LOCUS       NM_001417836            3947 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus WD repeat domain 48 (Wdr48), transcript variant 3,
            mRNA.
ACCESSION   NM_001417836 XM_006512246
VERSION     NM_001417836.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3947)
  AUTHORS   Yu,Z., Tong,L., Ma,C., Song,H., Wang,J., Chai,L., Wang,C., Wang,M.,
            Wang,C., Yan,R., Fu,Y., Jia,M., Zhao,W. and Zhao,C.
  TITLE     The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and
            Facilitates Antiviral Responses
  JOURNAL   J Immunol 212 (2), 295-301 (2024)
   PUBMED   38054892
  REMARK    GeneRIF: The UAF1-USP1 Deubiquitinase Complex Stabilizes cGAS and
            Facilitates Antiviral Responses.
REFERENCE   2  (bases 1 to 3947)
  AUTHORS   Ge,X., Ye,W., Zhu,Y., Cui,M., Zhou,J., Xiao,C., Jiang,D., Tang,P.,
            Wang,J., Wang,Z., Ji,C., Zhou,X., Cao,X., Liu,W. and Cai,W.
  TITLE     USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis and
            Improves Functional Recovery after Spinal Cord Injury through m6A
            Modification of YAP1 mRNA
  JOURNAL   J Neurosci 43 (9), 1456-1474 (2023)
   PUBMED   36653190
  REMARK    GeneRIF: USP1/UAF1-Stabilized METTL3 Promotes Reactive Astrogliosis
            and Improves Functional Recovery after Spinal Cord Injury through
            m[6]A Modification of YAP1 mRNA.
REFERENCE   3  (bases 1 to 3947)
  AUTHORS   Song,H., Zhao,C., Yu,Z., Li,Q., Yan,R., Qin,Y., Jia,M. and Zhao,W.
  TITLE     UAF1 deubiquitinase complexes facilitate NLRP3 inflammasome
            activation by promoting NLRP3 expression
  JOURNAL   Nat Commun 11 (1), 6042 (2020)
   PUBMED   33247121
  REMARK    GeneRIF: UAF1 deubiquitinase complexes facilitate NLRP3
            inflammasome activation by promoting NLRP3 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3947)
  AUTHORS   Man,J.C.K., Mohan,R.A., Boogaard,M.V.D., Hilvering,C.R.E.,
            Jenkins,C., Wakker,V., Bianchi,V., Laat,W., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3947)
  AUTHORS   Park,E., Kim,J.M., Primack,B., Weinstock,D.M., Moreau,L.A.,
            Parmar,K. and D'Andrea,A.D.
  TITLE     Inactivation of Uaf1 causes defective homologous recombination and
            early embryonic lethality in mice
  JOURNAL   Mol Cell Biol 33 (22), 4360-4370 (2013)
   PUBMED   24001775
REFERENCE   6  (bases 1 to 3947)
  AUTHORS   Williams,S.A., Maecker,H.L., French,D.M., Liu,J., Gregg,A.,
            Silverstein,L.B., Cao,T.C., Carano,R.A. and Dixit,V.M.
  TITLE     USP1 deubiquitinates ID proteins to preserve a mesenchymal stem
            cell program in osteosarcoma
  JOURNAL   Cell 146 (6), 918-930 (2011)
   PUBMED   21925315
REFERENCE   7  (bases 1 to 3947)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
REFERENCE   8  (bases 1 to 3947)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124662.10.
