LOCUS       NM_172445               4555 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WD repeat domain 37 (Wdr37), transcript variant 1,
            mRNA.
ACCESSION   NM_172445
VERSION     NM_172445.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4555)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4555)
  AUTHORS   Nair-Gill,E., Bonora,M., Zhong,X., Liu,A., Miranda,A., Stewart,N.,
            Ludwig,S., Russell,J., Gallagher,T., Pinton,P. and Beutler,B.
  TITLE     Calcium flux control by Pacs1-Wdr37 promotes lymphocyte quiescence
            and lymphoproliferative diseases
  JOURNAL   EMBO J 40 (9), e104888 (2021)
   PUBMED   33630350
  REMARK    GeneRIF: Calcium flux control by Pacs1-Wdr37 promotes lymphocyte
            quiescence and lymphoproliferative diseases.
REFERENCE   3  (bases 1 to 4555)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4555)
  AUTHORS   Kannan,M., Bayam,E., Wagner,C., Rinaldi,B., Kretz,P.F., Tilly,P.,
            Roos,M., McGillewie,L., Bar,S., Minocha,S., Chevalier,C., Po,C.,
            Chelly,J., Mandel,J.L., Borgatti,R., Piton,A., Kinnear,C., Loos,B.,
            Adams,D.J., Herault,Y., Collins,S.C., Friant,S., Godin,J.D. and
            Yalcin,B.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     WD40-repeat 47, a microtubule-associated protein, is essential for
            brain development and autophagy
  JOURNAL   Proc Natl Acad Sci U S A 114 (44), E9308-E9317 (2017)
   PUBMED   29078390
REFERENCE   5  (bases 1 to 4555)
  AUTHORS   Pan,J., Mor,G., Ju,W., Zhong,J., Luo,X., Aldo,P.B., Zhong,M.,
            Yu,Y., Jenkins,E.C., Brown,W.T. and Zhong,N.
  TITLE     Viral Infection-Induced Differential Expression of LncRNAs
            Associated with Collagen in Mouse Placentas and Amniotic Sacs
  JOURNAL   Am J Reprod Immunol 74 (3), 237-257 (2015)
   PUBMED   26073538
REFERENCE   6  (bases 1 to 4555)
  AUTHORS   Liakath-Ali,K., Vancollie,V.E., Heath,E., Smedley,D.P., Estabel,J.,
            Sunter,D., Ditommaso,T., White,J.K., Ramirez-Solis,R., Smyth,I.,
            Steel,K.P. and Watt,F.M.
  TITLE     Novel skin phenotypes revealed by a genome-wide mouse reverse
            genetic screen
  JOURNAL   Nat Commun 5, 3540 (2014)
   PUBMED   24721909
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4555)
  AUTHORS   Bulfone,A., Carotenuto,P., Faedo,A., Aglio,V., Garzia,L.,
            Bello,A.M., Basile,A., Andre,A., Cocchia,M., Guardiola,O.,
            Ballabio,A., Rubenstein,J.L. and Zollo,M.
  TITLE     Telencephalic embryonic subtractive sequences: a unique collection
            of neurodevelopmental genes
  JOURNAL   J Neurosci 25 (33), 7586-7600 (2005)
   PUBMED   16107646
REFERENCE   8  (bases 1 to 4555)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134699.1, AK036203.1 and AC132433.3.
            
            On Oct 22, 2013 this sequence version replaced NM_172445.2.
            
            Transcript Variant: This variant (1) encodes isoform a. Both
            variants 1 and 2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146209.1, AK032582.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 CJ134699.1         2-6
            6-2613              AK036203.1         2-2609
            2614-4555           AC132433.3         9791-11732
FEATURES             Location/Qualifiers
     source          1..4555
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 3.6 cM"
     gene            1..4555
                     /gene="Wdr37"
                     /note="WD repeat domain 37"
                     /db_xref="GeneID:207615"
                     /db_xref="MGI:MGI:1920393"
     exon            1..175
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            176..353
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     CDS             216..1706
                     /gene="Wdr37"
                     /note="isoform a is encoded by transcript variant 1; WD
                     repeat-containing protein 37"
