LOCUS       NM_026137               4233 bp    mRNA    linear   ROD 31-MAY-2024
DEFINITION  Mus musculus WD repeat domain 13 (Wdr13), transcript variant 1,
            mRNA.
ACCESSION   NM_026137
VERSION     NM_026137.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4233)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4233)
  AUTHORS   Singh,S., Pavuluri,S., Jyothi Lakshmi,B., Biswa,B.B.,
            Venkatachalam,B., Tripura,C. and Kumar,S.
  TITLE     Molecular characterization of Wdr13 knockout female mice uteri: a
            model for human endometrial hyperplasia
  JOURNAL   Sci Rep 10 (1), 14621 (2020)
   PUBMED   32883989
  REMARK    GeneRIF: Molecular characterization of Wdr13 knockout female mice
            uteri: a model for human endometrial hyperplasia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4233)
  AUTHORS   Mishra,A.P., Yedella,K., Lakshmi,J.B. and Siva,A.B.
  TITLE     Wdr13 and streptozotocin-induced diabetes
  JOURNAL   Nutr Diabetes 8 (1), 57 (2018)
   PUBMED   30369599
  REMARK    GeneRIF: Wdr13(-/0) mice exhibited higher serum insulin levels,
            better glucose clearance and significantly higher number of
            proliferating beta-cells; reiterating the finding that absence of
            WDR13 helps in beta-cell hyper-proliferation and recovery from
            diabetes
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4233)
  AUTHORS   Mitra,S., Sameer Kumar,G.S., Jyothi Lakshmi,B., Thakur,S. and
            Kumar,S.
  TITLE     Absence of Wdr13 Gene Predisposes Mice to Mild Social Isolation -
            Chronic Stress, Leading to Depression-Like Phenotype Associated
            With Differential Expression of Synaptic Proteins
  JOURNAL   Front Mol Neurosci 11, 133 (2018)
   PUBMED   29743870
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4233)
  AUTHORS   Singh,V.P., Katta,S. and Kumar,S.
  TITLE     WD-repeat protein WDR13 is a novel transcriptional regulator of
            c-Jun and modulates intestinal homeostasis in mice
  JOURNAL   BMC Cancer 17 (1), 148 (2017)
   PUBMED   28222755
  REMARK    GeneRIF: Results provide evidence that WDR13 is a novel
            transcriptional activator of AP1 target genes in the presence of
            JNK signal. The lack of Wdr13 gene conferred protection to a large
            extent against colitis-induced colorectal tumor in mice through
            reduced expression of AP1 target genes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4233)
  AUTHORS   Mitra,S., Sameer Kumar,G.S., Tiwari,V., Lakshmi,B.J., Thakur,S.S.
            and Kumar,S.
  TITLE     Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety,
            Better Performance in Spatial Memory Task, with Upregulation of
            Multiple Synaptic Proteins
  JOURNAL   Front Mol Neurosci 9, 73 (2016)
   PUBMED   27625594
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4233)
  AUTHORS   Singh,V.P., Alex,J.L., Lakshmi,B.J., Sailasree,S.P., Raj,T.A. and
            Kumar,S.
  TITLE     Role of mouse Wdr13 in placental growth; a genetic evidence for
            lifetime body weight determination by placenta during development
  JOURNAL   Sci Rep 5, 13371 (2015)
   PUBMED   26306915
  REMARK    GeneRIF: Using two types of heterozygous females carrying either
            maternally and paternally derived mutant Wdr13 allele we provide
            genetic evidence that development of placenta determines body
            weight of mice for the entire life.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4233)
  AUTHORS   Singh,V.P., Lakshmi,B.J., Singh,S., Shah,V., Goel,S., Sarathi,D.P.
            and Kumar,S.
  TITLE     Lack of Wdr13 gene in mice leads to enhanced pancreatic beta cell
            proliferation, hyperinsulinemia and mild obesity
  JOURNAL   PLoS One 7 (6), e38685 (2012)
   PUBMED   22715406
  REMARK    GeneRIF: WDR13 is a novel negative regulator of the pancreatic beta
            cell proliferation.
