LOCUS       NM_001159527            4376 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WD repeat domain 35 (Wdr35), transcript variant 2,
            mRNA.
ACCESSION   NM_001159527
VERSION     NM_001159527.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4376)
  AUTHORS   Quidwai,T., Wang,J., Hall,E.A., Petriman,N.A., Leng,W., Kiesel,P.,
            Wells,J.N., Murphy,L.C., Keighren,M.A., Marsh,J.A., Lorentzen,E.,
            Pigino,G. and Mill,P.
  TITLE     A WDR35-dependent coat protein complex transports ciliary membrane
            cargo vesicles to cilia
  JOURNAL   Elife 10, e69786 (2021)
   PUBMED   34734804
  REMARK    GeneRIF: A WDR35-dependent coat protein complex transports ciliary
            membrane cargo vesicles to cilia.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4376)
  AUTHORS   Nakano,Y., Wiechert,S. and Banfi,B.
  TITLE     Overlapping Activities of Two Neuronal Splicing Factors Switch the
            GABA Effect from Excitatory to Inhibitory by Regulating REST
  JOURNAL   Cell Rep 27 (3), 860-871 (2019)
   PUBMED   30995482
REFERENCE   3  (bases 1 to 4376)
  AUTHORS   Fu,W., Wang,L., Kim,S., Li,J. and Dynlacht,B.D.
  TITLE     Role for the IFT-A Complex in Selective Transport to the Primary
            Cilium
  JOURNAL   Cell Rep 17 (6), 1505-1517 (2016)
   PUBMED   27806291
REFERENCE   4  (bases 1 to 4376)
  AUTHORS   Caparros-Martin,J.A., De Luca,A., Cartault,F., Aglan,M.,
            Temtamy,S., Otaify,G.A., Mehrez,M., Valencia,M., Vazquez,L.,
            Alessandri,J.L., Nevado,J., Rueda-Arenas,I., Heath,K.E.,
            Digilio,M.C., Dallapiccola,B., Goodship,J.A., Mill,P., Lapunzina,P.
            and Ruiz-Perez,V.L.
  TITLE     Specific variants in WDR35 cause a distinctive form of Ellis-van
            Creveld syndrome by disrupting the recruitment of the EvC complex
            and SMO into the cilium
  JOURNAL   Hum Mol Genet 24 (14), 4126-4137 (2015)
   PUBMED   25908617
REFERENCE   5  (bases 1 to 4376)
  AUTHORS   Huang,L., Kondo,F., Gosho,M., Feng,G.G., Harato,M., Xia,Z.Y.,
            Ishikawa,N., Fujiwara,Y. and Okada,S.
  TITLE     Enhanced expression of WD repeat-containing protein 35 via
            CaMKK/AMPK activation in bupivacaine-treated Neuro2a cells
  JOURNAL   PLoS One 9 (5), e98185 (2014)
   PUBMED   24859235
  REMARK    GeneRIF: These results suggest that bupivacaine activates AMPK and
            p38 MAPK via CaMKK in Neuro2a cells, and that the CaMKK/AMPK/p38
            MAPK pathway is involved in regulating WDR35 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4376)
  AUTHORS   Mill,P., Lockhart,P.J., Fitzpatrick,E., Mountford,H.S., Hall,E.A.,
            Reijns,M.A., Keighren,M., Bahlo,M., Bromhead,C.J., Budd,P.,
            Aftimos,S., Delatycki,M.B., Savarirayan,R., Jackson,I.J. and
            Amor,D.J.
  TITLE     Human and mouse mutations in WDR35 cause short-rib polydactyly
            syndromes due to abnormal ciliogenesis
  JOURNAL   Am J Hum Genet 88 (4), 508-515 (2011)
   PUBMED   21473986
  REMARK    GeneRIF: In a mutation screen for developmental phenotypes, we
            identified a mutation in Wdr35 as the cause of midgestation
            lethality, with abnormalities characteristic of defects in the
            Hedgehog signaling pathway.
REFERENCE   7  (bases 1 to 4376)
  AUTHORS   Mukhopadhyay,S., Wen,X., Chih,B., Nelson,C.D., Lane,W.S.,
            Scales,S.J. and Jackson,P.K.
  TITLE     TULP3 bridges the IFT-A complex and membrane phosphoinositides to
            promote trafficking of G protein-coupled receptors into primary
            cilia
  JOURNAL   Genes Dev 24 (19), 2180-2193 (2010)
   PUBMED   20889716
REFERENCE   8  (bases 1 to 4376)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   9  (bases 1 to 4376)
  AUTHORS   Blacque,O.E., Li,C., Inglis,P.N., Esmail,M.A., Ou,G., Mah,A.K.,
            Baillie,D.L., Scholey,J.M. and Leroux,M.R.
