LOCUS       NM_181400               4223 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus WD repeat domain 47 (Wdr47), transcript variant 1,
            mRNA.
ACCESSION   NM_181400
VERSION     NM_181400.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4223)
  AUTHORS   Bayam,E., Tilly,P., Collins,S.C., Rivera Alvarez,J., Kannan,M.,
            Tonneau,L., Brivio,E., Rinaldi,B., Lecat,R., Schwaller,N.,
            Cotellessa,L., Maddirevula,S., Monteiro,F., Guardia,C.M.,
            Kitajima,J.P., Kok,F., Kato,M., Hamed,A.A.A., Salih,M.A., Al
            Tala,S., Hashem,M.O., Tada,H., Saitsu,H., Stabile,M., Giacobini,P.,
            Friant,S., Yuksel,Z., Nakashima,M., Alkuraya,F.S., Yalcin,B. and
            Godin,J.D.
  TITLE     Bi-allelic variants in WDR47 cause a complex neurodevelopmental
            syndrome
  JOURNAL   EMBO Mol Med 17 (1), 129-168 (2025)
   PUBMED   39609633
REFERENCE   2  (bases 1 to 4223)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 4223)
  AUTHORS   Liu,H., Zheng,J., Zhu,L., Xie,L., Chen,Y., Zhang,Y., Zhang,W.,
            Yin,Y., Peng,C., Zhou,J., Zhu,X. and Yan,X.
  TITLE     Wdr47, Camsaps, and Katanin cooperate to generate ciliary central
            microtubules
  JOURNAL   Nat Commun 12 (1), 5796 (2021)
   PUBMED   34608154
  REMARK    GeneRIF: Wdr47, Camsaps, and Katanin cooperate to generate ciliary
            central microtubules.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4223)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4223)
  AUTHORS   Chen,Y., Zheng,J., Li,X., Zhu,L., Shao,Z., Yan,X. and Zhu,X.
  TITLE     Wdr47 Controls Neuronal Polarization through the Camsap Family
            Microtubule Minus-End-Binding Proteins
  JOURNAL   Cell Rep 31 (3), 107526 (2020)
   PUBMED   32320668
REFERENCE   6  (bases 1 to 4223)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4223)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   8  (bases 1 to 4223)
  AUTHORS   Wang,W., Lundin,V.F., Millan,I., Zeng,A., Chen,X., Yang,J.,
            Allen,E., Chen,N., Bach,G., Hsu,A., Maloney,M.T., Kapur,M. and
            Yang,Y.
  TITLE     Nemitin, a novel Map8/Map1s interacting protein with Wd40 repeats
  JOURNAL   PLoS One 7 (4), e33094 (2012)
   PUBMED   22523538
  REMARK    GeneRIF: we identify a novel LisH/WD40 repeat protein, tentatively
            named nemitin (neuronal enriched MAP interacting protein), as a
            potential regulator of MAP8-associated microtubule function
REFERENCE   9  (bases 1 to 4223)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Aizawa,H., Yuasa,S.,
            Nakajima,D., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: II. The complete nucleotide sequences of 400 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (1), 35-48 (2003)
   PUBMED   12693553
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL683823.11.
