCSVFEAQSRPQGLPNPFGPFPNRSSNLVVSH
                     SRYPSFTSSGSCSSMSDPGFNTGGWNIAGRETEHISSPWGESSPEELRFGSLTYSDPR
                     ERERDQHDKNKRLLDPANTQQFDDFKKCYGEILYRWGLREKRAEVLKFVSCPPDPHKG
                     IEFGVYCSHCRSEVRGTQCAICKGFTFQCAICHVAVRGSSNFCLTCGHGGHTSHMMEW
                     FRTQEVCPTGCGCHCLLESTF"
     exon            165..214
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            215..350
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            351..436
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            437..517
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            518..555
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            556..644
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            645..761
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            762..839
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            840..996
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1076
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1209
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1334
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1499
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1595
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            1596..1752
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1822
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1976
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2033
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2167
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2249
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2362
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            2363..2513
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            2514..2586
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2713
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            2714..2856
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     exon            2857..5155
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5124..5129
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /note="hexamer: AATAAT"
     polyA_site      5155
                     /gene="Wdr59"
                     /gene_synonym="5430401O09Rik; Cdw12"
                     /note="major polyA site"
ORIGIN      
        1 ggatttatta gcaggctgtg tggggcttac tcacgcgggg agtctcggac ttgggggtgg
       61 ggttgggggt ggagggtcgc ctgctggcac cccacgatcg ggctagtgag atggcggcgc
      121 gctggagcag cgagaacgtg gtggtggagt ttcgagactc tcaggcaact gccatgtctg
      181 tggactgtct tgggcagcat gcagtgcttt ctggccgacg attcctgtac atcgtcaatc
      241 tagatgcccc ttttgaaggt caccggaaga tctcccgcca gagcaaatgg gacattggag
      301 ctgtgcagtg gaaccctcat gacagcttcg cacactattt tgcagcttcg agtaatcaac
      361 gggtcgacct ttataagtgg aaagatggca gcggggaagt tggtacaact ttacaggggc
      421 acactcgagt tatcagcgac ttggactggg cagtgtttga gccagatctc ctggtcacca
      481 gctctgtgga cacctacatc tacatctggg atatcaaaga cacaaggaaa cctactgttg
      541 cactgtcggc tgtagctggt gcctcccagg tcaaatggaa taagaagaac gccaactacc
      601 ttgccaccag tcacgatggt gacgtacgga tatgggacaa gcgaaaaccc agtacagctg
      661 tggaatatct agcagcccac ctctccaaga tccacggcct ggactggcac ccagacagtg
      721 agcacatctt tgccacctcc agtcaagata actctgtcaa gttctgggat taccgccagc
      781 ctcggaaata cctcaatatc ctcccttgcc aggtgcctgt ctggaaagcc agatacacgc
      841 ctttcagcaa cgggctagtg accgtgatgg ttccccagct gcggagggag aacagcctgc
      901 tcctgtggaa cgcgtctgac ttgaacgctc cagttcacac ctttgtgggt catgatgacg
      961 tggtgctgga gttccagtgg aggaggcaga aggaaggatc caaggactat caactggtta
     1021 catggtcccg tgatcagacc ttgagaatgt ggcgagtgga ctatcaaatg cagaggctct
     1081 gtgccaatga catactggat ggtgttgatg agttcattga gagcatctct ctcctgccgg
     1141 aaccagagaa gaccccacat cctcaagaca tagatcacca gcccagctta agccatggag
     1201 aggaagatgc cataaaggaa gaccctccca gcagtttgct ggaagagaag agatcagacc
     1261 aactaggcct cccccagact ctgcaacagg agttctcctt gatcaacgtg cagatccgga
     1321 atgtcaatgt ggagatggac gctgcagacc ggagctgcac agtgtctgtg cactgcagca
     1381 accaccgtgt gaagatgctg gtgaccttcc cggcgcagta ccctaacaac gctgctcctt
     1441 ccttccagtt cattaatcct accactatca cgtctgccgt gaaggccaag ctgctgaaga
     1501 tcctaaagga cacttcactg cagaaagtga aacgcaacca gagctgtttg gagccttgcc
     1561 tgcgccagct tgtctcgtgc cttgagtctt ttgtgaacca agaggacagt gcttctagca
     1621 acccatttgc actccaaaac tctgtcacac cacccttgcc gacatttgca cgggtgacca
