LOCUS       NM_001290792            1601 bp    mRNA    linear   ROD 22-DEC-2022
DEFINITION  Mus musculus WD repeat domain 45 (Wdr45), transcript variant 1,
            mRNA.
ACCESSION   NM_001290792 XM_006527655
VERSION     NM_001290792.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1601)
  AUTHORS   Noda M, Ito H and Nagata KI.
  TITLE     Physiological significance of WDR45, a responsible gene for
            beta-propeller protein associated neurodegeneration (BPAN), in
            brain development
  JOURNAL   Sci Rep 11 (1), 22568 (2021)
   PUBMED   34799629
  REMARK    GeneRIF: Physiological significance of WDR45, a responsible gene
            for beta-propeller protein associated neurodegeneration (BPAN), in
            brain development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1601)
  AUTHORS   Biagosch CA, Vidali S, Faerberboeck M, Hensler SV, Becker L, Amarie
            OV, Aguilar-Pimentel A, Garrett L, Klein-Rodewald T, Rathkolb B,
            Zanuttigh E, Calzada-Wack J, da Silva-Buttkus P, Rozman J, Treise
            I, Fuchs H, Gailus-Durner V, de Angelis MH, Janik D, Wurst W, Mayr
            JA, Klopstock T, Meitinger T, Prokisch H and Iuso A.
  TITLE     A comprehensive phenotypic characterization of a whole-body Wdr45
            knock-out mouse
  JOURNAL   Mamm Genome 32 (5), 332-349 (2021)
   PUBMED   34043061
  REMARK    GeneRIF: A comprehensive phenotypic characterization of a
            whole-body Wdr45 knock-out mouse.
REFERENCE   3  (bases 1 to 1601)
  AUTHORS   Ji C, Zhao H, Li D, Sun H, Hao J, Chen R, Wang X, Zhang H and Zhao
            YG.
  TITLE     Role of Wdr45b in maintaining neural autophagy and cognitive
            function
  JOURNAL   Autophagy 16 (4), 615-625 (2020)
   PUBMED   31238825
  REMARK    GeneRIF: Role of Wdr45b in maintaining neural autophagy and
            cognitive function.
REFERENCE   4  (bases 1 to 1601)
  AUTHORS   Wan H, Wang Q, Chen X, Zeng Q, Shao Y, Fang H, Liao X, Li HS, Liu
            MG, Xu TL, Diao M, Li D, Meng B, Tang B, Zhang Z and Liao L.
  TITLE     WDR45 contributes to neurodegeneration through regulation of ER
            homeostasis and neuronal death
  JOURNAL   Autophagy 16 (3), 531-547 (2020)
   PUBMED   31204559
  REMARK    GeneRIF: WDR45 contributes to neurodegeneration through regulation
            of ER homeostasis and neuronal death.
REFERENCE   5  (bases 1 to 1601)
  AUTHORS   Zhao YG, Sun L, Miao G, Ji C, Zhao H, Sun H, Miao L, Yoshii SR,
            Mizushima N, Wang X and Zhang H.
  TITLE     The autophagy gene Wdr45/Wipi4 regulates learning and memory
            function and axonal homeostasis
  JOURNAL   Autophagy 11 (6), 881-890 (2015)
   PUBMED   26000824
  REMARK    GeneRIF: Nes-Wdr45(fl/Y) mice recapitulate some hallmarks of
            beta-propeller protein-associated neurodegeneration, including
            cognitive impairment and defective axonal homeostasis
REFERENCE   6  (bases 1 to 1601)
  AUTHORS   Tang F, Barbacioru C, Nordman E, Bao S, Lee C, Wang X, Tuch BB,
            Heard E, Lao K and Surani MA.
  TITLE     Deterministic and stochastic allele specific gene expression in
            single mouse blastomeres
  JOURNAL   PLoS One 6 (6), e21208 (2011)
   PUBMED   21731673
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL671995.4.
            
            [WARNING] On Dec 8, 2023 this sequence was replaced by
            NM_001290792.2.