            
            On Mar 18, 2008 this sequence version replaced NM_181400.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040337.1, SRR1660813.243368.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-320               AL683823.11        111485-111804
            321-487             AL683823.11        130084-130250
            488-571             AL683823.11        131563-131646
            572-656             AL683823.11        134540-134624
            657-1459            AL683823.11        138697-139499
            1460-1586           AL683823.11        143530-143656
            1587-1765           AL683823.11        144764-144942
            1766-2023           AL683823.11        147410-147667
            2024-2099           AL683823.11        149899-149974
            2100-2257           AL683823.11        153268-153425
            2258-2427           AL683823.11        157198-157367
            2428-2598           AL683823.11        158100-158270
            2599-2730           AL683823.11        158833-158964
            2731-2949           AL683823.11        163269-163487
            2950-4223           AL683823.11        164653-165926
FEATURES             Location/Qualifiers
     source          1..4223
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 47.38 cM"
     gene            1..4223
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /note="WD repeat domain 47"
                     /db_xref="GeneID:99512"
                     /db_xref="MGI:MGI:2139593"
     exon            1..320
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            321..487
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     CDS             330..3092
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 47; nemitin; neuronal enriched
                     MAP interacting protein"
                     /codon_start=1
                     /product="WD repeat-containing protein 47 isoform 1"
                     /protein_id="NP_852065.2"
                     /db_xref="CCDS:CCDS17765.1"
                     /db_xref="GeneID:99512"
                     /db_xref="MGI:MGI:2139593"
                     /translation="MTAEETVNVKEVEIIKLILDFLNSKKLHISMLALEKESGVINGL
                     FSDDMLFLRQLILDGQWDEVLQFIQPLECMEKFDKKRFRYIILKQKFLEALCVNNAMS
                     AEDEPQHLEFTMQEAVQCLHALEEYCPSKDDYSKLCLLLTLPRLTNHAEFKDWNPSTA
                     RVHCFEEVCVMVAEFIPADRKLSEAGFKASNNRLFQLVMKGLLYECCVEFCQSKATGE
                     EITESEVLLGIDLLCGNGCDDLDLSLLSWLQNLPSSVFSCAFEQKMLNIHVDKLLKPT
                     KAAYADLLTPLISKLSPYPSSPMRRPQSADAYMTRSLNPALDGLTCGLTSHDKRISDL
                     GNKTSPMSHSFANFHYPGVQNLSRSLMLENTECHSIYEESPERSDTPVEAQQPVSSEA
                     MCQGSGLEKEPANGAQNPVPAKQEKNELRDSTEQFQEYYRQRLRYQQHLEQKEQQRQM
                     YQQMLLEGGVNQEDGPDQQQNLTEQFLNRSIQKLGELNIGMDSLGNEVPVLNQQCSGS
                     KNNGSNNSSVTSFSTPPQDSSQRLIHDTANIHTSTPRNPGSTNHIPFHEDSPCGSQNS
                     SEHSVIKPSPGDSSGNLSRSKGEEDDKSKKQFVCINTLEDTQAVRAVAFHPSGSLYAV
                     GSNSKTLRVCAYPEKMDASAHDNPKQPVVRFKRNKHHKGSIYCVAWSPCGQLLATGSN
                     DKYVKVLPFNAETCNATGPDLEFSMHDGTIRDLAFMEGPESGGAILISAGAGDCNIYT
                     TDCQRGQGLHALSGHTGHILALYTWSGWMIASGSQDKTVRFWDLRVPSCVRVVGTTFH
                     GTGSAVASVAVDPSGRLLATGQEDSSCMLYDIRGGRMVQSYHPHSSDVRSVRFSPGAH
