LOCUS       NM_021312               2946 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus WD repeat domain 12 (Wdr12), transcript variant 2,
            mRNA.
ACCESSION   NM_021312
VERSION     NM_021312.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2946)
  AUTHORS   Yin,L., Li,L., Gao,M., Qi,Y., Xu,L. and Peng,J.
  TITLE     circMIRIAF aggravates myocardial ischemia-reperfusion injury via
            targeting miR-544/WDR12 axis
  JOURNAL   Redox Biol 73, 103175 (2024)
   PUBMED   38795544
  REMARK    GeneRIF: circMIRIAF aggravates myocardial ischemia-reperfusion
            injury via targeting miR-544/WDR12 axis.
REFERENCE   2  (bases 1 to 2946)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2946)
  AUTHORS   Chern,T., Achilleos,A., Tong,X., Hill,M.C., Saltzman,A.B.,
            Reineke,L.C., Chaudhury,A., Dasgupta,S.K., Redhead,Y., Watkins,D.,
            Neilson,J.R., Thiagarajan,P., Green,J.B.A., Malovannaya,A.,
            Martin,J.F., Rosenblatt,D.S. and Poche,R.A.
  TITLE     Mutations in Hcfc1 and Ronin result in an inborn error of cobalamin
            metabolism and ribosomopathy
  JOURNAL   Nat Commun 13 (1), 134 (2022)
   PUBMED   35013307
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2946)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 2946)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 2946)
  AUTHORS   Nal,B., Mohr,E., Silva,M.I., Tagett,R., Navarro,C., Carroll,P.,
            Depetris,D., Verthuy,C., Jordan,B.R. and Ferrier,P.
  TITLE     Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a
            notchless-like amino-terminal domain
  JOURNAL   Genomics 79 (1), 77-86 (2002)
   PUBMED   11827460
  REMARK    GeneRIF: Amino-terminal similarity to Notchless WD repeat protein.
            May function in the modulation of Notch signaling activity.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX564842.1 and BC052386.1.
            
            On Nov 19, 2010 this sequence version replaced NM_021312.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1-3 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052386.1, AK031436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                CX564842.1         2-30
            30-2946             BC052386.1         1-2917
FEATURES             Location/Qualifiers
     source          1..2946
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 30.45 cM"
     gene            1..2946
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /note="WD repeat domain 12"
                     /db_xref="GeneID:57750"
                     /db_xref="MGI:MGI:1927241"
     exon            1..401
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     CDS             361..1632
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /note="nuclear protein Ytm1; WD repeat-containing protein
                     12"
                     /codon_start=1
                     /product="ribosome biogenesis protein WDR12"
                     /protein_id="NP_067287.1"
                     /db_xref="CCDS:CCDS14988.1"
                     /db_xref="GeneID:57750"
                     /db_xref="MGI:MGI:1927241"
                     /translation="MAQLQARFYSENKKYAVDDVPFSIPAAAEVADLSNIINKLLETK
                     NELHKHVEFDFLIKGQFLRVPLVKHMELENISSEEVVELEYVEKYTAPQPEQCMFHDD
                     WISSIEGAEEWILSGSYDKTSRIWSLEGKSIMTIVGHTDVVKDVAWVKKDSLSCLLLT
                     ASMDQTVLLWEWNVEKNKVKALHCCRGHAGSVDAIAVDSSGAKFCSGSWDKMLKIWST
                     VPTDEEDEMEEATNRPRKKQKTEQLGLTRTPLVTLSGHTEAISSVLWSDAEEICSASW
                     DHTIRVWDVESGGLKSTLTGNKVFNCISYSPLCKRLASGSTDRHIRLWDPRTKDGSLV
                     SLSLTSHTGWVTSVKWSPTHEQQLISGSLDNIVKLWDTRSCKAPLYDLAAHEDKVLSV
                     DWTDTGLLLSGGADNKLYSYSYSPTTSHVGA"
     exon            402..496
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            497..591
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            592..698
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            699..814
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            815..969
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1015
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1101
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1242
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1348
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1481
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1554
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     exon            1555..2928
