LOCUS       NM_172470               4409 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WD repeat domain 35 (Wdr35), transcript variant 1,
            mRNA.
ACCESSION   NM_172470
VERSION     NM_172470.3
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4409)
  AUTHORS   Quidwai,T., Wang,J., Hall,E.A., Petriman,N.A., Leng,W., Kiesel,P.,
            Wells,J.N., Murphy,L.C., Keighren,M.A., Marsh,J.A., Lorentzen,E.,
            Pigino,G. and Mill,P.
  TITLE     A WDR35-dependent coat protein complex transports ciliary membrane
            cargo vesicles to cilia
  JOURNAL   Elife 10, e69786 (2021)
   PUBMED   34734804
  REMARK    GeneRIF: A WDR35-dependent coat protein complex transports ciliary
            membrane cargo vesicles to cilia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4409)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 4409)
  AUTHORS   Fu,W., Wang,L., Kim,S., Li,J. and Dynlacht,B.D.
  TITLE     Role for the IFT-A Complex in Selective Transport to the Primary
            Cilium
  JOURNAL   Cell Rep 17 (6), 1505-1517 (2016)
   PUBMED   27806291
REFERENCE   4  (bases 1 to 4409)
  AUTHORS   Caparros-Martin,J.A., De Luca,A., Cartault,F., Aglan,M.,
            Temtamy,S., Otaify,G.A., Mehrez,M., Valencia,M., Vazquez,L.,
            Alessandri,J.L., Nevado,J., Rueda-Arenas,I., Heath,K.E.,
            Digilio,M.C., Dallapiccola,B., Goodship,J.A., Mill,P., Lapunzina,P.
            and Ruiz-Perez,V.L.
  TITLE     Specific variants in WDR35 cause a distinctive form of Ellis-van
            Creveld syndrome by disrupting the recruitment of the EvC complex
            and SMO into the cilium
  JOURNAL   Hum Mol Genet 24 (14), 4126-4137 (2015)
   PUBMED   25908617
REFERENCE   5  (bases 1 to 4409)
  AUTHORS   Huang,L., Kondo,F., Gosho,M., Feng,G.G., Harato,M., Xia,Z.Y.,
            Ishikawa,N., Fujiwara,Y. and Okada,S.
  TITLE     Enhanced expression of WD repeat-containing protein 35 via
            CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells
  JOURNAL   PLoS One 9 (5), e98185 (2014)
   PUBMED   24859235
  REMARK    GeneRIF: These results suggest that bupivacaine activates AMPK and
            p38 MAPK via CaMKK in Neuro2a cells, and that the CaMKK/AMPK/p38
            MAPK pathway is involved in regulating WDR35 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4409)
  AUTHORS   Mill,P., Lockhart,P.J., Fitzpatrick,E., Mountford,H.S., Hall,E.A.,
            Reijns,M.A., Keighren,M., Bahlo,M., Bromhead,C.J., Budd,P.,
            Aftimos,S., Delatycki,M.B., Savarirayan,R., Jackson,I.J. and
            Amor,D.J.
  TITLE     Human and mouse mutations in WDR35 cause short-rib polydactyly
            syndromes due to abnormal ciliogenesis
  JOURNAL   Am J Hum Genet 88 (4), 508-515 (2011)
   PUBMED   21473986
  REMARK    GeneRIF: In a mutation screen for developmental phenotypes, we
            identified a mutation in Wdr35 as the cause of midgestation
            lethality, with abnormalities characteristic of defects in the
            Hedgehog signaling pathway.
REFERENCE   7  (bases 1 to 4409)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
REFERENCE   8  (bases 1 to 4409)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   9  (bases 1 to 4409)
  AUTHORS   Blacque,O.E., Li,C., Inglis,P.N., Esmail,M.A., Ou,G., Mah,A.K.,
            Baillie,D.L., Scholey,J.M. and Leroux,M.R.
  TITLE     The WD repeat-containing protein IFTA-1 is required for retrograde
            intraflagellar transport
  JOURNAL   Mol Biol Cell 17 (12), 5053-5062 (2006)
   PUBMED   17021254
REFERENCE   10 (bases 1 to 4409)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056925.1 and AK029896.1.