                     YLLTGSYDMKIKVTDLQGDLTKQLPLMVVGEHKDKVIQCRWHTQDLSFLSSSADRTVT
                     LWTYSG"
     exon            488..571
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            572..656
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            657..1459
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1586
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1765
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..2023
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            2024..2099
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            2100..2257
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2427
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            2428..2598
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2730
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            2731..2949
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     exon            2950..4223
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4201..4206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /note="hexamer: AATAAA"
     polyA_site      4223
                     /gene="Wdr47"
                     /gene_synonym="1810073M12Rik; mKIAA0893"
                     /note="major polyA site"
ORIGIN      
        1 tgcctagccg cctcgcgagg aggggtcctg aggcggctcc agggacgagc agtgattggc
       61 tgcagctggc ggctggagct ccgttccagc ggcgcttgac aaccgcagtc cgcggagcgg
      121 agcggtcgga ggcgggatcg gggcggacgc gagcaggacc ggctgacgag ctgatggatt
      181 gacgtgcggg ctgcttagcc cagaccgccg ccctcgcgct cgcgccttag actggaattg
      241 gctgtctcgg ggctctggcc gccggcctct cctccgcgtt ttcctccacc gcttctgccg
      301 gctccgcccg gagctctcag gctagcaata tgactgctga agaaacggtg aatgtgaaag
      361 aggttgagat cattaagctg attttggact tcttgaattc aaagaagctt cacattagta
      421 tgctggcgct ggagaaggaa agtggagtca taaatggcct gttttcagat gatatgctct
      481 tcctgaggca gctgatcctg gatggccaat gggatgaagt tcttcagttc attcagcctc
      541 tagaatgtat ggagaaattt gacaaaaaaa ggtttcgtta tattatcctg aagcagaagt
      601 ttctagaagc tttgtgtgtt aacaatgcaa tgtctgcaga agatgagccc cagcatttgg
      661 aatttaccat gcaggaagcg gtgcagtgtc tgcatgctct ggaggagtac tgcccttcta
      721 aagacgatta cagcaagcta tgtctgctcc tcaccttgcc tcgtttgacc aatcacgctg
      781 agtttaagga ctggaatccc agcactgcac gagttcactg ctttgaagag gtctgtgtca
      841 tggttgcaga gttcattcct gctgacagga agctaagtga ggctggtttt aaagcaagta
      901 acaatcgctt attccagctc gtaatgaagg gcctacttta tgaatgctgc gtagaatttt
      961 gtcagagtaa agcaactggt gaagaaatta cagaaagtga agtccttctt ggcatcgacc
     1021 tgttatgtgg caacggttgt gacgatttag atctaagttt attgtcttgg cttcagaatc
     1081 tcccttcttc agtcttttct tgtgcatttg aacagaaaat gcttaatatt catgttgaca
     1141 aacttctgaa gcctacaaaa gctgcatatg ctgatctgtt gactcctctt atcagcaaac
     1201 tgtctcccta cccttcatct ccaatgagaa gacctcagtc agctgatgcc tatatgactc
     1261 gctctctcaa tcctgctttg gatggcctca catgtgggtt aaccagtcat gataagagga
     1321 tctcagatct tgggaacaaa acttctccaa tgtcacactc ctttgctaac ttccactatc
     1381 caggggtaca gaacctcagc agaagtctca tgcttgagaa tacagagtgt cacagcatct
     1441 atgaagaatc tcctgagcga agtgatacgc ctgttgaggc ccagcagcct gtgagcagtg
     1501 aagccatgtg ccaggggtca gggttagaaa aagagcctgc aaatggagca cagaacccag
     1561 ttccagctaa acaagaaaaa aatgagcttc gagattccac tgaacaattt caggaatatt
