LOCUS       NM_175450               2952 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WD repeat domain 18 (Wdr18), transcript variant 1,
            mRNA.
ACCESSION   NM_175450 XM_892621 XM_900218 XM_900222 XM_900224 XM_900227
            XM_914259 XM_923132 XM_923137 XM_923141 XM_923147
VERSION     NM_175450.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2952)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2952)
  AUTHORS   Fanis,P., Gillemans,N., Aghajanirefah,A., Pourfarzad,F.,
            Demmers,J., Esteghamat,F., Vadlamudi,R.K., Grosveld,F.,
            Philipsen,S. and van Dijk,T.B.
  TITLE     Five friends of methylated chromatin target of
            protein-arginine-methyltransferase[prmt]-1 (chtop), a complex
            linking arginine methylation to desumoylation
  JOURNAL   Mol Cell Proteomics 11 (11), 1263-1273 (2012)
   PUBMED   22872859
  REMARK    GeneRIF: Recruitment of the protein complex 5FMC to Zbp-89, a
            zinc-finger transcription factor, affects its sumoylation status
            and transactivation potential.[5FMC]
REFERENCE   3  (bases 1 to 2952)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC151846.3.
            
            On Mar 24, 2023 this sequence version replaced NM_175450.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168691.1, AK166113.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-218               AC151846.3         39627-39844         c
            219-329             AC151846.3         38887-38997         c
            330-463             AC151846.3         34940-35073         c
            464-605             AC151846.3         34648-34789         c
            606-749             AC151846.3         33876-34019         c
            750-814             AC151846.3         33729-33793         c
            815-939             AC151846.3         33530-33654         c
            940-1106            AC151846.3         33273-33439         c
            1107-1175           AC151846.3         32611-32679         c
            1176-2952           AC151846.3         30752-32528         c
FEATURES             Location/Qualifiers
     source          1..2952
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2952
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /note="WD repeat domain 18"
                     /db_xref="GeneID:216156"
                     /db_xref="MGI:MGI:2158400"
     exon            1..218
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             9..1304
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /codon_start=1
                     /product="WD repeat-containing protein 18"
                     /protein_id="NP_780659.2"
                     /db_xref="CCDS:CCDS24000.1"
                     /db_xref="GeneID:216156"
                     /db_xref="MGI:MGI:2158400"
                     /translation="MAAPMEVVVCTDAAAQLWSCVVWELHSGANLLTYRGGQAGPRGL
                     ALLNGEYLLAAQQGKNYICAWELQRKDQLQQKIMCPGPVTCLTTAPNGLYVLAGIAES
                     IYLWEVCTGNLLVILSRHYQDVSCLKFTGDGSHFVSAGKDCLALAWSLCSVLQADPSR
                     ILAPRHVWSQHTLPITDLHCGFGGPMARVATASLDQTVKLWAISSGDLLLSVLFDMGI
                     TSVTMDLAEHHIFCGGSDGSIFQVDLCSWPGLREHSFQPEQNTGKVFKGHRNQVTCLS
                     VSTDGSVLLSGSHDESVRLWDVKSKQCLRTVTLKGPVTNAAIILAPPSMLNPEFRPSL
                     PLPHFNKHLLGAEHGDEAQGGGLRLQLGLHLQGKEPSYLERLEQLQAVLSSYLEKNML
                     GSQMLPARVFDLEDEVRSLRKINRDLFDFSTRIITRPSK"
     exon            219..329
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            330..463
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            464..605
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            606..749
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            750..814
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            815..939
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1106
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1175
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..2952
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1374..1379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /note="hexamer: ACTAAA"