  TITLE     The WD repeat-containing protein IFTA-1 is required for retrograde
            intraflagellar transport
  JOURNAL   Mol Biol Cell 17 (12), 5053-5062 (2006)
   PUBMED   17021254
REFERENCE   10 (bases 1 to 4376)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC056925.1 and AK029896.1.
            
            Transcript Variant: This variant (2) lacks an in-frame exon in the
            coding region, as compared to variant 1. The encoded isoform (2)
            thus lacks an internal segment, as compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029896.1, AK083971.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BC056925.1         110-155
            47-2865             AK029896.1         2-2820
            2866-4376           BC056925.1         3008-4518
FEATURES             Location/Qualifiers
     source          1..4376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 3.97 cM"
     gene            1..4376
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /note="WD repeat domain 35"
                     /db_xref="GeneID:74682"
                     /db_xref="MGI:MGI:1921932"
     exon            1..179
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..3668
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /note="isoform 2 is encoded by transcript variant 2; WD
                     repeat-containing protein 35"
                     /codon_start=1
                     /product="WD repeat-containing protein 35 isoform 2"
                     /protein_id="NP_001152999.1"
                     /db_xref="CCDS:CCDS49027.1"
                     /db_xref="GeneID:74682"
                     /db_xref="MGI:MGI:1921932"
                     /translation="MFFYLSKKIAVPNNVKLKCISWNKDQGFIACGGEDGLLKVLRLE
                     TQTDDSKLRGLAAPSNLSMNQNLEGHSGAVQVVTWNEQYQKLTTSDQNGLIIVWMLYK
                     GSWYEEMINNRNKSVVRSMSWNADGQKICIVYEDGAVIVGSVDGNRIWGKDLKGIQLC
                     HVTWSADSKILLFGMANGEIHIYDNQGNFIMKMKLNCLVNVTGAISIAGIHWYHGTEG
                     YVEPDCPCLAICFDNGRCQIMRHENDQNPVLIDTGMYVVGIQWNHIGSVLAVAGSQKV
                     VTQDKDINIVQFYTPFGEHLGTLKVPGKQMCSLSWEGGGLKIALAVDSFIYFANIRPD
                     YKWGYCSNTVVYAYTRPDRPEYCVVFWDTKNSEKYVKYVKSLISITTCGDFCILATKA
                     DENHPQFVLVLCNSIGTPLDPKYIDLVPLFVAMTKTHVIAASKEAFYTWQYRVAKKLT
                     ALEINQITRSRKEGRERIYHVDDVPSGSVDGVFDYSKAIQGTRDPICAITASDKTLIV
                     GRESGVIQRYSFPNVALIQKYSLDCRACQLSLNCNSSRLAIIDIAGVLTFFDLDTRVT
                     DSTGQQVVGELLKLERKDVWDMKWAKDNPDLFAMMEKTRMYVFRNLDPEEPIQTSGYI
                     CNFEDLEIKSVLLDEILKDPEHPSKDYIMNFEIRSLRDSRALIEKVGIEDASQFIEDN
                     PHPRLWRLLAEAALQKLDLYTAQQAFVRCKDYQGIKFVKLLGNLQSESMKQAEVIAYF
                     GRFEDAERMYQDMDRRDLAIGLRMKLGDWFRVLQLLKTGSGDADDSLLEQANNAIGEY
                     FADRQKWQNAVQYYVKGRNQERLAECYYMLEDYEGLETLANSLPENHKLLPEIAQMFV
                     RVGMCEQAVSAFLKCNQPKAAVDTCVHLNQWNKAVELAKSHSMKEIGSLLARYASHLL
                     EKNKTLDAIELYRKASYFFDAAKLMYKIADEEAKKRTKPLRVKKLYVLSALLIEQYHE
                     QMKNAQRGKVKGKNSEATSALAGLLEEEVLSTTSRFTDNAWRGAEAYHFFILAQRQLY
                     EGYVDTALKTALHLRDYEDIIPSVEIYSLLALCACASRAFGTCSKAFIKLESLETLSA
                     EQKQQYEDLALEIFTKHTPKDNRKSELNSLLEGGEGKLPTCIATGSPIIEYQFWVCKV
                     CKHYVLAQEISNYNFCPLCHSSVE"
     exon            180..297
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            298..369
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            370..462
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            463..591
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            592..725
