LOCUS       NM_011715               2989 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus WD repeat domain 1 (Wdr1), mRNA.
ACCESSION   NM_011715
VERSION     NM_011715.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2989)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2989)
  AUTHORS   Hu,J., Pi,S., Xiong,M., Liu,Z., Huang,X., An,R., Zhang,T. and
            Yuan,B.
  TITLE     WD Repeat Domain 1 Deficiency Inhibits Neointima Formation in Mice
            Carotid Artery by Modulation of Smooth Muscle Cell Migration and
            Proliferation
  JOURNAL   Mol Cells 43 (8), 749-762 (2020)
   PUBMED   32868491
  REMARK    GeneRIF: WD Repeat Domain 1 Deficiency Inhibits Neointima Formation
            in Mice Carotid Artery by Modulation of Smooth Muscle Cell
            Migration and Proliferation.
REFERENCE   3  (bases 1 to 2989)
  AUTHORS   Wang,J., Kou,X.L., Chen,C., Wang,M., Qi,C., Wang,J., You,W.Y.,
            Hu,G., Chen,J. and Gao,J.
  TITLE     Hippocampal Wdr1 Deficit Impairs Learning and Memory by Perturbing
            F-actin Depolymerization in Mice
  JOURNAL   Cereb Cortex 29 (10), 4194-4207 (2019)
   PUBMED   30590446
  REMARK    GeneRIF: Hippocampal Wdr1 Deficit Impairs Learning and Memory by
            Perturbing F-actin Depolymerization in Mice.
REFERENCE   4  (bases 1 to 2989)
  AUTHORS   Koopmans,F., van Nierop,P., Andres-Alonso,M., Byrnes,A.,
            Cijsouw,T., Coba,M.P., Cornelisse,L.N., Farrell,R.J.,
            Goldschmidt,H.L., Howrigan,D.P., Hussain,N.K., Imig,C., de
            Jong,A.P.H., Jung,H., Kohansalnodehi,M., Kramarz,B., Lipstein,N.,
            Lovering,R.C., MacGillavry,H., Mariano,V., Mi,H., Ninov,M.,
            Osumi-Sutherland,D., Pielot,R., Smalla,K.H., Tang,H., Tashman,K.,
            Toonen,R.F.G., Verpelli,C., Reig-Viader,R., Watanabe,K., van
            Weering,J., Achsel,T., Ashrafi,G., Asi,N., Brown,T.C., De
            Camilli,P., Feuermann,M., Foulger,R.E., Gaudet,P., Joglekar,A.,
            Kanellopoulos,A., Malenka,R., Nicoll,R.A., Pulido,C., de
            Juan-Sanz,J., Sheng,M., Sudhof,T.C., Tilgner,H.U., Bagni,C.,
            Bayes,A., Biederer,T., Brose,N., Chua,J.J.E., Dieterich,D.C.,
            Gundelfinger,E.D., Hoogenraad,C., Huganir,R.L., Jahn,R.,
            Kaeser,P.S., Kim,E., Kreutz,M.R., McPherson,P.S., Neale,B.M.,
            O'Connor,V., Posthuma,D., Ryan,T.A., Sala,C., Feng,G., Hyman,S.E.,
            Thomas,P.D., Smit,A.B. and Verhage,M.
  TITLE     SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the
            Synapse
  JOURNAL   Neuron 103 (2), 217-234 (2019)
   PUBMED   31171447
REFERENCE   5  (bases 1 to 2989)
  AUTHORS   Huang,X., Li,Z., Hu,J., Yang,Z., Liu,Z., Zhang,T., Zhang,C. and
            Yuan,B.
  TITLE     Knockout of Wdr1 results in cardiac hypertrophy and impaired
            cardiac function in adult mouse heart
  JOURNAL   Gene 697, 40-47 (2019)
   PUBMED   30794912
  REMARK    GeneRIF: Findings demonstrate that WDR1 is a critical factor for
            normal structure and function of adult mouse heart.
REFERENCE   6  (bases 1 to 2989)
  AUTHORS   Yu,X., Bauer,K., Koczan,D., Thiesen,H.J. and Ibrahim,S.M.
  TITLE     Combining global genome and transcriptome approaches to identify
            the candidate genes of small-effect quantitative trait loci in
            collagen-induced arthritis
  JOURNAL   Arthritis Res Ther 9 (1), R3 (2007)
   PUBMED   17244351
REFERENCE   7  (bases 1 to 2989)
  AUTHORS   Kile,B.T., Hentges,K.E., Clark,A.T., Nakamura,H., Salinger,A.P.,
            Liu,B., Box,N., Stockton,D.W., Johnson,R.L., Behringer,R.R.,
            Bradley,A. and Justice,M.J.
  TITLE     Functional genetic analysis of mouse chromosome 11
  JOURNAL   Nature 425 (6953), 81-86 (2003)
   PUBMED   12955145
REFERENCE   8  (bases 1 to 2989)
  AUTHORS   Hurle,B., Ignatova,E., Massironi,S.M., Mashimo,T., Rios,X.,
            Thalmann,I., Thalmann,R. and Ornitz,D.M.
