LOCUS       NM_080848               2916 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WD repeat domain 5 (Wdr5), mRNA.
ACCESSION   NM_080848
VERSION     NM_080848.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2916)
  AUTHORS   Liu,L., Guo,X., Wang,Y., Li,G., Yu,Y., Song,Y., Zeng,C., Ding,Z.,
            Qiu,Y., Yan,F., Zhang,Y.X., Zhao,C., Zhang,Y., Dou,Y., Atadja,P.,
            Li,E. and Wang,H.
  TITLE     Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by
            suppressing Myc targets
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (2), 166600 (2023)
   PUBMED   36402263
  REMARK    GeneRIF: Loss of Wdr5 attenuates MLL-rearranged leukemogenesis by
            suppressing Myc targets.
REFERENCE   2  (bases 1 to 2916)
  AUTHORS   Ma,M., Zhou,J., Ma,Z., Chen,H., Li,L., Hou,L., Yin,B., Qiang,B.,
            Shu,P. and Peng,X.
  TITLE     The Ash2l SDI Domain Is Required to Maintain the Stability and
            Binding of DPY30
  JOURNAL   Cells 11 (9), 1450 (2022)
   PUBMED   35563756
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2916)
  AUTHORS   Li,Q., Huang,Y., Xu,J., Mao,F., Zhou,B., Sun,L., Basinski,B.W.,
            Aksu,M., Liu,J., Dou,Y. and Rao,R.C.
  TITLE     p53 inactivation unmasks histone methylation-independent WDR5
            functions that drive self-renewal and differentiation of
            pluripotent stem cells
  JOURNAL   Stem Cell Reports 16 (11), 2642-2658 (2021)
   PUBMED   34715053
  REMARK    GeneRIF: p53 inactivation unmasks histone methylation-independent
            WDR5 functions that drive self-renewal and differentiation of
            pluripotent stem cells.
REFERENCE   4  (bases 1 to 2916)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2916)
  AUTHORS   Rojas,A., Sepulveda,H., Henriquez,B., Aguilar,R., Opazo,T.,
            Nardocci,G., Bustos,F., Lian,J.B., Stein,J.L., Stein,G.S., van
            Zundert,B., van Wijnen,A.J., Allende,M.L. and Montecino,M.
  TITLE     Mll-COMPASS complexes mediate H3K4me3 enrichment and transcription
            of the osteoblast master gene Runx2/p57 in osteoblasts
  JOURNAL   J Cell Physiol 234 (5), 6244-6253 (2019)
   PUBMED   30256410
  REMARK    GeneRIF: Our results show that an enrichment of activating histone
            marks at the Runx2/p57 P1 promoter is accompanied by the
            simultaneous interaction of Wdr5 and Utx proteins in
            differentiating MC3T3 mouse osteoblasts
REFERENCE   6  (bases 1 to 2916)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
REFERENCE   7  (bases 1 to 2916)
  AUTHORS   Gori,F., Friedman,L.G. and Demay,M.B.
  TITLE     Wdr5, a WD-40 protein, regulates osteoblast differentiation during
            embryonic bone development
  JOURNAL   Dev Biol 295 (2), 498-506 (2006)
   PUBMED   16730692
  REMARK    GeneRIF: Wdr5 accelerates osteoblast differentiation in association
            with activation of the canonical Wnt pathway.
REFERENCE   8  (bases 1 to 2916)
  AUTHORS   Brown,S.A., Ripperger,J., Kadener,S., Fleury-Olela,F., Vilbois,F.,
            Rosbash,M. and Schibler,U.
  TITLE     PERIOD1-associated proteins modulate the negative limb of the
            mammalian circadian oscillator
  JOURNAL   Science 308 (5722), 693-696 (2005)
   PUBMED   15860628
  REMARK    GeneRIF: identified two proteins, NONO and WDR5, that can associate
            with the mammalian PER1 protein; WDR5 augmented PER-mediated
            transcriptional repression, and its reduction by RNAi diminished
            circadian histone methylations at the promoter of a clock gene
REFERENCE   9  (bases 1 to 2916)
  AUTHORS   Gori,F. and Demay,M.B.