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            726..891
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1037
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1163
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1349
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1410
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1411..1555
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1625
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1626..1679
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1789
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2000
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2001..2081
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2218
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..2422
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2569
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2570..2702
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2813
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2814..2978
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            2979..3119
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            3120..3276
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            3277..3517
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     exon            3518..4359
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4340..4345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /note="hexamer: AATAAA"
     polyA_site      4359
                     /gene="Wdr35"
                     /gene_synonym="4930459M12Rik; 4931430C06; mKIAA1336"
                     /note="major polyA site"
ORIGIN      
        1 gaagttctct aagcgccccg gatgcgactg ggcggcggtg gttgccaggc gacgggagct
       61 tctccgatcc accagtgctc gcaaatggag gtgtagaacc cgttatatat tagcgtgcct
      121 tgaccgctgt gggtcgtctt ctccgagttc ccacgatgtt cttctacctg agcaagaaaa
      181 ttgctgttcc caataatgtg aagctgaaat gtatatcctg gaacaaggac caagggttca
      241 tagcatgtgg cggtgaggat ggattactga aagttttaag actcgagaca cagacagatg
      301 actcaaagct gaggggtcta gccgccccta gtaacctttc catgaaccaa aatcttgaag
      361 gtcatagtgg tgctgttcaa gttgtaacgt ggaatgaaca gtatcagaag ttgactacca
      421 gtgatcaaaa tgggcttatc attgtctgga tgctgtataa aggctcttgg tatgaggaga
      481 tgatcaacaa tcgcaacaag tctgtggttc gaagcatgag ctggaatgcg gacggacaga
      541 agatctgcat tgtgtacgaa gatggagctg tgatcgtcgg ctcagtagac gggaatcgga
      601 tttgggggaa agacctgaag ggaattcagc tgtgccatgt gacctggtct gcagatagta
      661 aaatcctact ttttggaatg gcaaatggag aaatacacat ttatgataat caaggaaatt
      721 ttataatgaa aatgaagctg aattgcttgg tgaacgtcac tggagcgatc agtatcgctg
      781 ggattcactg gtaccatggc accgaaggct acgtggagcc cgattgccct tgcctggcaa
      841 tttgctttga caatgggaga tgccaaataa tgcggcatga gaatgaccaa aacccggttt
      901 tgatcgacac gggcatgtat gtggtaggca tccagtggaa ccacatcggc agtgtgttag
      961 ctgtggccgg ctcccagaag gtagtcactc aggacaagga catcaacatc gtgcagttct
     1021 acacaccgtt cggtgagcat ctgggtactt tgaaagttcc aggaaagcag atgtgttcgc
     1081 tgtcttggga aggaggcgga ctgaagattg ctctagctgt tgactccttt atatattttg
     1141 caaatattcg acctgattat aagtggggct actgttccaa cacagtggtt tatgcgtaca
     1201 ccagacccga tcgtcccgaa tactgtgttg tgttctggga cacaaaaaac agtgagaaat
     1261 acgttaaata tgtgaagagc ctcatttcta tcaccacgtg tggagatttc tgcattttgg
     1321 ctacaaaagc tgatgagaat caccctcagt ttgtgcttgt cctttgcaat tctattggca
     1381 cacccttgga ccctaaatac attgatcttg taccattatt tgttgcaatg accaaaaccc
     1441 atgtgatagc agcttcaaaa gaagcatttt atacctggca atatcgtgtg gcaaagaagc