REFERENCE   9  (bases 1 to 4233)
  AUTHORS   Suresh,A., Shah,V., Rani,D.S., Singh,B.N., Prasad,G.U.,
            Subramanian,S., Kumar,S. and Singh,L.
  TITLE     A mouse gene encoding a novel member of the WD family of proteins
            is highly conserved and predominantly expressed in the testis
            (Wdr13)
  JOURNAL   Mol Reprod Dev 72 (3), 299-310 (2005)
   PUBMED   16094675
  REMARK    GeneRIF: WDR13 is localized to the locus XA1.1 and is predominantly
            expressed in the testis.
REFERENCE   10 (bases 1 to 4233)
  AUTHORS   Derry,J.M., Gormally,E., Means,G.D., Zhao,W., Meindl,A.,
            Kelley,R.I., Boyd,Y. and Herman,G.E.
  TITLE     Mutations in a delta 8-delta 7 sterol isomerase in the tattered
            mouse and X-linked dominant chondrodysplasia punctata.
            jderry@immunex.com
  JOURNAL   Nat Genet 22 (3), 286-290 (1999)
   PUBMED   10391218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC057366.1, AK017549.1, BC080853.1 and AL663032.9.
            
            On Mar 20, 2014 this sequence version replaced NM_026137.4.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC108332.1, AK017549.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-538               BC057366.1         1-538
            539-3134            AK017549.1         121-2716
            3135-4231           BC080853.1         3050-4146
            4232-4233           AL663032.9         75673-75674         c
FEATURES             Location/Qualifiers
     source          1..4233
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 3.67 cM"
     gene            1..4233
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /note="WD repeat domain 13"
                     /db_xref="GeneID:73447"
                     /db_xref="MGI:MGI:1914661"
     exon            1..572
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..1989
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /note="isoform 1 is encoded by transcript variant 1; WD
                     repeat-containing protein 13; memory-related protein"
                     /codon_start=1
                     /product="WD repeat-containing protein 13 isoform 1"
                     /protein_id="NP_080413.2"
                     /db_xref="CCDS:CCDS29986.1"
                     /db_xref="GeneID:73447"
                     /db_xref="MGI:MGI:1914661"
                     /translation="MAAVWQQVLAVDARYNAYRTPTFPQFRTQYIRRRSQLLRENAKA
                     GHPPALRRQYLRLRGQLLGQRYGPLSEPGSARAYSNSIVRSSRTTLDRMEDFEDDPRA
                     LGARGHRRSVSRGSYQLQAQMNRAVYEDRPPGSVVPTSVAEASRAMAGDTSLSENYAF
                     AGMYHVFDQHVDEAVPRVRFANDDRHRLACCSLDGSISLCQLVPAPPTVLHVLRGHTR
                     GVSDFAWSLSNDILVSTSLDATMRIWASEDGRCIREIPDPDGAELLCCTFQPVNNNLT
                     VVGNAKHNVHVMNISTGKKVKGGSSKLTGRVLALSFDAPGRLLWAGDDRGSVFSFLFD
                     MATGKLTKAKRLVVHEGSPVTSISARSWVSREARDPSLLINACLNKLLLYRVVDNEGA
                     LQLKRSFPIEQSSHPVRSIFCPLMSFRQGACVVTGSEDMCVHFFDVERAAKAAVNKLQ
                     GHSAPVLDVSFNCDESLLASSDASGMVIVWRREQK"
     exon            573..813
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     exon            814..923