            
            On Apr 18, 2009 this sequence version replaced NM_172470.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056925.1, SRR7974084.17866.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849390
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2054              BC056925.1         110-2163
            2055-2898           AK029896.1         1977-2820
            2899-4409           BC056925.1         3008-4518
FEATURES             Location/Qualifiers
     source          1..4409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 3.97 cM"
     gene            1..4409
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /note="WD repeat domain 35"
                     /db_xref="GeneID:74682"
                     /db_xref="MGI:MGI:1921932"
     exon            1..179
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..3701
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 35"
                     /codon_start=1
                     /product="WD repeat-containing protein 35 isoform 1"
                     /protein_id="NP_766058.3"
                     /db_xref="CCDS:CCDS25807.1"
                     /db_xref="GeneID:74682"
                     /db_xref="MGI:MGI:1921932"
                     /translation="MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLE
                     TQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYK
                     GSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLC
                     HVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEG
                     YVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKV
                     VTQDKDINIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPD
                     YKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNSEKYVKYVKSLISITTCGDFCILATKA
                     DENHPQEENEMETFGATFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEAFY
                     TWQYRVAKKLTALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPIC
                     AITASDKTLIVGRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGV
                     LTFFDLDTRVTDSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLD
                     PEEPIQTSGYICNFEDLEIKSVLLDEILKDPEHPSKDYIMNFEIRSLRDSRALIEKVG
                     IEDASQFIEDNPHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKLLGNLQSE
                     SMKQAEVIAYFGRFEDAERMYQDMDRRDLAIGLRMKLGDWFRVLQLLKTGSGDADDSL
                     LEQANNAIGEYFADRQKWQNAVQYYVKGRNQERLAECYYMLEDYEGLETLANSLPENH
                     KLLPEIAQMFVRVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIG
                     SLLARYASHLLEKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYV
                     LSALLIEQYHEQMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAY
                     HFFILAQRQLYEGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAF
                     IKLESLETLSAEQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSP
                     IIEYQFWVCKVCKHYVLAQEISNYNFCPLCHSSVE"
     exon            180..297
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            298..369
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            370..462
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            463..591
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            592..725
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            726..891
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1037
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1163
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1349
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1382
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1443
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1588
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1658
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1659..1712
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1822
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..2033
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2114
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2251
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2455
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2602
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2735
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..2846
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..3011
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            3012..3152
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            3153..3309
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            3310..3550
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            3551..4392
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4373..4378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /note="hexamer: AATAAA"
     polyA_site      4392
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /note="major polyA site"
ORIGIN      
        1 gaagttctct aagcgccccg gatgcgactg ggcggcggtg gttgccaggc gacgggagct
       61 tctccgatcc accagtgctc gcaaatggag gtgtagaacc cgttatatat tagcgtgcct
      121 tgaccgctgt gggtcgtctt ctccgagttc ccacgatgtt cttctacctg agcaagaaaa
      181 ttgctgttcc caataatgtg aagctgaaat gtatatcctg gaacaaggac caagggttca