  TITLE     Non-syndromic vestibular disorder with otoconial agenesis in
            tilted/mergulhador mice caused by mutations in otopetrin 1
  JOURNAL   Hum Mol Genet 12 (7), 777-789 (2003)
   PUBMED   12651873
REFERENCE   9  (bases 1 to 2989)
  AUTHORS   Hurle,B., Lane,K., Kenney,J., Tarantino,L.M., Bucan,M.,
            Brownstein,B.H. and Ornitz,D.M.
  TITLE     Physical mapping of the mouse tilted locus identifies an
            association between human deafness loci DFNA6/14 and vestibular
            system development
  JOURNAL   Genomics 77 (3), 189-199 (2001)
   PUBMED   11597144
REFERENCE   10 (bases 1 to 2989)
  AUTHORS   Adler,H.J., Winnicki,R.S., Gong,T.W. and Lomax,M.I.
  TITLE     A gene upregulated in the acoustically damaged chick basilar
            papilla encodes a novel WD40 repeat protein
  JOURNAL   Genomics 56 (1), 59-69 (1999)
   PUBMED   10036186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084322.18 and AC171271.4.
            
            On May 12, 2018 this sequence version replaced NM_011715.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004858.1, AK169835.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC084322.18        40617-40800         c
            185-306             AC084322.18        40181-40302         c
            307-397             AC171271.4         3517-3607
            398-545             AC171271.4         7893-8040
            546-726             AC171271.4         9130-9310
            727-804             AC171271.4         14106-14183
            805-885             AC171271.4         14400-14480
            886-1119            AC171271.4         14738-14971
            1120-1207           AC171271.4         17758-17845
            1208-1364           AC171271.4         19644-19800
            1365-1452           AC171271.4         21413-21500
            1453-1563           AC171271.4         23859-23969
            1564-1737           AC171271.4         24874-25047
            1738-1882           AC171271.4         25315-25459
            1883-2989           AC171271.4         27072-28178
FEATURES             Location/Qualifiers
     source          1..2989
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 20.63 cM"
     gene            1..2989
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /note="WD repeat domain 1"
                     /db_xref="GeneID:22388"
                     /db_xref="MGI:MGI:1337100"
     exon            1..184
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1989
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /note="actin-interacting protein 1; WD40 repeat protein 1"
                     /codon_start=1
                     /product="WD repeat-containing protein 1"
                     /protein_id="NP_035845.1"
                     /db_xref="CCDS:CCDS51485.1"
                     /db_xref="GeneID:22388"
                     /db_xref="MGI:MGI:1337100"
                     /translation="MPYEIKKVFASLPQVERGVSKILGGDPKGDHFLYTNGKCVILRN
                     IDNPAIADIYTEHAHQVVVAKYAPSGFYIASGDISGKLRIWDTTQKEHLLKYEYQPFA
                     GKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDTGSSVGEITGHNKVINSVDIKQTRPY
                     RLATGSDDNCAAFFEGPPFKFKFTIGDHSRFVNCVRFSPDGNRFATASADGQIFIYDG
                     KTGEKVCALGESKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVNVNSVVSTFPMGS
                     NVLDQQLGCLWQKDHLLSISLSGYINYLDKNNPSKPLRVIKGHSKSIQCLTVHRNGGK
                     SYIYSGSHDGHINYWDSETGENDSFSGKGHTNQVSRMTVNESEQLVSCSMDDTVRYTN
                     LTLRDYSGQGVVKLDVQPKCVAVGPGGYTVVVCIGQIVLLKDQKKCFSIDNPGYEPEV
                     VAVHPGGDTVAVGGTDGNVRVYSILASTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCD
                     ASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPET
                     KVKIQDAHRLHHVSSLAWLDEHTLVTTSHDASVKEWTITY"
     exon            185..306
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            307..397
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            398..545
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            546..726
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            727..804
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            805..885
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1119
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            1120..1207
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1364
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            1365..1452
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1563
