LOCUS       NM_172255               4566 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus WD repeat domain 11 (Wdr11), mRNA.
ACCESSION   NM_172255
VERSION     NM_172255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4566)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4566)
  AUTHORS   Lee,J., Kim,Y., Ataliotis,P., Kim,H.G., Kim,D.W., Bennett,D.C.,
            Brown,N.A., Layman,L.C. and Kim,S.H.
  TITLE     Coordination of canonical and noncanonical Hedgehog signalling
            pathways mediated by WDR11 during primordial germ cell development
  JOURNAL   Sci Rep 13 (1), 12309 (2023)
   PUBMED   37516749
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4566)
  AUTHORS   Anania,C., Acemel,R.D., Jedamzick,J., Bolondi,A., Cova,G.,
            Brieske,N., Kuhn,R., Wittler,L., Real,F.M. and Lupianez,D.G.
  TITLE     In vivo dissection of a clustered-CTCF domain boundary reveals
            developmental principles of regulatory insulation
  JOURNAL   Nat Genet 54 (7), 1026-1036 (2022)
   PUBMED   35817979
REFERENCE   4  (bases 1 to 4566)
  AUTHORS   Kim,Y.J., Osborn,D.P., Lee,J.Y., Araki,M., Araki,K., Mohun,T.,
            Kansakoski,J., Brandstack,N., Kim,H.T., Miralles,F., Kim,C.H.,
            Brown,N.A., Kim,H.G., Martinez-Barbera,J.P., Ataliotis,P.,
            Raivio,T., Layman,L.C. and Kim,S.H.
  TITLE     WDR11-mediated Hedgehog signalling defects underlie a new
            ciliopathy related to Kallmann syndrome
  JOURNAL   EMBO Rep 19 (2), 269-289 (2018)
   PUBMED   29263200
  REMARK    GeneRIF: Our study reveals a novel class of ciliopathy caused by
            WDR11 mutations and suggests that CHH/KS may be a part of the human
            ciliopathy spectrum.
REFERENCE   5  (bases 1 to 4566)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4566)
  AUTHORS   Kim,H.G., Ahn,J.W., Kurth,I., Ullmann,R., Kim,H.T., Kulharya,A.,
            Ha,K.S., Itokawa,Y., Meliciani,I., Wenzel,W., Lee,D.,
            Rosenberger,G., Ozata,M., Bick,D.P., Sherins,R.J., Nagase,T.,
            Tekin,M., Kim,S.H., Kim,C.H., Ropers,H.H., Gusella,J.F.,
            Kalscheuer,V., Choi,C.Y. and Layman,L.C.
  TITLE     WDR11, a WD protein that interacts with transcription factor EMX1,
            is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann
            syndrome
  JOURNAL   Am J Hum Genet 87 (4), 465-479 (2010)
   PUBMED   20887964
REFERENCE   7  (bases 1 to 4566)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4566)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 4566)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   10 (bases 1 to 4566)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104753.10, CK638976.1, AK043051.1, AK173155.1 and AW489876.1.