            
            On Mar 20, 2014 this sequence version replaced XM_006527655.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (a). Variants 1, 2, and 3
            encode isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK018409.1, SRR7652917.651408.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-159               AL671995.4         31866-32024
            160-231             AL671995.4         33495-33566
            232-306             AL671995.4         33670-33744
            307-411             AL671995.4         33833-33937
            412-517             AL671995.4         35577-35682
            518-612             AL671995.4         35844-35938
            613-692             AL671995.4         36332-36411
            693-901             AL671995.4         36524-36732
            902-1003            AL671995.4         36816-36917
            1004-1149           AL671995.4         36993-37138
            1150-1601           AL671995.4         37396-37847
FEATURES             Location/Qualifiers
     source          1..1601
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.48 cM"
     gene            1..1601
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /note="WD repeat domain 45"
                     /db_xref="GeneID:54636"
                     /db_xref="MGI:MGI:1859606"
     exon            1..159
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            160..231
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..1259
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /note="isoform a is encoded by transcript variant 1; WD
                     repeat domain phosphoinositide-interacting protein 4; WD
                     repeat-containing protein 45; WD repeat domain, X-linked
                     1"
                     /codon_start=1
                     /product="WD repeat domain phosphoinositide-interacting
                     protein 4 isoform a"
                     /protein_id="NP_001277721.1"
                     /db_xref="CCDS:CCDS29970.1"
                     /db_xref="GeneID:54636"
                     /db_xref="MGI:MGI:1859606"
                     /translation="MTQQPLRGVTSLHFNQDQSCFCCAMETGVRIYNVEPLMEKGHLD
                     HEQVGSVGLVEMLHRSNLLALVGGGSSPKFSEISVLIWDDAREGKDSKDKLVLEFTFT
                     KPVLAVRMRHDKIVIVLRNRIYVYSFPDSPRKLFEFDTRDNPKGLCDLCPSLEKQLLV
                     FPGHKCGSLQLVDLASTKPGTSSAPFTINAHQSDVACVSLNQPGTVVASASQKGTLIR
                     LFDTQSKEKLVELRRGTDPATLYCINFSHDSSFLCASSDKGTVHIFALKDTRLNRRSA
                     LARVGKVGPMIGQYVDSQWSLASFTVPAESACICAFGRNTSKNVNSVIAICVDGTFHK
                     YVFTPDGNCNREAFDVYLDICDDEDF"
     exon            232..306
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            307..411
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            412..517
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            518..612
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            613..692
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            693..901
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1003
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1149
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1601
                     /gene="Wdr45"
                     /gene_synonym="DXImx38e; JM5; Sfc19; Wdrx1; WIPI-4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctcctccgga agtaagacct gatgtaaaca gcagagctgg gcaccaaagc ccgggaggtc
       61 agaaatttgt gccgcaggcg gcaccaacgg ctagggcagg ggtcggggag gggtgatcaa
      121 gtcggcagag gtgacgcgca tctggagcaa gatccaaggg aaggccgtcc tgaatcatga
      181 ctcagcagcc acttcgaggt gtgaccagcc tacatttcaa ccaagaccaa agctgctttt
      241 gctgcgccat ggagacaggc gtccggatct acaatgtgga gccacttatg gagaaggggc
      301 atcttgacca cgagcaggta ggcagcgtgg gcctggtaga gatgctgcac cgatccaacc
      361 tgctggccct ggtgggcggt gggagcagcc ccaagttctc tgagatctca gtgctgatct
      421 gggacgatgc ccgagaaggc aaggactcca aggacaaact ggtgctggag ttcaccttca
      481 ccaagccagt gctggctgtg cgcatgcgcc atgacaagat cgtgattgtg ctgaggaacc
      541 gcatctatgt gtactccttc cctgacagtc caagaaagct gtttgagttt gacactcggg
      601 acaaccccaa ggggctgtgt gacctctgtc caagcctgga gaagcagctg ctcgtgtttc
      661 ctggacacaa gtgtggaagt ctgcaacttg tggatctcgc aagcacaaag cctggtactt
      721 cgtcggcgcc attcactatc aatgcacatc agagtgatgt ggcctgtgtg tccctgaacc
      781 agccaggcac tgtagtggcg tcagcctccc agaagggcac ccttattcgt ctctttgata
      841 cccaatccaa ggaaaagctg gtagagcttc gaagaggcac cgaccctgcc accctgtact
      901 gcattaactt cagccacgac tcctccttcc tctgtgcttc cagtgacaag ggcactgtcc
      961 acatcttcgc tcttaaagac acccgcctta accgccgctc tgcgctggct cgtgtgggca
     1021 aagtgggacc tatgattggg caatacgtgg actctcagtg gagcctggcc agctttactg
     1081 tgcctgctga gtcagcctgc atctgcgcct ttggtcgaaa tacttccaag aatgtcaatt
     1141 ctgtaattgc catctgtgta gatgggacct tccacaaata tgtcttcact cctgatggaa
     1201 actgcaacag agaggccttt gacgtgtacc ttgacatctg tgatgacgag gacttctaaa
     1261 gcatcctggc agctgtactg ggaacctaca gtaccgatgg ccggccgaac tgagtcttga
     1321 gggtgttgaa ccagccagca agcataaatg agcctttcac tctgcatcaa acacagctgt
     1381 gtctaaataa acagctcgct tccacgagca ctttttgtga ctggagtgct aaaggccaga
     1441 ggacagctta gtctgtccct gggcctccta gtctggaaaa caccagggac ccaaagggat
     1501 tatactaatc caacctaagg atttaaaaat aatggttacc aggagatagt ctctgtaatg
     1561 tatatgaata aaaggccttt gagtggcatt tatgacttga c
//