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1054
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1362
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     exon            1363..1543
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..1685
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     exon            1686..1804
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..4233
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4125..4130
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /note="hexamer: ATTAAA"
     polyA_site      4147
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /note="major polyA site"
     regulatory      4208..4213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /note="hexamer: AATAAA"
     polyA_site      4231
                     /gene="Wdr13"
                     /gene_synonym="1700060B08Rik; 5730411P10Rik; DXHXS7467e;
                     mMg21"
                     /note="major polyA site"
ORIGIN      
        1 cgatttgctc tgtgctccgc agctctttct cgttgcaggc agccatcttg cctggagctt
       61 gagacaggga gaagagagag aaggaaccgg tgacactggg ctcagggtcg ccgggggggg
      121 ggggcgcctc aagagctagg ggtagccccg gaggtggtcc tggatcctga gctatgctct
      181 aggactagaa aagggaaggc ggagggcaga aggcttgatg ggtggggaat gtcaaacaag
      241 acttgctatg ggggggaggg gcgttgctac ggcaactgga gagggcgggg tcatgtctga
      301 actgctgctg tgagtcaccg gagtgctgcc caggaaaggc agggctgggg tgatgaccac
      361 gctaacgacc cagtgggatt tcgcgacatc acctgtgtgg agggacttcg tgtctatggc
      421 aactgtcacc tggtgggcgg aactagattt tctctgcctg ggacgctgac attccaagcc
      481 cttgccctgc aggctcccgc aggcagacaa accaaagaag gaagccaggg aatggccgcg
      541 gtgtggcagc aagtattagc agtggacgcg aggtacaacg cctaccgtac accaacgttt
      601 ccacagtttc ggacccagta tatccgccgg cgcagccagc tgcttcggga gaatgccaaa
      661 gctggtcacc ccccagcatt gcgtcggcag tacctgaggc tacggggcca gctattgggc
      721 caacggtacg ggccactctc agaaccaggc agtgctcgtg cctatagcaa cagcattgtc
      781 cgcagcagcc gaacaaccct tgatcgaatg gaggactttg aagatgaccc cagagccctg
      841 ggggctcgag gacaccgccg atctgtcagc cgaggttcct accagctgca ggcacaaatg
      901 aaccgtgcag tctatgagga caggcctcct ggcagtgtgg tacccacgtc ggtggcagag
      961 gcaagtcggg ccatggccgg ggacacgtcg ctgagtgaga actatgcctt tgcaggcatg
     1021 taccatgttt ttgaccaaca cgtggatgag gcagtcccaa gggtgcgctt cgccaatgac
     1081 gaccggcacc gcctggcctg ctgctccctg gacggcagca tctccctgtg ccagctggtg
     1141 cctgccccac ccactgtgct ccatgtgcta cggggccata cacgtggcgt ctcggacttc
     1201 gcctggtccc tctccaatga catccttgtg tccacctccc tcgatgccac catgcgcatc
     1261 tgggcctccg aggacggccg ctgcatccgt gagatccctg accctgatgg cgccgaattg
     1321 ctctgctgca ccttccagcc agtcaacaac aacctcactg tggtggggaa cgccaagcac
     1381 aacgtgcatg tcatgaacat ctccacaggc aagaaagtga agggtggctc cagcaagctc
     1441 accggccgcg tcctcgccct gtcctttgat gcccctggtc ggctgctctg ggcaggcgat
     1501 gaccgcggca gtgtcttctc ctttctcttt gacatggcca caggaaagct gaccaaagcc
     1561 aagcgactag tagtgcatga aggcagccct gtaaccagca tttctgcccg gtcctgggtc
     1621 agccgtgaag cacgggaccc ctctctgctc atcaatgcct gcctcaacaa gctgctactc
     1681 tacagagtgg tggacaacga aggggcgcta cagctgaaga gaagcttccc cattgaacag