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            1564..1737
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1882
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     exon            1883..2989
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2822..2827
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /note="hexamer: ATTAAA"
     polyA_site      2842
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /note="major polyA site"
     regulatory      2962..2967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /note="hexamer: ATTAAA"
     polyA_site      2982
                     /gene="Wdr1"
                     /gene_synonym="Aip1; D5Wsu185e; rede"
                     /note="major polyA site"
ORIGIN      
        1 gggttgtccg cagcggtagc gcgcggggca ggcgcgtacg ggtctcggag ccgggtctcg
       61 gaccgccccc tccgcgcccg gcacgcccgg cgccgccttc cgcgctgtcc ctgggctcgg
      121 ccactgcgag gttccactcg agcgcagcgc cgtaacaagt gggcgaggat gccgtacgag
      181 atcaagaagg tgttcgccag cctcccccag gtggagcggg gcgtctctaa gatcctcggt
      241 ggagacccca agggcgatca tttcctctac accaatggca agtgcgtcat cctaagaaac
      301 atcgataacc ctgctattgc tgatatctac acagaacatg cccatcaagt ggtagtagcc
      361 aagtatgcac ccagcggatt ctacattgct tctggagaca tctctgggaa gctaaggatc
      421 tgggatacca cacagaagga gcatcttcta aagtatgagt accagccttt cgctgggaag
      481 atcaaggaca ttgcctggac ggaagacagt aagaggatcg ccgtggtcgg ggaaggaagg
      541 gagaagtttg gagctgtctt cttatgggac actggctctt ctgtgggtga gatcacagga
      601 cacaacaaag tcatcaacag tgtggacata aagcagacca ggccctaccg actagcaaca
      661 gggagtgatg ataactgtgc tgcgttcttc gagggccctc cattcaagtt caagttcaca
      721 attggtgacc acagccgctt tgtcaactgt gtgcgattct ctcctgatgg gaacagattt
      781 gccacagcta gcgctgatgg ccagattttc atttatgatg ggaagacggg agagaaggtg
      841 tgtgcccttg gagaaagcaa ggcccatgat ggaggaattt atgccattag ttggagtcct
      901 gatagcactc atttgctatc tgcctctgga gacaaaacct ctaagatttg ggatgtcaat
      961 gtaaactctg tggtcagcac gtttcccatg ggctccaatg ttctggacca gcagctgggc
     1021 tgcctctggc agaaggacca cctcctcagc atctccctgt ctggatacat caactacctg
     1081 gacaagaaca accccagcaa acccctccgg gtcatcaagg gtcacagtaa atccatccag
     1141 tgtctgaccg tgcacagaaa tggtggcaag tcctacatct attctgggag ccatgatgga
     1201 catatcaatt actgggattc agagacagga gagaatgact ccttctctgg aaaaggccac
     1261 acaaatcagg tgtccaggat gactgtgaat gagtctgagc agttggtcag ctgcagcatg
     1321 gatgacacag tgcggtacac caacctcaca ctgagggact acagtggaca aggcgttgtg
     1381 aaactggatg ttcaaccaaa gtgtgtagct gttggccctg ggggatatac tgtggtcgtg
     1441 tgcattggac agattgtcct tctgaaggac cagaagaagt gcttcagcat cgacaaccct
     1501 ggctacgagc ctgaagtcgt cgctgtgcac cctggtgggg acacagtggc tgttggtggc
     1561 acggatggca atgtgcgtgt gtactccatc ctggcctcca cactaaagga tgaaggcaaa
     1621 ctcctagagg ccaagggacc agtaacagac gtggcctact ctcatgatgg tgccttcctg
     1681 gctgtgtgtg atgccagcaa ggtggtcaca gtattcagtg tagctgatgg ctattcggag
     1741 aataatgttt tttatggaca ccatgcaaaa attgtgtgcc tggcctggtc accagataat
     1801 gaacactttg cctctggcgg catggatatg atggtgtacg tctggacgct gagtgaccca
     1861 gagaccaaag tcaagatcca agatgctcac cggctgcacc acgtcagcag cctggcctgg
     1921 ctagacgaac acacactggt caccacctcc catgacgcct ctgtgaagga gtggacaatc
     1981 acctactgag gacgccgctc accccaagga ccgaatcagg gactagagtt taactgcctc
     2041 agagcaccct tctcttaact atttctctaa cgctcccctt cctgcctgct ctgggagtag
     2101 ggagggccta cgagtaccct cctctcttca gggtgtccgt gtctgtacgc gtccttctga
     2161 gagctttaga cagttacagt ttgcacatga gaaataaagc aagcacttaa acagcatgtg
     2221 gagcgtacct aaaaccttac agcccaccag accatgagag cgtggaacat tccagaggca
     2281 gcagcctcca aagcacagac ccaagcccct gtggctcttg cagcttctca ggaggctggg
     2341 tagggagcag gccagggctc cccttcccca tgcaggatgc atttgcactg gagaggagga
     2401 gccgctctac agccgccagc attctgtgta gagcaggtct gtttctcggt gtaagtcatg
     2461 tcacatggct gcctccctgg acccatcccc agatcccatg gggacatgtg aaccttgatc
     2521 tcattgtcag attttgtgct tgatttttaa gaatggaatc atgggaattt ttttcttttt
     2581 ttttttttaa tgtatcttga ctgttgtctg tcttgttcct gacctggcac gctgacagta
     2641 ccttgtccag ataagtagag cccttgttag ccagactgag gtgtcctggt cacgtgatta
     2701 ccatgcttca gtgtttccct gtctcttccc aactctggcc ccaagagcag agattaagga
     2761 caagaagatg ttactgtaat ttgtcatgtt tttacctttt tttttctttt tcagtgcaga
     2821 aattaaagta agtataaagc cccgtgattg gcagtttctt tgcgtgtgtc ggaatcactg
     2881 gtaaatgttg gctgagaaca atccctcccc ttgcacttgt gaaaacactt tgaacgcttt
     2941 aagagattag actgagaaat aattaaatat cttttctctt gattgtgga
//
