LOCUS       NM_028866               6206 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WD repeat domain 33 (Wdr33), transcript variant 1,
            mRNA.
ACCESSION   NM_028866 NM_027004
VERSION     NM_028866.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6206)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6206)
  AUTHORS   Ito,S., Sakai,A., Nomura,T., Miki,Y., Ouchida,M., Sasaki,J. and
            Shimizu,K.
  TITLE     A novel WD40 repeat protein, WDC146, highly expressed during
            spermatogenesis in a stage-specific manner
  JOURNAL   Biochem Biophys Res Commun 280 (3), 656-663 (2001)
   PUBMED   11162572
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161511.3, AC124393.5 and AC131761.4.
            
            On Jan 16, 2010 this sequence version replaced NM_028866.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR9219380.22337.1,
                                           SRR10223969.18480.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AC161511.3         23754-23951         c
            199-425             AC161511.3         520-746             c
            426-494             AC124393.5         157113-157181
            495-599             AC124393.5         157756-157860
            600-695             AC124393.5         161191-161286
            696-847             AC124393.5         161464-161615
            848-945             AC124393.5         163265-163362
            946-1072            AC131761.4         89684-89810         c
            1073-1227           AC131761.4         88009-88163         c
            1228-1306           AC131761.4         87818-87896         c
            1307-1417           AC131761.4         86552-86662         c
            1418-1512           AC131761.4         82364-82458         c
            1513-1599           AC131761.4         81731-81817         c
            1600-1739           AC131761.4         81040-81179         c
            1740-1892           AC131761.4         79985-80137         c
            1893-2963           AC131761.4         78694-79764         c
            2964-3072           AC131761.4         74736-74844         c
            3073-3508           AC131761.4         70798-71233         c
            3509-3672           AC131761.4         65347-65510         c
            3673-3768           AC131761.4         65157-65252         c
            3769-3984           AC131761.4         63383-63598         c
            3985-6206           AC131761.4         58847-61068         c
FEATURES             Location/Qualifiers
     source          1..6206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 17.85 cM"
     gene            1..6206
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /note="WD repeat domain 33"
                     /db_xref="GeneID:74320"
                     /db_xref="MGI:MGI:1921570"
     exon            1..198
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            199..425
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..4214
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 33; WD repeat-containing protein
                     WDC146; pre-mRNA 3' end processing protein WDR33; WD
                     repeat-containing protein of 146 kDa"
                     /codon_start=1
                     /product="pre-mRNA 3' end processing protein WDR33 isoform
                     1"
                     /protein_id="NP_083142.2"
                     /db_xref="CCDS:CCDS29112.1"
                     /db_xref="GeneID:74320"
                     /db_xref="MGI:MGI:1921570"
                     /translation="MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFD
                     GKRMRKAVNRKTIDYNPSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNP
                     MNAVTTKFVRTSTNKVKCPVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAH
                     DSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFA
                     TCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPK
                     TGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEA
                     TAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCS
                     GSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNSLAVIPGMGIPEQL
                     KLAMEQEQMGKDESSEIEMTIPGLDWGMEEVMQKDQKKVPQKKVPYAKPIPAQFQQAW
                     MQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAEIEQEMATLQYTNPQLLEQLKIERLAQ
                     KQADQIQPPPSSGTPLLGPQPFSGQGPISQIPQGFQQPHPSQQMPLVPQMGPPGPQGQ
                     FRAPGPQGQMGPQGPPMHQGGGGPQGFMGPQGPQGPPQGLPRPQDMHGPQGMQRHPGP
                     HGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQGPPASQGHMGPQGPPGTQGMQ
                     GPPGPRGMQGPPHPHGIQGGPASQGIQGPLMGLNPRGMQGPPGPRENQGPAPQGLMIG
                     HPPQEMRGPHPPSGLLGHGPQEMRGPQEMRGMQGPPPQGSMLGPPQELRGPSGSQGQQ
                     GPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPIPFQQQKAPLLGDGPRAPFNQ
                     EGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDTRGPPNHHLGPMSERRHEQS
                     GGPEHGPDRGPFRGGQDCRGPPDRRGSHPDFPDDFRPDDFHPDKRFGHRLREFEGRGG
                     PLPQEEKWRRGGPGPPFPPDHREFNEGDGRGAARGPPGAWEGRRPGDDRFPRDPDDPR
                     FRGRREESFRRGAPPRHEGRAPPRGRDNFPGPDDFGPEEGFDASDEAARGRDLRGRGR
                     GTPRGGSRKCLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDAPRPDHPPHDGHS
                     PASRERSSSLQGMDMASLPPRKRPWHDGSGTSEHREMEAQGGPSEDRGSKGRGGPGPS
                     QRVPKSGRSSSLDGDHHDGYHRDEPFGGPPGSSSSSRGARSGSNWGRGSNMNSGPPRR
                     GTSRGSGRGR"
     exon            426..494
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            495..599
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            600..695
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            696..847
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            848..945
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1072
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1073..1227
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1228..1306
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1417
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1418..1512
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1599
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1600..1739
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1740..1892
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2963
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3072
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3073..3508
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3509..3672
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3673..3768
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3769..3984
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     exon            3985..6206
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4590..4595
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /note="hexamer: AATACA"
     polyA_site      4591
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /note="major polyA site"
     polyA_site      4621
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
     polyA_site      4730
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
     regulatory      5019..5024
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /note="hexamer: AACAAA"
     polyA_site      5064
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
     regulatory      5158..5163
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
                     /note="hexamer: AATAAA"
     polyA_site      5187
                     /gene="Wdr33"
                     /gene_synonym="1110001N06Rik; 2310011G05Rik;
                     2810021O11Rik; 8430413N20Rik; WDC146"
ORIGIN      
