LOCUS       NM_173741               3099 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus WD repeat domain 24 (Wdr24), mRNA.
ACCESSION   NM_173741
VERSION     NM_173741.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3099)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3099)
  AUTHORS   Dai,X., Jiang,C., Jiang,Q., Fang,L., Yu,H., Guo,J., Yan,P., Chi,F.,
            Zhang,T., Inuzuka,H., Asara,J.M., Wang,P., Guo,J. and Wei,W.
  TITLE     AMPK-dependent phosphorylation of the GATOR2 component WDR24
            suppresses glucose-mediated mTORC1 activation
  JOURNAL   Nat Metab 5 (2), 265-276 (2023)
   PUBMED   36732624
  REMARK    GeneRIF: AMPK-dependent phosphorylation of the GATOR2 component
            WDR24 suppresses glucose-mediated mTORC1 activation.
REFERENCE   3  (bases 1 to 3099)
  AUTHORS   Jiang,C., Dai,X., He,S., Zhou,H., Fang,L., Guo,J., Liu,S.,
            Zhang,T., Pan,W., Yu,H., Fu,T., Li,D., Inuzuka,H., Wang,P., Xiao,J.
            and Wei,W.
  TITLE     Ring domains are essential for GATOR2-dependent mTORC1 activation
  JOURNAL   Mol Cell 83 (1), 74-89 (2023)
   PUBMED   36528027
REFERENCE   4  (bases 1 to 3099)
  AUTHORS   Kowalsky,A.H., Namkoong,S., Mettetal,E., Park,H.W., Kazyken,D.,
            Fingar,D.C. and Lee,J.H.
  TITLE     The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase
            activation
  JOURNAL   J Biol Chem 295 (7), 1769-1780 (2020)
   PUBMED   31915252
REFERENCE   5  (bases 1 to 3099)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159277.3.
            
            On Aug 25, 2009 this sequence version replaced NM_173741.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037651.1, AK078694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1060              AC159277.3         208682-209741       c
            1061-1238           AC159277.3         207537-207714       c
            1239-1911           AC159277.3         206744-207416       c
            1912-2030           AC159277.3         206215-206333       c
            2031-2152           AC159277.3         206012-206133       c
            2153-2257           AC159277.3         205836-205940       c
            2258-2598           AC159277.3         205375-205715       c
            2599-2783           AC159277.3         205030-205214       c
            2784-3099           AC159277.3         204638-204953       c
FEATURES             Location/Qualifiers
     source          1..3099
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 12.92 cM"
     gene            1..3099
                     /gene="Wdr24"
                     /note="WD repeat domain 24"
                     /db_xref="GeneID:268933"
                     /db_xref="MGI:MGI:2446285"
     exon            1..1060
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1238
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     exon            1239..1911
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2030
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2152
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     exon            2153..2257
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2598
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     exon            2599..2783
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..3099
                     /gene="Wdr24"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3075..3080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr24"
                     /note="hexamer: AATAAA"
     polyA_site      3093
                     /gene="Wdr24"
                     /note="major polyA site"
ORIGIN      
        1 ggactacttc cggtaatggg cgggcagtag gtgagtctct tccggtactg tagctgaaga
       61 ccactctgtg ctttcggtaa atgactggcg tgcgacgggg cagaggcttt tctagcacct
