LOCUS       NM_172590               3035 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WD repeat domain 41 (Wdr41), mRNA.
ACCESSION   NM_172590 XM_006517583 XM_011244648 XM_017315491 XM_912765
VERSION     NM_172590.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3035)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3035)
  AUTHORS   Lan,Y., Sullivan,P.M. and Hu,F.
  TITLE     SMCR8 negatively regulates AKT and MTORC1 signaling to modulate
            lysosome biogenesis and tissue homeostasis
  JOURNAL   Autophagy 15 (5), 871-885 (2019)
   PUBMED   30696333
REFERENCE   3  (bases 1 to 3035)
  AUTHORS   McAlpine,W., Sun,L., Wang,K.W., Liu,A., Jain,R., San Miguel,M.,
            Wang,J., Zhang,Z., Hayse,B., McAlpine,S.G., Choi,J.H., Zhong,X.,
            Ludwig,S., Russell,J., Zhan,X., Choi,M., Li,X., Tang,M.,
            Moresco,E.M.Y., Beutler,B. and Turer,E.
  TITLE     Excessive endosomal TLR signaling causes inflammatory disease in
            mice with defective SMCR8-WDR41-C9ORF72 complex function
  JOURNAL   Proc Natl Acad Sci U S A 115 (49), E11523-E11531 (2018)
   PUBMED   30442666
REFERENCE   4  (bases 1 to 3035)
  AUTHORS   Zhang,Y., Burberry,A., Wang,J.Y., Sandoe,J., Ghosh,S., Udeshi,N.D.,
            Svinkina,T., Mordes,D.A., Mok,J., Charlton,M., Li,Q.Z., Carr,S.A.
            and Eggan,K.
  TITLE     The C9orf72-interacting protein Smcr8 is a negative regulator of
            autoimmunity and lysosomal exocytosis
  JOURNAL   Genes Dev 32 (13-14), 929-943 (2018)
   PUBMED   29950492
REFERENCE   5  (bases 1 to 3035)
  AUTHORS   Yang,M., Liang,C., Swaminathan,K., Herrlinger,S., Lai,F.,
            Shiekhattar,R. and Chen,J.F.
  TITLE     A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual
            role in autophagy
  JOURNAL   Sci Adv 2 (9), e1601167 (2016)
   PUBMED   27617292
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3035)
  AUTHORS   Xu,C. and Min,J.
  TITLE     Structure and function of WD40 domain proteins
  JOURNAL   Protein Cell 2 (3), 202-214 (2011)
   PUBMED   21468892
  REMARK    Review article
REFERENCE   7  (bases 1 to 3035)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082348.1, AK149993.1, AK046853.1, BM943554.1 and BQ043504.1.
            
            On or before Jul 30, 2020 this sequence version replaced
            XM_017315491.2, NM_172590.3.
            
            Summary: This gene encodes a protein of unknown function, but which
            contains a WD40 domain consisting of six WD40 repeats. The WD40
            domain is one of the most abundant protein domains in eukaryotes,
            and is found in proteins with widely varying cellular functions.
            However, proteins with this domain often provide a rigid scaffold
            for protein-protein interactions. [provided by RefSeq, Aug 2012].
            
