LOCUS       NM_175552               3444 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WD repeat domain 3 (Wdr3), transcript variant 1, mRNA.
ACCESSION   NM_175552
VERSION     NM_175552.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3444)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3444)
  AUTHORS   Liu,W., Xie,A., Xiong,J., Li,S., Yang,L. and Liu,W.
  TITLE     WDR3 promotes stem cell-like properties in prostate cancer by
            inhibiting USF2-mediated transcription of RASSF1A
  JOURNAL   J Gene Med 25 (7), e3498 (2023)
   PUBMED   36905106
  REMARK    GeneRIF: WDR3 promotes stem cell-like properties in prostate cancer
            by inhibiting USF2-mediated transcription of RASSF1A.
REFERENCE   3  (bases 1 to 3444)
  AUTHORS   Kobayashi-Tanabe,M., Furuie,H., Yamada,M. and Yamada,M.
  TITLE     Characterization of a WD-repeat family protein WDR3 in the brain of
            WDR3 hetero knockout mice
  JOURNAL   Brain Res 1800, 148188 (2023)
   PUBMED   36463953
  REMARK    GeneRIF: Characterization of a WD-repeat family protein WDR3 in the
            brain of WDR3 hetero knockout mice.
REFERENCE   4  (bases 1 to 3444)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3444)
  AUTHORS   Garcia-Quispes,W.A., Pastor,S., Galofre,P., Biarnes,J., Castell,J.,
            Velazquez,A. and Marcos,R.
  TITLE     Possible role of the WDR3 gene on genome stability in thyroid
            cancer patients
  JOURNAL   PLoS One 7 (9), e44288 (2012)
   PUBMED   23049746
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC102209.11, BY125127.1 and BC063100.1.
            
            On Sep 23, 2017 this sequence version replaced NM_175552.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063100.1, AK050797.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC102209.11        20296-20299
            5-18                BY125127.1         2-15
            19-3444             BC063100.1         1-3426
FEATURES             Location/Qualifiers
     source          1..3444
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.46 cM"
     gene            1..3444
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /note="WD repeat domain 3"
                     /db_xref="GeneID:269470"
                     /db_xref="MGI:MGI:2443143"
     exon            1..64
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            65..267
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2925
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 3"
                     /codon_start=1
                     /product="WD repeat-containing protein 3 isoform 1"
                     /protein_id="NP_780761.1"
                     /db_xref="CCDS:CCDS17674.1"
                     /db_xref="GeneID:269470"
                     /db_xref="MGI:MGI:2443143"
                     /translation="MGLTKQYLRYVASAVFGLIGSQKGNIVFVTLRGEKGRYVAVPAC
                     EHVFIWDLRKGEKILILQGNKQEVTCLCPSPDGLHLAVGYEDGAIRIFSLLSGEGNIT
                     FNGHKAAVTSLKYDQLGGRLASGSKDTDVIIWDVINESGLYRLKGHKDAVTQALFLRE
                     RNLLVTSGKDTMVKWWDLDNQHCFKTMVGHRTEVWGLVLVSEEKRLITGAADSELRAW
                     DIDYLQEIDDPEEPEPKKIKECPGIQDTPESEDSTLEADDEKSEDRILSCSKAGSIMR
                     EGRDRVVNLAVDKTGRILACHGTDSVLEVFCILSKAEVQKKMDKKLKKARKKARLNSA
                     NEEEDPETSVSMTLQDEILRVAKIKTSAKIKSFDLIHSPQGELKAVFLLQNNLVELYS
                     LNASLPAPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRT
                     MPCEYALCSFFVPGDRQVVIGTKTGNLQLYDLASGTLLETIAAHDGALWSMSLSPDQR
                     GFVTGGADKAVKFWDFELVTDKNSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVS
                     LLDCTVKVFYVDTLKFFLSLYGHKLPVLCMDISHDGALIATGSADRNVKIWGLDFGDC
                     HRSLFAHDDSVMYLRFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV
                     SPSGDYVVSASHDKSLRLWERTREPLILEEEREMQREAEYEESVAKEDQPAVPGETQG
                     DNYFTGKKTIETVKAAERIMEAIELHREETAKMKEHRAICKAAGKEVPLPVNPILMAH
                     GNISPSAYVLETFKGIRSSELEEALLVLPFSYVPDVLTLFNEFIQTGLDVELLCRCLF
                     FLLRIHFGQITSNQMLVPVIEKLKETTISKVRQVQDAIGFNMAGLDYLKRECEAKSEV
                     MFFAEATSHLEEKKKKRKNRKRMILTLT"
     exon            268..477
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            478..596
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            597..675
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            676..771
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            772..885
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            886..987
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1085
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1190
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1421
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1515
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..1617
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1618..1703
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1839
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1896
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1897..1997
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1998..2109
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2244
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..2295
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2296..2361
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2362..2454
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2455..2502
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2503..2546
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2547..2675
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2676..2769
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..3432
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3413..3418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      3432
                     /gene="Wdr3"
                     /gene_synonym="D030020G18Rik"
                     /note="major polyA site"
ORIGIN      
        1 aatcggaccg gaagtggcgg gtctcgtagg cagcgctgtc tgctggagcc tcgtggagag
       61 tgagattgcc ttcccggtgt catcagacag cccagcatgg ggcttactaa acagtatctg
      121 cgctatgtgg ctagtgctgt ctttggcttg attggcagcc aaaaaggtaa cattgttttt
      181 gtgacactcc gtggtgagaa aggacgctat gtggcagtac ccgcctgtga acacgttttt
      241 atctgggact taaggaaagg cgagaagatc cttatccttc aggggaataa acaagaagtc
      301 acttgcttgt gtccttcccc agatgggctg catctagctg ttggctatga ggatggagcc
      361 atccgaatct tcagcctcct cagtggtgaa ggaaacataa ccttcaatgg acacaaagca
      421 gctgtcacca gcttaaagta cgatcagcta ggaggcaggc tggcttctgg gtctaaggat
      481 acagatgtca ttatttggga tgtgatcaat gaaagtggcc tctaccgtct aaagggacac
      541 aaggatgctg tcacacaagc tttgtttctc cgagaaagga atctgctggt tacaagtggg
      601 aaagacacta tggtaaagtg gtgggacctg gataaccagc actgcttcaa aacaatggtt
      661 ggccaccgaa ctgaggtgtg gggcttggtt ctggtttcag aagaaaagcg actaatcact