        1 gcggggcgta gcgccgtgag gccgtgatga cgcacaggcg tacgctcggt ggctcctcgg
       61 gtaagatggc ggctgcatct ttgaaggaga ggaattgaag agtgaggaga agggaaggag
      121 gaccagactg gagagacgtt ccctgcggcg ccaaaggacg ccgcgctcgc ggttaggagc
      181 tcctcccggc cccccacgtg acttagtagg aaaacatcac catggctaca gaaattggct
      241 ctcctccacg atttttccat atgccgaggt ttcaacatca ggctccccga caattatttt
      301 ataagcgacc tgattttgca cagcagcaag caatgcagca gctcaccttt gatggaaaac
      361 gaatgagaaa agctgtaaac cgaaaaacca tagactacaa tccctctgta attaagtatt
      421 tggagaatag gatatggcaa agagatcaga gagatatgcg ggcaattcag ccggatgcag
      481 gttattataa tgatctggtc ccaccaatag gaatgttgaa taatcctatg aatgcagtaa
      541 caacaaaatt tgttaggaca tcaacaaaca aagttaaatg cccagtattt gttgtgaggt
      601 ggaccccgga aggaagacga ttggtcactg gagcttctag tggggagttc accttgtgga
      661 atgggctgac tttcaacttt gaaaccatat tgcaggctca tgatagccct gtgagggcca
      721 tgacttggtc acataatgac atgtggatgt tgacagcaga tcatggagga tatgtgaaat
      781 attggcaatc caacatgaac aacgtcaaga tgttccaggc acataaggag gcgattagag
      841 aggccagttt ctcacccacg gataataaat ttgctacatg ctctgatgac ggcactgtta
      901 gaatctggga ttttcttcgt tgccatgagg aaagaattct ccgaggccat ggtgctgatg
      961 tgaagtgtgt agactggcat ccaaccaaag ggttagtcgt ttcaggaagt aaagatagcc
     1021 agcagccaat caagttctgg gatcccaaga ctgggcagag tcttgcaaca ctccacgccc
     1081 acaagaacac tgtgatggaa gtgaagttaa acctcaacgg caattggctc ctcacggcct
     1141 ctcgggacca tctctgtaag ctctttgata tccgaaacct gaaagaagag cttcaagtat
     1201 tccgaggtca caagaaggag gccacagctg tagcctggca tcctgttcat gaaggacttt
     1261 ttgccagtgg aggatctgac ggctctctgt tattctggca tgttggggta gagaaggagg
     1321 taggtgggat ggagatggcc cacgaaggga tgatctggag tttggcttgg catcctctgg
     1381 gacatatcct ctgctcaggc tcaaatgacc ataccagcaa attctggact cgaaaccggc
     1441 caggtgataa aatgcgagat cgatataatc tgaacctttt gcctggcatg tcagaagacg
     1501 gagtggagta tgatgacctg gagcctaata gcctggcagt gatcccgggg atgggaatac
     1561 cagaacaact gaagttagct atggagcagg aacagatggg gaaagatgaa tcaagtgaaa
     1621 ttgaaatgac aattccaggc ttggattggg gaatggagga agtaatgcaa aaggatcaga
     1681 aaaaagtccc ccagaagaaa gtcccctatg cgaagcccat tcctgcccag ttccagcagg
     1741 cctggatgca aaataaagtc ccaattcctg ctccaaatga ggtgctgaat gacaggaaag
     1801 aggatattaa gttagaagag aagaaaaaaa cccaagcaga aattgagcaa gaaatggcca
     1861 cattacagta caccaacccg cagcttttag agcaacttaa aattgaaagg cttgcacaga
     1921 aacaggctga tcagatccag cctcctccct catctgggac ccctctcctg ggacctcagc
     1981 ccttttctgg tcagggtccg atatctcaga ttcctcaagg ttttcagcag cctcatccgt
     2041 ctcagcagat gccattggtg cctcaaatgg ggcctccagg tcctcagggc cagttcagag
     2101 cccctggacc ccagggacaa atgggaccac aaggccctcc aatgcatcaa ggaggcgggg
     2161 gcccacaagg attcatggga ccacaaggac cccagggccc tccccaggga ctgccacggc
     2221 ctcaagacat gcacggtcca caaggaatgc agaggcaccc tggacctcat ggccctttgg
     2281 gtcctcaagg gccacccgga cctcaaggta gttctggtcc tcaaggtcat atgggccctc
     2341 agggcccacc aggaccacag ggtcacattg gcccccaagg ccctcctgct tctcagggtc
     2401 acatgggccc tcagggtcca cccggtactc aaggaatgca gggaccacct ggtcccagag
     2461 gaatgcaagg acctccccat ccacatggga tacagggggg cccagcgtct caagggatcc
     2521 agggacctct gatgggactg aatccaagag gcatgcaggg gcctccagga cctcgggaga
     2581 atcagggtcc tgctcctcaa gggttaatga ttggccaccc acctcaagag atgagaggac
     2641 cacatcctcc aagtggattg ctgggacatg gccctcagga aatgagaggt cctcaggaga
     2701 tgcggggcat gcagggtccc ccaccacagg gctcaatgtt gggccctccc caggaacttc
     2761 gaggaccttc aggttcacaa gggcagcagg ggccacccca gggctctttg ggacctccac
     2821 cccagggtgg catgcaagga ccccctggac ctcagggaca gcagaacccg gcaagagggc
     2881 cacatccatc tcaagggcca ataccgttcc agcagcagaa agcacctctg ctaggtgatg
     2941 ggccccgggc ccccttcaat caggaaggac agagtacagg tcccccaccc ttgataccag
     3001 gcctagggca acagggtgca caaggccgca tccctcctct gaaccctgga caaggacctg
     3061 gccctaacaa aggtgacact cgaggccctc ccaaccatca cctgggcccc atgtcagaga
