LOCUS       NM_001110015            3226 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WD repeat domain 36 (Wdr36), transcript variant 1,
            mRNA.
ACCESSION   NM_001110015
VERSION     NM_001110015.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3226)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3226)
  AUTHORS   Blankenbach,K.V., Bruno,G., Wondra,E., Spohner,A.K., Aster,N.J.,
            Vienken,H., Trautmann,S., Ferreiros,N., Wieland,T., Bruni,P. and
            Meyer Zu Heringdorf,D.
  TITLE     The WD40 repeat protein, WDR36, orchestrates sphingosine kinase-1
            recruitment and phospholipase C-beta activation by Gq-coupled
            receptors
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1865 (7), 158704 (2020)
   PUBMED   32244061
  REMARK    GeneRIF: The WD40 repeat protein, WDR36, orchestrates sphingosine
            kinase-1 recruitment and phospholipase C-beta activation by
            Gq-coupled receptors.
REFERENCE   3  (bases 1 to 3226)
  AUTHORS   Gallenberger,M., Kroeber,M., Marz,L., Koch,M., Fuchshofer,R.,
            Braunger,B.M., Iwata,T. and Tamm,E.R.
  TITLE     Heterozygote Wdr36-deficient mice do not develop glaucoma
  JOURNAL   Exp Eye Res 128, 83-91 (2014)
   PUBMED   25261604
  REMARK    GeneRIF: Our data obtained in Wdr36(+/-) mice do not support the
            assumption of a causative role for WDR36 in the pathogenesis of
            primary open-angle glaucoma.
REFERENCE   4  (bases 1 to 3226)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 3226)
  AUTHORS   Gallenberger,M., Meinel,D.M., Kroeber,M., Wegner,M., Milkereit,P.,
            Bosl,M.R. and Tamm,E.R.
  TITLE     Lack of WDR36 leads to preimplantation embryonic lethality in mice
            and delays the formation of small subunit ribosomal RNA in human
            cells in vitro
  JOURNAL   Hum Mol Genet 20 (3), 422-435 (2011)
   PUBMED   21051332
  REMARK    GeneRIF: results provide evidence that WDR36 is an essential
            protein in mammalian cells which is involved in the nucleolar
            processing of small subunit 18S rRNA
REFERENCE   6  (bases 1 to 3226)
  AUTHORS   Chi,Z.L., Yasumoto,F., Sergeev,Y., Minami,M., Obazawa,M.,
            Kimura,I., Takada,Y. and Iwata,T.
  TITLE     Mutant WDR36 directly affects axon growth of retinal ganglion cells
            leading to progressive retinal degeneration in mice
  JOURNAL   Hum Mol Genet 19 (19), 3806-3815 (2010)
   PUBMED   20631153
  REMARK    GeneRIF: WDR36 plays an important functional role in the retina
            homeostasis and mutation to this gene can cause devastating retinal
            damage.
REFERENCE   7  (bases 1 to 3226)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
REFERENCE   8  (bases 1 to 3226)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140983.4.
            
            On Jan 27, 2022 this sequence version replaced NM_001110015.1.
            
            Transcript Variant: This variant (1) represents the longest variant
            and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156822.1, BC022132.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC140983.4         83105-83407
            304-331             AC140983.4         85281-85308
            332-432             AC140983.4         86892-86992
            433-550             AC140983.4         87746-87863
            551-683             AC140983.4         89611-89743
            684-738             AC140983.4         91440-91494
            739-871             AC140983.4         92679-92811
            872-1047            AC140983.4         92991-93166
            1048-1168           AC140983.4         93438-93558
            1169-1234           AC140983.4         94145-94210
            1235-1321           AC140983.4         94922-95008
            1322-1470           AC140983.4         96236-96384
            1471-1585           AC140983.4         97830-97944
            1586-1751           AC140983.4         98334-98499
            1752-1860           AC140983.4         98713-98821
            1861-1940           AC140983.4         100629-100708
            1941-2048           AC140983.4         105069-105176
            2049-2146           AC140983.4         106876-106973