     1741 agttcccacc ctgtacgcag tatcttctgc cccctcatgt ccttccgcca gggggcctgt
     1801 gtggtgacag gcagtgaaga tatgtgcgtt cacttctttg acgtggagcg ggcagccaag
     1861 gctgctgtta acaagctgca gggccacagc gcgcccgtgc ttgacgtcag cttcaactgt
     1921 gacgagagtc tgctggcctc cagtgatgcc agtggcatgg tcatcgtctg gagacgagag
     1981 caaaagtagg gttctgtcac cctgtgctgc ccactgatcc ctcctccttc actccagtct
     2041 tgcgttataa attaaattcc tgtggttgtg ttgaagggct ctcagctctc ccaccaggag
     2101 gcagtaggga gctctcaggc ctccagtgga gtggggacca gttcctcgat tgtgcagtga
     2161 tgtgctcatc cattcaacaa gcacttgctg agcatctgct gtgatgtatc acgtaggcat
     2221 gcagtcagta gaaggaggga gggtaccaac tgtggtcagg agctgttctg ggaagtaggg
     2281 atacagctat ggcttcaact gaaattccta cccctgtggg ctggcatccc agcagaggca
     2341 agcatacagg agacagacgt tctgagctgt tctgggaagt agggatacag ctgtggcttc
     2401 aactgacaga aattcctacc cctgtgggct ggcatcccaa tagaggcaag cacatgggag
     2461 acgaaagtac agccattcct tggtgtagaa tttgctttat aatttttcaa ctttataaat
     2521 ttttgacctt ccagtggtag cgaaccacac gcatataccc agttctggtt ttctcctttc
     2581 agtatggtgt tcagtaaatt atgtgagcta gtcactttgt tataaaatag actttgcatt
     2641 aggtaagttt gcctaactgt agaataatgt cagcgttgtg ggcacattta aggtaggtga
     2701 cactaagcta gggtgttcgg taggttaggt atatttatgc attttcaaca taagacagtt
     2761 caagacagat ttgttggggt ctaaccccgt gtgatgaagt cacatctgta tataatagag
     2821 ttaaagatga gtgctaggaa gaaaagcaaa gggccagatg agcttgcaca aaagggaggg
     2881 gcaaagtcat caggaagagt gttcccaacc agatgacagt tttaaagatc tgagtgaaat
     2941 agagcctgga ataatgtgat tgggcggagt gtatgagatg atgggagaca ggtctttggg
     3001 acatcttggg ccatagcaag gaaggaagct ttccttattc cctgagtgag gaaggtgagg
     3061 aaggctcaga cagcagtagg gaaattaggt gcagaatgtt aagttcaacc acggggcttt
     3121 caccaggtta ggttgtcaaa ctccccaaca ttggcagcta ctgtttgggt ggaccccaca
     3181 cttgcctgtg cgttgagttg tgtcccacaa gcagtgagca gaagtgtcga gttcttggag
     3241 ctagattagc atgcatacag ccatgaactc tggggctgag ccacagttcc tgctgtgggg
     3301 tggaagaaac agaaaatctc taagctcacc cctgtctcct gccatgtcta tctggggccc
     3361 ttatttcagt cctggacctg ctcagagacc aaatactaat gttcattatt gagtattggc
     3421 aaggagataa attactaaat gactcttggt aattaggtca tgacgaaatg tgaaggtttg
     3481 aagaatcacc aggagttctt gcagctccca tatgctacta catttgtagc aattggaact
     3541 ttggctaaca tcctggaacc gctgagtctt gccaacctgg tgatctatag aactaacagc
     3601 agctctttga ggaaaaaaga tgatttccta tttgtttcgt ttcttgttta agagtatggt
     3661 cacttccagc caaaacattt ctgactccat cagtcagatt ttaggcaaat ggttattaga
     3721 ttggaatgtt agtgagctgg actggtcatt gtagtcaaga tcatatatgt gtgccaacat
     3781 ccctaatcca gcttcagggt cagtgatttt tctatgagga ctgtaactta ctatagcaaa
     3841 gggtgccaga cagcaattaa gtgctaatct ctttaaagac cctcccaagg ttagcagttc
     3901 agacctgtgc actggctctt ctgtaccaaa tggatgcact tattcagcca aggtctgggg
     3961 gtagcaacag aatttgggta cataacagtt ttctctaact ttctcctttt cttcactctc
     4021 tccattttct ttaatgagtc tggtttcagg atgattggtg atgaatattg tttgcatgat
     4081 tttggggggg ttccttgtgc aatttttgag gtggcagagt tgacattaaa ttatctactt
     4141 taaattatct tggtgacact tttgtctcac aacctgaagg aaaataaaca ctgagcaaac
     4201 aagaaagaat aaaaaataat gttgctggtt aga
//