      241 tagcatgtgg cggtgaggat ggattactga aagttttaag actcgagaca cagacagatg
      301 actcaaagct gaggggtcta gccgccccta gtaacctttc catgaaccaa aatcttgaag
      361 gtcatagtgg tgctgttcaa gttgtaacgt ggaatgaaca gtatcagaag ttgactacca
      421 gtgatcaaaa tgggcttatc attgtctgga tgctgtataa aggctcttgg tatgaggaga
      481 tgatcaacaa tcgcaacaag tctgtggttc gaagcatgag ctggaatgcg gacggacaga
      541 agatctgcat tgtgtacgaa gatggagctg tgatcgtcgg ctcagtagac gggaatcgga
      601 tttgggggaa agacctgaag ggaattcagc tgtgccatgt gacctggtct gcagatagta
      661 aaatcctact ttttggaatg gcaaatggag aaatacacat ttatgataat caaggaaatt
      721 ttataatgaa aatgaagctg aattgcttgg tgaacgtcac tggagcgatc agtatcgctg
      781 ggattcactg gtaccatggc accgaaggct acgtggagcc cgattgccct tgcctggcaa
      841 tttgctttga caatgggaga tgccaaataa tgcggcatga gaatgaccaa aacccggttt
      901 tgatcgacac gggcatgtat gtggtaggca tccagtggaa ccacatcggc agtgtgttag
      961 ctgtggccgg ctcccagaag gtagtcactc aggacaagga catcaacatc gtgcagttct
     1021 acacaccgtt cggtgagcat ctgggtactt tgaaagttcc aggaaagcag atgtgttcgc
     1081 tgtcttggga aggaggcgga ctgaagattg ctctagctgt tgactccttt atatattttg
     1141 caaatattcg acctgattat aagtggggct actgttccaa cacagtggtt tatgcgtaca
     1201 ccagacccga tcgtcccgaa tactgtgttg tgttctggga cacaaaaaac agtgagaaat
     1261 acgttaaata tgtgaagagc ctcatttcta tcaccacgtg tggagatttc tgcattttgg
     1321 ctacaaaagc tgatgagaat caccctcagg aggagaatga aatggagaca tttggtgcaa
     1381 cgtttgtgct tgtcctttgc aattctattg gcacaccctt ggaccctaaa tacattgatc
     1441 ttgtaccatt atttgttgca atgaccaaaa cccatgtgat agcagcttca aaagaagcat
     1501 tttatacctg gcaatatcgt gtggcaaaga agctcacagc actggaaatt aatcagatca
     1561 cacggtctcg aaaagaagga agagaaagaa tttatcacgt tgatgatgtc ccttccggat
     1621 ctgtggatgg ggtgtttgat tacagtaaag ccattcaagg tacaagggat ccaatttgtg
     1681 ccattactgc atctgataag acattgattg tggggcgtga atctggcgtc attcagaggt
     1741 acagctttcc taatgttgct ctgattcaaa agtattccct ggattgccgt gcctgccagt
     1801 tatctctgaa ctgcaactcc agtcgtcttg ctatcatcga catcgctgga gtcttgactt
     1861 tctttgactt ggacactcgg gtgaccgaca gtacagggca gcaggtcgtt ggcgagttgc
     1921 taaaactgga gcgcaaagac gtctgggata tgaagtgggc caaggacaat cctgatttgt
     1981 ttgcaatgat ggagaagacg agaatgtatg ttttcagaaa cttggatcct gaggaaccca
     2041 ttcagacctc tggatatatt tgcaactttg aggatttgga aattaagtct gttctcttgg
     2101 atgagatact gaaggaccca gagcacccta gcaaggatta cataatgaac tttgagatcc
     2161 ggtccctgcg agacagccga gcattgattg agaaagttgg aattgaagat gcgtctcagt
     2221 tcatagagga caacccacac ccccgacttt ggcgcctgct ggctgaagct gctctccaga
     2281 agctggacct gtacaccgca cagcaagcgt ttgtgcgctg caaggattac caaggcatca
     2341 agtttgtgaa gctcctgggc aatctgcaga gcgagtcaat gaagcaggct gaagttattg
     2401 cctactttgg caggttcgaa gatgccgaaa ggatgtatca agatatggac agacgggacc
     2461 tcgctattgg tctcagaatg aaattggggg actggttcag agtactgcag ctcctgaaaa
     2521 ctggatctgg tgatgcagac gacagtctcc ttgaacaagc taacaatgcc attggagagt
     2581 actttgctga ccgacagaag tggcagaatg ctgtgcaata ttatgtaaaa ggcaggaacc
     2641 aggagcgcct ggccgaatgc tattatatgc tagaagatta tgaggggtta gagactcttg
     2701 ccaattcact tccagaaaac cataagttgc ttccagaaat agcccagatg tttgtgagag
     2761 ttggaatgtg tgagcaagct gtgagcgcat tcttgaagtg taaccaacca aaggcagcgg
     2821 tggacacctg tgtacacctg aaccaatgga acaaagccgt cgaactggct aaaagtcata
     2881 gtatgaagga gattggatct ctgttagcta ggtacgcgtc ccatttactg gagaagaaca
     2941 agactctcga tgccattgaa ctctatagga aagccagcta cttttttgat gcagctaaac
     3001 tgatgtataa gattgcagat gaagaggcga agaaaaggac caagcccctg cgtgtgaaga
     3061 aactctacgt gctgtcggct ctgctcatcg agcagtatca cgagcagatg aaaaacgccc
     3121 agcgcggcaa agttaaaggc aagaactcag aggccacttc tgctttggct ggcttgctag
     3181 aagaggaggt tctctctaca actagtcggt tcacagataa cgcctggaga ggagcggagg
     3241 cctaccattt ctttatactc gcgcagcggc agctctacga gggctacgtt gacactgcat
     3301 tgaagacagc tcttcacctg agagactatg aagacatcat tccctcagtt gagatctact
     3361 ctctgttagc actctgtgcg tgtgcaagca gagcttttgg tacctgttca aaagctttta
     3421 ttaaactgga atctttagag acgctcagtg cagagcagaa gcagcaatat gaagacctgg
     3481 ctctggaaat cttcaccaaa cacacgccaa aagacaacag gaagtctgaa ttaaacagcc
     3541 ttcttgaagg cggggaaggc aaactgccga cctgtatcgc cactggcagc ccaatcatcg
     3601 agtatcagtt ctgggtgtgc aaagtctgca agcactacgt cctcgcccag gagatcagca
     3661 actacaactt ttgcccttta tgccacagct cggtagaata aaggaaagaa gactctcagt
     3721 tgtacagtgc tggaagcaca cacgcttctc tgcacccgac tgtgtcgtag agcttgattt
     3781 cctaaggatt cataggaaaa tcacctcatc atctgctagt tgtatttttg tataaaatat
     3841 atattacaaa agaaaataaa agtaaaggga gggctggcat gtgctcagtg gtagcatgcg
     3901 ttccaagcct gcgcaggtcc tgggtccact gtcagtactg gaaaaaaaag ataatccata
     3961 catcacagtg caaccaagag acagtttgat tcttttcaca taagatttac aggtgtgaac
     4021 taattttttt gtagttcctg tctgttcatt taccatttat ataacttata gtttgtggca
     4081 aattaccaca gaactagttc tctcttgcca aggttaccag ttggttagag accccttggg
     4141 aggtagctgg ggatggcaga gggtaggagg ggctgccttg aagcagagaa cagacatgac
     4201 ctgggttcag ggaggctcag cagcggctta ggacatgagc tctgtttcta cttaaggtta
     4261 aatttctgta tgttcataaa tgaggaaatg gcattttaag actttttatt atttgaagtt
     4321 ttaaagacta caagcctcat tcaagaggaa gcatttggtc tcttttcttt gtaataaaca
     4381 tgaattaact gaaaaaaaaa aaaaaaaaa
//