     3121 ggcggcatga gcagagtggt ggccctgagc atggtcctga caggggacct ttccggggtg
     3181 gccaggactg caggggtcct cctgacaggc gtggctctca ccctgatttc cctgatgact
     3241 tcagaccaga tgacttccat cctgacaagc gctttggcca ccggttacgg gagtttgagg
     3301 gacgaggagg acccttacca caagaagaga agtggaggcg agggggccct ggacctccct
     3361 tcccacctga tcacagggaa ttcaatgagg gggatggccg gggagcagcc cgaggccccc
     3421 caggggcatg ggaaggccgc agacctggag atgaccgctt cccccgggat cctgatgacc
     3481 cgcgatttcg agggcgcagg gaagagagct ttagaagagg tgctccccca agacacgaag
     3541 gccgcgctcc tccaagagga agggacaact ttcctggtcc tgatgacttt ggtccagaag
     3601 agggttttga tgcttctgat gaagcagccc gaggacgaga tctccgtggt cgaggccgtg
     3661 gcacccctcg aggaggatcc aggaagtgct tactccccac tcctgatgag tttcctcgct
     3721 ttgaaggagg acggaagcca gactcctggg atggaaatcg agagcccggg ccaggtcatg
     3781 aacactttcg ggatgctccc cgacctgatc atccccctca cgatggccat tcgccagcta
     3841 gcagagagcg ctcctcttct ctccaaggca tggacatggc ctccctacca ccccggaagc
     3901 gcccctggca tgatgggtcg ggcacgtctg aacacagaga gatggaggcc caaggaggcc
     3961 cctcggaaga ccgaggaagc aaaggccgag ggggcccagg accttcccag agagtgccaa
     4021 aatccggccg ttccagctct ttggatggag accatcacga cggataccac agagatgaac
     4081 cttttggtgg ccctccaggc agcagctcat cctctcgagg cgcccggagt ggcagtaact
     4141 ggggtagagg gagtaacatg aactctggcc ctccaaggcg aggcacttca agaggtagtg
     4201 ggaggggccg gtaggagggc caaacagtcc atggcctctc tggatactat ttaagacgtt
     4261 cttgtgggct caccactgaa gcagaaacaa gcctttacca ctgtagccct gaccgcttct
     4321 tctggggcag ctgaggtcta ggagcccagg tggggtactc gagacgaaag actgatgccg
     4381 actccctccc cagggagttg gccctgcttg gtcttgtatc tcctcgttgc tctgactctt
     4441 cccgtttgtt tgtgaagata aaagctggaa tcctttttta agtgtcctga gaaatggagc
     4501 acctccacaa agttcagttc atgtccgatt ggagatttat ttctatatgt acagtttgtc
     4561 agagaaaaaa aaaacccttg ttttgtatga atacagaatg tgatttactg agttaacagc
     4621 agcacccact gtgcagtgct ggccttaagg agcccttgct ttcagcgtcg ctgacctgct
     4681 gagggtgacc ttgctactgg cacttccaac agatgaaggt catttgccaa ctctgtgctt
     4741 ttcacatcat ttttaccttt ctgttgttac actgttcttg ttatgcgata aggcatactt
     4801 taaaattgct ctaacatgtt caagaaggct caaaacctca gacatgctct atgaggtcaa
     4861 aaattactct gaagaaaaat ttgaatcttc tgggtcttca actagaggtt ctcccttgga
     4921 tgcatctcct agcagtttag ctttgaatag tcactgagag agagatccgg tgtaaacaac
     4981 attaacttgg tgcatcttat gccgctcaaa ggacggggaa caaagtatct acattttgga
     5041 aaacaatctc ctctttcaca cgtactctgt gactctgtga tgatttcagg gttcagggta
     5101 caggatagaa gttaccagaa agctctttgc tgtgacaaat ttcttgcttt aaaaataaat
     5161 aaaaagctgg gtggggaggc gaaggcagaa aggtctctga gttcaaggcc aacctagtct
     5221 acaaatcaag ttctaagaca gcctaggcta cacggagaaa ccctgtcaaa accaccacca
     5281 ccctaaaaaa gccatacata tatccaagat agcctgggct acatggagaa accctgtcaa
     5341 aaccatcacc accctaaaaa gccatacata catacataca tacatacata catacataca
     5401 tgcatacaaa agcaaaggta ggaaaggtag gacttggaga ggtggctcag cagttaagag
     5461 ctcacagaga ctggaagcca gcttcagcac ctatgatcag gcagctcaca tatacatata
     5521 tagagagatc ctctcttaaa aaaaaacacc taactatatc tgggcccaca tacataattt
     5581 agcttttgtg gggtgaacta ggtggatcag aagtccagtg ctgtccttgg ctacacagta
     5641 gtcagggcag cctgggactc cacttctccc cctccccaaa gctcttgttg aagtcagact
     5701 gagattctcc ttcctatgct gacctttcca ttcttcttct tttttaagca ccccctcccc
     5761 ccgacccttt ttaatggatg ctttgtctga gtttctgttt gtgtatcagt tgtgtgtctg
     5821 gtgtcttacg aggccagaag tgagcatcag atcccctgga actggaataa taggcagttg
     5881 tcagtgctag gaattgaatc catgtctcct ggaggagcag ccactgagct gctcttaacc
     5941 actgagctgc ctcttcagcc ctgaccactg gcctttctaa gaaagccttt ataaaagtca
     6001 cggcattacc agctgtttgt cccgtgaaga caggtttact tggcaagttg agtggtgctg
     6061 gacataaaga gatgctgaca cagttggaca gtgcacagaa agcttcccta gctccgaggg
     6121 tatggagtga ggaaatgggg agtctctgga tgctcgaacc tgaaggtttc tagtcaactt
     6181 caaaaataaa catgtcagca ctcaca
//