            CCDS Note: This CCDS ID was updated to correctly position the short
            fifth coding exon, which was mis-positioned in version 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046853.1, AK149993.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK082348.1         34-36
            4-735               AK149993.1         2-733
            736-1802            AK046853.1         737-1803
            1803-2331           AK149993.1         1801-2329
            2332-2628           BM943554.1         306-602
            2629-3035           BQ043504.1         97-503
FEATURES             Location/Qualifiers
     source          1..3035
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 49.22 cM"
     gene            1..3035
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /note="WD repeat domain 41"
                     /db_xref="GeneID:218460"
                     /db_xref="MGI:MGI:2445123"
     exon            1..214
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     CDS             164..1546
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /codon_start=1
                     /product="WD repeat-containing protein 41"
                     /protein_id="NP_766178.2"
                     /db_xref="CCDS:CCDS56896.2"
                     /db_xref="GeneID:218460"
                     /db_xref="MGI:MGI:2445123"
                     /translation="MLRWLIGGGREPQGLAEKAALQTIGEDQGQNPYTELLVLEAHRD
                     IVRFLVRLDDFRFASAGDDGIIVVWNAQTGEKLLELRGHTQKITAVIAFPPLDSCEAS
                     SQLLLTASADRTVGVWDCDTGRQIQRVTCFQSTVKCLTVLQRLDIWLSGGSDLGVWNR
                     KLDLLCKTSHLSDTGISALVEIPGNCVAAAVGRELIIFRLVTPTEELPEWDIIEVKRL
                     LDHQDNILSLANINDTGFVTGSHVGELLIWDALDWTVQACERTFWSPTAQLDAQQEIK
                     LFQKQNDISINHFTCDEENIFAAVGRGLYVYNLQLKRVIACQKTAHDSNILHIDKLPN
                     RQLISCSEDGAVRMWEVREKQQLAAEPVPTGFFNMWGFGRVNKQASQPVKKQEENVTT
                     CSLELIGDLIGHSSSVEMFLYFEDHGLVTCSADHLIILWKNGERESGVRSLKLFQKLE
                     ENGDLYPESP"
     exon            215..330
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            331..379
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            380..509
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            510..512
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            513..574
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            575..686
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            687..749
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            750..860
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1045
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1167
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1256
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1390
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..3035
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /note="hexamer: AATATA"
     polyA_site      3035
                     /gene="Wdr41"
                     /gene_synonym="B830029I03Rik; MSTP048"
                     /note="major polyA site"
ORIGIN      
        1 actggggacg cggaacctcc gcctccgccg tcgcggcctt cagtgcgggc gccccaacga
       61 gacttctgtt ttcccgctgc ctcgccccag gctcactcgg ccgcagcccc agcacctgcg
      121 ccgcggcggc cctcgctccg tgggccgcgg acgccccggc ccgatgctgc gctggctgat
      181 cggaggaggc cgcgagccgc agggcctagc cgagaaagct gctttgcaga caataggaga
      241 ggaccaaggt cagaacccct atactgaact gctggtactg gaggctcatc gcgacattgt
      301 ccgcttcctg gtgaggctcg atgacttcag gtttgcatct gctggcgatg atggaattat
      361 agttgtgtgg aatgcccaga caggagaaaa acttctggaa ctcagaggac acactcagaa
      421 gataacggct gtcattgcgt ttcctcccct agactcgtgt gaggccagca gtcagcttct
      481 cttgacagcc tcggctgacc ggactgtcgg tgtttgggat tgcgacaccg gccggcaaat
      541 ccagagagtc acgtgcttcc agtctacggt aaagtgcttg accgttcttc agagactgga
      601 catttggctg tcaggcggta gtgacctagg cgtgtggaac cgaaagttag atctgctgtg
      661 taaaaccagc cacctatccg acacagggat cagtgctttg gttgaaatcc ctgggaactg
      721 tgtcgccgca gcagtgggca gagaattgat aatttttagg cttgtgacac ccacagaaga
      781 attgccggaa tgggatatta ttgaagttaa acgccttctt gatcaccagg acaatattct
      841 gtcattggct aacatcaatg atacaggttt cgtcactggc tcccacgttg gcgagctgct
      901 catctgggat gccctggact ggactgtgca ggcctgtgag cgcaccttct ggagcccgac
      961 cgcacagctg gatgcccagc aggaaataaa gctcttccaa aaacaaaatg atatttctat
     1021 taatcatttc acatgcgatg aagagaatat atttgctgca gttggaaggg ggttatatgt
     1081 gtataaccta cagttgaagc gtgtgattgc ctgccagaaa actgcacatg attccaacat
     1141 cctacacatc gataaacttc caaacaggca gttaatctca tgctcggaag atggcgctgt
     1201 gcgcatgtgg gaggtccgag aaaaacagca gctggcagct gagccagtcc caacaggatt
     1261 ttttaatatg tggggatttg gaagagtaaa caaacaggcc agccagcctg ttaaaaagca
     1321 ggaagaaaac gttaccacgt gttccctgga gctcatcgga gatctcattg gacattcatc
     1381 gtctgtcgag atgtttctat actttgagga tcatggacta gtgacatgct ctgcagatca
     1441 tctcattatt ttgtggaaaa atggagagcg agaatctgga gtacgcagct taaagttatt
     1501 tcagaagtta gaagagaacg gtgacttata cccagagtcc ccttgaagga gccagacagg
     1561 cgtgcagacc cgaaccccgc acagccaaca cagcgcgccc ggtaccctga aaaccatcag
     1621 cacactgacc ccttactgta ctcttttctt gcctgtgaag gtctgtctgt ctgtctgtct
     1681 gtctgtctgt aacacctgtc cactcaagaa catagcacaa catggccttg ttgctgtgca
     1741 agtggtgggt gctgtgttct gtcccttaaa acggtagaaa aaatgataac tgtaaggttg
     1801 ccacacacta tttacaagtg ttcttttggg ttcccttaga gactgtctga gacttgtcat
     1861 gggagatgta tcctctctgc tgctcctcag aagccatctg tgtccaacag aaccagactt
     1921 gaatattagc cccccaaaag gaattctact ctttaagtac aatgattttg tttggtacca
     1981 actaatttaa gtcattgaaa aaataatatt tactcttgcc cactaaaatc cctgtgtcct
     2041 ccggtcccca ggcgtcatct gagcatttct ttctcagtgt gaactggcct gacccctcac
     2101 tgacagaata gtcttcaggt gtttctggga tgcgtcctgg gttaggaagg aggcacagct
     2161 ttttctcagg tcaggaactg tagctgagtt gtcctgtttg ccttaaatgg ttgagagcag
     2221 cttcactgtt cagctctctg aacatccact aagactggac catgttcctc gccctaccag
     2281 cctgatgaca gtactcactt tgggcactaa aatgtaaaat atactccaca cagtaagaat
     2341 gggggagggg agggttgatt aagaaatctt attaaagaca ggcaagatga atgtacgtct
     2401 acagatgtgt gtgtgtacac acgtactctg ctccctagat ggacacgcga aattcttgct
     2461 tccgctagtt ctaacattca cagctgtcta cagccaaagc ttggtagcat taaaatcata
     2521 gggcgatgag tggcaaaatg ttagacgtga ggaagccaag accggggtag gaaagccctc
     2581 tctccagtgc ccatcaccat cactgaacag ccttaaaagc agaggccaga ggaggagagt
     2641 gaggagggct gagcgggtga cctggtgacc aagttaggaa aaccagagtg ttcccagtcc
     2701 ttgctgctgg cacagttcac aatgaaaata gctttatata aaaagatagc attacagcat
     2761 gagctgcctt agttaggacg tagcaggatg caaatgggaa aatctagtgt cttttagcca
     2821 gaaaaccatt gttctttgag gagtcagcac aggaggcagg tttgtcatca cccaccctgc
     2881 agatgtcatg ggggaagcac ccaccagcca ggcagacgcg ccgtccgctc aaagtgacag
     2941 gagtgcatcc ccttgccgtt tactttggct aaattgtttt aggctattgg tttgtaaaga
     3001 tgttttctta aataatataa gacaaagaac tcata
//