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1634..1639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /note="hexamer: AATGAA"
     polyA_site      1653
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /note="major polyA site"
     regulatory      2080..2085
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /note="hexamer: AATACA"
     polyA_site      2103
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
     regulatory      2732..2737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /note="hexamer: ATTAAA"
     polyA_site      2753
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
                     /note="hexamer: AATAAA"
     polyA_site      2928
                     /gene="Wdr12"
                     /gene_synonym="4933402C23Rik; Ytm1; Ytm1p"
ORIGIN      
        1 agcgctgagt ctaaagggtc tgggtctaaa gacacgctta aaatttggct caagctagtt
       61 attttcttta ttttcctaat agattacgaa tctagataga taagaaacaa aagtcttaag
      121 gggactggat gcttttagga ctacgcttga ctaatcgatg tttcctaaat ctcggaatag
      181 gtacttgatg tgtgcgggct gggcgctggt ggaaatcgaa cctcgtggta tgttctgtag
      241 gaacctgagg gagctaactg aagcctagct cctgctgcgc ttgcggcgca gtctacctta
      301 gagctgcttg attatcaacg cacacatttt cgtggagaag tctcgtgtgt atattcagcc
      361 atggcacaac tccaggcacg tttctacagc gagaacaaga aatacgcagt ggatgatgtc
      421 cctttctcaa tccctgccgc tgctgaagtt gcggacctta gtaacattat caataagttg
      481 ctggagacca aaaatgaact ccacaagcat gtcgagtttg atttccttat caagggccag
      541 tttcttcgag tgcccttggt caaacacatg gaactggaga acatttcatc ggaagaggtt
      601 gtggaactag aatatgtgga aaagtacacc gcaccccagc cagagcagtg catgttccat
      661 gatgactgga tcagctcaat tgaaggggca gaagaatgga tcctgtctgg ttcttatgat
      721 aagacttctc ggatctggtc cttggaagga aagtcgataa tgacaattgt gggacataca
      781 gatgttgtga aagatgtggc ttgggtgaaa aaagacagtt tgtcctgctt actactgacg
      841 gcctcgatgg accagactgt tctcttatgg gagtggaatg tagagaagaa caaagtgaaa
      901 gctctgcact gctgccgagg gcatgctggg agtgtggacg ccatcgcagt cgatagctcg
      961 ggagctaagt tttgcagtgg ctcctgggat aagatgctaa agatctggtc tacagtccct
     1021 acagatgaag aagatgaaat ggaagaagcc acaaatcgac caagaaaaaa gcaaaaaaca
     1081 gaacaattgg gactaacaag aacacccttg gtgaccctct ctggccacac agaagcaatt
     1141 tcctcagtcc tttggtcaga cgctgaagaa atctgtagtg catcttggga tcacacaatt
     1201 agagtgtggg atgttgagtc tggcggtctt aagtcaactc tgacaggaaa taaagtgttt
     1261 aattgtattt cctattctcc cctttgtaaa cgtttggcat ctggaagcac agacaggcat
     1321 attagactgt gggatccccg aactaaagat ggttctttgg tgtcgctgtc tctcacctca
     1381 cacacaggct gggtgacatc agtgaagtgg tctcctaccc atgaacagca gctcatctcg
     1441 ggctctttag ataacattgt gaagctatgg gatacaagaa gctgtaaggc tcctctctac
     1501 gatctagctg ctcatgaaga caaagttcta agtgtggact ggacagacac agggctactt
     1561 ctgagtggag gagcagacaa taaattgtat tcctacagct attcccctac cacttcccat
     1621 gtgggggctt gaaaatgaat ggctgagaag agacttcctt gttgggtctt gtcttaattc
     1681 ttagtgtctc actgttattt cataaactga atcaaatttg agagaggact tatagtacag
     1741 ctcagctggt agaatgcttg cctaaaatgt gcacagccct gcatgctatc tccagcactg
     1801 cccaaagaaa aatgggcatg gtagcacatt cctgtaatcc cagtcctaga ggttggaagc
     1861 aagagcatca gaaattcaag gtcaccctct gctgtatagt gagcttaaag gcagccagcc
     1921 atggttccct gagtctctgt ctccataaga aagaaatcaa tggataatcc tctgatatca
     1981 ttgtcaatgc agagacagga agcagccttt taaaatttgg ataacagttc atctttcata
     2041 atagcaacat tttactgtct ttgtccttcg tgcttataaa atacagtaag tatgtggtct
     2101 gaattctgtc tacattttac cctatgtaga ctcctaaaac ttgaatttca gaaagtatac
     2161 tttttaaagg gatatagtac aaatgtagta aatttgtttt tttttgtctt tttgttttgt
     2221 tttagtttga ctttttagtt agctatttga agagaaacat ctagaaaaga ctaataatgc
     2281 tataggagcc aggcatcata gcacacactt ataaccctag catttaagaa gtagaagcaa
     2341 aaggcttggg acttgagtag gattggcttc ataactagtt caagtcagga gcaggatgag
     2401 actcggtctc aaataaagaa aatgaaaact tataggaggg tcatcaaaat ggctcagtga
     2461 ctaaagatgc ttgctgccaa ttctgatagc gtgagttcag ttctcaggtc tgaactcctg
     2521 caagctgtcc ttttccccac acacatgcac acatactgtg gcatgcatac aactaacctg
     2581 taaataaatt taaagaaaaa agaagtttat aaaagtatgg ggaaaacagt catctaacat
     2641 taaaagcaaa tagtaaaaaa caacaacaac aaaacaccac acactaaaag gtagtgtgta
     2701 taagaaaata agactgttga gtgttcagag cattaaaaca atgtagatgt taatttgtcc
     2761 attcattgag cagcagggca gtgatggttc acatctttaa tgccagcacc tgggaagcag
     2821 gtggatgtct gtgggttcaa ggatagcctg gtgagtttca ggacagccag ggataaacag
     2881 agagaccctg actcaaacgc aataaaaaaa aaaaatagtc tttcctgaaa aaaaaaaaaa
     2941 aaaaaa
//