            
            On Apr 28, 2009 this sequence version replaced NM_172255.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037177.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC104753.10        109783-109793
            12-382              CK638976.1         1-371
            383-2745            AK043051.1         1-2363
            2746-4546           AK173155.1         391-2191
            4547-4566           AW489876.1         1-20                c
FEATURES             Location/Qualifiers
     source          1..4566
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 72.37 cM"
     gene            1..4566
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /note="WD repeat domain 11"
                     /db_xref="GeneID:207425"
                     /db_xref="MGI:MGI:1920230"
     exon            1..201
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     CDS             116..3787
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /note="bromodomain and WD repeat domain containing 2;
                     bromodomain and WD repeat-containing protein 2"
                     /codon_start=1
                     /product="WD repeat-containing protein 11"
                     /protein_id="NP_758459.2"
                     /db_xref="CCDS:CCDS40155.1"
                     /db_xref="GeneID:207425"
                     /db_xref="MGI:MGI:1920230"
                     /translation="MLPYTVNFKVSARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVV
                     VIDSNTAQTLQVLEKHKADIVKVRWARENYHHNIGSPYCLRLASADVTGKIIVWDVAA
                     GVAQCEIQEHVKPIQDVQWLWNQDASRDLLLAIHPPNYIVLWNADTGTKLWKKSYADN
                     ILSFSFDPFDPSHLTLLTSEGIVFISDFSPSKPPSGPGKKVYISSPHSSPAHNKLAAA
                     TGAKKALNKVKILITQEKPSADFVALNDCLQLAYLPSKRNHMLLLYPREILILDLEVN
                     QTVGVIAIERTGVPFLQVIPCSQRDGLFCLHENGCITLRVRRSYNSICTTSNDEPDLD
                     PVQELTYDLRSQCDAIRVTKTVRPFSMVCCPVNENAAALIVSDGRVMIWELKSAVCSR
                     NARNSSGVSPLYSPVSFCGIPGGVLQNKLPDLSLDNMIGQSAIAGEEHPKGSILQEVH
                     LKFLLTGLLSGLPSPQFAIRMCPPLTTKNIKMYQPLLAVGTSNGSVLVYHLTSGLLHK
                     ELSVHSCEVKGIEWTSLTSFLSFAASTPNNMGLVRNELQLVDLPTGRSTAFRGDRGND
                     ESPIEMIKVSHLKQYLAVVFKDKPLELWDIRTCTLLREMSKSFPAITALEWSPSHNLK
                     SLRKKQLATREAMARQTVVSDAELGAVESSVISLLQEAESKAELSQNISAREHFVFTD
                     NDGQVYHLTVEGNSVKDSARIPPDGSMGSITCIAWKGDTLVLGDMDGNLNFWDLKARV
                     SRGIPTHRSWVRKIRFAPGKGNQKLIAMYNDGAEVWDTKEVQMVSSLRSGRNVTFRIL
                     DVDWCTSDKVILASDDGCIRVLEMSMKSTCFRMDEQELVEPVWCPYLLVPRAALALKA
                     FLLHQPWNGRYSLDISHIDYPENEEIKTLLQEQLHALSNDIKKLLLDPDFSLLQRCLL
                     VSRLYGDESELHFWTVAAHYLHSLSQAKSGDTVVTKEGAPKDRLSNPLDICYDVLCEN
                     TYFQKFQLERVNLQEVKRSTYDHTRKCTDQLLLLGQTDRAVQLLLETSADNQHYYCDS
                     LKACLVTTVTSSGPSQSTIKLVATNMIANGKLAEGVQLLCLIDKAADACRYLQTYGEW
                     NRAAWLAKVRLNSEECADVLKRWVDHLCSPQVNQKSKALLVLLSLGCFVSVAETLHSM
                     RYFDRAALFVEACLKYGAFEVSEDTEKLIAAIYADYARSLKSLGFRQGAVRFASKAGA
                     AGRDLLNELGSTKEELTES"
     exon            202..313
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            314..467
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            468..641
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            642..828
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            829..994
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1109
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1305
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1406
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1583