                     /codon_start=1
                     /product="WD repeat-containing protein 37 isoform a"
                     /protein_id="NP_766033.1"
                     /db_xref="CCDS:CCDS26232.1"
                     /db_xref="GeneID:207615"
                     /db_xref="MGI:MGI:1920393"
                     /translation="MPTESGSCSTARQAKQKRKSHSLSIRRTNSSEQERTGLPREMLE
                     GQDSKLPSSVRSTLLELFGQIEREFENLYIENLELRREIDTLNERLAGEGQAIDGAEL
                     SKGQLKTKASHSTSQLSQKLKTTYKASTSKIVSSFKTTTSRAICQLVKEYIGHRDGIW
                     DVSVTRTQPIVLGTASADHTALLWSIETGKCLVKYAGHVGSVNSIKFHPSEQLALTAS
                     GDQTAHIWRYVVQLPTPQPVADTSQQISGEDEIECSDKDEPDIDGDVSSDCPTVRVPL
                     TSLKSHQGVVIAADWLVGGKQVVTASWDRTANLYDVETSELVHSLTGHDQELTHCCTH
                     PTQRLVVTSSRDTTFRLWDFRDPSIHSVNVFQGHTDTVTSAVFTVGDNVVSGSDDRTV
                     KVWDLKNMRSPIATIRTDSAINRINVCVGQKIIALPHDNRQVRLFDMSGVRLARLPRS
                     SRQGHRRMVCCSAWSEDHPICNLFTCGFDRQAIGWNINIPALLQEK"
     exon            354..450
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            451..546
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            547..611
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            612..747
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            748..819
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            820..864
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            865..941
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1182
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1324
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1459
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1574
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..4555
                     /gene="Wdr37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4504..4509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr37"
                     /note="hexamer: ATTAAA"
     polyA_site      4526
                     /gene="Wdr37"
                     /note="major polyA site"
ORIGIN      
        1 agttaccgga agtacgggcg cgccagttcg ggtcgccggg ttgtgtcagt gcgggaatcg
       61 gccggttttt tttcctgctc tgggtctgcc tcgggagcct cgtcgcgggg ggatctacga
      121 attgagtgcg acgtaggctg gttccaggcg gacgcgagtg ctgctgctgt gacagcttat
      181 tgcaggagtg accaggacac taccttctag aagtaatgcc cacagaaagc ggaagttgtt
      241 caactgctcg ccaagcaaaa caaaagcgca agtctcatag cctttctata cgaagaacta
      301 acagctcaga acaagagagg actggactgc caagagaaat gttagaagga caagattcta
      361 aactgccgtc ctcagttcgc agtacactgc tggaattgtt tggccagata gaaagagaat
      421 ttgaaaatct ttacatcgaa aacttagaat tgcgcagaga aattgatact cttaatgaac
      481 gtttagctgg tgaaggacaa gcgatcgatg gggcagaatt gagtaagggc caactcaaaa
      541 caaaagccag tcacagtacc agtcagcttt ctcagaagct taagaccacc tacaaggctt
      601 ccaccagcaa gattgtttcc agctttaaga ctaccacatc cagggccatc tgtcagcttg
      661 tgaaggagta tattggccac agggatggca tctgggatgt cagtgttaca aggacacagc
      721 ctattgttct tgggacagca tctgctgatc acacggcttt gttgtggagc atagagactg
      781 gcaaatgtct tgtcaagtac gctggccatg tgggctcagt aaattctata aaattccatc
      841 cctcagagca gttggctctt actgcttctg gagatcagac tgctcatatc tggagatacg
      901 tggtacagct tccaacacct cagcctgttg ccgacactag tcaacaaatt tctggtgaag
      961 atgaaataga atgctctgat aaagatgagc ctgacattga tggagacgtg tccagtgact
     1021 gtcctactgt ccgagtccca ctgacatctc tcaaaagcca ccagggtgtg gttattgctg
     1081 ctgactggct ggttggtggg aaacaagtgg tgacagcctc atgggacaga actgccaacc
     1141 tgtatgatgt ggagacatct gaactcgttc attccctgac agggcatgac caggagttaa
     1201 cacattgttg cactcacccc acccagcggc tcgtggtgac ctcctcccgt gacacaactt
     1261 tccgtctctg ggatttcagg gacccttcca tccactccgt gaatgttttc caaggacaca
     1321 cggacactgt gacctctgct gtgttcactg tgggagacaa cgtcgtttca ggcagtgatg
     1381 accgcacagt aaaagtctgg gatttaaaaa atatgagatc tccaattgcg acaattcgta