      721 ggggctgcag acagtgagct gagagcctgg gacatcgact atctgcaaga gattgatgac
      781 ccagaagaac cagagcccaa gaaaatcaaa gagtgtcctg gaatacagga cacacctgaa
      841 tcagaggaca gcacccttga ggcggatgat gaaaaatctg aagatcgcat actttcgtgt
      901 agtaaagctg gctccataat gcgggaagga agggacagag ttgtgaacct cgccgtggac
      961 aagacaggca ggattcttgc ttgccacgga actgattctg tgttagaagt attttgtatt
     1021 ctttccaaag cagaagttca gaagaaaatg gataagaagc taaagaaagc tagaaagaaa
     1081 gcaaggttga actctgccaa tgaggaggag gaccctgaaa cgagtgtctc gatgacactg
     1141 caggacgaga tccttcgagt agccaagatc aagacttctg ccaagatcaa atcttttgac
     1201 ctgattcact cgcctcaagg agagttaaag gccgtcttct tgctgcagaa caatctggtg
     1261 gagttgtatt cgctcaatgc gtccttgcca gcccctcagc ctgtgaggac aagccggatc
     1321 accattggag gccaccgcag cgacgtgcgc actttgtcct tcagctcgga taatatagct
     1381 gtgctttcag cagcagccga ttccattaag atctggaaca ggtctaccct gcagtgtatc
     1441 cgcaccatgc cttgtgaata tgctctctgc tccttcttcg ttcccggcga taggcaggtg
     1501 gtcataggaa caaagacagg aaatctgcaa ctttacgacc tggcctcagg cactctcttg
     1561 gagacaatag ctgcccatga tggagccctg tggtccatgt ctctttctcc agatcagcgt
     1621 ggctttgtga caggtggcgc tgacaaagct gtcaagttct gggattttga gttggtgaca
     1681 gataaaaata gtacccagaa gagactttct gtgaagcaga ctcgaacctt gcagctagat
     1741 gaggacgtcc tgtgtgtcag ctactctccc aatcaaaagc tgctggctgt gtctttgctg
     1801 gactgcactg tgaaggtttt ctatgttgac actttaaagt tttttctctc actgtatgga
     1861 cacaaactgc ctgttttatg catggacatc tcccatgatg gagcactaat agcaactggt
     1921 tctgctgata gaaatgtgaa aatctggggt ctggactttg gggactgcca caggtctctc
     1981 tttgcacatg atgacagtgt gatgtatcta cgctttgtgc ctaagtctca cctcttcttc
     2041 accgctggga aggaccacaa gatcaagcag tgggatgcag acaagtttga gcacatccaa
     2101 acgctggagg gacaccacca ggaaatatgg tgtttggctg tcagccccag tggagactac
     2161 gttgtatcag catctcatga caagtcgctg agactctggg agagaacgag agagcctctt
     2221 attctcgagg aagaaaggga aatgcaaagg gaagcagagt atgaggagag cgtggccaaa
     2281 gaagaccagc cggcagttcc aggggagacc caaggtgaca actatttcac tgggaagaag
     2341 acaattgaaa cagtcaaagc ggctgagagg atcatggagg ccatcgagct gcatcgagaa
     2401 gaaactgcaa aaatgaaaga acacagagcc atttgtaaag cagcggggaa agaggttcct
     2461 cttcctgtca accccatcct gatggctcat ggcaatattt ctccttcagc gtatgtgtta
     2521 gagactttta aagggatcag gtcaagtgaa ctagaagagg ccctgcttgt gctgccattc
     2581 tcctatgtcc cagacgttct tacactgttc aatgaattca tccagacggg cttggatgtc
     2641 gagctcttgt gccggtgcct cttttttctc ctcaggattc actttggcca gatcaccagc
     2701 aaccagatgc ttgtgcccgt gatagagaaa ctaaaggaaa caactatttc aaaagtcaga
     2761 caagtccagg atgccattgg cttcaatatg gctggtctcg attatctcaa gagagagtgt
     2821 gaagcaaaga gtgaagtgat gttttttgca gaagctacta gtcacttgga agagaagaag
     2881 aaaaaacgaa aaaacaggaa aaggatgatt ttaacactga cttagaactg gaatgcagtg
     2941 ttttttcctg cttcttctca aaggagcgta cacataaact gagctgttgt ggagttggca
     3001 acataaaaat accaaaaaaa gatcatgttg tagatcttgg ggtacagatg tcagccttgg
     3061 ttgaagaaac caacatggct gtgactactg tctttcatct tttgaaaagg acggatttag
     3121 tttaaaaatc tgcatttttc agagttggac ctttaaattg tgtcaagaag caaaataata
     3181 ttttttaatt gtgtatttga ttccgaagtg tctcatattt atggcagatt atttgtatta
     3241 gagcttttct gtttaccgtg tgtgtcattg tcctctaaag gaagcgccat ggactggggc
     3301 tgaaagggat gatggcctgc taagagctgc ctgcttacac cagtgcaggt tggtgagtct
     3361 gcatgtaagg tcataatgct gtttgtactt ttggaaatac aatagctttt tcattaaaac
     3421 cacttaaaat gaaaaaaaaa aaaa
//