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            1584..1668
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            1669..1775
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            1776..1851
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            1852..1960
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2085
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2233
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            2234..2340
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            2341..2455
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2627
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            2628..2736
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..2799
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            2800..2865
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..3043
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3139
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            3140..3305
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            3306..3403
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            3404..3549
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            3550..3629
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     exon            3630..4550
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4527..4532
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /note="hexamer: AATAAA"
     polyA_site      4548
                     /gene="Wdr11"
                     /gene_synonym="2900055P10Rik; Brwd2; mKIAA1351"
                     /note="major polyA site"
ORIGIN      
        1 tgggatttca cggaacccaa ctgctggcgc ggacgcgact acccggactt tggaacggaa
       61 gagctgctcg tgtcgcttcc tgcctgccgg tggggagggc cggggtgccg ccgcgatgtt
      121 accctacacc gtaaacttca aggtgtcagc gcgcaccctc accggggctc tcaacgcgca
      181 caacaaggcg gcggtggact ggggctggca aggtttaatt gcatatggat gccattcact
      241 ggtggtagtg atcgattcca atactgccca aactctacaa gttctagaaa aacataaagc
      301 tgatattgtt aaggtcaggt gggccaggga gaactatcac cataacatcg gctctccata
      361 ctgcctgcgc ttggcttctg cggatgtcac tgggaagatc attgtctggg atgtagcagc
      421 cggagtagcc cagtgtgaga tccaagagca cgtgaagccc atccaagatg tgcagtggct
      481 gtggaatcag gacgcttccc gagacttgct gctcgctatc cacccgccta attacatcgt
      541 gctgtggaat gcagacacag gcaccaagct gtggaagaag agctacgcag ataacatcct
      601 ttctttttct tttgaccctt ttgatccttc acatttaact ttactcacca gcgagggcat
      661 cgttttcatc tcagacttct ctccatccaa gcctccctcc ggccctggga agaaagtgta
      721 catctccagc ccacactcca gcccagctca taacaagctg gccgcagcca cgggagccaa
      781 gaaggctctt aataaagtaa agattttaat cactcaggag aaaccgagtg ctgattttgt
      841 agctctcaat gactgcctcc agttagccta tctgccttca aaaaggaatc acatgctgtt
      901 gctctaccct cgggagattt taatccttga cctggaagtg aatcaaacag ttggtgtgat
      961 tgcaatcgag agaacaggcg ttccctttct gcaggtaata ccatgctctc agcgagatgg
     1021 cttgttttgc ctacatgaaa atggctgcat aaccttacgt gtccggaggt cttataacag
     1081 catctgtact acatcaaatg atgaaccaga tctagatcct gtccaggagc ttacctatga
     1141 cttgagaagc cagtgtgatg caatcagggt gacgaaaact gtccgtccct tcagtatggt
     1201 gtgctgtcct gttaatgaga atgcagctgc cctcatagta agcgacggca gagtcatgat
     1261 atgggaactc aagtctgctg tgtgcagtcg aaatgcacgg aacagttccg gtgtgtctcc
     1321 tttatactcg ccagtgtcct tctgtgggat tcctggagga gtgctacaga ataaactccc
     1381 agacctttcc ctagataata tgatcgggca gagtgcaatt gctggggaag aacaccccaa
     1441 aggctccatt ctgcaggaag tgcacctcaa gttcctgctg acgggactgc tctcaggact
     1501 cccttcccct cagtttgcca tccgaatgtg cccaccactg accacaaaaa acattaagat
     1561 gtaccagcca ctccttgctg ttggtacgag taacggttct gtcctggtgt accacctcac