            2147-2292           AC140983.4         107351-107496
            2293-2412           AC140983.4         108774-108893
            2413-2494           AC140983.4         109030-109111
            2495-2682           AC140983.4         110502-110689
            2683-3226           AC140983.4         111702-112245
FEATURES             Location/Qualifiers
     source          1..3226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 18.13 cM"
     gene            1..3226
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /note="WD repeat domain 36"
                     /db_xref="GeneID:225348"
                     /db_xref="MGI:MGI:1917819"
     exon            1..303
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..2832
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="WD repeat-containing protein 36 isoform 1"
                     /protein_id="NP_001103485.1"
                     /db_xref="CCDS:CCDS50246.1"
                     /db_xref="GeneID:225348"
                     /db_xref="MGI:MGI:1917819"
                     /translation="MAEMESAVEGRTASVLFAGFRALGLFSNEVPHVVRYSALKRRFY
                     VTTCVGKSFHTYDVQKLSLVAVSNSVPQDICCMAADGRLVFAAYGNVFSAFARNKEIV
                     HTFKGHKAEIHLLQPFGDHVISVDTDSVLIIWHIYSEEEYLQLTFDKSVFKISTILHP
                     STYLNKVLLGSEQGSLQLWNIKSNKLLYTFPGWKVGVTALQQAPAVDVVAIGLVSGQV
                     VIHNIKYDETLMKFHQDWGPITSISFRTDGHPIMAAGSPCGHIGLWDLEDKKLINQMR
                     NAHSTAISGLTFLHREPLLVTNGADNALRIWIFDGPAGEGRLLRFRMGHSASLTKIRY
                     YGQNGQQILSASQDGTLQSFSTVHEKFNKSLGHGLVNKKIVKRKGLQNTMSVRLPPIT
                     QFAAEEARQSDWDGIIACHQGKRSCSTWNYQRSTIGAYFLKPRGVKTNSNLTATAVDI
                     TSCGNFAIIGLSSGAVDVYNMQSGIHRGNFGDDKAHTGSVRGVAVDGLNQLVVTAGSE
                     RLLKFWNFKSKVLIHSLGLDSSPNMMLLHRDSGILGLAMDDFSIAVLDIETRKIVREF
                     SGHHGQINDMTFSPDGRWLISAAMDCSVRTWDLPSGCLIDCFLLDSAPLNVTMSPTGD
                     FLATSHVDHLGIYLWSNISLYSVVSLRPLPPDYVPSIVMLPGTCQTQGMEDLEEKTEP
                     SDEMIEYESPEQLSEQLVTLSLLPESRWKNLLNLDVIKKKNKPKEPPKVPQSAPFFIP
                     TVPGLVPRFAVPEPSSDPQQSKVVNLGILAQKSNFYLKLEEGLLNNQYEAALNLLKEL
                     GPSGIETELRNLSPDDGGSVEVMRSFLSMIGMMLDRKRDFELAQAYLALFLKLHLRTL
                     PSEPALLEELVKLSSQVEKDWTHLQSLFNQSMCVLNYIKSAFL"
     exon            304..331
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            332..432
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            433..550
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            551..683
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            684..738
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            739..871
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1047
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1168
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1234
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1321
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1470
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1585
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1751
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..1860
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1940
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            1941..2048
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2146
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2147..2292
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2293..2412
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2413..2494
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..2682
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     exon            2683..3226
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2835..2840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /note="hexamer: AATAAA"
     polyA_site      2863
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /note="major polyA site"
     regulatory      3157..3162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /note="hexamer: ATTAAA"
     polyA_site      3180
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
     regulatory      3219..3224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /note="hexamer: ATTAAA"