     1681 ctgcctacgg ctcctaccag gatgccaaca ttccctttcc taggacctct ggggccaggt
     1741 tctgtggagc aggttacctg gtgtacttca cacgacccat gacgatgcat cgagcagtgt
     1801 ctcccacaga gcctactcct aggtctctct cagccctgtc tgcttatcat actggtttga
     1861 ttgcaccaat gaagatccgc accgaggccc ctgggaacct gcgtctgtac agtgggagcc
     1921 caactcgcag tgagaaagag caggtctcca tcagttcctt ctattacaag gaacggatgt
     1981 ctcctcgctc tgcccggcga cgttggtcca tacaagcaat taacgacttc ccgaaatcga
     2041 ggaggtggaa gagtaagcgg gaaggctctg actccggcaa ccgacccatt aaggctgctg
     2101 gcaaggtcat catccaggat gtctcgtgcc tccttcccgt tcataagtcc ttgggagagc
     2161 tgtacatatt gaatgtgaac gacactcagg agacatgtca gaagaatgcc acttctgcca
     2221 tgcttgtggg aaggaaggat cttgtccagg tttggtcgct ggctacggta gctacagatc
     2281 tttgccttgg gccgaagtct gacccagatt tggaaacacc ttgggctcga catccatttg
     2341 ggcgacaact gctggagtcc ctactggctc actattgcca actccgagat gttcagacct
     2401 tggctatgct ctgtagcgtg tttgaagccc agtcccggcc tcagggctta ccaaaccctt
     2461 ttgggccttt ccctaatcgt tcttctaatc ttgtggtgtc ccacagccgc tatcccagct
     2521 tcacctcctc ggggtcctgc tccagcatgt cagatccagg gttcaacacc ggtggctgga
     2581 acatagcagg aagagagaca gaacacatat cttcaccttg gggggagtct tcgccagagg
     2641 agctccgctt tgggagtctg acctacagtg acccccggga gcgggaacga gaccagcatg
     2701 ataaaaacaa aaggctcctg gaccctgcca atacccagca gtttgacgac tttaagaagt
     2761 gctacggaga gatcctctac cgctggggtc tgagagagaa gcgagcagaa gtgctgaagt
     2821 ttgtgtcctg ccctcctgac cctcacaaag ggatcgagtt tggtgtgtac tgcagtcact
     2881 gtcggagcga ggtccgtggc acccagtgcg ccatctgcaa aggcttcacc ttccagtgtg
     2941 ccatctgcca tgtggccgtg cggggttcat ccaacttctg cctgacctgt gggcatggtg
     3001 gccacacgag ccacatgatg gagtggtttc ggacccagga ggtatgtccc acggggtgtg
     3061 gctgccactg cctgctggag agcaccttct gaacttaaag gacagtggca cttccggaaa
     3121 tcccagagga ctccataagt gctggagaag gctctctgct gctgctggtg gaaagtccta
     3181 gaaccagggc catcctcgtg atttaggatg gagagtatcc tctcacagac tgtcacagca
     3241 tccgctcgtg atcctgtgtg ttcccttctc cttggctgcc gggcacggat ggtgctggaa
     3301 gaagggaggg ggacgcacag agctgaccct cctgtactgt ctgttgagtc cacagtggat
     3361 gttttcatga ggaaaagcac ctgtttccag agccatcaga gctagcatca gccttcaaga
     3421 ttctgtcctt gaaccaggaa tggaccctcc agatgccagt acaaaggcac acagcagctg
     3481 caaaacagac tcctgagcca gaagacgctg gctcttagtg ccatccacaa gtgagctatg
     3541 gtatctgtga cttagaagtt ggcaccttga tgatggcctt ataaaataca atactaaagt
     3601 gtaatatatg atggacatat attcagcatt ctttttcttg gtacagggct ggaactcagc
     3661 gccttgcaca tactggtgag cagccatacc actgagttac attccagccc cataagaaac
     3721 ttaagatgta tatgttttct gtttctcttc atctgctttc ctttaactaa tagaagtttg
     3781 tacttgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgagtgagtg
     3841 agtgagtgag agagagagag agagagagag agagagggag agagagagga tgaataagga
     3901 aagtgaccgt cttagtgact cattttgcat tgtacttctg gttgaaggga actgttttgg
     3961 accggactag aattagtctc atgacttgta aaggaaatgc catttgactt tgatcatctg
     4021 acagaggaaa cggaatctga cattaaggtt ctctctagcc gcaagagtct cataattatt
     4081 tcttctagca caggggaaat gagattgcat ttcagcactg ataccagagt ctctctctgc
     4141 ctctgggcag gctggctggg ctccaggggt actttttact tgaactccct tgcaaactca
     4201 tcatgatttt caggggtttc acttgtctat accagggaag agagtttaaa aaaaaaaaca
     4261 agacccacta tactgaaatc tctctctctt agaaatttaa attccttggg cctgtcataa
     4321 ggctcagtgg gcagaggtgc ctgccactaa gcttactaac ctcagttttc tccctcgcat
     4381 gagccaccat agaagaactg actcctaaga gttgtcctct gacttccaca tgtgtgcttt
     4441 gatatgtgaa tgtacacaca cacatacaaa aaatgtaatt taacaatttt atgattccaa
     4501 actaattaac cggagacaca taagtaattt gtgtcattgg attatggttg cacgtgtttg
     4561 tagtcccttc actcacgggg ctgaggtaag agggtttcaa gtttgagacc atcctgggct
     4621 acacagtgag gtgatggcca gcctcactta tatatgaaga cacttacaag caaacgtcat
     4681 aaagaagatc tggagagatc gcttagtaat caaatgcttg gctagcatac aggaggtgat
     4741 gtgtttgatc ctcagcaaca cacacactga cactcaaact aaaacaaaac aaaatactac
     4801 atgttccata ataggtaagt gttgtatatc actttgtttg aaactatgat ttaagactca
     4861 tgaatggatt aggaaatcag tctcgtagat aaaaaccaac actttctatt ttcaaggatt
     4921 actttgtgtg tgtaaatctc tgtgtcttca agtgtatgtt gtgtgggaca gaagaggcca
     4981 tctggttcct tggtgctagg attatcagtc ttttcaggac accttgtgtc atgtgtgttc
     5041 agggatccta acttggatct tcatgattgc aaagtcagaa ctgttttgtc tccagccccc
     5101 aaactgtcat ataaagaaag taaaataatg tgggtgagag acaatcgtgt actaa
//