     1621 cagtggcctg ctgcacaagg agctcagtgt ccactcgtgt gaagtcaagg gtattgaatg
     1681 gacaagcttg accagtttcc tttcttttgc tgcttcgacc ccaaacaaca tggggttagt
     1741 aagaaatgaa cttcagctgg ttgatctccc aacagggagg agcactgctt tccgtggtga
     1801 ccggggcaat gacgaatcac ccattgaaat gatcaaagtg tctcatctga aacagtattt
     1861 ggcagttgtt ttcaaagata agcccctgga attatgggat attagaactt gcactcttct
     1921 tagagaaatg tctaaaagtt tccctgctat aactgcattg gagtggtcac catctcacaa
     1981 cctgaagagc ctgagaaaga agcagcttgc cacccgggag gccatggccc gccagactgt
     2041 ggtctccgat gcagagctgg gtgctgttga atcatctgtg atcagtttat tacaggaggc
     2101 agagagtaag gctgaactca gtcagaacat ctctgctcgg gagcattttg tgtttactga
     2161 caatgatggc caagtttatc atctcactgt tgaaggaaat tctgtgaaag acagtgctcg
     2221 gattccacca gatggtagca tgggcagtat tacctgcatc gcttggaagg gggatacatt
     2281 agtgcttgga gatatggatg gaaatttaaa cttctgggat ttgaaagcca gagtatccag
     2341 aggaataccc acacatagaa gttgggtgag gaagattcgc tttgcccccg gcaagggaaa
     2401 ccagaagcta atagcaatgt ataatgatgg tgctgaagtg tgggatacta aagaggttca
     2461 gatggtgagc agtttaagaa gtggaagaaa tgtaaccttc cggattttgg atgtggactg
     2521 gtgcacatca gataaggtga tcttggcatc tgatgacggc tgcatcagag tcctggagat
     2581 gtcaatgaag tctacgtgtt tcagaatgga tgagcaggag ttagtagagc ctgtgtggtg
     2641 cccgtacctc cttgttccga gggctgccct tgctttgaaa gccttcctac tgcatcagcc
     2701 ttggaatggg cgatattcgt tggacatttc tcacattgat tatccagaaa atgaagaaat
     2761 aaagactctc cttcaagaac agttgcatgc attgtctaac gacataaaga aactcctgct
     2821 tgatcccgac ttctctctct tgcagaggtg cctgctcgtg tccaggctgt acggcgatga
     2881 atcggagctg cacttctgga cagtggcggc ccactacctg cacagcttgt cccaggccaa
     2941 gtctggggac acagtggtaa ccaaggaagg tgctcctaag gacaggctga gcaacccatt
     3001 ggacatctgc tacgatgtgc tctgtgagaa cacctacttc cagaaatttc agctagaaag
     3061 agttaatcta caggaagtaa aacggtcaac ttatgatcac acgagaaagt gcacagacca
     3121 gctcctgctg ctaggccaga cagacagagc tgtgcagctg ctgttggaaa caagtgcaga
     3181 taaccagcac tactactgcg actctctgaa agcttgcttg gtcaccactg tcacctcttc
     3241 aggcccttct cagagcacaa ttaagctggt agcaaccaat atgatcgcca atggcaagct
     3301 ggcagagggt gttcagttac tctgcttgat agacaaggct gcggacgcct gtcgctacct
     3361 gcagacgtat ggcgagtgga atcgggcggc atggcttgca aaggttcggt taaattctga
     3421 agaatgtgca gatgttctga agcggtgggt tgaccacctt tgttctccac aagtcaacca
     3481 gaagtccaag gccctcctgg tcctcctctc tctgggttgc tttgtcagcg tggcagagac
     3541 gcttcacagc atgagatact tcgatagagc tgccttgttt gtggaagcct gtctcaagta
     3601 cggtgcattt gaagtcagtg aggacacaga gaagctcatt gctgccatct acgcagacta
     3661 tgcccggagc ctgaagagcc tcggctttag acagggagca gtgcgttttg cttcaaaagc
     3721 tggagcggct ggcagagatt tgttgaatga gcttgggtcc accaaggaag agctaacgga
     3781 aagttgacag gctccgcgca ggaatctgat gtcggaagcg aggggtgagg agagctgacc
     3841 tggctgtgct cctggtcaca gctatggtca gtccagacct gcgtgagggc ttggcccttg
     3901 ttagctgtga caccaccttc ttaagttcga aggtgctcag cagcataggc ccatacacta
     3961 ggagccagtt ctgtgtccca ggtgacctca aaatggggac acatagtggg aaagtatatg
     4021 gtatttatac tttggaaagt gcttttaaga tctctgtgaa tacttttcaa tttttgtaac
     4081 ttaaaaattc aaaaaactga attactgtcc tttctcatta gctattttga agatgtttaa
     4141 gaaatctgtg gcaagagatg gggcttctga tggattttca gatatgtgct gtgtgtgcct
     4201 gtgttgataa gcagtcattt aggacacagc agggcagaag catttgacca accacagcac
     4261 ctcttttctt gaggacgtgg tggattcttt gctttagaca ttgctgaact ttgtatttgg
     4321 ggctcatagt cttcatggag cacgtctaag cttaatgttt agcgtccgtg gtctctgatg
     4381 gtctgaattt taactcccag gatatgttcc agaaacctca tttctgaagc ctctttgtac
     4441 atttcccacc tttgttttct tccactagat gtaattatta taaattatta ctcagaactt
     4501 aaacatctgt gactataaaa atgataaata aaggaaaatc ccagccaaga aaaaaaaaaa
     4561 aaaaaa
//