     1501 tcacagcact ggaaattaat cagatcacac ggtctcgaaa agaaggaaga gaaagaattt
     1561 atcacgttga tgatgtccct tccggatctg tggatggggt gtttgattac agtaaagcca
     1621 ttcaaggtac aagggatcca atttgtgcca ttactgcatc tgataagaca ttgattgtgg
     1681 ggcgtgaatc tggcgtcatt cagaggtaca gctttcctaa tgttgctctg attcaaaagt
     1741 attccctgga ttgccgtgcc tgccagttat ctctgaactg caactccagt cgtcttgcta
     1801 tcatcgacat cgctggagtc ttgactttct ttgacttgga cactcgggtg accgacagta
     1861 cagggcagca ggtcgttggc gagttgctaa aactggagcg caaagacgtc tgggatatga
     1921 agtgggccaa ggacaatcct gatttgtttg caatgatgga gaagacgaga atgtatgttt
     1981 tcagaaactt ggatcctgag gaacccattc agacctctgg atatatttgc aactttgagg
     2041 atttggaaat taagtctgtt ctcttggatg agatactgaa ggacccagag caccctagca
     2101 aggattacat aatgaacttt gagatccggt ccctgcgaga cagccgagca ttgattgaga
     2161 aagttggaat tgaagatgcg tctcagttca tagaggacaa cccacacccc cgactttggc
     2221 gcctgctggc tgaagctgct ctccagaagc tggacctgta caccgcacag caagcgtttg
     2281 tgcgctgcaa ggattaccaa ggcatcaagt ttgtgaagct cctgggcaat ctgcagagcg
     2341 agtcaatgaa gcaggctgaa gttattgcct actttggcag gttcgaagat gccgaaagga
     2401 tgtatcaaga tatggacaga cgggacctcg ctattggtct cagaatgaaa ttgggggact
     2461 ggttcagagt actgcagctc ctgaaaactg gatctggtga tgcagacgac agtctccttg
     2521 aacaagctaa caatgccatt ggagagtact ttgctgaccg acagaagtgg cagaatgctg
     2581 tgcaatatta tgtaaaaggc aggaaccagg agcgcctggc cgaatgctat tatatgctag
     2641 aagattatga ggggttagag actcttgcca attcacttcc agaaaaccat aagttgcttc
     2701 cagaaatagc ccagatgttt gtgagagttg gaatgtgtga gcaagctgtg agcgcattct
     2761 tgaagtgtaa ccaaccaaag gcagcggtgg acacctgtgt acacctgaac caatggaaca
     2821 aagccgtcga actggctaaa agtcatagta tgaaggagat tggatctctg ttagctaggt
     2881 acgcgtccca tttactggag aagaacaaga ctctcgatgc cattgaactc tataggaaag
     2941 ccagctactt ttttgatgca gctaaactga tgtataagat tgcagatgaa gaggcgaaga
     3001 aaaggaccaa gcccctgcgt gtgaagaaac tctacgtgct gtcggctctg ctcatcgagc
     3061 agtatcacga gcagatgaaa aacgcccagc gcggcaaagt taaaggcaag aactcagagg
     3121 ccacttctgc tttggctggc ttgctagaag aggaggttct ctctacaact agtcggttca
     3181 cagataacgc ctggagagga gcggaggcct accatttctt tatactcgcg cagcggcagc
     3241 tctacgaggg ctacgttgac actgcattga agacagctct tcacctgaga gactatgaag
     3301 acatcattcc ctcagttgag atctactctc tgttagcact ctgtgcgtgt gcaagcagag
     3361 cttttggtac ctgttcaaaa gcttttatta aactggaatc tttagagacg ctcagtgcag
     3421 agcagaagca gcaatatgaa gacctggctc tggaaatctt caccaaacac acgccaaaag
     3481 acaacaggaa gtctgaatta aacagccttc ttgaaggcgg ggaaggcaaa ctgccgacct
     3541 gtatcgccac tggcagccca atcatcgagt atcagttctg ggtgtgcaaa gtctgcaagc
     3601 actacgtcct cgcccaggag atcagcaact acaacttttg ccctttatgc cacagctcgg
     3661 tagaataaag gaaagaagac tctcagttgt acagtgctgg aagcacacac gcttctctgc
     3721 acccgactgt gtcgtagagc ttgatttcct aaggattcat aggaaaatca cctcatcatc
     3781 tgctagttgt atttttgtat aaaatatata ttacaaaaga aaataaaagt aaagggaggg
     3841 ctggcatgtg ctcagtggta gcatgcgttc caagcctgcg caggtcctgg gtccactgtc
     3901 agtactggaa aaaaaagata atccatacat cacagtgcaa ccaagagaca gtttgattct
     3961 tttcacataa gatttacagg tgtgaactaa tttttttgta gttcctgtct gttcatttac
     4021 catttatata acttatagtt tgtggcaaat taccacagaa ctagttctct cttgccaagg
     4081 ttaccagttg gttagagacc ccttgggagg tagctgggga tggcagaggg taggaggggc
     4141 tgccttgaag cagagaacag acatgacctg ggttcaggga ggctcagcag cggcttagga
     4201 catgagctct gtttctactt aaggttaaat ttctgtatgt tcataaatga ggaaatggca
     4261 ttttaagact ttttattatt tgaagtttta aagactacaa gcctcattca agaggaagca
     4321 tttggtctct tttctttgta ataaacatga attaactgaa aaaaaaaaaa aaaaaa
//