  TITLE     BIG-3, a novel WD-40 repeat protein, is expressed in the developing
            growth plate and accelerates chondrocyte differentiation in vitro
  JOURNAL   Endocrinology 145 (3), 1050-1054 (2004)
   PUBMED   14657013
  REMARK    GeneRIF: BIG-3 accelerates chondrocyte differentiation in vitro,
            and is expressed in the growth plate during embryonic development,
            so is is likely to play an in vivo regulatory role in the
            developing growth plate.
REFERENCE   10 (bases 1 to 2916)
  AUTHORS   Gori,F., Divieti,P. and Demay,M.B.
  TITLE     Cloning and characterization of a novel WD-40 repeat protein that
            dramatically accelerates osteoblastic differentiation
  JOURNAL   J Biol Chem 276 (49), 46515-46522 (2001)
   PUBMED   11551928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA023626.1 and AF416510.1.
            
            On Apr 25, 2009 this sequence version replaced NM_080848.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC025801.1, AK144091.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AA023626.1         1-67
            68-2916             AF416510.1         73-2921
FEATURES             Location/Qualifiers
     source          1..2916
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 19.38 cM"
     gene            1..2916
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /note="WD repeat domain 5"
                     /db_xref="GeneID:140858"
                     /db_xref="MGI:MGI:2155884"
     exon            1..134
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            135..298
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1222
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /note="BMP2-induced 3-kb gene protein; WD
                     repeat-containing protein BIG-3"
                     /codon_start=1
                     /product="WD repeat-containing protein 5"
                     /protein_id="NP_543124.1"
                     /db_xref="CCDS:CCDS15829.1"
                     /db_xref="GeneID:140858"
                     /db_xref="MGI:MGI:2155884"
                     /translation="MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGH
                     TKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL
                     VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT
                     GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVS
                     FVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVS
                     GSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
                     "
     exon            299..407
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            408..481
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            482..571
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            572..661
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            662..745
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..801
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            802..848
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            849..924
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            925..958
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1033
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1121
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..2900
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2877..2882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /note="hexamer: AATAAA"
     polyA_site      2900
                     /gene="Wdr5"
                     /gene_synonym="2410008O07Rik; Big; Big-3"
                     /note="major polyA site"
ORIGIN      