            
            On Mar 10, 2023 this sequence version replaced XM_006512246.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861859.3714503.1,
                                           SRR13422598.408189.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-182               AC124662.10        85300-85481         c
            183-323             AC124662.10        78190-78330         c
            324-402             AC124662.10        76260-76338         c
            403-485             AC124662.10        75331-75413         c
            486-615             AC124662.10        75119-75248         c
            616-704             AC124662.10        73400-73488         c
            705-806             AC124662.10        72829-72930         c
            807-1031            AC124662.10        71041-71265         c
            1032-1106           AC124662.10        69518-69592         c
            1107-1209           AC124662.10        68147-68249         c
            1210-1307           AC124662.10        66891-66988         c
            1308-1415           AC124662.10        63783-63890         c
            1416-1512           AC124662.10        63409-63505         c
            1513-1608           AC124662.10        62059-62154         c
            1609-1714           AC124662.10        60862-60967         c
            1715-1802           AC124662.10        59972-60059         c
            1803-1879           AC124662.10        57922-57998         c
            1880-2069           AC124662.10        56349-56538         c
            2070-3947           AC124662.10        54030-55907         c
FEATURES             Location/Qualifiers
     source          1..3947
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..3947
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /note="WD repeat domain 48"
                     /db_xref="GeneID:67561"
                     /db_xref="MGI:MGI:1914811"
     exon            1..182
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..2165
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /note="isoform 3 is encoded by transcript variant 3; WD
                     repeat-containing protein 48; USP1-associated factor 1"
                     /codon_start=1
                     /product="WD repeat-containing protein 48 isoform 3"
                     /protein_id="NP_001404765.1"
                     /db_xref="GeneID:67561"
                     /db_xref="MGI:MGI:1914811"
                     /translation="MGLLPAHLPLLSAAFLRNSRDPAAEASRRPRVSYVIRDEVEKYN
                     RNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDVVLCCNG
                     KTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD
                     VNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKL
                     MKLKGHTDNVKALLLHRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVN
                     DAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKS
                     TVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILT
                     KDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDE
                     SDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVTPMDEEENEVNHVS
                     GGQESRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETEAMLLNETVPQWVI
                     DITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDN
                     ESQTTSSSNNEKPEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDL
                     TLHYRQKST"
     exon            183..323
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..402
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            403..485
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            486..615
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..704
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            705..806
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            807..1031
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1106
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1209
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1307
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1415
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1512
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1608
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1609..1714
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1802
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1879
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..2069
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     exon            2070..3947
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3926..3931
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /note="hexamer: AATAAA"
     polyA_site      3947
                     /gene="Wdr48"
                     /gene_synonym="8430408H12Rik; mKIAA1449; Uaf1"
                     /note="major polyA site"
ORIGIN      