      121 ggttctggtc cctcagttgc cgctgcacgg tgcaattaga cacctgcact tattgctgta
      181 gcctctcttc tgcattccaa ggtgtatgaa ctcagtccat acccatctag cttctctgcc
      241 ctttccactc ggttgttttt cctcttggaa gccccgcaat cctcggaggc atggggctgt
      301 gaagtcagga gccactcccc gcccccagga tctcactgat ggagaattaa ccacatagaa
      361 tcgggagacg tcagatatgg tgctgacgaa cctcaggtta gctctggagc cttctggaga
      421 actccaatga atgtgaacct tcctaagata acgactggct gatggaccat ctcaggccga
      481 aggttcgaga ggagactgaa cctgaattgt taggacacca tggctgacca ggtcagcaca
      541 cttcactgac ctcctcctgc ctctgatacc tgtgcagaca tggaaaagat gtcccgagtt
      601 agcacagccc tgagcggcag tgctctgacg ggccgaacca tgcactgcca tctggacgcg
      661 ccagctaatg ccatcagcgt gtgccgcgac gctgcccagg ttgtcgtggc aggccgaagc
      721 atcttcaaga tttatgccat tgaggaggag cagttcgtag agaagctgaa tttacgtgtg
      781 ggtaggaagc cctcgctcaa cctgagctgt gctgatgtgg tctggcacca gatggatgag
      841 aatctgctgg ccacagcagc caccaatggt gtggtggtta catggaacct aggtcggcca
      901 tcccgcaaca agcaggatca gctgttcaca gaacacaagc gcacagtgaa caaagtctgt
      961 ttccatccca ccgaggccca tgtgctgctc agtggctctc aggatggctt catgaagtgc
     1021 tttgacctcc gaaggaagga ctctgtcagc accttctctg gccagtctga gagcgtgcgg
     1081 gatgtgcagt tcagtatccg tgactacttt acctttgctt ccacctttga gaatggcaac
     1141 gtacagctct gggacatccg ccgacccgac cgctgtgaga ggatgttcac agcccacaat
     1201 gggcctgtct tctgctgtga ttggcaccca gaggacaggg gctggctggc cacgggtgga
     1261 cgtgacaaga tggtaaaggt ctgggacatg accacacatc gtgccaaaga gatacactgt
     1321 gtgcagacaa tcgcttcagt ggcccgagtc aagtggcggc ctgaatgccg ccaccacctg
     1381 gccacgtgtt ccatgatggt ggaccacaac atctatgtat gggatgtacg ccgccccttc
     1441 gtgccagctg ctatgtttga agagcatcgt gatgtcacaa caggcattgc ctggcgtcat
     1501 ccgcatgacc cctctttcct gctctccggc tccaaggaca gcacgttatg ccagcacctg
     1561 tttcgggatg ccagtcagcc tgttgagcgt gccaaccctg agggtctctg ctatggcctc
     1621 tttggggacc tggcctttgc tgttaaggaa agcctggtgg ctgctgaatc tggacgtaaa
     1681 ccctatgctg gtgaccggcg ccaccccatc ttcttcaagc gcaagttgga ccctgcagaa
     1741 cctttttctg gcctcgcttc cagtgcactg agcgtctttg agacggagtc tagcggtggc
     1801 agcatgagct ggttcgtgga tacagctgaa cgttatgttc tggctggccg gccactagcc
     1861 gagctctgtg atcacaatgc aaaagtggct cgggagcttg gccgcaatca ggtggcacag
     1921 acatggacca tgttacggat tatctactgt agccctggct tggtatcctc tgccaatctc
     1981 aaccacagcg tcggcaaagg cagctcctgc ggcctaccgc tcatgaacag cttcaatctg
     2041 aaggatatgg gcccggggct gggcagtgag acacggctgg atcgcagcaa aggggacaca
     2101 cggagtgatg cggcgctgct tgactcttca gccacactcg tcaccaatga ggataatgag
     2161 gaaacagaag ggagtgatgt gcctgctgac tacctgctgg gtgacgtaga aggagaggac
     2221 gatgagctgt acccacttga cacagaacat gtgcactccg aggagcctga atatgtgctg
     2281 ccacaagagg ccttcccact gcgccatgaa attgtagaca caccatctgg gcccgagcat
     2341 ctgcaggaca aggcggactc tccgcacgtg agcggcaatg aggcagacac agcttcatta
     2401 gccccggtgg actcctcctc ctccctcctc tccgtctcac atgcactcta tgacagccgc
     2461 ctgccacctg acttcttcag tgtattggta cgggacatgt tgcgcttcta cgctgagcag
     2521 ggcgacgtgc agatggctgt gtctgttctc atcgtgctgg gtgagagagt gcgaaaggac
     2581 atcgatgagc agacccagga gcactggtac acatcctaca tagatctgct gcagcgcttc
     2641 tgcctctgga atgtgtccaa tgaggtggtg aagctgagca ccagcagggc agttagctgc
     2701 ctcaaccaag cctccaccac gctgcatgtc aactgtagtc actgcaagcg gcccatgagc
     2761 agccgcggct gggtctgtga caggtgccac cgctgtgcca gcatgtgtgc tgtctgccat
     2821 catgtggtta aaggcctgtt cgtgtggtgt cagggttgca gtcatggtgg ccatcttcag
     2881 cacatcatga aatggctgga aggcagctcc cactgccctg caggctgcgg ccacctctgt
     2941 gaatactcct gacctggcct tccctaaggc tgatgcagcg tcctcagctc gatcccgatg
     3001 tccaccggac taggctcaca gccccttacc catcctgtgt accaggatgg aaggtggcta
     3061 caacttttta acccaataaa aatccagagc tgctgtttg
//
