LOCUS       NM_025793               2344 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WD repeat domain 45B (Wdr45b), mRNA.
ACCESSION   NM_025793
VERSION     NM_025793.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2344)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2344)
  AUTHORS   Yamaguchi,H., Honda,S., Torii,S., Shimizu,K., Katoh,K., Miyake,K.,
            Miyake,N., Fujikake,N., Sakurai,H.T., Arakawa,S. and Shimizu,S.
  TITLE     Wipi3 is essential for alternative autophagy and its loss causes
            neurodegeneration
  JOURNAL   Nat Commun 11 (1), 5311 (2020)
   PUBMED   33082312
  REMARK    GeneRIF: Wipi3 is essential for alternative autophagy and its loss
            causes neurodegeneration.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2344)
  AUTHORS   Ji,C., Zhao,H., Li,D., Sun,H., Hao,J., Chen,R., Wang,X., Zhang,H.
            and Zhao,Y.G.
  TITLE     Role of Wdr45b in maintaining neural autophagy and cognitive
            function
  JOURNAL   Autophagy 16 (4), 615-625 (2020)
   PUBMED   31238825
REFERENCE   4  (bases 1 to 2344)
  AUTHORS   Barth,H., Meiling-Wesse,K., Epple,U.D. and Thumm,M.
  TITLE     Autophagy and the cytoplasm to vacuole targeting pathway both
            require Aut10p
  JOURNAL   FEBS Lett 508 (1), 23-28 (2001)
   PUBMED   11707261
REFERENCE   5  (bases 1 to 2344)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146101.1 and BY618193.1.
            
            On Jul 15, 2009 this sequence version replaced NM_025793.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146101.1, BC004595.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2309              AK146101.1         2-2310
            2310-2344           BY618193.1         341-375
FEATURES             Location/Qualifiers
     source          1..2344
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 85.24 cM"
     gene            1..2344
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /note="WD repeat domain 45B"
                     /db_xref="GeneID:66840"
                     /db_xref="MGI:MGI:1914090"
     exon            1..221
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             155..1189
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /note="WDR45-like protein; WD repeat-containing protein
                     45-like; Wdr45 like; WD repeat-containing protein 45B"
                     /codon_start=1
                     /product="WD repeat domain phosphoinositide-interacting
                     protein 3"
                     /protein_id="NP_080069.2"
                     /db_xref="CCDS:CCDS25773.1"
                     /db_xref="GeneID:66840"
                     /db_xref="MGI:MGI:1914090"
                     /translation="MNLLPCNPHGNGLLYAGFNQDHGCFACGMENGFRVYNTDPLKEK
                     EKQEFLEGGVGHVEMLFRCNYLALVGGGKKPKYPPNKVMIWDDLKKKTVIEIEFSTEV
                     KAVKLRRDRIVVVLDSMIKVFTFTHNPHQLHVFETCYNPKGLCVLCPNSNNSLLAFPG
                     THTGHVQLVDLASTEKPPVDIPAHEGVLSCIALNLQGTRIATASEKGTLIRIFDTSSG
                     HLIQELRRGSQAANIYCINFNQDASLICVSSDHGTVHIFAAEDPKRNKQSSLASASFL
                     PKYFSSKWSFSKFQVPSGSPCICAFGTEPNAVIAICADGSYYKFLFSPKGECVRDVCA
                     QFLEMTDDKL"
     exon            222..296
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..398
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            399..486
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..581
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..772
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            773..858