        1 cgcccctcgc gcacgcgcaa tccctcccgc ctcccgcgcc gctgccgcct agtccagcag
       61 atcgtctgct ctcgcgcgta gggctagccg acgcgacgcc agagcgcccg gccccgccgc
      121 cgcggccccg gcaggcccct tactatagag ttcagctgac agcctcttcc attgtgactc
      181 ccccttcacg gtgtcctgcc ctgtgggctt cagagccatg gccacagagg agaagaagcc
      241 agagacagag gctgcaagag cacagcccac tccttcctca tcagccacac agagcaagcc
      301 cacaccagtt aagccaaact atgccctgaa gttcaccctg gctggccaca ccaaagctgt
      361 gtcctctgtg aagttcagcc ccaatgggga atggttggca agttcatctg ctgataaact
      421 cattaaaatt tggggagcat atgatggaaa gtttgagaaa actatatctg gtcacaaact
      481 gggaatatct gatgtagcgt ggtcatcaga ttctaacctc cttgtgtctg cctctgatga
      541 taaaactttg aagatttggg acgtgagttc cgggaagtgt ctgaagaccc tgaagggcca
      601 cagtaactac gtcttctgct gcaacttcaa cccccagtcc aacctcatcg tctcagggtc
      661 ttttgatgaa agtgtgagga tatgggacgt gaagacaggg aagtgcctca agactttgcc
      721 tgcccattcg gacccagtct cagccgttca tttcaaccgt gatggatcat tgattgtttc
      781 cagtagctat gatggcctct gccgaatctg ggacaccgcc tctggccagt gtctgaagac
      841 actcattgat gatgacaatc ctccagtgtc cttcgtgaag ttctctccaa atggcaaata
      901 catcctggct gcaactttgg acaacacact gaagctctgg gactacagca aggggaagtg
      961 cctgaagaca tacactggcc acaagaatga gaagtactgc atatttgcca acttctccgt
     1021 gacaggcggg aagtggattg tgtctggttc tgaagataac ctggtgtata tctggaatct
     1081 gcagaccaag gagattgtgc agaagttgca gggtcacaca gatgttgtga tttccacggc
     1141 ttgtcacccg acagagaaca tcattgcctc agcagcgtta gagaacgaca aaacaatcaa
     1201 actgtggaag agtgactgct aagtcctggc tccatgggag acttaaggaa gccacccgga
     1261 ttggcaagaa acacatgtgg ggcagaggca tggggccagg ctgggttgac aggcctggtg
     1321 cacctcctat ctgaagatgt cggctcaggg gagtgcacac taccgagtct tgatagccac
     1381 tgtgatattt cttgccaatt ctgtctctgc ctggggaagt tcctggtctg ttctgtgctc
     1441 agaggcaaca aatttttaat ttttttatta caagagtgag ttcagctcct catgggttgt
     1501 ttttctctgt ggttgttgtt ttggtattgt attgcccagt gcacactgga acaggaccta
     1561 cagccctact cccattccct gcctcctgcc ctggcctgct tgttcaattt tcctgcctgt
     1621 aatagtaccc agcgtgcttc catgagtttc tggaaacaca gaaaggttgt aagttgtatc
     1681 cgtgtcaagt ccctttgttc ttttggagtt cataggtcaa cactgacctc tcagtggttg
     1741 aaatgtctcc ttgtctcact ggtatcactc agtaagctac acacactgta ataaaaggtg
     1801 ggtatggact gggtgtggcc ctgagttctg accaggctct ttgacacctg gctttataaa
     1861 gccctcctcc cttcctggca ggagttggaa aggtctctgg gaggatggat ccttgttgtg
     1921 cctcttcttc ccagtggctg ctgtgggtgc tgagtgttgg agaggaagaa cctcagatga
     1981 gaaagagtgg aaggaagtct tggaaaggca ccatgtagtg aggttctgga cctctttatt
     2041 ctgtgagagg ctcagggtca cctgtgcagg agggaggagt tcaatatggt gcttgcccca
     2101 gcaggtacag cttcctgcct tggcctctaa acccaccaaa cctctcttat gtccttggcc
     2161 cccgccccag gtcaccgcct caggtgacca ggactggaaa gaggtagtgg ccaagctcag
     2221 gactacacag cattttcaca actgctgctg gctgaaccca gggtgaccta ctgtggagca
     2281 gactgcagag gttctgggag tacagatggg tggcggaggc tgctgggcac agacatgggt
     2341 ggaaaggaga ttctgggttt gctctggttg cagcagcaac catctgtgag gccaacactg
     2401 atgtgtattg aagccacatc acccagggca gtagctgctc tactctgcct ttgccaaggc
     2461 ttgtccccag ctgtggtcct gacagccctt tctccctcca tcgtgcataa taagaatcca
     2521 aaggtattgg aaaagaaacc ccatacattg tcacttcctt gagggagatg gtgtgtaaat
     2581 gggctatcac atcgaagaag ccattgttaa agagggtggc ttgtcacact gacatgggct
     2641 ctggggcccc tggcgtctgt tggatagatg aacctgggtt ctggtcaatg ttgtgggcat
     2701 gttgctgggg tttctggagg gtagtaaggt ccttccagct gtggcctggt gtgcggcctc
     2761 ctcctgaggg agggagcttg cttgccatgt cgagcacagt atccccgagt atagtttatt
     2821 ttttctacag ttgaactctg ttgtagattt atgtaaaaat acattctctt tttaaaaata
     2881 aagattttca tgccttgtaa aaaaaaaaaa aaaaaa
//