        1 ggactgggcg cgcgggcctc gcgagcggtc gcggggaacc gccgtcccgg cgaaccgccg
       61 tcccgggaca ccgggcctgc ggcggcgcca tgggcctgct gcccgctcac ctgcctctgc
      121 tctcggccgc cttcctccgg aacagccgcg acccggcggc ggaggcctcg cggcgcccgc
      181 gggtttctta tgtaattcga gatgaagtgg agaaatacaa tcggaatgga gtcaatgccc
      241 tgcaactgga cccagcactc aacagactct tcacagcagg tcgagactcc atcataagaa
      301 tatggagtgt caatcagcac aagcaagatc cgtacatagc atctatggag caccatacag
      361 actgggtaaa tgatgtcgtg ctctgttgca atgggaaaac gctaatttct gcttcttcag
      421 acacaacagt caaagtctgg aatgcacata aagggttctg catgtccaca ctcaggacgc
      481 ataaggacta tgtaaaggcc ttagcgtacg ccaaggataa agagctggta gcgtcagctg
      541 ggctggacag acagatattc ctttgggatg tgaacactct gacggcactg actgcctcaa
      601 acaacaccgt tacaacttct tctttaagtg ggaacaaaga ctccatttat agcctggcca
      661 tgaaccaact gggaacaatc attgtatcag ggtccactga gaaggttctg agagtgtggg
      721 atccaagaac ctgcgcgaaa ctcatgaagc tgaaaggaca tacggacaat gtgaaggcct
      781 tgctgctgca cagggacggc acacagtgcc tctctgggag ttctgacggg accattcgcc
      841 tgtggtccct tggccagcag agatgtatag caacataccg agtccatgat gaaggtgttt
      901 gggccctaca ggtcaacgat gcctttacac atgtatattc tggaggacga gacaggaaaa
      961 tctactgcac agacctaagg aaccctgaca ttcgggtact gatttgtgaa gaaaaagcac
     1021 cagttctcaa gatggaactt gacagatcag cagatccccc tcctgcaatc tgggttgcaa
     1081 caacaaagtc cacagtaaat aagtggacac tgaagggaat tcataatttt cgagcctctg
     1141 gtgattatga caatgattgt acaaacccca taacgcccct ctgcacacag cccgaccaag
     1201 ttattaaagg gggcgctagt attattcagt gccacatcct aaatgacaag cgacacatat
     1261 taaccaaaga tacgaataac aatgtggcgt actgggatgt attgaaggca tgcaaagtgg
     1321 aagatttggg caaagtggac tttgaagatg aaattaagaa aagatttaaa atggtgtatg
     1381 ttccaaattg gttctcagta gacctaaaaa cagggatgct gaccattacc ctggatgaga
     1441 gtgactgctt cgctgcctgg gtttctgcga aagatgctgg ctttagcagt cctgatgggt
     1501 cagacccaaa actgaactta ggaggacttc tactacaggc actgctggaa tactggccca
     1561 ggacacatgt gactcccatg gatgaagaag agaatgaagt gaaccatgtg agtgggggac
     1621 aggagagcag agtccagaag ggaaatggtt atttccaagt gcccccacac accccggtga
     1681 tctttggaga agctggaggt cgcacactat tcaggctgct ctgccgggac tccgggggtg
     1741 agactgaggc gatgcttctc aatgagacgg tgccacaatg ggtgattgac atcactgtgg
     1801 ataaaaatat gcccaaattc aacaaaattc ctttctacct ccaacctcat gcatcttcag
     1861 gagcaaaaac tttaaaaaaa gacaggctgt ctgccagtga catgctgcag gtccggaagg
     1921 tgatggagca cgtctacgag aagattatca acctggacaa tgagtcccaa accaccagct
     1981 cttctaataa tgaaaagcca gagcaggaga aggaggagga catcgcggta ttggcagagg
     2041 agaaaattga acttctgtgc caggaccagg ttttggaccc aaatatggac cttcggacag
     2101 taaagcactt catatggaag agtggtgggg acctcaccct ccattaccgt cagaagtcca
     2161 cgtgagggtg ggcccatgct cctgggttct tcaccaacca cctttctctg tggccccaag
     2221 agtagtccta ggaagcccac cacgtcctac gggagcaaga cctccaaccg gcctatttgg
     2281 tgacgtgact aatggagatg taatatagaa accaggctcc atgcatagat taaggtgtcc
     2341 ccagggactc aagagtgcaa ggacaagccc ctggcactgt ccggggagat gtacagagaa
     2401 tctacaacag gccagtgcag acttcgctga ctccttttga aggacccccc tttgtctctt
     2461 agcacttgtt agagaacatc agcggggcca catcagtcgc catgtttcag tttcaaaccc
     2521 acaggctctg cagcttttcc aagtacattc cactcatgca gtacctatga aggctttttc
     2581 caaatttgtc attatataaa aaaaaacaag ttgttttcac tatgtaagag ttatttttaa
     2641 tggaaatcac tgttgcacaa ttcaagagcc agcccatttc ctgagaaatg accatgttgg
     2701 gctacttttg aaatgccacg tctcagctgt gctcttgtag gaagacctgc aactccaggg
     2761 ctggagcctg cgcagcacgt ggacctgcag gctgccaccc acagcctgtg ctgcgcagtg
     2821 ctgcccatgg cgccctggct gtccgatagc ccaagctgct gtggccactc cttccgccag
     2881 tcttcctcgc gggcaaagcc agcgaagcca cagcttcctg ctccgcgtga gcagcacgac
     2941 aactgtcaga acttacggcc atgctgaagt tgcagtttca ttcagatgct acctaaagtt
     3001 tatgttacta gagtaaaaag atctcacagt gagttggttt gatatttata ttgtggttca
     3061 tgtttgtttt tccagtttta tacacgggct tttgttacgc cttcgtccag gtctttctgc
     3121 cgtctttcta acagtcaaaa gctttcatag actcacttgg atcttgtaca gaatattaac
     3181 ttattgggga taaacacttc aacttttggc aaaaactact ttggattctt cccaaggtca
     3241 tttacattca gacaaatggt ccagcccgtg aagctgcagg agatgaacct ttgagcacag
     3301 cggaagcaca cgtgccttgg gggtgggggg tgcagctttc cccatccgtc cgtctgctcc
     3361 tgccttgtgt gtgtggtccc tgcccacagg agcacagggg aggggggctt ggggaagaaa
     3421 gatgttttct ctctatctca caggtcctgc agggaacagc tgaggggccc agatctgtcc
     3481 cttacaaatt gactgcagaa cagggtcccc tcacttaact ctggaacaca gacaggccat
     3541 ggcttccata ccctcaagtg agcaagaaca cttgccagtg ttaaaccatt ctccgcccta
     3601 gagtagccag cttttctaca gaagtccttt ctatgctgga cacatcggtg cacttttggt
     3661 gcatattttt tagtgatagc tataaagtaa aagcaggggg tggggtggtc gtgtttgcag
     3721 gaggggcctc tgcactaagc gtagggtttg ctggttggtt cactggcgca gtactgatcc
     3781 acaggcagtt gtgcccctat ggaggagttt accccagcat ggttgtaatt ttttccccag
     3841 ctagtcaaaa atcagtacta agtttccaga aaactggaca gtctgcaacg ccaaaggggc
     3901 agagtctgta tctcgggttg tatagaataa agctttagtt acaaaca
//