     1621 acaggcaaag actgcggtac cagcagcacc tagaacagaa ggagcaacag cggcagatgt
     1681 accagcagat gttacttgaa ggaggcgtga accaagagga tggtcctgat cagcagcaga
     1741 atcttactga acaattcctt aataggtcta ttcagaagct tggcgaatta aatattggaa
     1801 tggatagtct tggtaatgag gtgccagtgc tcaaccagca atgcagcggg agcaaaaaca
     1861 atggatcaaa taattcctct gtgactagtt tcagtacacc accccaagat tccagtcaga
     1921 ggttaataca tgatactgcc aatattcaca caagcactcc tcgtaatcct ggatcaacga
     1981 atcacatccc ttttcatgaa gactcacctt gtggaagcca gaactcatca gaacattctg
     2041 tcattaagcc atcacctgga gattcttcag gaaatctatc aaggtcaaaa ggggaagagg
     2101 atgacaagtc gaaaaagcag tttgtttgta ttaataccct agaagacaca caggctgtta
     2161 gagccgtggc gtttcatcca agtggtagtt tatatgctgt tggttcaaat tcaaaaactc
     2221 tgagagtgtg tgcctatcca gaaaaaatgg atgcaagtgc acacgacaat cctaagcagc
     2281 cagtggtgcg atttaaaaga aacaaacatc ataaaggatc tatttattgt gtggcttgga
     2341 gtccgtgtgg acagttgtta gcaacaggat caaatgacaa atatgtaaaa gtgctgccct
     2401 tcaatgcaga gacatgtaat gcaacaggac cagatctgga atttagcatg catgatggga
     2461 caattcgaga tttggcattt atggaaggcc cagaaagtgg tggagctatt ttaataagtg
     2521 ctggagcagg agattgtaac atttatacaa cagactgtca aagaggacag ggtcttcatg
     2581 ctttgagtgg acacactggg cacattttag cactttatac ctggagtggg tggatgattg
     2641 cgtctggttc ccaggataag actgttagat tctgggatct tcgtgtacca agctgtgttc
     2701 gtgtggttgg cacaacattc catggaactg gcagtgcagt ggcatctgtg gctgtggacc
     2761 ccagtggccg tctcttagct acaggtcagg aggactctag ctgcatgctg tacgacataa
     2821 gaggaggcag aatggtccag agttaccacc ctcactccag tgacgttcgc tctgttcgct
     2881 tctctcctgg agctcactat ctgctgacag gctcttacga tatgaaaata aaggtgacag
     2941 acctgcaagg ggacctcacc aagcagcttc ctctcatggt ggtgggggag cacaaggaca
     3001 aggtgatcca gtgcagatgg cacacccagg atctctcctt cctctcatcc tctgcggaca
     3061 gaactgtgac cctctggact tacagtggct agaggccacc ctgcactggc ctatgccgtg
     3121 caaacacaga ccccagacta ctgaactgtt aggactacag gcctgaagaa cgcgtcctgc
     3181 cccagaaaga gcttaagtgg aggaagcccc cttattacca tttcctatga acagaaggtg
     3241 ttgggtggtg gttttcagtc ttccatgtgt gttcatgctg ctgtgtagtt tccttgccaa
     3301 agtctgcaga agagctctta tgttgttggt ttgcatccca agtcatggtc caggatgggt
     3361 tcatggttat taagtgcact ccttgggtgt tacccaggtc acagtttata ctcacactga
     3421 catggaatta taatttaagt aattgttaca catactaggt ccaggttctc ccccagctaa
     3481 aacagaggta ttcagaaatg actttgctct tgtcacgatc ccatactgta tcacgtgtct
     3541 tctagaggtc agggtttggt aagtctccaa ttttacctga tcatctttgc atagggctca
     3601 ccacagagcc tccagatgaa aggagagctg cttcttcctc ttaacccagg ggtgtggttg
     3661 ctaatttgac acgtcacttt gtttcaggct aaaaggtaat aaccattttg ctttgggaac
     3721 ttgttgactt cagttttttg aatgcacaag gtcccccccc cctccaaaca gcactgtaga
     3781 agcagagcgg cagctgttac gtggaacaat agtcaatggt aggttaactt accaggtagc
     3841 attttcctct tcaaaattaa gactttgcca tgaccctagc atggcttgaa aagctatgtt
     3901 tgcatgataa tttaaaatgg aaaactgaaa ctttgcactc cagaagctta ttcggatttt
     3961 cttgcacagt tttgtgtaat gaggaataat gattttattt gtacagtact atatatccta
     4021 acattttatg tatctttatt ttcatattgt tcagtatttt actttaagtt attaaatagg
     4081 ctactttatt tatttcagct gcagtggtat tgacctgtct gtgcactata tgtagcaagc
     4141 attttaaatc tatagtacac aagtgggagg taatagaagt gtaactgtgc tttttatttc
     4201 aataaagacc tcttgacact caa
//