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            859..960
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1082
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..2344
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2286..2291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /note="hexamer: AATAAA"
     polyA_site      2315
                     /gene="Wdr45b"
                     /gene_synonym="0610008N23Rik; D16Bwg0193e; Wdr45l; WIPI-3"
                     /note="major polyA site"
ORIGIN      
        1 gcactgatga cgcagcactg acgacacacg cacgacgcaa gtccccagga ccctggcttc
       61 cggccgcggc ggccctagcg ccgcgcgacc ggagagatcg cctggttgcg agcggtatgc
      121 ggtgctgagg agccacagtc cctacgacgg cgccatgaac ctcctgccgt gtaaccctca
      181 cggcaacggg ctgctgtacg ccggcttcaa ccaggaccac gggtgttttg catgtggaat
      241 ggaaaatgga ttccgagtct ataataccga tccactcaaa gaaaaagaga aacaagaatt
      301 tttagaagga ggagttggcc atgtggaaat gttatttcgc tgtaactatt tagctttagt
      361 tggtggtgga aaaaaaccga aataccctcc caacaaagtg atgatctggg atgatctgaa
      421 gaagaagaca gtcatcgaga tagaattctc cacagaggtc aaggctgtca agttgcggag
      481 agatagaatt gtggtggttc tggactccat gattaaggtg ttcacgttca cacacaatcc
      541 ccaccagttg cacgtctttg aaacctgcta caaccctaaa ggcctctgtg tcctgtgtcc
      601 caacagtaac aactcccttc ttgccttccc tggcactcac actggccacg tacagcttgt
      661 ggacctggcc agcactgaaa agccacccgt ggacattccc gcacatgagg gtgtcctgag
      721 ctgtattgct ctcaacctgc agggaacaag aattgcaact gcatctgaaa aagggaccct
      781 tataagaata tttgatactt catcagggca tttaatccag gagctacgaa gaggatctca
      841 agcagccaat atctattgca tcaacttcaa tcaggacgct tctctcatct gtgtgtccag
      901 tgatcatggc actgtgcaca tttttgcagc cgaagatcca aaaaggaata aacagtctag
      961 tttggcatca gccagtttcc ttccaaaata cttcagctcc aagtggagtt tttccaagtt
     1021 tcaggttcct tcaggctcac catgcatctg tgcctttgga acagagccca atgcagtcat
     1081 tgctatctgt gcagatggca gctactacaa gttcctgttc agtccgaagg gcgagtgtgt
     1141 ccgggacgtg tgtgcacagt tcctggagat gaccgatgac aagctgtgac tgtgcctgtg
     1201 agcgcaggtg atgccaccac ccagccgccc tgtggactcc tggggctggt gccagtgccc
     1261 caggcctgtg ggtgaggggc tcaaggcccc cctggaggac cttggtctcg aagccatacg
     1321 tggttgtctg ccttcctgag caaggcttct catcccatat taaaggatca tcatcatggt
     1381 tctgcagaca ctccgtggct ctgggcggtt cgtgcccttg ctagccacta cccttcaatt
     1441 cacctgtgat gctagcatta atggcaccac catattcatg ccagtaggct ccctgcagtc
     1501 cttgggaact atccaagcac gaatcagcag aagcttgtag gatgagtgtg tcggggctta
     1561 aatactagac agttccaatg agataacact atcagcttgt ctggtagagc accccctgcc
     1621 tcacatgggg agcactgttc agagcacaca ctggggagtt ctgactttgg ccattagagt
     1681 gagtcacatc ccagacctac cagagagcag aatgcttgtg gcacccattt gaggcacagc
     1741 cctcaggatg cagggtgctg ggtcttctgg ttttgtttgg gttaaaacag aactttccca
     1801 ttatctgtag ggaacagagt aacgcatagt ctttaaaaat cagtcccaga agagagcatt
     1861 gctttactga ggggccttct cagtgcagtg tccatgtgcc tctagctccc gttggtgtgg
     1921 agggtactgc cttggcctgt ggcgtttgtc ctgtctcatc tctcccagca tccataggaa
     1981 cacactaaca ttgggatggc aggcacatcc tggtactggc acagactgaa gagtctgtgt
     2041 ttctgtacca cttgaggtat atgtttagtt tttttacgta tcttctaaga agctcagttt
     2101 tgcggttttg atttcaggtt gcaaacattt aaattgtgca cagcaacagg ttctcagttc
     2161 tgccagttcc tttatgctcc tgtaatcggc taactgtgga tttgatgtca agtatgcatg
     2221 ttaccttatg tgtatttaat catgaaactt aatttttgca cacttgtttg tactgttttc
     2281 tttgaaataa aagtgactaa ttttgtcgta ctctatctgt aaagagcaga gccatatgta
     2341 atgt
//