     polyA_site      1397
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /note="major polyA site"
     regulatory      2930..2935
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      2952
                     /gene="Wdr18"
                     /gene_synonym="2310012I10Rik"
ORIGIN      
        1 agagcaagat ggcggcgccc atggaagtgg tggtgtgtac tgacgccgcg gcacagctct
       61 ggagctgcgt ggtgtgggag cttcattcgg gcgccaacct gctcacctac cgaggcggcc
      121 aagcggggcc gcgaggcctg gcgctactca atggcgagta cctgctggcg gcgcagcagg
      181 gcaagaacta catctgcgcc tgggagctgc agcgtaagga tcagctccaa cagaaaatca
      241 tgtgtcctgg gcctgtcacc tgtctgacca cagcacctaa tggcttgtat gtcctggcag
      301 gaattgcaga gagcatctac ctgtgggagg tctgcaccgg gaacctcctg gtcatcctca
      361 gccggcacta ccaggacgtg tcctgcctga agtttacagg ggatggcagt cattttgtct
      421 cagcgggcaa ggactgcttg gcgctggcct ggagcctctg cagtgtgcta caggcagacc
      481 catccaggat ccttgcccca agacatgtct ggtcccagca cacgctccca atcacagacc
      541 tgcactgcgg cttcggaggc cccatggccc gggtggccac cgcttcattg gaccagactg
      601 tgaagctctg ggccatctcc tcgggggacc tgctgctgtc tgtcttgttt gacatgggca
      661 tcacatctgt gaccatggac ctggccgagc accacatatt ctgtggaggc agcgatggct
      721 ccatcttcca ggtggacctg tgcagctggc ccggactgag ggagcacagc ttccagcctg
      781 agcagaacac agggaaggtc ttcaaaggac acaggaacca agtgacatgc ctgtcagtgt
      841 caacagacgg cagtgttctg ctctctggct cccacgatga atcagtgagg ctgtgggacg
      901 tgaagagcaa gcagtgcttg cgcacagtca ccctcaaagg cccagtgacc aatgcagcca
      961 tcattctggc cccacccagc atgctgaacc ctgaattcag gcccagcctg cccctgcccc
     1021 acttcaacaa gcacctgctg ggggctgagc atggagatga agcccagggt gggggcctgc
     1081 gcctgcagct agggctccac ctgcagggca aagagcctag ctacctggag cgtctggagc
     1141 agctgcaggc agtgttgtcc agctacctgg agaagaacat gctaggcagc cagatgctgc
     1201 cagcacgtgt gtttgatctg gaggatgagg tgcgtagcct gcgcaagatc aacagggacc
     1261 tgttcgactt ctccacgcgc atcatcacac ggccctccaa gtgagacgtg ctgggccact
     1321 gccacacaaa cacttgccac ggggctgtga tctagtgttt taacaaagga tggactaaag
     1381 gatggacaat tcttaaattg tgcgccttgg ttgttctgtc cctatctggg ctggggcttg
     1441 gttggaaggc ctcgggcctg ggggatgggg tgcggtgagt ggggggccga ctgcagagtc
     1501 cccattcatg agggccaatc aggcagcaat cagtccttca cagctgtcca aagctcagtg
     1561 ttcacatcgt gtcctggggc tacctcaaat acccaaatac caacagaacc ttccagaaag
     1621 ctgcctgcaa ctgacagccc tgcttaacaa tccagaagat ctgtgattta tcagagctgt
     1681 tgccactgca gctcagaaga gctgtgccct caggtggcaa gatgtgacca taccctgggg
     1741 gaccacagcc tcctatgaca tggacctctg ggtcctcttc cctgtacttt ccttcctttc
     1801 caccctggcc cctcccctag tcccctggct ccttgtagct gttgctccct cagggaaggt
     1861 ctggagagag acaagaaggt atgcactcta ccagccatgg gtccccagga cccaaccaaa
     1921 ggcctctgga ggtctcttga gactgggtgt tcattatact cctaattatg tctcagattc
     1981 tggctaggga cagtggcaga tgttgggtgg agccataact tgccacccaa atattgggtc
     2041 cccacctgct gtggctggac tgagagacca tctgcctgta cttcccccat ccaagccaga
     2101 acctcactag cccaggctgg cttggaaggc agggtccccc tgcagatctg cttcatctgt
     2161 cccagcctcc ttactaagcc ttgctgtatt ccctcatttg tctgcctcag cttccccgca
     2221 ctgactggag aattcagcct ttgtaaatac taggctgggt gaatgccaag caagatctaa
     2281 gtccccagtc tcctgagcag tggggcagcc tgcaccaagc ccccataaac ttcctcgggc
     2341 aacaggagtg gggcagtgta gaccagtaca gccccattcc ccatgggagg gaagtggacg
     2401 ctgtgtggtc cagccatcaa gtacggagga accttgagga caaaggccac tgaagggttc
     2461 catggcagga aatgtctgga acagtattcg gggggataat tcacatttgt gagatgtgct
     2521 ttcccactcc ccaaaaaggc cttgcatgaa tttcctgtca ttcagctgga gtggaaggtc
     2581 ccacttggcc cttctgttag gagtgatagt gaatcctgac aggcctgcag tccagctgtc
     2641 tcatgttcag tgagtggaat agagccggca cccaggactg tgtggtgacc tactgaaaga
     2701 gtgccaggtg acagtataga caaaaaggag atgtcagagg aaggggagct aaggctggca
     2761 acatctcagc ttcaggaaga gcaccctgag gatctctgaa gtggttggtg acaatggcaa
     2821 ctaggacaga ctagccccag actggaaccc taaaggaccc caagcctgat gtcctttgga
     2881 tccctggcca ggtgcctaga cagcctgcca tcttgagcca agccatctca ttaaaaacca
     2941 gctcaaagtg ca
//