     polyA_site      3226
                     /gene="Wdr36"
                     /gene_synonym="5730444A13Rik; Ta-wdrp"
                     /note="major polyA site"
ORIGIN      
        1 cctgtaccat cggctccgga tcccggaagc acgcctcgct ctcctgctcc ggcacgggct
       61 cttcctgggg cgtgttgcgg ctctcctggc acgcactcgc caccgggccg cgagctgagt
      121 ggaatcccgt ctatggcgga gatggagagc gctgtggaag gccgcacggc cagcgtgctg
      181 ttcgcggggt tccgggcctt ggggctgttc agcaacgagg ttccacacgt ggtgcggtac
      241 agcgcgctca agcgccgctt ctacgtgacg acttgcgtgg gcaagagctt ccacacatat
      301 gacgttcaga aacttagtct ggttgcagta agtaactctg ttccacagga tatctgttgc
      361 atggcagccg atgggaggct agtcttcgct gcatatggga acgttttctc tgcatttgcc
      421 cggaataaag agatagtaca tacttttaag ggccataagg cagaaataca tcttttgcaa
      481 ccctttgggg atcacgttat ctcagtggat actgacagcg ttcttattat ttggcacatt
      541 tattcagaag aagaatacct tcagctgact tttgacaagt cagtttttaa aatctctaca
      601 attttgcatc caagcaccta tttgaataaa gtcctactgg gcagtgagca gggaagccta
      661 cagttatgga atataaagtc caataagctt ctatatacat ttccagggtg gaaagttgga
      721 gtgacagctc ttcaacaggc accagctgtg gatgttgttg ccattggtct tgtgtctggt
      781 caagttgtca ttcacaacat taagtatgat gaaacattaa tgaagttcca tcaggactgg
      841 ggacccatta cttccatttc atttcgcaca gatggtcatc caataatggc agctggaagc
      901 ccgtgtggcc atattggact ctgggatctg gaagacaaaa aattaattaa tcaaatgaga
      961 aatgcacact ctacagcaat atctgggctg acatttctcc atagagagcc gttgcttgtt
     1021 acaaatggcg ctgataatgc tcttaggata tggatctttg acggccccgc gggtgaagga
     1081 cggttgttga gattcagaat ggggcatagt gcttctctta ccaagattag atattatgga
     1141 caaaatggac agcagatttt aagtgcaagt caagatggga ctctacagtc attttctaca
     1201 gttcatgaaa aattcaacaa gagcttgggt catggattag taaacaaaaa gatagttaaa
     1261 cggaaaggac ttcagaacac catgtcagta aggctcccac ctatcacaca gtttgctgct
     1321 gaggaagctc gtcaaagtga ctgggatggt atcattgctt gccatcaagg gaagcggtct
     1381 tgctcaacct ggaattacca aaggtctaca ataggtgctt attttctcaa gcccagaggt
     1441 gtaaagacaa atagcaacct cactgcaaca gcagtagata taacttcctg tggaaacttt
     1501 gcaataattg gcctctcttc aggagctgta gatgtgtata acatgcagtc tggtatacat
     1561 cgaggaaatt ttggagatga taaagctcac accggctctg ttagaggtgt tgccgtggat
     1621 ggattaaacc agctggtggt tacagctgga agtgaacggt tactcaaatt ctggaacttt
     1681 aaaagcaaag ttttgatcca ctctctgggc cttgattcgt ctccaaatat gatgctgcta
     1741 cacagggaca gcggcatcct gggccttgct atggatgact tctccattgc tgtcctcgac
     1801 atagagacta ggaagatcgt cagagagttt tctggacacc acggccaaat aaatgacatg
     1861 acgttcagtc ctgatggccg ctggttgata agcgctgcga tggattgctc tgttaggact
     1921 tgggaccttc cttctgggtg ccttatcgac tgctttttgt tggactcagc gcctctaaat
     1981 gttactatgt ccccaactgg agactttcta gcaacttccc atgtggatca ccttggaatt
     2041 tatctatggt cgaatatttc cctctattca gttgtctccc tgcgaccact tcctccagat
     2101 tatgtccctt ccatagtgat gcttcctggt acttgtcaaa cccaaggtat ggaagacttg
     2161 gaagaaaaga ctgagccaag tgatgaaatg atagagtatg agtcgccaga acagttgagt
     2221 gagcaactgg tgactctctc ccttctccct gagtcacgct ggaaaaacct tctgaatctt
     2281 gatgttatca agaaaaagaa taaacccaaa gagccgccca aggttcccca gtcagctccg
     2341 tttttcatcc caacagttcc tgggcttgtc cccaggtttg ctgtacccga acccagcagt
     2401 gacccccagc agtctaaggt ggtaaacctt gggattttgg ctcaaaagtc aaatttctac
     2461 ctgaaacttg aagaaggatt actaaataat cagtatgaag ctgctcttaa ccttctgaaa
     2521 gaattgggcc catctgggat tgaaacagag ctgcgaaacc tgtcccctga tgacggtggg
     2581 tcggtagaag tcatgcggag ctttttaagc atgattggaa tgatgttgga cagaaagcgt
     2641 gatttcgagt tggcccaggc ataccttgca ttgtttttga agttacacct cagaacgctt
     2701 ccttcggagc cagcgctttt agaggagctg gtgaagttgt catcacaggt agaaaaagat
     2761 tggactcact tacagtccct cttcaatcaa agcatgtgtg tcttaaatta catcaaaagt
     2821 gctttcttgt aaagaataaa cttaagtgat tacagaaatc aaagctatgt gccaagtgtg
     2881 ctgtttaact tgtcttcact ctcagctcag agtgggagtg accagctcgt gtattttaag
     2941 ttcaaaagcc tttgtagatg tgaaattgta ccttctttct tttttttttt tttttttttc
     3001 ctgtaccttc tttctagaag ctctgcacat cgagagaact taaaaccacc tgagatcatc
     3061 agacaagtca catacatggg actttttgaa ttattgccat tttgtatttt tatcatgtta
     3121 tgtgtaaaag acagtgccta ttctgtgttt tactgaatta aattgacaat gtcagataaa
     3181 gcgtatctgt aatatactta taaaaatgca tttctgatat taaaaa
//
