LOCUS       NP_067297                456 aa            linear   ROD 12-JUN-2025
DEFINITION  tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4
            isoform a [Mus musculus].
ACCESSION   NP_067297 XP_030105793 XP_909582
VERSION     NP_067297.2
DBSOURCE    REFSEQ: accession NM_021322.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 456)
  AUTHORS   Ma,J., Zheng,S., An,C., Han,H., Li,Q., Huang,Y., Xiong,G., Chen,S.,
            Guo,S., Wang,Z., Wei,W., Shang,Y., Ji,Y., Yang,C., Choe,J.,
            Yuan,Q., Fan,Y., Zhang,C. and Lin,S.
  TITLE     Pathogenic mechanism and therapeutic intervention of impaired
            N7-methylguanosine (m7G) tRNA modification
  JOURNAL   Proc Natl Acad Sci U S A 121 (45), e2405886121 (2024)
   PUBMED   39471230
REFERENCE   2  (residues 1 to 456)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 456)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 456)
  AUTHORS   Wu,P.R., Chiang,S.Y., Midence,R., Kao,W.C., Lai,C.L., Cheng,I.C.,
            Chou,S.J., Chen,C.C., Huang,C.Y. and Chen,R.H.
  TITLE     Wdr4 promotes cerebellar development and locomotion through
            Arhgap17-mediated Rac1 activation
  JOURNAL   Cell Death Dis 14 (1), 52 (2023)
   PUBMED   36681682
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 456)
  AUTHORS   Lee,C.C. and Hsieh,T.S.
  TITLE     Wuho/WDR4 deficiency inhibits cell proliferation and induces
            apoptosis via DNA damage in mouse embryonic fibroblasts
  JOURNAL   Cell Signal 47, 16-26 (2018)
   PUBMED   29574139
  REMARK    GeneRIF: WDR4 protein deficiency would induces gammaH2AX protein
            level elevation, heterochromatin relaxation and DNA damage
            down-stream sequences, including p53 activation, caspase-mediated
            apoptotic pathway, and p21-mediated G2/M cell cycle arrest.
REFERENCE   6  (residues 1 to 456)
  AUTHORS   Kenney-Hunt,J.P., Vaughn,T.T., Pletscher,L.S., Peripato,A.,
            Routman,E., Cothran,K., Durand,D., Norgard,E., Perel,C. and
            Cheverud,J.M.
  TITLE     Quantitative trait loci for body size components in mice
  JOURNAL   Mamm Genome 17 (6), 526-537 (2006)
   PUBMED   16783635
REFERENCE   7  (residues 1 to 456)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (residues 1 to 456)
  AUTHORS   Gitton,Y., Dahmane,N., Baik,S., Ruiz i Altaba,A., Neidhardt,L.,
            Scholze,M., Herrmann,B.G., Kahlem,P., Benkahla,A., Schrinner,S.,
            Yildirimman,R., Herwig,R., Lehrach,H. and Yaspo,M.L.
  CONSRTM   HSA21 expression map initiative
  TITLE     A gene expression map of human chromosome 21 orthologues in the
            mouse
  JOURNAL   Nature 420 (6915), 586-590 (2002)
   PUBMED   12466855
REFERENCE   9  (residues 1 to 456)
  AUTHORS   Reymond,A., Marigo,V., Yaylaoglu,M.B., Leoni,A., Ucla,C.,
            Scamuffa,N., Caccioppoli,C., Dermitzakis,E.T., Lyle,R., Banfi,S.,
            Eichele,G., Antonarakis,S.E. and Ballabio,A.
  TITLE     Human chromosome 21 gene expression atlas in the mouse
  JOURNAL   Nature 420 (6915), 582-586 (2002)
   PUBMED   12466854
REFERENCE   10 (residues 1 to 456)
  AUTHORS   Michaud,J., Kudoh,J., Berry,A., Bonne-Tamir,B., Lalioti,M.D.,
            Rossier,C., Shibuya,K., Kawasaki,K., Asakawa,S., Minoshima,S.,
            Shimizu,N., Antonarakis,S.E. and Scott,H.S.
  TITLE     Isolation and characterization of a human chromosome 21q22.3 gene
            (WDR4) and its mouse homologue that code for a WD-repeat protein
  JOURNAL   Genomics 68 (1), 71-79 (2000)
   PUBMED   10950928
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166172.1.
            
            On or before Apr 20, 2022 this sequence version replaced
            XP_030105793.1, NP_067297.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.525699.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..456
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 16.56 cM"
     Protein         1..456
                     /product="tRNA (guanine-N(7)-)-methyltransferase
                     non-catalytic subunit WDR4 isoform a"
                     /note="tRNA (guanine-N(7)-)-methyltransferase subunit
                     WDR4; WD repeat-containing protein 4; WD40 repeat protein
                     4; tRNA (guanine-N(7)-)-methyltransferase non-catalytic
                     subunit WDR4; protein Wuho homolog"
                     /calculated_mol_wt=50274
     Region          60..>272
                     /region_name="WD40"
                     /note="WD40 domain, found in a number of eukaryotic
                     proteins that cover a wide variety of functions including
                     adaptor/regulatory modules in signal transduction,
                     pre-mRNA processing and cytoskeleton assembly; typically
                     contains a GH dipeptide 11-24 residues from...; cl29593"
                     /db_xref="CDD:475233"
     Region          110..147
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          150..186
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          194..229
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     CDS             1..456
                     /gene="Wdr4"
                     /gene_synonym="D530049K22Rik; mWH; Wh"
                     /coded_by="NM_021322.3:260..1630"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS28606.2"
                     /db_xref="GeneID:57773"
                     /db_xref="MGI:MGI:1889002"
ORIGIN      
        1 mrlrparmll dgtpfarrrv tsltsanrkg aarrtcpeaa ggpmassagl alcaqtlvvr
       61 ggsrflafst tgsdddcvft ydcstaekka tpedkgedgq padtgsdsil astfsksgry
      121 faltddskrl ilfrtkpwqc lsvrmvvrrc taltftased rvlvadksgd vysfsvlepd
      181 gcgrlelghl smlldvavsp ddqfvltadr dekirvswaa aphsiesfcl ghtefvsril
      241 vvpshpelll sssgdgtlrl weyrsgrqlq ccdlaglqep geqpghkgla asriafwgqe
      301 syvvllcecv pvvfvfqlda srqqlvfrqr ltfphrvwdv vfeearglwv lqdcrdaplv
      361 lwrpvggewq aapdgavspr lcshlreswa mlegsvgtdd sfrslykatf dnmtsylkkk
      421 eerlqqqlkk krqrspfpgs peqtkkacpg qsalsc
//