     1441 cagactctgc cattaatagg atcaatgtgt gtgttggcca aaaaatcata gccctccccc
     1501 atgacaaccg gcaagtgcga ttgtttgata tgtcgggagt gaggctagca cggcttcccc
     1561 ggagcagccg acagggtcac agacgaatgg tgtgctgctc agcgtggagt gaagaccacc
     1621 ccatatgcaa tctatttacc tgtgggttcg ataggcaagc tattgggtgg aacatcaata
     1681 ttcctgcact gttacaagaa aaataagtca ctgatgttcc ttagctccaa gtttgccatg
     1741 gacttttgat tcatgcaggc tcttctgcat attaatcagc cattatagtg agagtttgac
     1801 cctgggaagg gtgccttgta tatgttcttt tcacattgtg cccagcttgc atgaagtgta
     1861 cagagagatg tgtgattctg ttttttattt ttgtcttgtg tataatggca tcctctggtc
     1921 agtagaagtg aagctcactc catgtagcat acaaaatgct ttgagttgtt gaagctgaca
     1981 gatgagcagt agggcattac attacattgt atgaatcaaa tgtgaactgt gtgtctattg
     2041 tgaggcataa acagtctgtt acattgtctg gagtaactag acataactac cttgtcctgg
     2101 gaagactgca gagctcattt gcattggcta gcacgaggca ggactgacag atttcattct
     2161 tacttggttt atgtgaagtt gtagaacgtg ctgttgtgta atttcatttc gactcttgac
     2221 ttctgttccg gtcctgtaaa agaaacctgg atttgcaacg ttttgtgcag aatttctttt
     2281 gagaagaaaa tgtttctgct attttgtaga aaatgatttc aatctcttga ggtctcatac
     2341 aagcaaattt taaaatacga ttattctaat catcgatttt agacattaaa cagaattcaa
     2401 agcactttaa tttatagctg tggttataaa cagtttttag aagtttcaaa tgatttatcc
     2461 attgaatgtg acttgatctt tatacaaagg cccttctacc tgaagacaaa atattattta
     2521 ttttctacat ctttggtttt catatttcta aatgggttca cttccttggt ggtgtttgga
     2581 gagccaagaa tgcaaataaa tgagcactac ctcaaaataa atattgggaa acctttggag
     2641 tctcactgct gcatggataa agcacttgat ttaaagctgg attattgaat tcaaggcaga
     2701 aggcaagaaa gacaaccgca ccctatgtag cttgcaggtg aaaggctctc taggtagcct
     2761 gggaaggtga tagccgtggc agacagttat ataggcaacc agaagcgctt gtcttgaaca
     2821 gcttggatac ctctcagtgc cagtctttct actgcacgag tgagcctttt gttctctcct
     2881 tctagacatc actgttcatc tgatgtttgt aagtttgtgt ttcatacaga gttacagttt
     2941 tgataaagag acatctcagt tactgcccct aaggcattaa tcctttccat accgccctac
     3001 ggagagtgac catttaggga gaagagaaga ggtaatacac tgttatggtc accccccccc
     3061 cccaacccca acccctggct ttctcgttgg gtggcatagg agggcacctg aactctagta
     3121 agtggtagga agtttggtat aagatgtcta atgtgcatag aacatttggg tggcatagga
     3181 gggcacctga actctagtaa gtggtaggaa gtttggtata agatgtctaa tgtgcataga
     3241 acatttgggt ggcactttcc aggagtgaga acttggttat tgacatcttt gacttgggca
     3301 ccaaagttgc tgatcttagg aacttcgtat ctgactcgtt agaaagattc tttgagtaat
     3361 tttgtttttg caactttaaa aaaaaaaaaa acattgtatt tttaaagttt gaccgtttct
     3421 gatcacgagt ctcactgtgg tgtatttgag agctgagtcc ggctggtcac tgtagttgat
     3481 taaaatgtta gagccagctc tggctgtctt gaatgtattt tgcttgatgg tggaatactg
     3541 tgtgacgatg atcctggtgg actgcttgac tttacagcca cgcagggttt ccatacccct
     3601 ccattccact ctgttcacag agttgttcat gtcagtggca agccatgttc ttatgttctt
     3661 tgcatcttaa tcccaaagtc taggtatagt taggaacatt gaaaaaatgt atgcaaatac
     3721 aaacagcaaa atcaaacata ggacctacca gacacaattt tggagcttta aaaagtcttt
     3781 attggtgatc atcgacttgt atacaaacta gtgtccttca ctgccaatgg ctgcttattt
     3841 tctttggcta actggaggga cgagcctctg acatagacat gaggctcccc acgcatttcc
     3901 acgagggcag aagacgctaa tggtgctcga tgagagtact caggggcaga tgtgacttac
     3961 attaactgct gtttgtcgtc tgtcctcacc ccgttgctgc tgtgagcaca gtgttatctt
     4021 taagagtctg tgattggcat gggcttgagc tcatgaatgt gtgtaggcct tgtacgtgtg
     4081 gctaaggata tgtcatgcta tcagccacag ctaatcttat attagaaata gtgtttggaa
     4141 ttaggaacac tattatgtgc tggagtgtcc agaatttcat ttaataatgg aggggaaata
     4201 tgtggttact aaatgtgcat taatataaaa tttcccaaga gatttgttgg acagaaatat
     4261 ccctgccctc accataactg aagcatacca gtttttgtag agtcaaaaaa gctgtacata
     4321 tttgggaatc tgaagactat gtaaatcatt tgttacttaa atctgtgaaa aaaggtttta
     4381 ttttgttttg ttttattttt gagggaaaag tgcatttata agtgttctgt ggaatcagtt
     4441 atctttactg tgttgatgta actgtttgta aatgttcagt gtcttcattg aaatacgaag
     4501 ttcattaaaa catttgtgtt ccataattac tattataaag gtttgtgtta ttggg
//
